- May 2022
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Pathogenic germline variants in DICER1 underlie an autosomal dominant, pleiotropic tumor-predisposition disorder.
gene name: DICER 1 PMID (PubMed ID): 33570641 HGNCID: n/a Inheritance Pattern: autosomal dominant Disease Entity: benign and malignant tumor mutation Mutation: somatic Zygosity: heterozygous Variant: n/a Family Information: n/a Case: people of all sexes, ages, ethnicities and races participated CasePresentingHPOs: individuals with DICER1-associated tumors or pathogenic germline DICER1 variants were recruited to participate CasePreviousTesting: n/a gnomAD: n/a
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watermark.silverchair.com watermark.silverchair.com
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DICER1 syndrome is an autosomal-dominant,pleiotropic, tumor-predisposition disorder arisingfrom pathogenic germline variants in DICER1, whichencodes an endoribonuclease integral to processingmicroRNAs
DICER1 is the gene name. PubMed ID, HGCNCID, and Variant: I can't find Inheritance Pattern: autosomal-dominant The disease entity: DICER1 syndrome The type of mutation: germline. Zygosity: not known. Family Information: a family was used, DICER1 carriers, and non DICER1 variant used, some of the family members had tumors from DICER1 Case Information: mean age is 34, the range of age is 18.6 to 43 years, male, and female used, ethnicity can't find Case Presenting HPO: cancer testing, chemotherapy, radiotherapy gnomeAD: 9.2,8.3.2 Mutation type: Pleiotropic, loss of function, missense
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Embryonal rhabdomyosarcoma (ERMS) of the uterus has recently been shown to frequently harbor DICER1 mutations.
HGNCID:
Tags
- Mutation: c.4420A>G
- PMID (PubMed ID): 33846547
- pathogenicity: only 2 of 17 patients died from disease
- Mutation: c.5438 A> C
- Mutation: c.5125G > A
- Disease Entity: Embryonal rhabdomyosarcoma (ERMS)
- case wt: m&f 0.5-19
- Mutation: c.5428G>T
- Zygosity: Some Cases displayed homozygosity
- Mutation: c.3580delA
- Mutation: c5113G>A
- Mutation: 5428 G>C
- Family Information: not identified
- Inheritance Pattern: Non- inheritance(DNA methylation)
- GeneName: DICER1
- case mut: f 28-67
- Mutation: c.4267G>T
- Variant: Clinvar ID not identified
Annotators
URL
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- Apr 2022
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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long COVID
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SARS-CoV-2
Tags
Annotators
URL
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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DICER1 syndrome is an autosomal-dominant, pleiotropic tumor-predisposition disorder
Gene Name:DICER1 PMID: 30715996 HGNCID: Not on document Inheritance Pattern: Autosomal Dominant Disease Entity: Pleiotropic Tumor-Predisposition Disorder Mutation: Pathogenic Germline Variants Zygosity: Not in document Variant: Not in document Family Information: An individual was found who had family members who were also affected by this mutation. Because of this, those family members were also chosen to participate in this study. Mutation Type: Missense Case: The study was done on more than one individual. Roughly more than half of the individuals were female
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www.science.org www.science.org
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Mathew, D., Giles, J. R., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., Kuri-Cervantes, L., Pampena, M. B., D’Andrea, K., Manne, S., Chen, Z., Huang, Y. J., Reilly, J. P., Weisman, A. R., Ittner, C. A. G., Kuthuru, O., Dougherty, J., Nzingha, K., … Wherry, E. J. (2020). Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science, 369(6508), eabc8511. https://doi.org/10.1126/science.abc8511
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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Taylor, S. (2021). The Psychology of Pandemics. Annual Review of Clinical Psychology. https://doi.org/10.1146/annurev-clinpsy-072720-020131
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twitter.com twitter.com
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Dr. Deepti Gurdasani. (2022, January 24). When did 4.5% of children in any age group being infected every wk become ok for any disease? [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1485670994320793602
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twitter.com twitter.com
