This demonstrates that tolerance is possible. However, exposure in humans lasts only several minutes at a time. Let's assume 3 exposures per day lasting 10 minutes each (i.e. 30 minutes total). It would take 68 days to reach 34 hours of exposure. Alternatively, that's a ratio of 1 to 47 exposure to non-exposure. It's unclear whether that would be sufficient for tolerance.

In the 50% exposure group, convulsion score was effectively zero by hour 6 (from full text). This does not mean that withdrawal symptoms were gone. However, it does imply that recovery is rapid. It seems plausible that 20 hours between doses is sufficient to reach baseline, rendering tolerance in humans extremely unlikely. I will need to compare to alcohol withdrawal to confirm.

Edit: Alcohol withdrawal in mice can be induced with 72 hours of alcohol exposure. That implies it is similar to NO. In humans, "the shakes" appear to last 1 or two weeks. In mice, convulsions appear to be half gone in 25 hours, suggesting that they last a few days. Thus, it appears that NO withdrawal is possibly an order of magnitude shorter than alcohol withdrawal.

In conclusion, NO used in a normal fashion is unlikely to be harmful (except for risk of inducing B12 deficiency). Even if it is harmful, the short half life means that it will be apparent very quickly. I'm aware of several reports of B12 deficiency from NO abuse, but I haven't seen any reports of withdrawal symptoms.

• Since 2009, alcohol companies have been funding increasingly more research - evidenced by almost 13,500 studies funded by the alcohol industry.
• There are many legitimate fields for research, however there’s a group of these studies that claim health benefits of alcohol, or that substance abuse is a choice.
• Another problem is that the alcohol industry funds this research through affiliate organisations, and the funding source is often not shown in those papers.
• Researchers believe that the alcohol industry is too deeply involved, and certain studies should be conducted by independent academics.

Racine, S. E., Miller, A. E., Mehak, A., & Trolio, V. (2020, September 14). Examining Risk and Protective Factors for Psychological Health during the COVID-19 Pandemic. https://doi.org/10.31234/osf.io/ys8fn

Bar Installs Electric Fence After Customers Fail to Socially Distance. (n.d.). Retrieved 15 July 2020, from https://www.vice.com/en_us/article/g5pdkx/bar-installs-electric-fence-after-customers-fail-to-socially-distance

This minimizes the chances that the benefits are due to abstainer bias. Nonetheless, I'm finding it hard to verify that there are benefits to low dose alcohol.

UCLA Connections—How is the global health crisis impacting alcohol habits/instances of addiction? (2020, May 20). UCLA. https://www.youtube.com/watch?v=t9bW2YnLrDY

This comment, framed as "egregiously offensive, derogatory, and insulting to the furry fandom and our participants", undermines the prevailing sense of identity in the furry fandom. I understand the transformative powers of alcohol, but in my uneducated opinion, it's a stretch that the furry identity for many people is activated by alcohol, and is not something that exists in all states of being (e.g.: sobriety).

Maintaining health and wellbeing during the COVID-19 pandemic | Institute of Psychiatry, Psychology & Neuroscience | King’s College London. https://www.kcl.ac.uk/ioppn/maintaining-health-and-wellbeing-during-the-covid-19-pandemic

McPhee, M., Keough, M. T., Rundle, S., Heath, L. M., Wardell, J., & Hendershot, C. S. (2020). Depression, Environmental Reward, Coping Motives and Alcohol Consumption During the COVID-19 Pandemic [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/zvs9f

Charles, N. E. (2020, June 17). Increased mood disorder symptoms, perceived stress, and alcohol use among college students during the COVID-19 pandemic. https://doi.org/10.31234/osf.io/rge9k

The Lancet Gastroenterology & Hepatology. (2020). Drinking alone: COVID-19, lockdown, and alcohol-related harm. The Lancet Gastroenterology & Hepatology, 5(7), 625. https://doi.org/10.1016/S2468-1253(20)30159-X

The Lancet Public Health, May 2020, Volume 5, Issue 5, Pages e235-e296. https://www.thelancet.com/journals/lanpub/issue/current

Sotis, C. (2020). Health, News and Economic Concerns During COVID-19: A Lotka-Volterra Analysis of Google Trends [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/j9s3h

Clay, J. M., & Parker, M. O. (2020). Alcohol use and misuse during the COVID-19 pandemic: A potential public health crisis? The Lancet Public Health, S2468266720300888. https://doi.org/10.1016/S2468-2667(20)30088-8

Pierz notes that the Ojibwe are shocker actually people,and get corrupted by white vices, like alcohol

PDD-NOS & FASD & related disorders. Is there a connection?

This article discusses the effects of fetal alcohol exposure in adult learning by studying the effects of exercises that stimulates the hippo-campus in the adult rats that were effected by fetal alcohol exposure. The study is entirely based on the scientific research of the neurology of the participants, but provides a course of action that could be applied to human participants as well. The encouraging results indicated that partial restoration of neurological functions in the adult rats was achieved. This inspires hope of introducing exercise to human participants and warrants further exploration of the application to humans since this is not an invasive therapy with low risk to participants. This may also provide some educational changes in special education to include exercise as part of the classroom experience.

RATING: 5/10

Also, the Germans

Behind the WCTU's temperance reform was "protection of the home." The slogan "For God and Home and Native Land" (later changed to "Every Land") expressed the WCTU's priorities. Through education and example the WCTU hoped to obtain pledges of total abstinence from alcohol, and later also tobacco and other drugs. The white ribbon bow was selected to symbolize purity, and the WCTU's watchwords were "Agitate - Educate - Legislate."

I made an earlier note on this, but it really can't be understated how important the Temperance Movement was in the triad of women's movements in 19th Century America. I feel it's overlooked because, unlike slavery and women voting, it's an issue that failed, and we generally support its failure today, but it still had an important role in organizing women in the 19th and early 20th century. Plus, Carrie Nation is one hell of a historical woman that is unfortunately too often overlooked.

What's interesting to me is the general intersection of the lot. The National Parks Service has a chart that shows a general outline of three movements and how leadership worked across them. It's worth taking a moment to look at, especially with the first line in this paragraph and the contemporary reality that many liberal and leftist groups today tend to trip up with intersectionality.

Surely, Gorgias or one of the other Sophists has metaphorically identified Rhetoric and alcohol.

Appealing to the religious integrity of the immigrants may than constitute a way to reduce the sexual violence then.