24 Matching Annotations
  1. Jan 2020
    1. The addition of supraphysiologic doses of L-T4 (300 mcg per day) to an otherwise stable medication regimen of standard treatments resulted in a significant decline in depression scores during the 6-week, double-blind treatment phase. At endpoint (week 6), the mean HamD score showed a group difference of 3.7 points in favor of L-T4. Such difference is generally considered to be clinically meaningful in a short-term treatment trial for major depression. NICE used a 3.0-point difference in HamD change scores as a criterion of clinical significance.27

      This is consistent with the open label data. The dose is also similar. Combining this placebo-controlled trial with the three open-label supraphysiological thyroxine studies that I've seen, that is sufficient for me to conclude efficacy. Namely, Pfeiffer et al (350 mcg), Rudas et al (235 mcg) and Bauer et al (482 mcg)

      I would like to see if this study mentions nonresponders. Those three other studies found roughly a 50% response rate. Thus, the effect size in responders may be twice as significant.

    1. L-thyroxine at an average dose of 350 micro g/die. Outcomes were moderate in 39.3% and very good in 21.5%, corresponding to 21-item HAMD scores of < or =16 and < or =8 and clinical judgement. Of all patients, 39.3% had to stop treatment due to nonresponse or side effects.

      Another study consistent with the 50% remission figue. The dose is also similar, between Rudas et al (235 mcg) and Bauer et al (482 mcg)

    1. RESULTS: Two patients dropped out of the study owing to side effects. The remaining 7 patients received a final mean dose of T4 of 235 +/- 58 micrograms/day (range: 150-300 micrograms/day). Their scores on the Hamilton Depression Rating Scale had fallen from a mean of 21.1 +/- 4.1 before inclusion in the study to a mean of 8.0 +/- 2.8 at the end of the 8th week. Five patients were full responders, 1 a partial responder, and 1 a nonresponder.CONCLUSIONS: Augmentation with high-dose T4 proved to have an antidepressant effect in more than 50% of the previously treatment-resistant patients with chronic depression and/or dysthymia.

      Thyroxine working in about 50% of patients was also found in Bauer et al. This dose was not quite as high as Bauer, but 235 mcg is still above a full replacement dose.

      I'd like to see results on minor depression. However, such studies are unlikely.

    1. Thyroxine was added to their antidepressant medication, and the doses were increased to a mean of 482 ± 72 μg/day.

      This is the highest dose of levothyroxine that I've seen administered. Even treatment for thyroid cancer rarely goes beyond 300 mcg (or even 200 mcg, which is more common).

  2. Dec 2019
    1. Case histories are presented showing rapid recovery (less than 7 days) from major depression using 125-300 mg of magnesium (as glycinate and taurinate) with each meal and at bedtime. Magnesium was found usually effective for treatment of depression in general use.

      Sounds like 500-1200 mg per day (i.e. 125-300 mg four times daily). While 500 mg daily seems fairly normal, 1200 mg is rather high. That dose may require highly bioavailable forms to avoid side effects. I think that this is the study I've been searching for ever since I lost track of it. So far, this is the highest dose of elemental magnesium that I'm aware of being studied.

  3. Apr 2019
    1. His clinical experience led him to develop the theory of positive disintegration (TPD), which posits that, far from being destructive and undesirable, many forms of psychological suffering—anxiety, depression, doubts, inner conflicts, even psychosis—are positive and necessary for emotional and personality development. More often than not, they are expressive of the emerging understanding of the multilevel nature of reality, inner and external, and, related, an objectively existing hierarchy of human values. This understanding becomes a basis of personality growth through positive disintegration
    1. Nobody can “treat” a war, or abuse, rape, molestation, or any other horrendous event, for that matter; what has happened cannot be undone. But what can be dealt with are the imprints of the trauma on body, mind, and soul: the crushing sensations in your chest that you may label as anxiety or depression; the fear of losing control; always being on alert for danger or rejection; the self-loathing; the nightmares and flashbacks; the fog that keeps you from staying on task and from engaging fully in what you are doing; being unable to fully open your heart to another human being.
  4. Feb 2019
    1. I made the library, and these initial zines, as a personal act to get out of a depression

      Heard that. resonates at like frequency with author of this site

      ty for your work, my friend. 🙏🏼

    1. ‪if you’re ever feeling down, just remember that the greatest talents of our time were all once consistently fooled by peek-a-boo ‬
  5. Nov 2018
    1. In this test, endogenous depressives showed a significantly reduced HGH response to clonidine as compared to normal controls, neurotic-reactive depressives, and schizophrenics. However, no differences were found between the endogenous depressives and a group of schizoaffective patients.

      It's possible that this is related to the hyper-vigilance observed in depressives.

  6. May 2018
    1. One group received citalopram (up to 60 mg/day) plus vitamin C (up to 1,000 mg/day). The other group received citalopram plus placebo.

      Considering the results of other trials with different depression severities and vitamin C dosage and forms (sustained release) (covered in this article), it is astonishing that the researchers used such a single, modest, non-sustained release dose.

      The plasma peak of vitamin C is obtained a few hours after the administration. For the rest of the day, the subject is back to baseline.

      This is common knowledge.