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Freja Kirsebom. (2022, January 28). Two important updates from our team this week: - Vaccine effectiveness (VE) against symptomatic disease after Omicron BA.2 shows that VE remains unchanged—VE against death after Omicron BA.1 shows VE is 95% at 2+ weeks after booster 1/7 Full report https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1050721/Vaccine-surveillance-report-week-4.pdf [Tweet]. @freja_kirsebom. https://twitter.com/freja_kirsebom/status/1486730977464369160
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video.ibm.com video.ibm.com
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Advisory Committee on Immunization Practices- ACIP. (n.d.). Retrieved April 27, 2022, from https://video.ibm.com/channel/VWBXKBR8af4
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www.cdc.gov www.cdc.gov
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Lindsley, W. G. (2021). Efficacy of Portable Air Cleaners and Masking for Reducing Indoor Exposure to Simulated Exhaled SARS-CoV-2 Aerosols—United States, 2021. MMWR. Morbidity and Mortality Weekly Report, 70. https://doi.org/10.15585/mmwr.mm7027e1
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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The DICER1 syndrome is an autosomal dominant tumor‐predisposi-tion disorder associated with pleuropulmonary blastoma, a rare pediatric lung cancer
GeneName:DICER1 PMID (PubMed ID): PMCID: PMC6418698 PMID: 30672147 HGNCID: NOT LISTED<br /> Inheritance Pattern: Autosomal Dominant Disease Entity: Cancer; benign and malignant tumors including pleuropulmonary blastoma, cystic nephroma, Sertoli-Leydig cell tumors, multinodular goiter, Thryoid cancer, rhabdomyosarcoma, and pineoblastoma. Mutation: Somatic missense variation Mutation type: missense Zygosity: None stated Variant: unregistered…. Family Information: Characterize germline variants in familial early-onset clorectal cancer patients; The observation of germline DICER1 variation with uterine corpus endometrial carcinoma merits additional investigation. CasePresentingHPOs: uterine and rectal cancers in germline mutation
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www.abc.net.au www.abc.net.au
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Willis, O. (2021, October 19). The pandemic won’t end with a bang, but more likely a fizzle. Here’s how. ABC News. https://www.abc.net.au/news/health/2021-10-20/covid-19-pandemic-when-does-it-end-become-endemic-like-flu/100549816
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twitter.com twitter.com
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Prof Francois Balloux [@BallouxFrancois]. (2021, December 9). This may have sounded somewhat naïve in early 2020, but by now, I would have expected that anyone with an interest in covid-19 might have acquired some basic notions in infectious disease epidemiology. 1/ [Tweet]. Twitter. https://twitter.com/BallouxFrancois/status/1469063480334561285
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twitter.com twitter.com
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www.nature.com www.nature.com
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Levine-Tiefenbrun, M., Yelin, I., Alapi, H., Katz, R., Herzel, E., Kuint, J., Chodick, G., Gazit, S., Patalon, T., & Kishony, R. (2021). Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2. Nature Medicine, 1–3. https://doi.org/10.1038/s41591-021-01575-4
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www.covid-datascience.com www.covid-datascience.com
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Morris, J. (2021, August 17). Israeli data: How can efficacy vs. severe disease be strong when 60% of hospitalized are vaccinated? Covid Data Science. https://www.covid-datascience.com/post/israeli-data-how-can-efficacy-vs-severe-disease-be-strong-when-60-of-hospitalized-are-vaccinated
Tags
- vaccine
- is:blog
- efficacy
- variant
- hospitalization
- surge
- effective
- lang:en
- delta
- dose
- age
- severe disease
- COVID-19
- risk
- asymptomatic
- symptomatic
- Pfizer
Annotators
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twitter.com twitter.com
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Carl T. Bergstrom. (2021, August 18). 1. There has been lots of talk about recent data from Israel that seem to suggest a decline in vaccine efficacy against severe disease due to Delta, waning protection, or both. This may have even been a motivation for Biden’s announcement that the US would be adopting boosters. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1427767356600688646
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www.cdc.gov www.cdc.gov
