206 Matching Annotations
  1. Sep 2023
    1. He says that ultimately, about 50% of participants who were screened to be part of the control group couldn’t be included because of continuing symptoms.

      Honestly, this should be the headline. A full 50% of people who volunteered to be in the control were actually still suffering symptoms! Half! Of a self-selected group!

  2. Aug 2022
  3. Apr 2022
  4. Mar 2022
  5. Feb 2022
    1. Dr. Deepti Gurdasani. (2022, February 21). Did anyone hear any mention of long COVID, an illness affecting 1.3 million people, of whom 500,000 have had this for more than a year during the briefing? Are we just going to pretend it doesn’t exist? [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1495839416262311938

    1. APPG on Coronavirus. (2022, January 18). 🗣Dr.Claire Steves continued: “Looking in the national core studies, from cohort studies across the UK we’ve looked at 10 different longitudinal studies. Our best estimates are that about 5% of middle aged people are experiencing long term.. 27/ #APPGCoronavirus #LongCovid [Tweet]. @AppgCoronavirus. https://twitter.com/AppgCoronavirus/status/1483453895061999618

    1. Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., Kornilov, S. A., Scherler, K., Pavlovitch-Bedzyk, A. J., Dong, S., Lausted, C., Lee, I., Fallen, S., Dai, C. L., Baloni, P., … Heath, J. R. (2022). Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell, 0(0). https://doi.org/10.1016/j.cell.2022.01.014

    1. AbScent. (2022, February 7). ⁦the study quoted here looked at an 18 month time interval. In our Covid19 FB group of 34.5k, we have reports of recovery after 18 months—2 years is not unknown @Dr_Ellie⁩ ⁦@MailOnline⁩ https://t.co/5DdXDWLBSQ [Tweet]. @AbScentUK. https://twitter.com/AbScentUK/status/1490636119322644484

    1. Trisha Greenhalgh. (2022, January 8). Apart from (e.g.): 1. Severe disease in clinically vulnerable (they are people too); 2. Long covid in many; 3. Strokes / heart attacks / kidney failure from micro-clots; 4. New-onset diabetes and MIS-C in children; 5. High potential for recombinant mutations. [Tweet]. @trishgreenhalgh. https://twitter.com/trishgreenhalgh/status/1479738523511136258

    1. Elaine Maxwell. (2022, February 3). In the latest @ONS estimates of #LongCovid (up to 2nd Jan 2022), only 87 thousand of the 1.33 million cases were admitted to hospital with their acute Covid19 infection. [Tweet]. @maxwele2. https://twitter.com/maxwele2/status/1489179055412989953

    1. Deepti Gurdasani. (2022, January 29). Going to say this again because it’s important. Case-control studies to determine prevalence of long COVID are completely flawed science, but are often presented as being scientifically robust. This is not how we can define clinical syndromes or their prevalence! A thread. [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1487366920508694529

    1. Deepti Gurdasani. (2022, January 30). Have tried to now visually illustrate an earlier thread I wrote about why prevalence estimates based on comparisons of “any symptom” between infected cases, and matched controls will yield underestimates for long COVID. I’ve done a toy example below here, to show this 🧵 [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1487578265187405828

  6. Jan 2022
    1. Routen, A., O’Mahoney, L., Ayoubkhani, D., Banerjee, A., Brightling, C., Calvert, M., Chaturvedi, N., Diamond, I., Eggo, R., Elliott, P., Evans, R. A., Haroon, S., Herret, E., O’Hara, M. E., Shafran, R., Stanborough, J., Stephenson, T., Sterne, J., Ward, H., & Khunti, K. (2022). Understanding and tracking the impact of long COVID in the United Kingdom. Nature Medicine, 28(1), 11–15. https://doi.org/10.1038/s41591-021-01591-4

    1. ReconfigBehSci. (2022, January 21). RT @IndependentSage: Today at 1.30pm, Independent SAGE will discuss shaping policy to help Long Covid sufferers, with special guests includ… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1484475503394406402

    1. Frere, J. J., Serafini, R. A., Pryce, K. D., Zazhytska, M., Oishi, K., Golynker, I., Panis, M., Zimering, J., Horiuchi, S., Hoagland, D. A., Moller, R., Ruiz, A., Overdevest, J. B., Kodra, A., Canoll, P. D., Goldman, J. E., Borczuk, A. C., Chandar, V., Bram, Y., … tenOever, B. (2022). SARS-CoV-2 infection results in lasting and systemic perturbations post recovery (p. 2022.01.18.476786). https://doi.org/10.1101/2022.01.18.476786

    1. Townsend, L., Dyer, A. H., Naughton, A., Kiersey, R., Holden, D., Gardiner, M., Dowds, J., O’Brien, K., Bannan, C., Nadarajan, P., Dunne, J., Martin-Loeches, I., Fallon, P. G., Bergin, C., O’Farrelly, C., Cheallaigh, C. N., Bourke, N. M., & Conlon, N. (2021). Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health. Frontiers in Immunology, 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.676932

    1. Fernandez-Castaneda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., Yalcin, B., Taylor, K. R., Dutton, S., Acosta-Alvarez, L., Ni, L., Contreras-Esquivel, D., Gehlhausen, J. R., Klein, J., Lucas, C., Mao, T., Silva, J., Pena-Hernandez, M., Tabachnikova, A., … Monje, M. (2022). Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain (p. 2022.01.07.475453). https://doi.org/10.1101/2022.01.07.475453