  7. Dec 2017
    1. Gender socialization can direct some men to withhold or restrict emotional expression, leaving men with limited ways to express their feelings of emotional pain and psychological distress.

      ... Or not. It's just as likely, if not more likely, to be biological. Unless there has also been a sex-specific bias in autism diagnosis, it could just as easily be argued that men's autistic personalities cause this effect

  8. Jul 2017
    1. “Think of all the things that could interfere with graduating from college.” Then he instructs them to pick one of those items and to come up with as many solutions for that problem as possible. This is a classic divergent-convergent creativity challenge. A subset of respondents, like the proverbial Murphy, quickly list every imaginable way things can go wrong. But they demonstrate a complete lack of flexibility in finding creative solutions. It’s this inability to conceive of alternative approaches that leads to despair. Runco’s two questions predict suicide ideation—even when controlling for preexisting levels of depression and anxiety.In Runco’s subsequent research, those who do better in both problem-finding and problem-solving have better relationships. They are more able to handle stress and overcome the bumps life throws in their way. A similar study of 1,500 middle schoolers found that those high in creative self-efficacy had more confidence about their future and ability to succeed. They were sure that their ability to come up with alternatives would aid them, no matter what problems would arise.
  9. Mar 2017
    1. “Do you not see the reason for yourself,” he indifferently replied.

      Ah, answering a question with a question: either a deliberate rudeness or an apathetic request for attention. I think the latter is the case here.

  10. Dec 2016
    1. God works mysteriously. God is like a great attraction without a marquee or a billboard. God is pulling you along incessantly. Hopefully, the excess baggage in your life will be left aside sufficiently so that you can begin to experience the attraction itself, for this is the call of love to the lover. This is what you try to recreate with one another, this profound love and attraction.

      God, the Great Strange Attractor

      In the mathematical field of dynamical systems, an attractor is a set of numerical values toward which a system tends to evolve, for a wide variety of starting conditions of the system. System values that get close enough to the attractor values remain close even if slightly disturbed... An attractor is called strange if it has a fractal structure. This is often the case when the dynamics on it are chaotic, but strange nonchaotic attractors also exist. If a strange attractor is chaotic, exhibiting sensitive dependence on initial conditions, then any two arbitrarily close alternative initial points on the attractor, after any of various numbers of iterations, will lead to points that are arbitrarily far apart (subject to the confines of the attractor), and after any of various other numbers of iterations will lead to points that are arbitrarily close together. Thus a dynamic system with a chaotic attractor is locally unstable yet globally stable: once some sequences have entered the attractor, nearby points diverge from one another but never depart from the attractor.

  11. Dec 2015
    1. My solution to the problem posed by the incompatibility of depression and social media didn’t aim to change anyone’s life but my own. Yet maybe it was no less radical: Ruthlessly dispose of all fake intimacy and superficial interactions and focus what little energy I had on real connection. Take my feeble attention span and put it into the equivalent of an incubator. Learn to consider myself a worthy human being without the positive reinforcement of Twitter favs.
    2. Professor Heuser thought for a moment. “That’s only indirectly related to social media,” she finally said. “People suffering from depression are incredibly creative at convincing themselves they are losers. But we live in a world that’s hyper-communicative — not really communicative, but narcissistic. Everybody is always ‘sharing’ something, only that it isn’t really sharing, it’s posting something to a wall in the hope that as many people as possible will come past and ‘like’ it. The purpose is to feed our narcissism. It is a many-voiced monologue, a cacophony. Everybody is posting something, but we aren’t talking to each other.”

      During depression, you are likely to find your own past happiness hard to tolerate. It may be worse if that "happiness" was a put-on.

    3. However, the positive feeling that usually follows — your organism can’t mount that response anymore. That’s a classic symptom of depression. You can’t feel joy or connection to others anymore.” And because my brain knows what joy used to feel like, she explained, its absence, that emptiness, is experienced subconsciously as painful. The fact that I found it so hard to resist the lure of said dopamine release was also easy to explain, she said: “Will has to do with energy. And depression is characterised precisely by a lack of energy.”

      Social media may or may not be a contributing cause of depression. But it is generally not good for someone who is already depressed.

  12. Nov 2015
    1. the very simple finding is that the peoplewho laughed when talking about the relationship with their partners two and four years laterwere actually doing a lot better psychologically. Less anxiety, greater purpose in life, greaterrelationships with other people, less depression by finding perspective through laughter.

      he studied middle-aged individuals who on average were about 45 years of age. He brought them to the lab six months after their partner had died in their lives.

  13. Sep 2015
    1. Mauss shows that the more people strive for happiness, the more likely they will be to set a high standard for happiness—then be disappointed when that standard is not met.  This is especially true when people were in positive contexts, such as listening to an upbeat song or watching a positive film clip. It is as if the harder one tries to experience happiness, the more difficult it is to actually feel happy, even in otherwise pleasant situations. My colleagues and I are are building on this research, which suggests that the pursuit of happiness is also associated with serious mental health problems, such as depression and bipolar disorder. It may be that striving for happiness is actually driving some of us crazy.
  14. Oct 2014
    1. In the present study, the impact of PC on the activity and feedback regulation of the hypothalamic-pituitary-adrenal axis (HPA) impaired in depression has been studied in the model of shock-induced depression in rats.

      Shock induced depression