- Apr 2021
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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Conclusion: Our data suggest that the combination of VLF with morphine may be a relevant therapeutic implication to manage pain even when tolerance to morphine exists. Moreover, our data demonstrates the involvement of L-Arg/NO/cGMP pathway in the prevention of morphine tolerance and dependence by venlafaxine.
It's not clear if this has relevance to the subjective effects. I'm starting to think that I won't get an answer anytime soon.
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www.psicothema.es www.psicothema.es
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Results: The administration of sildenafi l reduced all of the morphine withdrawal symptoms.
An acute effect. Interesting but not particularly consequential. It does mean, however, that I need to be wary of studies using withdrawal as a netric when combining PDE5 inhibitors with opioids.
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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These results suggest that the elevation of the cyclic AMP levels is involved in the development of morphine withdrawal syndrome and that blockade of the morphine-induced reduction of cyclic AMP levels by chronic rolipram inhibits the development of dependence and the behavioural and biochemical changes induced by naloxone. Furthermore, rolipram may be a useful drug for attenuating the development of morphine dependence.
Excellent. This implies that theobromine may help prevent opioid tolerance.
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- Nov 2020
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www.plymouth.edu www.plymouth.edu
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phosphodiesterase
Known as PDE is an enzyme that helps break down the phosphodiester bonds.
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- Jul 2020
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Di Lauro, F., Croix, J.-C., Berthouze, L., & Kiss, I. (2020). PDE-limits of stochastic SIS epidemics on networks. ArXiv:2007.01043 [Physics, q-Bio]. http://arxiv.org/abs/2007.01043
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- Apr 2019
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iphysresearch.github.io iphysresearch.github.io
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A Discussion on Solving Partial Differential Equations using Neural Networks
有不少 insight 的讨论，如 Benefits and drawbacks of solving partial differential equations with neural networks:
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Augmented Neural ODEs
神经常微分方程无法表示某些简单函数，本文提出更具表现力的增强神经ODE，可有效降低计算成本、改善泛化性
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- Nov 2018
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iphysresearch.github.io iphysresearch.github.io
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Forward-Backward Stochastic Neural Networks: Deep Learning of High-dimensional Partial Differential Equations
惊艳到了~~ 又一篇关于求解偏微分方程的~ 拿来好好读读
Paper Summary
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