39 Matching Annotations
  1. Jul 2023
    1. I wish there was a certain question 01:22:26 that was asked to people who wanted to wield immense amounts of power that is often not asked. And that question is this. What would it take for you to think that you are no longer necessary in power?
      • critical question for all top leaders
        • I wish there was a certain question that was asked to people who wanted to wield immense amounts of power that is often not asked. And that question is this.
          • What would it take for you to think that you are no longer necessary in power?
        • In other words, what is the goal that you want to achieve with your power,
          • that if you were to achieve it, you would think it's time to step down?
        • And the reason that question is so important is because
          • it would cause most politicians to freeze like deer in the headlights.
        • They've never thought about it.
        • For them, power is the goal.
        • It would expose them as having never thought about it.
        • And for those who do actually answer that question, they would put themselves on the record as what they think their power is for, such that if they actually achieve it, they can retire.
        • And I think that's something that would be a great screening mechanism to see how people answer that question.
        • Most power-hungry people in leadership positions think, "I am God's gift to power, and therefore I should inhabit this role as long as I can stay here,"
          • which is why dictators cling to power as long as they can.
  2. Mar 2022
  3. Feb 2022
    1. There's a common design flaw on many many websites that require an email address to register; most recently I came across this bug on CNet's download.com site: for some reason they don't accept me when I try to register an email address containing a "+", and they then send me back saying my address is invalid. It isn't!
  4. Dec 2021
  5. Oct 2021
    1. Meuris, C., Kremer, C., Geerinck, A., Locquet, M., Bruyère, O., Defêche, J., Meex, C., Hayette, M.-P., Duchene, L., Dellot, P., Azarzar, S., Maréchal, N., Sauvage, A.-S., Frippiat, F., Giot, J.-B., Léonard, P., Fombellida, K., Moutschen, M., Durkin, K., … Darcis, G. (2021). Transmission of SARS-CoV-2 After COVID-19 Screening and Mitigation Measures for Primary School Children Attending School in Liège, Belgium. JAMA Network Open, 4(10), e2128757. https://doi.org/10.1001/jamanetworkopen.2021.28757

  6. Jun 2021
  7. May 2021
  8. Feb 2021
  9. Oct 2020
  10. Sep 2020
  11. Aug 2020
    1. Ferretti, A. P., Kula, T., Wang, Y., Nguyen, D. M., Weinheimer, A., Dunlap, G. S., Xu, Q., Nabilsi, N., Perullo, C. R., Cristofaro, A. W., Whitton, H. J., Virbasius, A., Olivier, K. J., Baiamonte, L. B., Alistar, A. T., Whitman, E. D., Bertino, S. A., Chattopadhyay, S., & MacBeath, G. (2020). COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2. MedRxiv, 2020.07.24.20161653. https://doi.org/10.1101/2020.07.24.20161653

  12. Jun 2020
  13. May 2020
    1. Döhla, M., Boesecke, C., Schulte, B., Diegmann, C., Sib, E., Richter, E., Eschbach-Bludau, M., Aldabbagh, S., Marx, B., Eis-Hübinger, A.-M., Schmithausen, R. M., & Streeck, H. (2020). Rapid point-of-care testing for SARS-CoV-2 in a community screening setting shows low sensitivity. Public Health. https://doi.org/10.1016/j.puhe.2020.04.009

    1. Arons, M. M., Hatfield, K. M., Reddy, S. C., Kimball, A., James, A., Jacobs, J. R., Taylor, J., Spicer, K., Bardossy, A. C., Oakley, L. P., Tanwar, S., Dyal, J. W., Harney, J., Chisty, Z., Bell, J. M., Methner, M., Paul, P., Carlson, C. M., McLaughlin, H. P., … Jernigan, J. A. (2020). Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility. New England Journal of Medicine, NEJMoa2008457. https://doi.org/10.1056/NEJMoa2008457

    1. Gudbjartsson, D. F., Helgason, A., Jonsson, H., Magnusson, O. T., Melsted, P., Norddahl, G. L., Saemundsdottir, J., Sigurdsson, A., Sulem, P., Agustsdottir, A. B., Eiriksdottir, B., Fridriksdottir, R., Gardarsdottir, E. E., Georgsson, G., Gretarsdottir, O. S., Gudmundsson, K. R., Gunnarsdottir, T. R., Gylfason, A., Holm, H., … Stefansson, K. (2020). Spread of SARS-CoV-2 in the Icelandic Population. New England Journal of Medicine, NEJMoa2006100. https://doi.org/10.1056/NEJMoa2006100

  14. Apr 2020
    1. The hit rate was found to be much lower thanthat of the fragment screen

      the author implied that fragment screening usually has higher hit rate than drug size library screening.

    2. a hit rate of about 4%

      hit rate of 4% by DSF is similar to that of screening against kinase targets, interesting.

    3. fragment library

      fragment screening for binders are really powerful. this library contains 800 fragments

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  15. Mar 2020