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Excess Deaths Associated with COVID-19. (2021, February 17). https://www.cdc.gov/nchs/nvss/vsrr/covid19/excess_deaths.htm
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twitter.com twitter.com
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Dr Greg Kelly. (2021, July 2). As a pediatrician I’m going on record saying that allowing kids to be freely infected with a novel disease that has unknown long term consequences is the worst idea of 2021 despite being a pretty crowded field so far #COVID19 [Tweet]. @drgregkelly. https://twitter.com/drgregkelly/status/1411083905034117120
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twitter.com twitter.com
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ReconfigBehSci. (2021, January 29). RT @IndependentSage: 3.7 million infected with #COVID19 in the UK. An estimated 5-10% will develop #LongCovid. We can’t afford to ignore th… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1355097550529945607
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Callaway, E. (2021). Heavily mutated Omicron variant puts scientists on alert. Nature, 600(7887), 21–21. https://doi.org/10.1038/d41586-021-03552-w
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- Mar 2022
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www.bccdc.ca www.bccdc.ca
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Getting a Vaccine. (n.d.). Retrieved 31 March 2022, from http://www.bccdc.ca/health-info/diseases-conditions/covid-19/covid-19-vaccine/getting-a-vaccine#under12
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Study finds brain changes similarly to Alzheimer’s after COVID-19. (n.d.). The Jerusalem Post | JPost.Com. Retrieved March 31, 2022, from https://www.jpost.com/health-and-wellness/coronavirus/article-696565
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www.theguardian.com www.theguardian.com
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Sample, I., & editor, I. S. S. (2022, March 10). UK Covid cases rising among those aged 55 and over. The Guardian. https://www.theguardian.com/world/2022/mar/10/uk-covid-cases-rising-among-those-aged-55-and-over
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twitter.com twitter.com
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Dr. Deepti Gurdasani. (2022, March 1). New study out yesterday suggesting that vaccine efficacy with current dose for 5-11 yr olds likely wanes quickly. Especially against infection, but also against hospitalisation, although protection against severe disease is higher. Seems to be closely linked to vaccine dose🧵 https://t.co/NojLODF1ED [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1498580243665367040
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psyarxiv.com psyarxiv.com
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Lehnen, N., Glasauer, S., Schröder, L., Regnath, F., Biersack, K., Bergh, O. V. den, & Werder, D. von. (2022). Post-COVID symptoms in the absence of organic deficit—Lessons from diseases we know. PsyArXiv. https://doi.org/10.31234/osf.io/yqar2
Tags
- organic impairment
- experience
- informational processing
- persistent symptoms
- brain
- symptom
- perception
- breathlessness
- experimental paradigm
- long COVID
- body symptoms
- body signals
- fatigue
- post-COVID
- dizziness
- lang:en
- predictive coding
- severe symptoms
- is:preprint
- disease
- COVID-19
- rebreathing
- organic deficit
- interoception
Annotators
URL
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twitter.com twitter.com
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ReconfigBehSci on Twitter: ‘this really is now a disinformation account. I retweeted posts earlier in the pandemic as part of a balanced spread of opinion. But this will be the last one...’ / Twitter. (n.d.). Retrieved 29 March 2022, from https://twitter.com/SciBeh/status/1478485258395951108
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name. (n.d.). På trods af historisk høje smittetal følger indlæggelserne ikke med. Retrieved 28 March 2022, from https://www.ssi.dk/aktuelt/nyheder/2022/paa-trods-af-hoeje-smittetal-foelger-indlaeggelserne-ikke-med
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www.pnas.org www.pnas.org
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Kerr, P. J., Cattadori, I. M., Liu, J., Sim, D. G., Dodds, J. W., Brooks, J. W., Kennett, M. J., Holmes, E. C., & Read, A. F. (2017). Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype. Proceedings of the National Academy of Sciences, 114(35), 9397–9402. https://doi.org/10.1073/pnas.1710336114
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www.medrxiv.org www.medrxiv.org
