252 Matching Annotations
  1. Aug 2022
    1. Politique documentaire Ensemble des objectifs et processus pilotant la gestion de l’information, incluant la politique d’acquisition, la politique de conservation et la politique de médiation des collections. La politique documentaire est une partie intégrante et essentielle du projet d'établissement, permettant de répondre aux missions de la structure et aux attentes des usagers.
  2. Jul 2022
    1. The first trap was hunting, the main way of life for about two million years in Palaeolithic times. As Stone Age people perfected the art of hunting, they began to kill the game more quickly than it could breed. They lived high for a while, then starved.

      Anthropology and Archelogy findings support the idea that humans began laying progress traps as early as two million years ago. Our great success at socialization and communication that harnessed the power of collaboration resulted in wiping out entire species upon which we depended. Short term success leading to long term failure is a central pattern of progress traps.

      Anthropology and Archelogy findings support the idea that humans began laying progress traps as early as two million years ago. Our great success at socialization and communication that harnessed the power of collaboration resulted in wiping out entire species upon which we depended. Short term success leading to long term failure is a central pattern of progress traps.

      A remarkable paper from Tel Aviv researchers studying early hunters in the Southern Levant as early as 1.5 million years ago revealed that our ancestors in this part of the world were poor resource managers and over many generations, continually hunted large game to extinction, forcing descendants to hunt progressively smaller game.

      Annotation of the 2021 source paper is here: https://hyp.is/go?url=https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fabs%2Fpii%2FS0277379121005230&group=world Annotation of a science news interview with the researchers here: https://hyp.is/go?url=https%3A%2F%2Fwww.sciencedaily.com%2Freleases%2F2021%2F12%2F211221102708.htm&group=world

      The researchers even surmise that the extinction of game animals by around 10,000 B.C. is what gave rise to agriculture itself!

  3. Jun 2022
  4. May 2022
    1. According to the “Korean age” system, a person turns one the day they are born and they then become a year older on New Year’s Day, irrespective of the date on which they were born.   This traditional method of determining age was used in a number of east Asian nations in the past, including China and Japan, and is believed to stem from the concept that time inside the mother’s womb counts as the first year of a child’s life.
    1. DICER1 syndrome encompasses a variety of benign and malignant manifestations including multinodular goitre

      Gene: DICER1 PMCID: PMC8451242 PMID: 34552563 Pathogenic Inheritance Pattern: Autosomal Dominant MultipleDiseaseEntities Disease Entity: DICER1 syndrome, multinodular goitre, cystic nephroma, anaplastic renal sarcoma, Wilms tumour, differentiated thyroid carcinoma, gynandroblastoma, ciliary body medulloepithelioma, embryonal rhabdomyosarcoma, pineoblastoma, pituitary blastoma, kidney cyst, pulmonary cyst, Sertoli-Leydig Cell Tumor. Mutation: Germline MultipleGeneVariants Variant & Clinvar IDs: c.3452_3453del (485534), c.316del (no ClinVar ID), c.171_172insAC (no ClinVar ID), c.3434del (no ClinVar ID), c.988C>T (933007), c.5388dup (no ClinVar ID) Zygosity: None provided. Case: At time of operation, the goitre patients living in Denmark were ages 21, 12, 21, 8, 14, and 16. Four underwent total thyroidectomies, and two underwent partial thyroidectomies. The patient originally aged 21 previously had a kidney cyst at age 14 and a pulmonary cyst at an unknown age. The patient aged 14 at time of partial thyroidectomy later manifested a Sertoli-Leydig Cell Tumor at age 15. All six patients were female. CasePresentingHPO: None provided. CasePreviousTesting: thyroidectomy gnomAD: ENSG00000100697.10, https://gnomad.broadinstitute.org/gene/ENSG00000100697 Mutation Type: Frameshift, Nonsense

  5. Apr 2022
    1. Carl T. Bergstrom. (2021, August 18). 1. There has been lots of talk about recent data from Israel that seem to suggest a decline in vaccine efficacy against severe disease due to Delta, waning protection, or both. This may have even been a motivation for Biden’s announcement that the US would be adopting boosters. [Tweet]. @CT_Bergstrom. https://twitter.com/CT_Bergstrom/status/1427767356600688646

    1. Dr Greg Kelly. (2021, July 2). As a pediatrician I’m going on record saying that allowing kids to be freely infected with a novel disease that has unknown long term consequences is the worst idea of 2021 despite being a pretty crowded field so far #COVID19 [Tweet]. @drgregkelly. https://twitter.com/drgregkelly/status/1411083905034117120

    1. Dr Duncan Robertson [@Dr_D_Robertson]. (2021, October 29). ONS Covid survey. 2% of the population +ve. “The percentage of people testing positive for COVID-19 increased for all age groups, except for those in school Year 12 to those aged 34 years, where the trend was uncertain in the week ending 22 October 2021” https://ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/coronaviruscovid19infectionsurveypilot/29october2021 https://t.co/1n9KVq6wDT [Tweet]. Twitter. https://twitter.com/Dr_D_Robertson/status/1454050450106376192

    1. Marc Lipsitch. (2021, July 20). At the risk of boiling down too much and certainly losing some detail, one way to summarize this wonderful thread is that when we think about vaccine effectiveness, we should think of 4 key variables: 1 which vaccine, 2 age of the person, 3 how long after vax, 4 vs what outcome. [Tweet]. @mlipsitch. https://twitter.com/mlipsitch/status/1417595538632060931

