12 Matching Annotations
  1. Last 7 days
  2. Apr 2019
    1. Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein predominantly produced in the kidney, with shedding of the amino-terminal extracellular domain into the systemic circulation. Circulating levels of soluble Klotho decrease with age, and the klotho gene is associated with increased risk of age-related diseases. The three forms of Klotho protein have distinct functions. Membrane Klotho forms a complex with fibroblast growth factor (FGF) receptors, functions as an obligatory co-receptor for FGF23, which is involved in aging and the development of chronic diseases via regulation of Pi and vitamin D metabolism. Secreted Klotho functions as a humoral factor with pleiotropic activities including regulation of oxidative stress, growth factor signaling, and ion homeostasis. Secreted Klotho is also involved in organ protection. The intracellular form of Klotho suppresses inflammation-mediated cellular senescence and mineral metabolism. Herein we provide a brief overview of the structure and function and recent research about Klotho.
  3. Mar 2018
    1. Mediates the ratio of acetyl-CoA/CoA•Decreases with age in plasma and in brain

      in humans.

  4. Oct 2017
    1. Drunk with fatigue

      War is not only difficult on the physical aspect of an individual; it is just as difficult on the emotional and mental capacity of a human. It is factual that WWI culminated an astronomical amount of casualties, destruction, and disablement. This reference to being “drunk” may help guide us into the notion that soldiers are not able to differentiate between fantasy and reality under the duress of mentioned “fatigue.” We can understand that the state of "drunk" alters your reality and can have dangerous repercussions; in this sense, the loss of one's mind or life. In the prior lines we have loss of physical functionalities of the human body with words such as “limped on,” “lame,” and “blind,” which coincides with the premature aging or physical deterioration of the soldiers.

    2. like old beggars

      With the introduction and evolution of chemical weapons used in this war (WWI); human bodies were no match for the damage these weapons were designed to inflict. Leading into the imagery of soldiers physically deteriorating when using phrases such as "bent double," "coughing like hags," and "men marched asleep;" would not lead one to believe that war is “sweet and fitting” in any capacity. With the use of the word “beggars” our minds may envision the effects of poverty and desperation which war seems to produce, and in this sense, we are given language expressing the overwhelming misery and accelerated age progression with the use of “old.” These descriptions challenge the assumptions the mind tends to gravitate towards when picturing what it means to "die for ones country."

  5. Jul 2017
    1. That progress has been spurred by huge investments from Silicon Valley titans, including Google’s Sergey Brin and Larry Page, Amazon’s Jeff Bezos, PayPal cofounder Peter Thiel, and Oracle cofounder Larry Ellison.

      Billionaires want to live forever.

  6. May 2017
    1. Mr. Russell, or some version of him, assays the role with a weird, disrupting digital face-lift that’s meant to suggest the young Ego, but really only makes you contemplate whether this Benjamin Button-style age-reversing is going to become an increasingly standard (and creepy) industry practice.

      So, in Ant Man, there is the same thing with Michael Douglas. I totally think it will be a common thing. Not just for flashbacks but for actors who want to play the role "younger."

  7. Jan 2017
    1. Hard work makes you feel bad in the moment. The Marine Corps has a motto that embodies this principle: “Pain is weakness leaving the body.” That is, the discomfort of exertion means you’re building muscle and discipline. Superagers are like Marines: They excel at pushing past the temporary unpleasantness of intense effort. Studies suggest that the result is a more youthful brain that helps maintain a sharper memory and a greater ability to pay attention.
    2. Of course, the big question is: How do you become a superager? Which activities, if any, will increase your chances of remaining mentally sharp into old age? We’re still studying this question, but our best answer at the moment is: work hard at something. Many labs have observed that these critical brain regions increase in activity when people perform difficult tasks, whether the effort is physical or mental. You can therefore help keep these regions thick and healthy through vigorous exercise and bouts of strenuous mental effort. My father-in-law, for example, swims every day and plays tournament bridge.
  8. Oct 2016
    1. , who was once handsome

      Things are dying in the wasteland and no longer glorious.

  9. Oct 2015
    1. And what they found was that the individuals who participated in the meditation programhad longer telomeres than the individuals who were in the control group after a three-monthexperience. This was first finding in that vein. Elissa Epel and her colleague did anotherresearch project where they looked at a mindfulness-based program for people with eating disorders andshowed that people who did the mindfulness had a 39% increase in telomerase activitywhich corresponds to lengthened telomeres and that this telomerase activity actuallypredicted benefits in other aspects of their treatment program having to do with the people’seating habits. So there’s this interesting effect that is being reiterated that mindfulnessactually seems to make people age more gracefully.
  10. Sep 2013
    1. There is, indeed, a capacity for long life that is quite independent of health or strength; for many people live long who lack the excellences of the body; but for our present purpose there is no use in going into the details of this.

      Or independence, getting to my earlier point.