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Bays, D., Whiteley, T., Pindar, M., Taylor, J., Walker, B., Williams, H., Finnie, T. J. R., & Gent, N. (2021). Mitigating isolation: The use of rapid antigen testing to reduce the impact of self-isolation periods (p. 2021.12.23.21268326). medRxiv. https://doi.org/10.1101/2021.12.23.21268326
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twitter.com twitter.com
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ReconfigBehSci. (2022, January 20). @OmicronData @timcolbourn I think there might be a difference here between what you are putting forward and what @timcolbourn is arguing any rational individual should be for analysing the expected costs and benefits of a course of action, and I assume we all agree on that. 1/2 [Tweet]. @i. https://twitter.com/i/web/status/1484080972459134976
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twitter.com twitter.com
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ReconfigBehSci on Twitter: ‘@STWorg @ProfColinDavis @rpancost @chrisdc77 @syrpis this is the most in depth treatment of the impact of equalities law on pandemic policy that I’ve been able to find- it would seem to underscore that there is a legal need for impact assessments that ask (some) of these questions https://t.co/auiApVC0TW’ / Twitter. (n.d.). Retrieved 22 March 2022, from https://twitter.com/SciBeh/status/1485927221449613314
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Halilova, J. G., Fynes-Clinton, S., Green, L., Myerson, J., Wu, J., Ruggeri, K., … Rosenbaum, R. (2022, January 28). Short-sighted decision-making by those not vaccinated against COVID-19. https://doi.org/10.31234/osf.io/6uqky
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psyarxiv.com psyarxiv.com
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Kourtesis, Panagiotis, Graham Wilson, and Mario Parra Rodrigues. ‘Factors Influencing Acceptance of Technology across Age: Amid the COVID-19 Pandemic’. PsyArXiv, 4 February 2022. https://doi.org/10.31234/osf.io/tsrk4.
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www.theguardian.com www.theguardian.com
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France-Presse, A. (2022, March 13). China battles worst Covid outbreak for two years as cases double in 24 hours. The Guardian. https://www.theguardian.com/world/2022/mar/13/china-battles-worst-covid-outbreak-for-two-years-as-cases-double-in-24-hours
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blog.petrieflom.law.harvard.edu blog.petrieflom.law.harvard.edu
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Reichel, C. (2022, March 1). Please Keep Your Masks On. Bill of Health. http://blog.petrieflom.law.harvard.edu/2022/02/28/please-keep-your-masks-on/
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www.cnn.com www.cnn.com
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CNN, T. A. and K. D. (n.d.). CDC estimates 140 million US Covid-19 infections. CNN. Retrieved 7 March 2022, from https://www.cnn.com/2022/03/01/health/140-million-covid-19-infections/index.html
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www.bmj.com www.bmj.com
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Mahase, E. (2022). Covid-19: Sanofi and GSK to seek regulatory authorisation for protein based vaccine. BMJ, 376, o526. https://doi.org/10.1136/bmj.o526
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- Feb 2022
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www.sanofi.com www.sanofi.com
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Sanofi: Press Releases, Wednesday, February 23, 2022. (n.d.). Https://Www.Sanofi.Com/En/Media-Room/Press-Releases/2022/2022-02-23-11-15-00-2390091. Retrieved 25 February 2022, from https://www.sanofi.com/media-room/press-releases/2022/2022-02-23 11-15-00 2390091
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www.nature.com www.nature.com
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Tseng, H. F., Ackerson, B. K., Luo, Y., Sy, L. S., Talarico, C. A., Tian, Y., Bruxvoort, K. J., Tubert, J. E., Florea, A., Ku, J. H., Lee, G. S., Choi, S. K., Takhar, H. S., Aragones, M., & Qian, L. (2022). Effectiveness of mRNA-1273 against SARS-CoV-2 Omicron and Delta variants. Nature Medicine, 1–1. https://doi.org/10.1038/s41591-022-01753-y
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www.medrxiv.org www.medrxiv.org
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Regev-Yochay, G., Gonen, T., Gilboa, M., Mandelboim, M., Indenbaum, V., Amit, S., Meltzer, L., Asraf, K., Cohen, C., Fluss, R., Biber, A., Nemet, I., Kliker, L., Joseph, G., Doolman, R., Mendelson, E., Freedman, L. S., Harats, D., Kreiss, Y., & Lustig, Y. (2022). 4th Dose COVID mRNA Vaccines’ Immunogenicity & Efficacy Against Omicron VOC (p. 2022.02.15.22270948). medRxiv. https://doi.org/10.1101/2022.02.15.22270948
