3 Matching Annotations
  1. Apr 2021
    1. These results suggest that the elevation of the cyclic AMP levels is involved in the development of morphine withdrawal syndrome and that blockade of the morphine-induced reduction of cyclic AMP levels by chronic rolipram inhibits the development of dependence and the behavioural and biochemical changes induced by naloxone. Furthermore, rolipram may be a useful drug for attenuating the development of morphine dependence.

      Excellent. This implies that theobromine may help prevent opioid tolerance.

    1. Humans can easily digest and excrete methylxanthines, the half life of theobromine being 2-3 hours.

      That is absurdly shorter than other citations. It is almost certainly wrong.

  2. Mar 2021