3 Matching Annotations
  1. Apr 2021
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor
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    1. Drugs_and_Ethics 09 Apr 2021
      These results suggest that the elevation of the cyclic AMP levels is involved in the development of morphine withdrawal syndrome and that blockade of the morphine-induced reduction of cyclic AMP levels by chronic rolipram inhibits the development of dependence and the behavioural and biochemical changes induced by naloxone. Furthermore, rolipram may be a useful drug for attenuating the development of morphine dependence.

      Excellent. This implies that theobromine may help prevent opioid tolerance.

      theobromine opioid tolerance cAMP PDE reverse-tolerance supersensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC1572651/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Chocolate poisoning
    1
    1. Drugs_and_Ethics 09 Apr 2021
      Humans can easily digest and excrete methylxanthines, the half life of theobromine being 2-3 hours.

      That is absurdly shorter than other citations. It is almost certainly wrong.

      theobromine half-life
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    ncbi.nlm.nih.gov/pmc/articles/PMC1215566/
  4. Mar 2021
  5. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Effects of theophylline and theobromine on exercise performance and implications for competition sport: A systematic review
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    1. Drugs_and_Ethics 28 Mar 2021
      theobromine on one

      This review was published recently, so I'm unlikely to find any additional evidence on theobromine and exercise performance.

      theobromine exercise
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    pubmed.ncbi.nlm.nih.gov/33188564/