8 Matching Annotations
  1. Apr 2021
    1. Conclusion: Our data suggest that the combination of VLF with morphine may be a relevant therapeutic implication to manage pain even when tolerance to morphine exists. Moreover, our data demonstrates the involvement of L-Arg/NO/cGMP pathway in the prevention of morphine tolerance and dependence by venlafaxine.

      It's not clear if this has relevance to the subjective effects. I'm starting to think that I won't get an answer anytime soon.

    1. Results: The administration of sildenafi l reduced all of the morphine withdrawal symptoms.

      An acute effect. Interesting but not particularly consequential. It does mean, however, that I need to be wary of studies using withdrawal as a netric when combining PDE5 inhibitors with opioids.

    1. These results suggest that the elevation of the cyclic AMP levels is involved in the development of morphine withdrawal syndrome and that blockade of the morphine-induced reduction of cyclic AMP levels by chronic rolipram inhibits the development of dependence and the behavioural and biochemical changes induced by naloxone. Furthermore, rolipram may be a useful drug for attenuating the development of morphine dependence.

      Excellent. This implies that theobromine may help prevent opioid tolerance.

  2. Nov 2020
  3. Jul 2020
  4. Apr 2019
    1. A Discussion on Solving Partial Differential Equations using Neural Networks

      有不少 insight 的讨论,如 Benefits and drawbacks of solving partial differential equations with neural networks:

    2. Augmented Neural ODEs

      神经常微分方程无法表示某些简单函数,本文提出更具表现力的增强神经ODE,可有效降低计算成本、改善泛化性

  5. Nov 2018
    1. Forward-Backward Stochastic Neural Networks: Deep Learning of High-dimensional Partial Differential Equations

      惊艳到了~~ 又一篇关于求解偏微分方程的~ 拿来好好读读

      Paper Summary