23 Matching Annotations
  1. Last 7 days
    1. CONCLUSION: This randomized double-blind, placebo-controlled clinical trial demonstrated that Amla could reduce frequencies of heartburn and regurgitation and improve heartburn and regurgitation severity in patients with NERD.

      Is there anything it can't do? I have noted, however, that larger doses cause nausea for me. That is, 3 or more grams on an empty stomach. I just vomited after taking 7.5 grams before my meal, but I have not yet established the causal link. It is the largest amount I've ever taken at one time. I suspect that it may have contributed significantly, but that it was also one out of half a dozen factors.

  2. Jul 2019
  3. Jun 2019
    1. In 99.3% of the time under unstressed conditions,

      Danism: A cell in a diseased state does not respond the same way as a cell in a non-diseased state. This is essential and has many roots. Translation Regulation being the most controversial.

  4. May 2019
    1. in February, 1977, Searle's law firm, Sidley & Austin, offered Skinner a job, which he accepted, recusing himself from the case

      The company being sued for the cover up of the negative side effects of aspartame hires the lawyer that represented the FDA thus resulting in the case never making it to trial.

    2. n January 1977, formally requested that a grand jury be convened to investigate whether indictments should be filed against Searle for knowingly misrepresenting findings and "concealing material facts and making false statements" in aspartame safety tests (the first time in the FDA's history that they request a criminal investigation of a manufacturer)

      Aspartame was so poorly misrepresented in the scientific research provided for its approval that it became the first case in history in which a lawsuit was brought against the manufacturer for concealing of material facts and false statements.

    1. elevated cortisol and gut dysbiosis via interactions with different biogenic amine may also have additional impact to modulate neuronal signaling lead to neurobiological impairments

      In summary aspartame increases the fire of neurotransmitters, increases heart rate and and blood pressure, and imbalances gut bacteria.

    2. aspartame metabolite; mainly Phy and its interaction with neurotransmitter and aspartic acid by acting as excitatory neurotransmitter causes this pattern of impairments

      Aspartame alters the chemical composition of the brain and excites neurotransmitters.

    1. examination showed fetal capillaries with condensed nuclei of endothelial cells, cytotrophoblasts with condensed fragmented nuclei and vacuolated cytoplasm, and syncytiotrophoblasts with irregular condensed fragmented nuclei

      In summary aspartame results in the death of cells that carry nutrients and energy to the growing embryo.

    2. Damage in the placenta was detected in the form of rupture of the interhemal membrane, lysis of glycogen trophoblast cells, spongiotrophoblast cells with vacuolated cytoplasm and darkly stained nuclei.

      Aspartame caused placenta cells to rupture and behave like they had been exposed to a pathogen or virus.

    1. Results reveal that the aspartame molecule is inherently amyloidogenic, and the self-assembly of aspartame becomes a toxic trap for proteins and cells

      Aspartame inhibits the function of organs and tissues via clusters of proteins/“plaque”.

    2. amyloidogenic

      producing or tending to produce amyloid deposits. These are associated with malfunction of organs.

    1. Amyloids are aggregates of proteins that become folded into a shape that allows many copies of that protein to stick together, forming fibrils. In the human body, amyloids have been linked to the development of various diseases.

      Amyloids are clusters of proteins that are associated with development of various diseases in humans.

  5. Mar 2019
    1. The virus is commonly found in Africa, Europe, the Middle East, North America and West Asia. The World Health Organization (WHO) documents that it was first isolated in a woman in the West Nile district of Uganda in 1937. It was identified in birds (crows and columbiformes like doves and pigeons) in the Nile delta region in 1953. Before 1997, WNV was not considered pathogenic for birds — but then, a more virulent strain caused the death in Israel of different bird species, presenting signs of encephalitis and paralysis. Human infections attributable to WNV have been reported in many countries in the World for over 50 years, the WHO says.

      Zoonotic in nature

    1. is a waterborne bacterial disease, caused by the leptospiro bacteria. It rarely spreads from person to person and can be treated with common antib

      The bacteria is found in the urine of rodents.

  6. Dec 2018
    1. Alzheimer's disease (AD) is not normally diagnosed until later in life, although evidence suggests that the disease starts at a much earlier age. Risk factors for AD, such as diabetes, hypertension and obesity, are known to have their affects during mid-life, though events very early in life, including maternal over-nutrition, can predispose offspring to develop these conditions. This study tested whether over-nutrition during pregnancy and lactation affected the development of AD in offspring, using a transgenic AD mouse model. Female triple-transgenic AD dam mice (3xTgAD) were exposed to a high-fat (60% energy from fat) or control diet during pregnancy and lactation. After weaning (at 3 weeks of age), female offspring were placed on a control diet and monitored up until 12 months of age during which time behavioural tests were performed. A transient increase in body weight was observed in 4-week-old offspring 3xTgAD mice from dams fed a high-fat diet. However, by 5 weeks of age the body weight of 3xTgAD mice from the maternal high-fat fed group was no different when compared to control-fed mice. A maternal high-fat diet led to a significant impairment in memory in 2- and 12-month-old 3xTgAD offspring mice when compared to offspring from control fed dams. These effects of a maternal high-fat diet on memory were accompanied by a significant increase (50%) in the number of tau positive neurones in the hippocampus. These data demonstrate that a high-fat diet during pregnancy and lactation increases memory impairments in female 3xTgAD mice and suggest that early life events during development might influence the onset and progression of AD later in life.
  7. Dec 2017
  8. Aug 2017
    1. The first note in Biovista Vizit the free unbiased visual pubmed search tool using hypothes.is

      Here is an example graph (click to go to the live graph)

  9. May 2017
    1. Scientists think that the increased melting of permafrost in polar regions could lead to the revival of viruses that haven't been around for thousands of years.

      This is scary!

    1. Though current medical and surgical treatments manage coronary artery disease, they do little to prevent or stop it. Nutritional intervention, as shown in our study and others, has halted and even reversed CAD
  10. Feb 2017
  11. Mar 2016
    1. scienceWhen the actor Michael J. Fox was in the initial stages of creating his foundation forresearch on Parkinson’s Disease, he came to recognize the negative impact thatcompetition among scientific groups has on the overall progress of research on thedisease. The director of one group actually said to him, ‘‘Well, if you don’t help us,then, at least, don’t help them’’ [1, p. 236]. Such was his introduction to thecompetitive world of U.S. science.

      Anecdote about how Michael J. Fox discovered scientific competition when he set up his foundation for Parkinson's disease.

  12. Jan 2016
    1. Heightened international concern about Zika was driven not by its relatively mild effect on infected adults, who typically recover in about a week, but by its devastating effect on babies in utero. In Brazil, cases of microcephaly, in which the brain does not develop fully before birth, surged from an average 150 per year to almost 4000 cases in 2015.

      Dr Shah warned that although there has been no local transmission of Zika as yet in the continental US, areas along the Gulf Coast have populations of the two species of Aedes mosquitoes that serve as vectors for Zika virus. He said that a patient with sufficiently high Zika viral load could, in theory, pass Zika to one of these mosquitoes.