521 Matching Annotations
  1. Last 7 days
    1. Yes, precisely because I've been involved in maintaining codebases built without real full stack frameworks is why I say what I said.The problem we have in this industry, is that somebody reads these blog posts, and the next day at work they ditch the "legacy rails" and starts rewriting the monolith in sveltekit/nextjs/whatever because that's what he/she has been told is the modern way to do full stack.No need to say those engineers will quit 1 year later after they realize the mess they've created with their lightweight and simple modern framework.I've seen this too many times already.It is not about gatekeeping. It is about engineers being humble and assume it is very likely that their code is very unlikely to be better tested, documented, cohesive and maintained than what you're given in the real full stack frameworks.Of course you can build anything even in assembler if you want. The question is if that's the most useful thing to do with your company's money.
  2. Jan 2022
    1. And contrary to that science-denying slogan of Margaret Thatcher’s, that “there is no such thing as society,” no human has ever survived or thrived without a tribe or society.

      Is this a general feature of the conservative far right of constantly denying our humanity and care for each other?

    1. “It was kind of fun. Like even though I was green, that doesn’t mean my green tops your yellow right? Whatever I did, I just did it with a lot of energy.”

      There's been a normalization of providing exterior indicators of internal ideas and people's mental states. Examples include pins indicating pronouns, arm bracelets indicating social distancing or other social norms.

      But why aren't we taking these even farther on the anthropological spectrum? Is one society better or worse than another? One religion, one culture? Certainly not. Just like Leah McGowen-Hare's green band indicating that she's a hugger isn't any more valuable than someone else's yellow fist bump indicator. We need to do a better job of not putting people into linear relationships which only exist in our minds until we realize how horrific and dehumanizing they are.


      Cross reference:

    1. You live only until an objection scares the people whose job is more and more to avoid objections — that new, primary executive function.

      Are there other examples of this job function in the broader American culture? What do these job descriptions and titles look like?

  3. Dec 2021
    1. ‘Noble’ savages are, ultimately, just as boring as savageones; more to the point, neither actually exist. Helena Valero washerself adamant on this point. The Yanomami were not devils, sheinsisted, neither were they angels. They were human, like the rest ofus.

      This is an interesting starting point for discussing the ills of comparative anthropology which will tend to put one culture or society over another in some sort of linear way and an expectation of equivalence relations (in a mathematical sense).

      Humans and their societies and cultures aren't always reflexive, symmetric, or transitive. There may not be an order relation (aka simple order or linear order) on humanity. We may not have comparability, nonreflexivity, or transitivity.

      (See page 24 on Set Theory and Logic in Topology by James R. Munkres for definition of "order relation")

    2. ‘Security’ takes manyforms. There is the security of knowing one has a statistically smallerchance of getting shot with an arrow. And then there’s the security ofknowing that there are people in the world who will care deeply if oneis.
    3. We are projects of collective self-creation. What if we approached human history that way? What if wetreat people, from the beginning, as imaginative, intelligent, playfulcreatures who deserve to be understood as such? What if, instead oftelling a story about how our species fell from some idyllic state ofequality, we ask how we came to be trapped in such tight conceptualshackles that we can no longer even imagine the possibility ofreinventing ourselves?
    1. Recently, Strong, concerned about press reports suggesting that he was “difficult,” sent me a text message saying, “I don’t particularly think ease or even accord are virtues in creative work, and sometimes there must even be room for necessary roughness, within the boundaries dictated by the work.”

      An interesting take on creative work by Jeremy Strong

  4. Nov 2021
    1. https://www.theatlantic.com/ideas/archive/2021/10/evangelical-trump-christians-politics/620469/

      Evangelical Christians have been held together more by political orientation and sociology than they have by a common theology. This has set them up for a schism which has been exacerbated by Donald J. Trump, COVID-19, and social changes.

      Similar to Kurt's quote, "We go to church to see and be seen", too many churches are focused on entertainment and being an ongoing institution that they aren't focusing on their core mission. This is causing problems in their overall identity.

      Time at church and in religious study is limited, but cable news, social media, and other distractions are always on and end up winning out.

      People are more likely to change their church because of politics than to change their politics because of church.

      The dichotomy of maleness and femaleness compound the cultural issues of the evangelical church.

      Southernization of the Church

      Pastors leaving the profession due to issues with a hostile work environment. Some leaving because parishioners are organizing and demanding they be fired.

      Peter Wehner looks at the rifts that are appearing in the Christian evangelical movement in America, some are issues that have been building for a while, while others are exaggerated by Donald J. Trump, the coronavirus, the culture wars, political news, political beliefs, and and hypocrisy.

