129 Matching Annotations
  1. Last 7 days
  2. Oct 2020
    1. The working class must utilize the next four weeks and beyond to unify and coordinate its struggles against the ruling class’s policy of “herd immunity,” social devastation, war, police violence and authoritarianism into an independent and revolutionary movement for socialism.
    1. Decerf, B., Ferreira, F. H. G., Mahler, D. G., & Sterck, O. (2020). Lives and Livelihoods: Estimates of the Global Mortality and Poverty Effects of the COVID-19 Pandemic. IZA Discussion Paper, 13549.

    1. t’s not clear why the sequence of the vaccines only mattered in girls, partly because there has been very little research into how male and female immune systems are different. “Somehow immunology has been blind to sex,” says Aaby. “If you read research about mortality in low income countries, there is no such thing as boys and girls – there are children. So we perceive that they have to be the same, and they are definitely not the same.”

      Take away: "Immune training" or bystander effects from other vaccinations may help to fight off Covid-19 or other infections, in spite of not being specific to that pathogen. Some of these effects are sex-specific.

      Claim: "Somehow immunology has been blind to sex"

      The evidence: This is not entirely true- there is actually a LOT of research into sex differences in the immune response, and it is well-known that women can generally mount stronger Th1-type immune responses against viral infections than men. This is thought to be partially linked to estrogen cycling, and partly due to the fact that women have 2 active copies of genes associated with immunity because those are encoded on the X chromosomes. Men only have 1 copy, and thus they don't generally mount as strong an inflammatory response. However, women are also more prone to autoimmune diseases as a consequence of having stronger inflammatory responses than men, which is seen in diseases such as multiple sclerosis, rheumatoid arthritis, and lupus.

      Sources: (https://www.nature.com/articles/nri.2016.90).

  3. Sep 2020
    1. Le Bert, N., Tan, A. T., Kunasegaran, K., Tham, C. Y. L., Hafezi, M., Chia, A., Chng, M. H. Y., Lin, M., Tan, N., Linster, M., Chia, W. N., Chen, M. I.-C., Wang, L.-F., Ooi, E. E., Kalimuddin, S., Tambyah, P. A., Low, J. G.-H., Tan, Y.-J., & Bertoletti, A. (2020). SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature, 584(7821), 457–462. https://doi.org/10.1038/s41586-020-2550-z

    1. O’Driscoll, M., Santos, G. R. D., Wang, L., Cummings, D. A. T., Azman, A. S., Paireau, J., Fontanet, A., Cauchemez, S., & Salje, H. (2020). Age-specific mortality and immunity patterns of SARS-CoV-2 infection in 45 countries. MedRxiv, 2020.08.24.20180851. https://doi.org/10.1101/2020.08.24.20180851

    1. López, J. A. M., Arregui-Garcĺa, B., Bentkowski, P., Bioglio, L., Pinotti, F., Boëlle, P.-Y., Barrat, A., Colizza, V., & Poletto, C. (2020). Anatomy of digital contact tracing: Role of age, transmission setting, adoption and case detection. MedRxiv, 2020.07.22.20158352. https://doi.org/10.1101/2020.07.22.20158352

    1. Aleta, A., Martín-Corral, D., Pastore y Piontti, A., Ajelli, M., Litvinova, M., Chinazzi, M., Dean, N. E., Halloran, M. E., Longini Jr, I. M., Merler, S., Pentland, A., Vespignani, A., Moro, E., & Moreno, Y. (2020). Modelling the impact of testing, contact tracing and household quarantine on second waves of COVID-19. Nature Human Behaviour, 1–8. https://doi.org/10.1038/s41562-020-0931-9

  4. Aug 2020
    1. Ferretti, A. P., Kula, T., Wang, Y., Nguyen, D. M., Weinheimer, A., Dunlap, G. S., Xu, Q., Nabilsi, N., Perullo, C. R., Cristofaro, A. W., Whitton, H. J., Virbasius, A., Olivier, K. J., Baiamonte, L. B., Alistar, A. T., Whitman, E. D., Bertino, S. A., Chattopadhyay, S., & MacBeath, G. (2020). COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2. MedRxiv, 2020.07.24.20161653. https://doi.org/10.1101/2020.07.24.20161653

    1. Walls, A. C., Fiala, B., Schäfer, A., Wrenn, S., Pham, M. N., Murphy, M., Tse, L. V., Shehata, L., O’Connor, M. A., Chen, C., Navarro, M. J., Miranda, M. C., Pettie, D., Ravichandran, R., Kraft, J. C., Ogohara, C., Palser, A., Chalk, S., Lee, E.-C., … King, N. P. (2020). Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2. BioRxiv, 2020.08.11.247395. https://doi.org/10.1101/2020.08.11.247395

    1. Consiglio, C. R., Cotugno, N., Sardh, F., Pou, C., Amodio, D., Zicari, S., Ruggiero, A., Pascucci, G. R., Rodriguez, L., Santilli, V., Tan, Z., Eriksson, D., Wang, J., Lakshmikanth, T., Marchesi, A., Lakshmikanth, T., Campana, A., Villani, A., Rossi, P., … Brodin, P. (2020). The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19. MedRxiv, 2020.07.08.20148353. https://doi.org/10.1101/2020.07.08.20148353

    1. Rodda, L. B., Netland, J., Shehata, L., Pruner, K. B., Morawski, P. M., Thouvenel, C., Takehara, K. K., Eggenberger, J., Hemann, E. A., Waterman, H. R., Fahning, M. L., Chen, Y., Rathe, J., Stokes, C., Wrenn, S., Fiala, B., Carter, L. P., Hamerman, J. A., King, N. P., … Pepper, M. (2020). Functional SARS-CoV-2-specific immune memory persists after mild COVID-19. MedRxiv, 2020.08.11.20171843. https://doi.org/10.1101/2020.08.11.20171843

  5. Jul 2020
    1. Seow, J., Graham, C., Merrick, B., Acors, S., Steel, K. J. A., Hemmings, O., O’Bryne, A., Kouphou, N., Pickering, S., Galao, R., Betancor, G., Wilson, H. D., Signell, A. W., Winstone, H., Kerridge, C., Temperton, N., Snell, L., Bisnauthsing, K., Moore, A., … Doores, K. (2020). Longitudinal evaluation and decline of antibody responses in SARS-CoV-2 infection. MedRxiv, 2020.07.09.20148429. https://doi.org/10.1101/2020.07.09.20148429

    1. Fontanet, A., Tondeur, L., Madec, Y., Grant, R., Besombes, C., Jolly, N., Pellerin, S. F., Ungeheuer, M.-N., Cailleau, I., Kuhmel, L., Temmam, S., Huon, C., Chen, K.-Y., Crescenzo, B., Munier, S., Demeret, C., Grzelak, L., Staropoli, I., Bruel, T., … Hoen, B. (2020). Cluster of COVID-19 in northern France: A retrospective closed cohort study. MedRxiv, 2020.04.18.20071134. https://doi.org/10.1101/2020.04.18.20071134

  6. Jun 2020