19 Matching Annotations
  1. Nov 2020
    1. Big corporations have been doing this for a while. In 1027, after Trump implemented the travel ban on people coming from countries that sponsor terrorism, Airbnb responded with an ad during the Super Bowl called “We Accept.” It featured people of different nationalities and declared, “We believe no matter who you are, where you’re from, who you love or who you worship, we all belong. The world is more beautiful the more you accept.”

      AirBnB ostensibly failed to realize that if you accept unacceptance, you're shooting yourself in the foot.

  2. Oct 2020
    1. Cessation of nitrous oxide resulted in characteristic convulsions similar to those seen in alcohol withdrawal in all mice.

      This demonstrates that tolerance is possible. However, exposure in humans lasts only several minutes at a time. Let's assume 3 exposures per day lasting 10 minutes each (i.e. 30 minutes total). It would take 68 days to reach 34 hours of exposure. Alternatively, that's a ratio of 1 to 47 exposure to non-exposure. It's unclear whether that would be sufficient for tolerance.

      In the 50% exposure group, convulsion score was effectively zero by hour 6 (from full text). This does not mean that withdrawal symptoms were gone. However, it does imply that recovery is rapid. It seems plausible that 20 hours between doses is sufficient to reach baseline, rendering tolerance in humans extremely unlikely. I will need to compare to alcohol withdrawal to confirm.

      Edit: Alcohol withdrawal in mice can be induced with 72 hours of alcohol exposure. That implies it is similar to NO. In humans, "the shakes" appear to last 1 or two weeks. In mice, convulsions appear to be half gone in 25 hours, suggesting that they last a few days. Thus, it appears that NO withdrawal is possibly an order of magnitude shorter than alcohol withdrawal.

      In conclusion, NO used in a normal fashion is unlikely to be harmful (except for risk of inducing B12 deficiency). Even if it is harmful, the short half life means that it will be apparent very quickly. I'm aware of several reports of B12 deficiency from NO abuse, but I haven't seen any reports of withdrawal symptoms.

  3. Sep 2020
  4. Aug 2020
  5. May 2020
    1. While somewhat modest in size, the literature on chronic tolerance to nicotine in humans is reasonably consistent in showing clear evidence of tolerance to subjective mood effects but little or no tolerance to cardiovascular, performance or other nicotine effects

      This is what I'd expect for tobacco, but it tells me little about nicotine. Most of the subjective effects are not from tobacco, so It's still plausible that nicotine does not develop tolerance. Indeed, the effects that don't go away are the effects expected from nicotine.

  6. Oct 2019
    1. “Under 'zero tolerance' — which is the reason they are separating families in the first place

      "Zero Tolerance" its main goal is to deter and punish at a very high cost the families that are seeking a safe place to live. to send a message to those who are contemplating to come to the US to stop or they will take their children.

  7. May 2019
  8. Mar 2019
    1. Das sei, sagt Schaal, nichts anderes, als mit den Emotionen anderer nüchtern und sachlich umgehen zu lernen. Dazu gehöre, die Weltbilder der anderen nicht pauschal als verrückt zu diffamieren, sondern sich in „Frustrationstoleranz zu üben“, wie er es nennt.
    1. CONCLUSION: Tolerance to famotidine occurs during continuous administration for 14 days, as previously shown in ranitidine studies.

      This is good for my purposes. It means high doses can be taken for brain effects without disturbing stomach acidity. The question remains, of course, whether coinciding CNS tolerance develops.

  9. Jan 2019
    1. inverse agonist activity was not required for mu-opioid receptor up-regulation and supersensitivity.

      The question, then, is whether the opioid receptors are involved at all in this upregulation. For example, it could be mediated by TLR4 or filamin A.

    1. . Ultra-low doses of opioid antagonists (naloxone and naltrexone), which selectively inhibit the excitatory effects

      I would not expect doses this small to impact the opioid receptors.

    1. Treatment effects were more pronounced at discharge

      Symptoms in the treatment group continually improved, whereas symptoms in the placebo group plateaued. Thus, I'm interested in seeing a longer treatment period. Projecting from symptom scores, elimination of symptoms would occur in about 10 days.

    1. Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

      I've found elsewhere that mu agonism combined with delta antagonism provides analgesia while minimizing tolerance.

  10. Nov 2018
    1. Nimodipine controlled the escalation of the morphine dose in 9 patients (65%), and placebo in 4 (28%), the difference being statistically significant (P=0.03). The dose of morphine was reduced from 313±52 to 174±33 mg/day (P<0.001) in the nimodipine group, and from 254±26 to 218±19 mg/day (not significant) in the placebo group.

      Nimodipine reduced morphine dose in already tolerant patients.

  11. Sep 2017
    1. This book is not about religion, although I talk about religion. It's about religious tolerance and the fight for human rights; the first battlefront in public discourse about human rights.

      Freedom of religion was the first base upon which other understandings of freedom have been built upon.

    2. This is the story of 16th century Europe, and the political earthquake that was protestantism. The overarching historical narrative unfolds around the lives of fictional characters who might have lived in this historic period.

      Follett's literary reenactment explores the intricacies of the Protestant Reformation through a cast of strategically diverse characters, whose stories span across multiple continents, nations, and cities. Each character is an important harbinger of larger historical trends. Within the masterfully established geo-political reality, each of their decisions serve to gradually reveal their distinct personalities and temperaments, belief systems and ideologies, and cultural identities.

    3. The real enemies, then as now, are not the rival religions. The true battle pitches those who believe in tolerance and compromise against the tyrants who would impose their ideas on everyone else—no matter what the cost.

      Reminiscent of our current geo-political climate. The extended cycles of history.

  12. Nov 2016
  13. Jun 2015
    1. Most people reading this will already be fairly tolerant. But there is a step beyond thinking of yourself as x but tolerating y: not even to consider yourself an x. The more labels you have for yourself, the dumber they make you.

      The only counter-argument that comes to mind for me didn't form itself until I had read this last paragraph a few times.

      If your identity marker connotes tolerance then it hopefully has the opposite effect. Insofar as the experience of marginalization promotes empathy such identities might be good evidence for intelligence, and I do think individuals who feel oppressed or marginalized tend to empathize with others who suffer for different, marginalized identities.

      These identities will only breed stupidity if the individual feels a competition for scarce resources that overwhelms their empathy, whence the perniciousness of the belief in zero sum attention economics as a greater threat to activism than inaction, ignorance, and exhaustion.