258 Matching Annotations
  1. Jan 2023
    1. one reason the Golden Age of Piracy remains the stuff oflegend is that pirates of that age were so skilled at manipulatinglegends; they deployed wonder-stories—whether of terrifyingviolence or inspiring ideals—as something very much like weaponsof war, even if the war in question was the desperate and ultimatelydoomed struggle of a motley band of outlaws against the entireemerging structure of world authority at the time.
    1. during Iron Age I, in the 12th–11thcenturies BCE, Ekron, which is located very near the Sorek Valley, was thedominant Philistine center, and the biblical tradition accordingly places thenarrative concerning the Philistines in that valley.
    2. duringIron Age IIA, the 10th–9th centuries BCE, Gath in the Elah Valley becamethe dominant Philistine center and the biblical tradition recounting theborder disputes between the Philistines and the Israelites accordingly shiftsfrom the Sorek Valley to the Elah Valley.
    3. Traditions connected to the Elah Valley are preserved in the books ofSamuel and Chronicles, which relate to Iron Age IIA.
  2. Dec 2022
  3. www.janeausten.pludhlab.org www.janeausten.pludhlab.org
    1. playfully

      Is Emma flirting or is this a younger sister teasing an older brother?

      The age gap and the family relationship both can make this a little icky - though people talk about it less than Marianne and Colonel Brandon in Sense and Sensibility

  4. Sep 2022
    1. most intriguing to me was the discovery which even today some 00:23:13 archaeologists deny but the evidence is actually overwhelming that oceans were no barriers to erectus they sailed across oceans so this is a quote from a 00:23:24 very good book on Paleolithic Stone Age seafarers Paleolithic books our ancestors have often been painted as unintelligent brutes however this simply is not the case evidence suggests that at least homo erectus and perhaps even 00:23:37 pre erectus hominids were early seafarers based on this evidence it seems that our early ancestors were successful seafarers biological studies suggest that considerable numbers of founder populations so when we find 00:23:50 evidence of erectus tools on an island there had to have been 2250 erectus arrived they're more or less the same time it's not just that one erectus got there we also know and I'll go into this 00:24:03 that they didn't just wash ashore it would have been almost impossible some archaeologists suggest that they got there by tsunamis but when I talked to friends of mine who are earth scientists they say that's not how 00:24:17 tsunamis work you know the tsunamis are pushing water to land and it is possible that afterwards some things flow out but most of the energy is towards the land and it is true that a few animals have 00:24:30 made it but we don't find regular systematic colonization by humans waiting to ride tsunamis most people don't try to do that

      !- homo erectus : was a seafarer

  5. Aug 2022
    1. Politique documentaire Ensemble des objectifs et processus pilotant la gestion de l’information, incluant la politique d’acquisition, la politique de conservation et la politique de médiation des collections. La politique documentaire est une partie intégrante et essentielle du projet d'établissement, permettant de répondre aux missions de la structure et aux attentes des usagers.
  6. Jul 2022
    1. The first trap was hunting, the main way of life for about two million years in Palaeolithic times. As Stone Age people perfected the art of hunting, they began to kill the game more quickly than it could breed. They lived high for a while, then starved.

      Anthropology and Archelogy findings support the idea that humans began laying progress traps as early as two million years ago. Our great success at socialization and communication that harnessed the power of collaboration resulted in wiping out entire species upon which we depended. Short term success leading to long term failure is a central pattern of progress traps.

      Anthropology and Archelogy findings support the idea that humans began laying progress traps as early as two million years ago. Our great success at socialization and communication that harnessed the power of collaboration resulted in wiping out entire species upon which we depended. Short term success leading to long term failure is a central pattern of progress traps.

      A remarkable paper from Tel Aviv researchers studying early hunters in the Southern Levant as early as 1.5 million years ago revealed that our ancestors in this part of the world were poor resource managers and over many generations, continually hunted large game to extinction, forcing descendants to hunt progressively smaller game.

      Annotation of the 2021 source paper is here: https://hyp.is/go?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fabs%2Fpii%2FS0277379121005230&group=world Annotation of a science news interview with the researchers here: https://hyp.is/go?url=https%3A%2F%2Fwww.sciencedaily.com%2Freleases%2F2021%2F12%2F211221102708.htm&group=world

      The researchers even surmise that the extinction of game animals by around 10,000 B.C. is what gave rise to agriculture itself!

