gene name: DICER 1 PMID (PubMed ID): 33570641 HGNCID: n/a Inheritance Pattern: autosomal dominant Disease Entity: benign and malignant tumor mutation Mutation: somatic Zygosity: heterozygous Variant: n/a Family Information: n/a Case: people of all sexes, ages, ethnicities and races participated CasePresentingHPOs: individuals with DICER1-associated tumors or pathogenic germline DICER1 variants were recruited to participate CasePreviousTesting: n/a gnomAD: n/a

DICER1 is the gene name. PubMed ID, HGCNCID, and Variant: I can't find Inheritance Pattern: autosomal-dominant The disease entity: DICER1 syndrome The type of mutation: germline. Zygosity: not known. Family Information: a family was used, DICER1 carriers, and non DICER1 variant used, some of the family members had tumors from DICER1 Case Information: mean age is 34, the range of age is 18.6 to 43 years, male, and female used, ethnicity can't find Case Presenting HPO: cancer testing, chemotherapy, radiotherapy gnomeAD: 9.2,8.3.2 Mutation type: Pleiotropic, loss of function, missense

HGNCID:

Gene Name:DICER1 PMID: 30715996 HGNCID: Not on document Inheritance Pattern: Autosomal Dominant Disease Entity: Pleiotropic Tumor-Predisposition Disorder Mutation: Pathogenic Germline Variants Zygosity: Not in document Variant: Not in document Family Information: An individual was found who had family members who were also affected by this mutation. Because of this, those family members were also chosen to participate in this study. Mutation Type: Missense Case: The study was done on more than one individual. Roughly more than half of the individuals were female

Mathew, D., Giles, J. R., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., Kuri-Cervantes, L., Pampena, M. B., D’Andrea, K., Manne, S., Chen, Z., Huang, Y. J., Reilly, J. P., Weisman, A. R., Ittner, C. A. G., Kuthuru, O., Dougherty, J., Nzingha, K., … Wherry, E. J. (2020). Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science, 369(6508), eabc8511. https://doi.org/10.1126/science.abc8511

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Dr. Deepti Gurdasani. (2022, January 24). When did 4.5% of children in any age group being infected every wk become ok for any disease? [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1485670994320793602

Freja Kirsebom. (2022, January 28). Two important updates from our team this week: - Vaccine effectiveness (VE) against symptomatic disease after Omicron BA.2 shows that VE remains unchanged—VE against death after Omicron BA.1 shows VE is 95% at 2+ weeks after booster 1/7 Full report https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1050721/Vaccine-surveillance-report-week-4.pdf [Tweet]. @freja_kirsebom. https://twitter.com/freja_kirsebom/status/1486730977464369160

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GeneName:DICER1 PMID (PubMed ID): PMCID: PMC6418698 PMID: 30672147 HGNCID: NOT LISTED<br /> Inheritance Pattern: Autosomal Dominant Disease Entity: Cancer; benign and malignant tumors including pleuropulmonary blastoma, cystic nephroma, Sertoli-Leydig cell tumors, multinodular goiter, Thryoid cancer, rhabdomyosarcoma, and pineoblastoma. Mutation: Somatic missense variation Mutation type: missense Zygosity: None stated Variant: unregistered…. Family Information: Characterize germline variants in familial early-onset clorectal cancer patients; The observation of germline DICER1 variation with uterine corpus endometrial carcinoma merits additional investigation. CasePresentingHPOs: uterine and rectal cancers in germline mutation

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Carl T. Bergstrom. (2021, August 18). 1. There has been lots of talk about recent data from Israel that seem to suggest a decline in vaccine efficacy against severe disease due to Delta, waning protection, or both. This may have even been a motivation for Biden’s announcement that the US would be adopting boosters. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1427767356600688646

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ReconfigBehSci. (2021, January 29). RT @IndependentSage: 3.7 million infected with #COVID19 in the UK. An estimated 5-10% will develop #LongCovid. We can’t afford to ignore th… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1355097550529945607

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Dr. Deepti Gurdasani. (2022, March 1). New study out yesterday suggesting that vaccine efficacy with current dose for 5-11 yr olds likely wanes quickly. Especially against infection, but also against hospitalisation, although protection against severe disease is higher. Seems to be closely linked to vaccine dose🧵 https://t.co/NojLODF1ED [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1498580243665367040

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ReconfigBehSci. (2022, January 20). @OmicronData @timcolbourn I think there might be a difference here between what you are putting forward and what @timcolbourn is arguing any rational individual should be for analysing the expected costs and benefits of a course of action, and I assume we all agree on that. 1/2 [Tweet]. @i. https://twitter.com/i/web/status/1484080972459134976

ReconfigBehSci on Twitter: ‘@STWorg @ProfColinDavis @rpancost @chrisdc77 @syrpis this is the most in depth treatment of the impact of equalities law on pandemic policy that I’ve been able to find- it would seem to underscore that there is a legal need for impact assessments that ask (some) of these questions https://t.co/auiApVC0TW’ / Twitter. (n.d.). Retrieved 22 March 2022, from https://twitter.com/SciBeh/status/1485927221449613314

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France-Presse, A. (2022, March 13). China battles worst Covid outbreak for two years as cases double in 24 hours. The Guardian. https://www.theguardian.com/world/2022/mar/13/china-battles-worst-covid-outbreak-for-two-years-as-cases-double-in-24-hours

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Deepti Gurdasani. (2022, January 10). Lots of people dismissing links between COVID-19 and all-cause diabetes. An association that’s been shown in multiple studies- whether this increase is due to more diabetes or SARS2 precipitating diabetic keto-acidosis allowing these to be diagnosed is not known. A brief look👇 [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1480546865812840450

