5 Matching Annotations
  1. Dec 2020
    1. The 5-HT2 antagonists reportedly produce a paradoxical down-regulation of 5-HT2 binding sites upon chronic treatment, rather than the expected supersensitivity. Chronic treatment with ritanserin (2.5 mg/kg/day for 7 days), but not mianserin (same regimen), attenuated a QMWS 24 h after the final injection, thus supporting with a functional measure, the down-regulation of such binding sites by ritanserin.

      Are they saying that mianserin did not downregulate the receptors? That's what it sounds like. Most likely this is just because it is a weaker antagonist than ritanserin.

  2. Nov 2020
    1. Rosemary enhanced the protective efficacy of AREDS and led to the greatest effect on the retinal genome in animals reared in high environmental light. Chronic administration of rosemary antioxidants may be a useful adjunct to the therapeutic benefit of AREDS in slowing disease progression in AMD.

      This is not in the least surprising. Dietary antioxidants also protect the skin during sunlight exposure.

      Oxidative stress likely also plays a role in diabetic retinopathy. It plays a role in the aging process itself. That said, there is probably a limit to protective powers of antioxidants. Nonetheless, I don't think that that limit has ever been realized in any population. I doubt we've even come close in rats.

  3. Oct 2020
    1. Cognitive Presence “is the extent to which learners are able to construct and confirm meaning through sustained reflection and discourse” (Community of Inquiry, n.d, para. 5). Video is often used as a unidirectional medium with information flowing from the expert or instructor to the learner. To move from transmission of content to construction of knowledge, tools such as Voice Thread (VoiceThread, 2016) support asynchronous conversation in a multimedia format.

      The author, Kendra Grant, is the Director of Professional Development and Learning for Quillsoft in Toronto Canada. Grant helps business succeed in education design and support. In this article Grant discusses how quickly the learning environment has changed through technological development. Grant explores the RAT Model, which guides instructors in the "use of technology to help transform instructional practice." Grant then examines the Community of Inquiry model, which seeks to create meaningful instruction through social, cognitive and teaching presence. Grant concludes by providing general principles for creating a positive video presence.

      Rating: 8/10

  4. Aug 2020
    1. The RAT model sees software development as an off-line program-construction activity composed of these parts: defining, decomposing, estimating, implementing, assembling, and finishing

      This is what can lead to the 'there is only version 1.0' problem - and improvements / iterations fall to the sidelines.

      This can have a number of consequences

      • over designed / engineered
      • doing unnecessary work
      • lack of user feedback and ability to accommodate it
      • rigid / fragile architecture
  5. Feb 2018