  7. Dec 2021
  8. Nov 2021
  9. Oct 2021
    1. Dr Nisreen Alwan 🌻 on Twitter: “New @ONS #LongCovid estimates published today: 1.1 MILLION (1.7% of the whole UK population). Up from the summer estimate of 1.5%. 211,000 people with daily activities ‘limited a lot’. Greatest % in working age (35-69y). Rising prevalence in 17-24y. A tsunami of chronic illness.” / Twitter. (n.d.). Retrieved October 10, 2021, from https://twitter.com/Dr2NisreenAlwan/status/1446110337753829379

  10. Sep 2021
  11. Aug 2021
  12. Jul 2021
    1. Dr. Jeff Benyacar on Twitter: “@AlexBerenson ‘Even if a link between myocarditis and the vaccine holds up, the condition is usually mild, requiring treatment only with anti-inflammatory drugs, whereas COVID-19 infection can also cause serious disease and long-term side effects, even in young people.’ https://t.co/3VQprF7bIz” / Twitter. (n.d.). Retrieved July 2, 2021, from https://twitter.com/jbenyacar/status/1399851524487106562?s=12

    1. adaptive systems likely activate innate cells through antibodies and cytokines

      Long COVID

      Damaged endothelial cells from initial viral infection circulate the blood a month after symptom onset https://doi.org/10.7554/eLife.64909

      These will activate monocytes and neutrophils, but are also thought to facilitate clotting which will add to symptoms.

      Importantly, this late in the disease recovery it is not surprising to note that IL-2 and other pro-T cell cytokines are elevated which correlates with enhanced effector T-cells https://doi.org/10.7554/eLife.64909

      These adaptive cells along with autoantibodies likely propagate the effects of COVID-19 long term.

  13. Jun 2021
    1. Osmanov, I. M., Spiridonova, E., Bobkova, P., Gamirova, A., Shikhaleva, A., Andreeva, M., Blyuss, O., El-Taravi, Y., DunnGalvin, A., Comberiati, P., Peroni, D. G., Apfelbacher, C., Genuneit, J., Mazankova, L., Miroshina, A., Chistyakova, E., Samitova, E., Borzakova, S., Bondarenko, E., … Sechenov StopCOVID Research Team. (2021). Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study [Preprint]. Pediatrics. https://doi.org/10.1101/2021.04.26.21256110

  14. May 2021
    1. Dr Ellie Murray. (2021, May 7). I’m seeing a lot of “these people are over-estimating risk” chatter that doesn’t acknowledge that the probability you die if you get covid is always less than the probability anyone dies if you get covid. It’s not “over-estimation” to consider community impacts. [Tweet]. @EpiEllie. https://twitter.com/EpiEllie/status/1390792624777334797

    1. Dr. Tom Frieden. (2021, April 30). Globally, the end of the pandemic isn’t near. More than a million lives depend on improving our response quickly. Don’t be blinded by the light at the end of the tunnel. There isn’t enough vaccine and the virus is gathering strength & speed. Global cooperation is crucial. 1/ [Tweet]. @DrTomFrieden. https://twitter.com/DrTomFrieden/status/1388172436999376899

  15. Apr 2021
    1. Eric-Feigl-Ding [@Dr EricDing} (2020) 5) If you’re an island like Britain is, you shouldn’t have 4.3 million #COVID19 cases, yet 🇬🇧 did somehow. Result is not just 127k deaths, but also 1.1 million #LongCovid cases... or 25% of all infected. Twitter. Retrieved from: https://twitter.com/SciBeh/status/1379787890826313728

  16. Mar 2021
  17. Feb 2021
  18. Jan 2021
  19. Dec 2020
  20. Oct 2020
  21. Sep 2020
  22. Aug 2020
    1. Hogan, A. B., Jewell, B. L., Sherrard-Smith, E., Vesga, J. F., Watson, O. J., Whittaker, C., Hamlet, A., Smith, J. A., Winskill, P., Verity, R., Baguelin, M., Lees, J. A., Whittles, L. K., Ainslie, K. E. C., Bhatt, S., Boonyasiri, A., Brazeau, N. F., Cattarino, L., Cooper, L. V., … Hallett, T. B. (2020). Potential impact of the COVID-19 pandemic on HIV, tuberculosis, and malaria in low-income and middle-income countries: A modelling study. The Lancet Global Health, 0(0). https://doi.org/10.1016/S2214-109X(20)30288-6

    1. Salahudeen, A. A., Choi, S. S., Rustagi, A., Zhu, J., O, S. M. de la, Flynn, R. A., Margalef-Català, M., Santos, A. J. M., Ju, J., Batish, A., Unen, V. van, Usui, T., Zheng, G. X. Y., Edwards, C. E., Wagar, L. E., Luca, V., Anchang, B., Nagendran, M., Nguyen, K., … Kuo, C. J. (2020). Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures. BioRxiv, 2020.07.27.212076. https://doi.org/10.1101/2020.07.27.212076

  23. Jul 2020
    1. Varatharaj, A., Thomas, N., Ellul, M. A., Davies, N. W. S., Pollak, T. A., Tenorio, E. L., Sultan, M., Easton, A., Breen, G., Zandi, M., Coles, J. P., Manji, H., Al-Shahi Salman, R., Menon, D. K., Nicholson, T. R., Benjamin, L. A., Carson, A., Smith, C., Turner, M. R., … Plant, G. (2020). Neurological and neuropsychiatric complications of COVID-19 in 153 patients: A UK-wide surveillance study. The Lancet Psychiatry. https://doi.org/10.1016/S2215-0366(20)30287-X

  24. Jun 2020