Deepti Gurdasani. (2022, February 8). Exactly this 👇 We never talk about the huge benefits mitigations have had in reducing other respiratory illnesses... Which means deaths from other causes have reduced. Excess deaths are not a good indicator of COVID-19 deaths—Which we should be doing a lot more to prevent! [Tweet]. @dgurdasani1. https://twitter.com/dgurdasani1/status/1491123632349024256

ReconfigBehSci. (2022, January 20). @timcolbourn @OmicronData I’m sorry but I genuinely do not see how this is a response to what I said about the presuppositions in the ‘delay framing’? This reply is about your views on disease burden, not -as mine is- how choice of terminology implicitly shapes the argument space [Tweet]. @i. https://twitter.com/i/web/status/1484191657318879234

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ReconfigBehSci. (2022, January 20). @timcolbourn @OmicronData As I said before, it’s not the function of this account to argue/advocate covid policies, but I will comment on the shape of the argument. The use of the frame “just delay” here seems hugely prejudicial. We don’t talk that way about flu or other diseases we might get repeatedly [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1484074977964011520

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ReconfigBehSci on Twitter: “RT @AliHMokdad: Vaccine effectiveness against BA.1 and BA.2. After 2 doses it was 9% (7-10%) and 13% (-26-40%) respectively for BA.1 and BA…” / Twitter. (n.d.). Retrieved January 30, 2022, from https://twitter.com/SciBeh/status/1487123660771106821

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James 💙 Neill - 😷 🇪🇺🇮🇪🇬🇧🔶. (2022, January 23). Of 51,141 deaths due to ischaemic heart diseases 32,872 (64.3%) had pre-existing conditions.💔 Do those 33k heart disease deaths not count? Or is an absence of pre-existing conditions only required for Covid deaths...😡⁉️ Source: ONS England 2019 [Tweet]. @jneill. https://twitter.com/jneill/status/1485327886164844546

ReconfigBehSci on Twitter: “RT @acweyand: Kids account for <0.2% of cancer deaths in US Kids account for <0.2% of heart disease deaths in US Kids account for <0.3% of…” / Twitter. (n.d.). Retrieved January 21, 2022, from https://twitter.com/SciBeh/status/1483869918332432388

Helder Nakaya. (2022, January 14). 75 years of research on human diseases in 1 minute https://t.co/1QtdijRTtJ [Tweet]. @helder_nakaya. https://twitter.com/helder_nakaya/status/1482095277813157888

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J.D, S. B., M. D. (n.d.). The Rate Of Covid-19 Related Multisystem Inflammatory Syndrome In Children Is Skyrocketing. Forbes. Retrieved 10 January 2022, from https://www.forbes.com/sites/saibala/2022/01/07/the-rate-of-covid-19-related-multisystem-inflammatory-syndrome-mis-in-children-is-skyrocketing/

CDC studies confirm mask-wearing in schools reduces spread of COVID-19. (2021, September 27). New Atlas. https://newatlas.com/health-wellbeing/cdc-mask-mandate-children-schools-coronavirus-effective/

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Savage, M., McKie, R., & Ungoed-Thomas, J. (2021, December 18). UK scientists: Bring in curbs now or face up to 2m daily Covid infections as Omicron spreads. The Observer. https://www.theguardian.com/world/2021/dec/18/uk-scientists-curbs-covid-infections-omicron-deaths-restrictions-sage

ReconfigBehSci on Twitter: "RT @vmcorman: “...With nearly 5 million children ages 5 to 11 now vaccinated against COVID-19, Centers for Disease Control and Prevention D…” / Twitter. (n.d.). Retrieved December 13, 2021, from https://twitter.com/SciBeh/status/1470066664301637632

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Kit Yates. (2021, November 26). European centres for disease prevention and control has designated B.1.1.259 as a variant of concern. Fast work. Https://t.co/f6JiWVvjJC [Tweet]. @Kit_Yates_Maths. https://twitter.com/Kit_Yates_Maths/status/1464285136137170947

Dr Ellie Murray, ScD. (2021, October 2). Everyone keeps talking about covid becoming endemic, but as I listen to the conversation, it’s becoming more & more clear to me that very few of you know what “endemic” means. So here’s a thread on how pandemics end. Https://t.co/uuYinUcynb [Tweet]. @EpiEllie. https://twitter.com/EpiEllie/status/1444088804961304581

JITSUVAX. (2021, November 8). 🤰UPDATE: The @SciBeh and @jitsuvax team has created a new page ‘COVID-19 Vaccines and Pregnancy’. Learn more about the risk of the disease, the safety of vaccination, breast-feeding and common myths about fertility https://c19vax.scibeh.org/pages/pregnancy https://t.co/g6BFn7DHPD [Tweet]. @jitsuvax. https://twitter.com/jitsuvax/status/1457654003467182084

Prof. Akiko Iwasaki. (2021, September 23). Thankfully, we have not seen any evidence of antibody-dependent enhancement of infection or disease by any COVID vaccines to date. Vaccine are not making infections worse, and are very effective in preventing disease. [Tweet]. @VirusesImmunity. https://twitter.com/VirusesImmunity/status/1441074260534075392

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Aeschlimann, J. R. (2021, October 15). Ivermectin Treats Many Infections in Humans – Just Not COVID-19. The Wire Science. https://science.thewire.in/health/ivermectin-treats-many-infections-in-humans-just-not-covid-19/

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