    1. Prof. Christina Pagel 🇺🇦. (2022, March 8). What could be causing it? Likely combo of: 1—Dominant BA.2 causing more infections (we await ONS!) 2—Reduction in masks, self-isolation & testing enabling more infections 3—Waning boosters in older people esp I worry that we will be stuck at high levels for long time. 2/2 https://t.co/xZ2SLFNVkS [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1501250081693048838

  6. Mar 2022
  7. Feb 2022
    1. Alastair Grant. (2022, February 16). Samples likely to be BA.2 (SGT positive in TaqPath data) now make up 34% of COVID cases in England. The proportion has roughly doubled in a week. That represents a growth in absolute numbers of BA.2, even if overall infections are falling at the same rate as reported cases https://t.co/LNr5baChby [Tweet]. @AlastairGrant4. https://twitter.com/AlastairGrant4/status/1493880986660225024

    1. F. Perry Wilson, MD MSCE. (2022, February 4). If you, like me, are “skipping ahead” during the ACIP meeting re: Moderna vaccine—This slide really drives home the benefit / risk paradigm among the group at highest risk of myocarditis (men 18-35). 2 million shots = 1903 avoided hospitalizations, and 68 myocarditis cases. Https://t.co/3nzWXGXyD1 [Tweet]. @fperrywilson. https://twitter.com/fperrywilson/status/1489649379979972609

  8. Jan 2022
    1. Patone, M., Mei, X. W., Handunnetthi, L., Dixon, S., Zaccardi, F., Shankar-Hari, M., Watkinson, P., Khunti, K., Harnden, A., Coupland, C. A., Channon, K. M., Mills, N. L., Sheikh, A., & Hippisley-Cox, J. (2021). Risk of myocarditis following sequential COVID-19 vaccinations by age and sex (p. 2021.12.23.21268276). medRxiv. https://doi.org/10.1101/2021.12.23.21268276

    1. Townsend, L., Dyer, A. H., Naughton, A., Kiersey, R., Holden, D., Gardiner, M., Dowds, J., O’Brien, K., Bannan, C., Nadarajan, P., Dunne, J., Martin-Loeches, I., Fallon, P. G., Bergin, C., O’Farrelly, C., Cheallaigh, C. N., Bourke, N. M., & Conlon, N. (2021). Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health. Frontiers in Immunology, 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.676932

  9. Dec 2021
  10. Nov 2021
  11. Oct 2021
  12. Sep 2021
    1. from the analog age to the digital age

      So what is the exact definition of digital age? When can we say that we live in a digital age?

    1. John Burn-Murdoch. (2021, August 23). NEW: in the last couple of weeks there have a lot of new studies out assessing vaccine efficacy, many of which have touched on the question of waning immunity. Unsurprisingly, these have prompted a lot of questions. Time for a thread to summarise what we do and don’t know: [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1429878189011111936

    1. Liu, W., Russell, R. M., Bibollet-Ruche, F., Skelly, A. N., Sherrill-Mix, S., Freeman, D. A., Stoltz, R., Lindemuth, E., Lee, F.-H., Sterrett, S., Bar, K. J., Erdmann, N., Gouma, S., Hensley, S. E., Ketas, T., Cupo, A., Cruz Portillo, V. M., Moore, J. P., Bieniasz, P. D., … Hahn, B. H. (2021). Predictors of Nonseroconversion after SARS-CoV-2 Infection. Emerging Infectious Diseases, 27(9), 2454–2458. https://doi.org/10.3201/eid2709.211042

  13. Aug 2021
    1. (((Howard Forman))). (2021, July 26). ‘Among those aged 60-plus, early vaccinators are twice as likely to get infected. For those aged 40-59 early vaccinators are 2.1 times more vulnerable, and among under 39s they are 1.6 more likely to catch the coronavirus.’ https://timesofisrael.com/hmo-those-who-inoculated-early-twice-as-likely-to-catch-covid-as-later-adopters/ [Tweet]. @thehowie. https://twitter.com/thehowie/status/1419647827458789383

  14. Jul 2021
    1. Collier, D. A., Ferreira, I. A. T. M., Kotagiri, P., Datir, R., Lim, E., Touizer, E., Meng, B., Abdullahi, A., Elmer, A., Kingston, N., Graves, B., Gresley, E. L., Caputo, D., Bergamaschi, L., Smith, K. G. C., Bradley, J. R., Ceron-Gutierrez, L., Cortes-Acevedo, P., Barcenas-Morales, G., … Gupta, R. K. (2021). Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2. Nature, 1–9. https://doi.org/10.1038/s41586-021-03739-1

  15. Jun 2021
    1. Helen McArdle on Twitter: “The good news: An astonishing 98.2% of over-60s in Scotland are now fully vaccinated. That’s an amazing uptake. It doesn’t mean they are 100% protected of course (and especially not when case rates are high) but their risk of hospitalisation/death is cut by over 90% https://t.co/DzAxkpLvcR” / Twitter. (n.d.). Retrieved June 30, 2021, from https://twitter.com/HMcArdleHT/status/1409821893557768195

  16. May 2021
    1. Prof. Christina Pagel. (2021, April 15). THREAD on VACCINATION & EQUITY in ENGLAND: I know I’ve tweeted about this before, but now we can look at how gaps by deprivation and ethnicity change with age groups and what that might mean... TLDR: widening gaps but access and communication will be key I suspect 1/5 [Tweet]. @chrischirp. https://twitter.com/chrischirp/status/1382725119773134848

  17. Apr 2021
  18. Mar 2021