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  1. Mar 2019
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection. - PubMed - NCBI
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    1. Drugs_and_Ethics 16 Mar 2019
      CONCLUSION: Tolerance to famotidine occurs during continuous administration for 14 days, as previously shown in ranitidine studies.

      This is good for my purposes. It means high doses can be taken for brain effects without disturbing stomach acidity. The question remains, of course, whether coinciding CNS tolerance develops.

      H2 histamine receptor antihistamine famotidine drug tolerance
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    ncbi.nlm.nih.gov/pubmed/12753150