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jamanetwork.com jamanetwork.com
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Auger, K. A., Shah, S. S., Richardson, T., Hartley, D., Hall, M., Warniment, A., Timmons, K., Bosse, D., Ferris, S. A., Brady, P. W., Schondelmeyer, A. C., & Thomson, J. E. (2020). Association Between Statewide School Closure and COVID-19 Incidence and Mortality in the US. JAMA, 324(9), 859–870. https://doi.org/10.1001/jama.2020.14348
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twitter.com twitter.com
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Deepti Gurdasani. (2022, January 10). Lots of people dismissing links between COVID-19 and all-cause diabetes. An association that’s been shown in multiple studies- whether this increase is due to more diabetes or SARS2 precipitating diabetic keto-acidosis allowing these to be diagnosed is not known. A brief look👇 [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1480546865812840450
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twitter.com twitter.com
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Deepti Gurdasani. (2022, February 8). Exactly this 👇 We never talk about the huge benefits mitigations have had in reducing other respiratory illnesses... Which means deaths from other causes have reduced. Excess deaths are not a good indicator of COVID-19 deaths—Which we should be doing a lot more to prevent! [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1491123632349024256
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twitter.com twitter.com
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ReconfigBehSci. (2022, January 20). @timcolbourn @OmicronData I’m sorry but I genuinely do not see how this is a response to what I said about the presuppositions in the ‘delay framing’? This reply is about your views on disease burden, not -as mine is- how choice of terminology implicitly shapes the argument space [Tweet]. @i. https://twitter.com/i/web/status/1484191657318879234
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twitter.com twitter.com
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World Health Organization (WHO) on Twitter. (n.d.). Twitter. Retrieved 13 February 2022, from https://twitter.com/WHO/status/1485554889900142599
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www.science.org www.science.org
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COVID-19 takes serious toll on heart health—A full year after recovery. (n.d.). Retrieved February 11, 2022, from https://www.science.org/content/article/covid-19-takes-serious-toll-heart-health-full-year-after-recovery
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twitter.com twitter.com
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ReconfigBehSci. (2022, January 20). @timcolbourn @OmicronData As I said before, it’s not the function of this account to argue/advocate covid policies, but I will comment on the shape of the argument. The use of the frame “just delay” here seems hugely prejudicial. We don’t talk that way about flu or other diseases we might get repeatedly [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1484074977964011520
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www.bmj.com www.bmj.com
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Mahase, E. (2022). Omicron sub-lineage BA.2 may have “substantial growth advantage,” UKHSA reports. BMJ, 376, o263. https://doi.org/10.1136/bmj.o263
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- Jan 2022
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twitter.com twitter.com
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ReconfigBehSci on Twitter: “RT @AliHMokdad: Vaccine effectiveness against BA.1 and BA.2. After 2 doses it was 9% (7-10%) and 13% (-26-40%) respectively for BA.1 and BA…” / Twitter. (n.d.). Retrieved January 30, 2022, from https://twitter.com/SciBeh/status/1487123660771106821
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www.cdc.gov www.cdc.gov
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French, G. (2021). Impact of Hospital Strain on Excess Deaths During the COVID-19 Pandemic—United States, July 2020–July 2021. MMWR. Morbidity and Mortality Weekly Report, 70. https://doi.org/10.15585/mmwr.mm7046a5
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twitter.com twitter.com
