13 Matching Annotations
  1. May 2019
  2. Mar 2019
    1. Das sei, sagt Schaal, nichts anderes, als mit den Emotionen anderer nüchtern und sachlich umgehen zu lernen. Dazu gehöre, die Weltbilder der anderen nicht pauschal als verrückt zu diffamieren, sondern sich in „Frustrationstoleranz zu üben“, wie er es nennt.
    1. CONCLUSION: Tolerance to famotidine occurs during continuous administration for 14 days, as previously shown in ranitidine studies.

      This is good for my purposes. It means high doses can be taken for brain effects without disturbing stomach acidity. The question remains, of course, whether coinciding CNS tolerance develops.

  3. Jan 2019
    1. inverse agonist activity was not required for mu-opioid receptor up-regulation and supersensitivity.

      The question, then, is whether the opioid receptors are involved at all in this upregulation. For example, it could be mediated by TLR4 or filamin A.

    1. . Ultra-low doses of opioid antagonists (naloxone and naltrexone), which selectively inhibit the excitatory effects

      I would not expect doses this small to impact the opioid receptors.

    1. Treatment effects were more pronounced at discharge

      Symptoms in the treatment group continually improved, whereas symptoms in the placebo group plateaued. Thus, I'm interested in seeing a longer treatment period. Projecting from symptom scores, elimination of symptoms would occur in about 10 days.

    1. Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

      I've found elsewhere that mu agonism combined with delta antagonism provides analgesia while minimizing tolerance.

  4. Nov 2018
    1. Nimodipine controlled the escalation of the morphine dose in 9 patients (65%), and placebo in 4 (28%), the difference being statistically significant (P=0.03). The dose of morphine was reduced from 313±52 to 174±33 mg/day (P<0.001) in the nimodipine group, and from 254±26 to 218±19 mg/day (not significant) in the placebo group.

      Nimodipine reduced morphine dose in already tolerant patients.

  5. Sep 2017
    1. This book is not about religion, although I talk about religion. It's about religious tolerance and the fight for human rights; the first battlefront in public discourse about human rights.

      Freedom of religion was the first base upon which other understandings of freedom have been built upon.

    2. This is the story of 16th century Europe, and the political earthquake that was protestantism. The overarching historical narrative unfolds around the lives of fictional characters who might have lived in this historic period.

      Follett's literary reenactment explores the intricacies of the Protestant Reformation through a cast of strategically diverse characters, whose stories span across multiple continents, nations, and cities. Each character is an important harbinger of larger historical trends. Within the masterfully established geo-political reality, each of their decisions serve to gradually reveal their distinct personalities and temperaments, belief systems and ideologies, and cultural identities.

    3. The real enemies, then as now, are not the rival religions. The true battle pitches those who believe in tolerance and compromise against the tyrants who would impose their ideas on everyone else—no matter what the cost.

      Reminiscent of our current geo-political climate. The extended cycles of history.

  6. Nov 2016
  7. Jun 2015
    1. Most people reading this will already be fairly tolerant. But there is a step beyond thinking of yourself as x but tolerating y: not even to consider yourself an x. The more labels you have for yourself, the dumber they make you.

      The only counter-argument that comes to mind for me didn't form itself until I had read this last paragraph a few times.

      If your identity marker connotes tolerance then it hopefully has the opposite effect. Insofar as the experience of marginalization promotes empathy such identities might be good evidence for intelligence, and I do think individuals who feel oppressed or marginalized tend to empathize with others who suffer for different, marginalized identities.

      These identities will only breed stupidity if the individual feels a competition for scarce resources that overwhelms their empathy, whence the perniciousness of the belief in zero sum attention economics as a greater threat to activism than inaction, ignorance, and exhaustion.