26 Matching Annotations
  1. Oct 2020
    1. Cessation of nitrous oxide resulted in characteristic convulsions similar to those seen in alcohol withdrawal in all mice.

      This demonstrates that tolerance is possible. However, exposure in humans lasts only several minutes at a time. Let's assume 3 exposures per day lasting 10 minutes each (i.e. 30 minutes total). It would take 68 days to reach 34 hours of exposure. Alternatively, that's a ratio of 1 to 47 exposure to non-exposure. It's unclear whether that would be sufficient for tolerance.

      In the 50% exposure group, convulsion score was effectively zero by hour 6 (from full text). This does not mean that withdrawal symptoms were gone. However, it does imply that recovery is rapid. It seems plausible that 20 hours between doses is sufficient to reach baseline, rendering tolerance in humans extremely unlikely. I will need to compare to alcohol withdrawal to confirm.

      Edit: Alcohol withdrawal in mice can be induced with 72 hours of alcohol exposure. That implies it is similar to NO. In humans, "the shakes" appear to last 1 or two weeks. In mice, convulsions appear to be half gone in 25 hours, suggesting that they last a few days. Thus, it appears that NO withdrawal is possibly an order of magnitude shorter than alcohol withdrawal.

      In conclusion, NO used in a normal fashion is unlikely to be harmful (except for risk of inducing B12 deficiency). Even if it is harmful, the short half life means that it will be apparent very quickly. I'm aware of several reports of B12 deficiency from NO abuse, but I haven't seen any reports of withdrawal symptoms.

  2. Sep 2020
    1. Increase in alcohol-industry funded research is a cause for concern, study suggests
      • Since 2009, alcohol companies have been funding increasingly more research - evidenced by almost 13,500 studies funded by the alcohol industry.
      • There are many legitimate fields for research, however there’s a group of these studies that claim health benefits of alcohol, or that substance abuse is a choice.
      • Another problem is that the alcohol industry funds this research through affiliate organisations, and the funding source is often not shown in those papers.
      • Researchers believe that the alcohol industry is too deeply involved, and certain studies should be conducted by independent academics.
  3. Aug 2020
    1. However, even moderate intake places women at higher risk for breast cancer and bone fractures

      This minimizes the chances that the benefits are due to abstainer bias. Nonetheless, I'm finding it hard to verify that there are benefits to low dose alcohol.

  4. Jul 2020
  5. Jun 2020
    1. She states that furry participants might identify as less than 100% human for reasons that she felt included, “not the least having a hangover from furry drinks the night before.” While it may be an attempt at humor, we find this comment to be egregiously offensive, derogatory, and insulting to the furry fandom and our participants. Ironically, this remark illustrates her subscription to the very stereotypes we were empirically testing and con-firms the necessity of our research.

      This comment, framed as "egregiously offensive, derogatory, and insulting to the furry fandom and our participants", undermines the prevailing sense of identity in the furry fandom. I understand the transformative powers of alcohol, but in my uneducated opinion, it's a stretch that the furry identity for many people is activated by alcohol, and is not something that exists in all states of being (e.g.: sobriety).

  6. May 2020
  7. Oct 2019
  8. newclasses.nyu.edu newclasses.nyu.edu
    1. cantruthfullyassertthattheIndiansareaphlegmatic,good-natured,unusuallypatientanddocilerace,whoarecapableofgoodimpulsesandwhointheiroriginalwildcon-dition,whentheyareawayfromtheevilworld,donotliveinawickedanddissolutemanner;theylistentoavisitingpriestwithadesireforknowledge;theygladlyacceptre-ligionandallowthemselvestobeeducatedasgoodandtrueChristians.Ontheotherhand,whereverthepoorIndianshavebeencontaminatedbygrossvicesof.whiteChristians,orhavebeenruinedthroughdrinkandmisledintofalseconcep-tionsofourholyreligionbyitsenemies,theybecomemuchmorestubborntoconversionandciviliz

      Pierz notes that the Ojibwe are shocker actually people,and get corrupted by white vices, like alcohol

  9. Feb 2019
  10. Nov 2018
    1. EXERCISE AND ENVIRONMENT AS AN INTERVENTION FOR NEONATALALCOHOL EFFECTS ON HIPPOCAMPAL ADULT NEUROGENESIS ANDLEARNING

      This article discusses the effects of fetal alcohol exposure in adult learning by studying the effects of exercises that stimulates the hippo-campus in the adult rats that were effected by fetal alcohol exposure. The study is entirely based on the scientific research of the neurology of the participants, but provides a course of action that could be applied to human participants as well. The encouraging results indicated that partial restoration of neurological functions in the adult rats was achieved. This inspires hope of introducing exercise to human participants and warrants further exploration of the application to humans since this is not an invasive therapy with low risk to participants. This may also provide some educational changes in special education to include exercise as part of the classroom experience.

      RATING: 5/10

  11. Feb 2017
    1. fend off perceived threats from urban Catholic immigrants

      Also, the Germans

    2. Woman's Christian Temperance Union (W

      Behind the WCTU's temperance reform was "protection of the home." The slogan "For God and Home and Native Land" (later changed to "Every Land") expressed the WCTU's priorities. Through education and example the WCTU hoped to obtain pledges of total abstinence from alcohol, and later also tobacco and other drugs. The white ribbon bow was selected to symbolize purity, and the WCTU's watchwords were "Agitate - Educate - Legislate."

    3. Alcohol became big business.

    1. Temperance

      I made an earlier note on this, but it really can't be understated how important the Temperance Movement was in the triad of women's movements in 19th Century America. I feel it's overlooked because, unlike slavery and women voting, it's an issue that failed, and we generally support its failure today, but it still had an important role in organizing women in the 19th and early 20th century. Plus, Carrie Nation is one hell of a historical woman that is unfortunately too often overlooked.

    2. as well as advocating for the rights of free African Americans and of Native Americans, for temperance, and for women's rights, including suffrage

      What's interesting to me is the general intersection of the lot. The National Parks Service has a chart that shows a general outline of three movements and how leadership worked across them. It's worth taking a moment to look at, especially with the first line in this paragraph and the contemporary reality that many liberal and leftist groups today tend to trip up with intersectionality.

    3. the pleasures of sobriety

      Surely, Gorgias or one of the other Sophists has metaphorically identified Rhetoric and alcohol.

  12. Jan 2016
  13. Oct 2015
    1. My wife and I recently witnessed a cockroach’s ability to find and consume food. We sat down to dinner at a well-known restaurant. Right next to our table was a fairly large painting. We decided to have a glass of wine before dinner. Within minutes of arrival of the wine, a German cockroach appeared from beneath the painting and walked out to the middle of our table. Of course, our reaction was not that of normal human beings and we decided to give it some wine. I placed a small drop of wine several inches from the roach which immediately recognized the presence of food through its antennae (smell). It walked over to the drop and tasted it with its maxillary palps. The roach proceeded to suck up the entire drop (which wasn’t much smaller than the roach). It then crawled back to the picture and disappeared. Much to our surprise, within a few minutes the roach reappeared and came back on the table. Of course I gave it another drop and it repeated the entire process of smelling, tasting and consuming the drop. Once finished this time it cleaned its antennae (as shown below) and returned to the picture. A few minutes later the roach dropped from the picture and began to spin on its back. Inebriated? I would think so.