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James 💙 Neill - 😷 🇪🇺🇮🇪🇬🇧🔶. (2022, January 23). Of 51,141 deaths due to ischaemic heart diseases 32,872 (64.3%) had pre-existing conditions.💔 Do those 33k heart disease deaths not count? Or is an absence of pre-existing conditions only required for Covid deaths...😡⁉️ Source: ONS England 2019 [Tweet]. @jneill. https://twitter.com/jneill/status/1485327886164844546
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twitter.com twitter.com
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ReconfigBehSci on Twitter: “RT @acweyand: Kids account for <0.2% of cancer deaths in US Kids account for <0.2% of heart disease deaths in US Kids account for <0.3% of…” / Twitter. (n.d.). Retrieved January 21, 2022, from https://twitter.com/SciBeh/status/1483869918332432388
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twitter.com twitter.com
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Helder Nakaya. (2022, January 14). 75 years of research on human diseases in 1 minute https://t.co/1QtdijRTtJ [Tweet]. @helder_nakaya. https://twitter.com/helder_nakaya/status/1482095277813157888
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Nash, D. (n.d.). The CDC Got Lost Trying to Follow the Science. Retrieved January 14, 2022, from https://www.barrons.com/articles/cdc-guidance-covid-isolation-pandemic-51641847943
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•. (n.d.). Even Mild COVID Infections Can Have Lasting Impacts Like ‘Chemo Brain,’ Study Finds. NBC New York. Retrieved 12 January 2022, from https://www.nbcnewyork.com/news/coronavirus/even-mild-covid-infections-can-have-lasting-impacts-like-chemo-brain-study-finds/3489958/
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www.forbes.com www.forbes.com
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J.D, S. B., M. D. (n.d.). The Rate Of Covid-19 Related Multisystem Inflammatory Syndrome In Children Is Skyrocketing. Forbes. Retrieved 10 January 2022, from https://www.forbes.com/sites/saibala/2022/01/07/the-rate-of-covid-19-related-multisystem-inflammatory-syndrome-mis-in-children-is-skyrocketing/
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CDC studies confirm mask-wearing in schools reduces spread of COVID-19. (2021, September 27). New Atlas. https://newatlas.com/health-wellbeing/cdc-mask-mandate-children-schools-coronavirus-effective/
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Jewett, C. (2021, November 4). Patients Went Into the Hospital for Care. After Testing Positive There for Covid, Some Never Came Out. Kaiser Health News. https://khn.org/news/article/hospital-acquired-covid-nosocomial-cases-data-analysis/
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Spiegelhalter, D., & Masters, A. (2022, January 2). Can you capture the complex reality of the pandemic with numbers? Well, we tried…. The Guardian. https://www.theguardian.com/commentisfree/2022/jan/02/2021-year-when-interpreting-covid-statistics-crucial-to-reach-truth
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McKie, R. (2022, January 2). Britain got it wrong on Covid: Long lockdown did more harm than good, says scientist. The Observer. https://www.theguardian.com/world/2022/jan/02/britain-got-it-wrong-on-covid-long-lockdown-did-more-harm-than-good-says-scientist
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- Dec 2021
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www.washingtonpost.com www.washingtonpost.com
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Perspective | Even the best-case scenario with omicron will still be bad. (n.d.). Washington Post. Retrieved December 23, 2021, from https://www.washingtonpost.com/outlook/2021/12/21/omicron-mild-cases-numbers/
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www.theguardian.com www.theguardian.com
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Savage, M., McKie, R., & Ungoed-Thomas, J. (2021, December 18). UK scientists: Bring in curbs now or face up to 2m daily Covid infections as Omicron spreads. The Observer. https://www.theguardian.com/world/2021/dec/18/uk-scientists-curbs-covid-infections-omicron-deaths-restrictions-sage
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ReconfigBehSci on Twitter: "RT @vmcorman: “...With nearly 5 million children ages 5 to 11 now vaccinated against COVID-19, Centers for Disease Control and Prevention D…” / Twitter. (n.d.). Retrieved December 13, 2021, from https://twitter.com/SciBeh/status/1470066664301637632
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journals.lww.com journals.lww.com
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Johnston, M. (2021). What Lies Beneath: Tackling Vaccine Hesitancy. Emergency Medicine News, 43(10), 7. https://doi.org/10.1097/01.EEM.0000795760.41732.33
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