- Jul 2021
Collectively, these results indicate that mirtazapine may help to maintain abstinence in opioid dependent patients.
I concur. This merits human analysis. I'd be curious to know the subjective effects of combining the two. In particular, I'm wondering if mirtazapine reduces "wanting" while enhancing "liking".
The main reason I'd been thinking this is due to comparison to similar drug combos in humans. I'd heard that combining hydroxyzine and opioids was sometimes prescribed to enhance the effectiveness of opioids and/or use lower opioid doses; I'd also read on some harm reduction forum that some people enjoy combining opioids with antihistamines. Given that mirtazapine is to a large extent just hydroxyzine but with added adrenergic effects, it seems likely that much of these data can be cross-applied (between mirtazapine and hydroxyzine in particular).