  7. Jun 2022
  8. May 2022
    1. According to the “Korean age” system, a person turns one the day they are born and they then become a year older on New Year’s Day, irrespective of the date on which they were born.   This traditional method of determining age was used in a number of east Asian nations in the past, including China and Japan, and is believed to stem from the concept that time inside the mother’s womb counts as the first year of a child’s life.
    1. DICER1 syndrome encompasses a variety of benign and malignant manifestations including multinodular goitre

      Gene: DICER1 PMCID: PMC8451242 PMID: 34552563 Pathogenic Inheritance Pattern: Autosomal Dominant MultipleDiseaseEntities Disease Entity: DICER1 syndrome, multinodular goitre, cystic nephroma, anaplastic renal sarcoma, Wilms tumour, differentiated thyroid carcinoma, gynandroblastoma, ciliary body medulloepithelioma, embryonal rhabdomyosarcoma, pineoblastoma, pituitary blastoma, kidney cyst, pulmonary cyst, Sertoli-Leydig Cell Tumor. Mutation: Germline MultipleGeneVariants Variant & Clinvar IDs: c.3452_3453del (485534), c.316del (no ClinVar ID), c.171_172insAC (no ClinVar ID), c.3434del (no ClinVar ID), c.988C>T (933007), c.5388dup (no ClinVar ID) Zygosity: None provided. Case: At time of operation, the goitre patients living in Denmark were ages 21, 12, 21, 8, 14, and 16. Four underwent total thyroidectomies, and two underwent partial thyroidectomies. The patient originally aged 21 previously had a kidney cyst at age 14 and a pulmonary cyst at an unknown age. The patient aged 14 at time of partial thyroidectomy later manifested a Sertoli-Leydig Cell Tumor at age 15. All six patients were female. CasePresentingHPO: None provided. CasePreviousTesting: thyroidectomy gnomAD: ENSG00000100697.10, https://gnomad.broadinstitute.org/gene/ENSG00000100697 Mutation Type: Frameshift, Nonsense

  9. Apr 2022
    1. Carl T. Bergstrom. (2021, August 18). 1. There has been lots of talk about recent data from Israel that seem to suggest a decline in vaccine efficacy against severe disease due to Delta, waning protection, or both. This may have even been a motivation for Biden’s announcement that the US would be adopting boosters. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1427767356600688646

    1. Dr Greg Kelly. (2021, July 2). As a pediatrician I’m going on record saying that allowing kids to be freely infected with a novel disease that has unknown long term consequences is the worst idea of 2021 despite being a pretty crowded field so far #COVID19 [Tweet]. @drgregkelly. https://twitter.com/drgregkelly/status/1411083905034117120

    1. Dr Duncan Robertson [@Dr_D_Robertson]. (2021, October 29). ONS Covid survey. 2% of the population +ve. “The percentage of people testing positive for COVID-19 increased for all age groups, except for those in school Year 12 to those aged 34 years, where the trend was uncertain in the week ending 22 October 2021” https://ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/coronaviruscovid19infectionsurveypilot/29october2021 https://t.co/1n9KVq6wDT [Tweet]. Twitter. https://twitter.com/Dr_D_Robertson/status/1454050450106376192

    1. Marc Lipsitch. (2021, July 20). At the risk of boiling down too much and certainly losing some detail, one way to summarize this wonderful thread is that when we think about vaccine effectiveness, we should think of 4 key variables: 1 which vaccine, 2 age of the person, 3 how long after vax, 4 vs what outcome. [Tweet]. @mlipsitch. https://twitter.com/mlipsitch/status/1417595538632060931

    1. Prof. Christina Pagel 🇺🇦. (2022, March 8). What could be causing it? Likely combo of: 1—Dominant BA.2 causing more infections (we await ONS!) 2—Reduction in masks, self-isolation & testing enabling more infections 3—Waning boosters in older people esp I worry that we will be stuck at high levels for long time. 2/2 https://t.co/xZ2SLFNVkS [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1501250081693048838

  10. Mar 2022
  11. Feb 2022
    1. Alastair Grant. (2022, February 16). Samples likely to be BA.2 (SGT positive in TaqPath data) now make up 34% of COVID cases in England. The proportion has roughly doubled in a week. That represents a growth in absolute numbers of BA.2, even if overall infections are falling at the same rate as reported cases https://t.co/LNr5baChby [Tweet]. @AlastairGrant4. https://twitter.com/AlastairGrant4/status/1493880986660225024

