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  1. Mar 2019
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection. - PubMed - NCBI
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    1. Drugs_and_Ethics 16 Mar 2019
      CONCLUSION: Tolerance to famotidine occurs during continuous administration for 14 days, as previously shown in ranitidine studies.

      This is good for my purposes. It means high doses can be taken for brain effects without disturbing stomach acidity. The question remains, of course, whether coinciding CNS tolerance develops.

      H2 histamine receptor antihistamine famotidine drug tolerance
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    ncbi.nlm.nih.gov/pubmed/12753150
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. - PubMed - NCBI
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    1. Drugs_and_Ethics 16 Mar 2019
      We have previously shown that antinociceptive effects of morphine are enhanced in histamine H1 receptor gene knockout mice.

      H1 antihistamines enhance the opioid high in humans. Hospitals sometimes administer antihistamines in combination with opioids. It's not hard to find people online who are using this combination recreationally.

      H2 histamine receptor H1 histamine receptor antihistamine opioid histamine knockout gene analgesia mouse study drug combination agonist antagonist
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    ncbi.nlm.nih.gov/pubmed/16806305