    1. F. Perry Wilson, MD MSCE. (2022, February 4). If you, like me, are “skipping ahead” during the ACIP meeting re: Moderna vaccine—This slide really drives home the benefit / risk paradigm among the group at highest risk of myocarditis (men 18-35). 2 million shots = 1903 avoided hospitalizations, and 68 myocarditis cases. Https://t.co/3nzWXGXyD1 [Tweet]. @fperrywilson. https://twitter.com/fperrywilson/status/1489649379979972609

  12. Jan 2022
    1. Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. A., Channon, K. M., Mills, N. L., Sheikh, A., & Hippisley-Cox, J. (2021). Risk of myocarditis following sequential COVID-19 vaccinations by age and sex (p. 2021.12.23.21268276). medRxiv. https://doi.org/10.1101/2021.12.23.21268276

    1. Townsend, L., Dyer, A. H., Naughton, A., Kiersey, R., Holden, D., Gardiner, M., Dowds, J., O’Brien, K., Bannan, C., Nadarajan, P., Dunne, J., Martin-Loeches, I., Fallon, P. G., Bergin, C., O’Farrelly, C., Cheallaigh, C. N., Bourke, N. M., & Conlon, N. (2021). Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health. Frontiers in Immunology, 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.676932

  13. Dec 2021
  14. Nov 2021
  15. Oct 2021
  16. Sep 2021
    1. from the analog age to the digital age

      So what is the exact definition of digital age? When can we say that we live in a digital age?

    1. John Burn-Murdoch. (2021, August 23). NEW: in the last couple of weeks there have a lot of new studies out assessing vaccine efficacy, many of which have touched on the question of waning immunity. Unsurprisingly, these have prompted a lot of questions. Time for a thread to summarise what we do and don’t know: [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1429878189011111936

    1. Liu, W., Russell, R. M., Bibollet-Ruche, F., Skelly, A. N., Sherrill-Mix, S., Freeman, D. A., Stoltz, R., Lindemuth, E., Lee, F.-H., Sterrett, S., Bar, K. J., Erdmann, N., Gouma, S., Hensley, S. E., Ketas, T., Cupo, A., Cruz Portillo, V. M., Moore, J. P., Bieniasz, P. D., … Hahn, B. H. (2021). Predictors of Nonseroconversion after SARS-CoV-2 Infection. Emerging Infectious Diseases, 27(9), 2454–2458. https://doi.org/10.3201/eid2709.211042

  17. Aug 2021
    1. (((Howard Forman))). (2021, July 26). ‘Among those aged 60-plus, early vaccinators are twice as likely to get infected. For those aged 40-59 early vaccinators are 2.1 times more vulnerable, and among under 39s they are 1.6 more likely to catch the coronavirus.’ https://timesofisrael.com/hmo-those-who-inoculated-early-twice-as-likely-to-catch-covid-as-later-adopters/ [Tweet]. @thehowie. https://twitter.com/thehowie/status/1419647827458789383

  18. Jul 2021
    1. Collier, D. A., Ferreira, I. A. T. M., Kotagiri, P., Datir, R., Lim, E., Touizer, E., Meng, B., Abdullahi, A., Elmer, A., Kingston, N., Graves, B., Gresley, E. L., Caputo, D., Bergamaschi, L., Smith, K. G. C., Bradley, J. R., Ceron-Gutierrez, L., Cortes-Acevedo, P., Barcenas-Morales, G., … Gupta, R. K. (2021). Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature, 1–9. https://doi.org/10.1038/s41586-021-03739-1

  19. Jun 2021
    1. Helen McArdle on Twitter: “The good news: An astonishing 98.2% of over-60s in Scotland are now fully vaccinated. That’s an amazing uptake. It doesn’t mean they are 100% protected of course (and especially not when case rates are high) but their risk of hospitalisation/death is cut by over 90% https://t.co/DzAxkpLvcR” / Twitter. (n.d.). Retrieved June 30, 2021, from https://twitter.com/HMcArdleHT/status/1409821893557768195

  20. May 2021
    1. Prof. Christina Pagel. (2021, April 15). THREAD on VACCINATION & EQUITY in ENGLAND: I know I’ve tweeted about this before, but now we can look at how gaps by deprivation and ethnicity change with age groups and what that might mean... TLDR: widening gaps but access and communication will be key I suspect 1/5 [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1382725119773134848