    2. Earlier this year, the Christian polling firm Barna Group found that 29 percent of pastors said they had given “real, serious consideration to quitting being in full-time ministry within the last year.” David Kinnaman, president of Barna, described the past year as a “crucible” for pastors as churches fragmented.

      What part does The Great Resignation have in part of this? Any? Is there overlap for any of the reasons that others are resigning?

      What about the overlap of causes/reasons for teachers leaving the profession since the pandemic? What effect does the hostile work environment of politics play versus a loss of identity and work schedule during a time period in which closures would have affected schedules?

      What commonalities and differences do all these cases have?

    1. it was assumed that rational thought was value free it was just you know about what was true in the world and so 00:26:06 on and it's not because you're concerned with empathy and morality when you're thinking and and with emotion rational thought is really value-based 00:26:19 now whoa let's go back one there's a further view Descartes assumed that all rationality was the same for everybody that it was universal that what made us 00:26:34 human beings was being rational and logical and that therefore everybody had the same mode of reasoning now if that's true then all you have to do let's say 00:26:47 in politics is tell something somebody to facts and everybody will reason to the same conclusion right sure not true that is if enlightenment reason were 00:27:01 right that would happen it doesn't happen it turns out that it is not the case that all concepts are you are universal and that all of them are 00:27:13 accessible to everybody and then there's another view of you coming out of the postmodern thought that says no concepts are universal they're all arbitrary that's also false many concepts are 00:27:26 universal and many are not a very and it's an empirical question which is which and they vary from language to language and that's important you need to know that it is not the case that 00:27:41 everything with all thought is universal and it's not the case that that's all language particular or particular that is you need to know empirically what part is shared with other people who 00:27:53 speak other languages and come from other cultures and what part is not and that is an important empirical study so the big myth is this but there is some objective rational structure to the 00:28:07 world out there and that human reason can fit it directly and characterize it literally without frames or metaphors and reason about it adequately with formal logic alone that's just false the 00:28:21 world is real that is whatever it is our bodies and brains provide understandings of the world which depend on frames metaphors image schemas prototypes narratives all of those things and it is 00:28:35 that that permits us to create

      Rational thought and emotions are entwined at the deepest level. Also, what Lakoff says about universals is very important as we consider how we unite and depolarize politics. We need to find the common denominators, but this is not such a simple task.

    1. A significant reduction in cognitive fatigue perception and overall FIS-40 score (p < 0.001 and p = 0.022, respectively)

      Given how cheap and easy this intervention is, I'd say this is adequate evidence that all ME/CFS patients should be taking these supplements. Moreover. given that the p-value is so low, it is almost certain to be replicated.

    1. e spoke, and the river stayed his current, stopped the waves breaking,and made all quiet in front of him and let him get safelyinto the outlet of the river.

      An example of a figure calming waters in myth.

      cross reference: Moses and the parting of the Red Sea

      To what dates might we attribute these two texts? Which preceded the other? What sort of potential cultural influences would the original had on the subsequent?

      Also cross reference the many deluge/flood stories in ancient literatures including Genesis 6-9, The Epic of Gilgamesh, etc.

    1. Since around 2010, Morton has become associated with a philosophical movement known as object-oriented ontology, or O.O.O. The point of O.O.O. is that there is a vast cosmos out there in which weird and interesting shit is happening to all sorts of objects, all the time. In a 1999 lecture, “Object-Oriented Philosophy,” Graham Harman, the movement’s central figure, explained the core idea:The arena of the world is packed with diverse objects, their forces unleashed and mostly unloved. Red billiard ball smacks green billiard ball. Snowflakes glitter in the light that cruelly annihilates them, while damaged submarines rust along the ocean floor. As flour emerges from mills and blocks of limestone are compressed by earthquakes, gigantic mushrooms spread in the Michigan forest. While human philosophers bludgeon each other over the very possibility of “access” to the world, sharks bludgeon tuna fish and icebergs smash into coastlines.We are not, as many of the most influential twentieth-century philosophers would have it, trapped within language or mind or culture or anything else. Reality is real, and right there to experience—but it also escapes complete knowability. One must confront reality with the full realization that you’ll always be missing something in the confrontation. Objects are always revealing something, and always concealing something, simply because they are Other. The ethics implied by such a strangely strange world hold that every single object everywhere is real in its own way. This realness cannot be avoided or backed away from. There is no “outside”—just the entire universe of entities constantly interacting, and you are one of them.

      Object Oriented Ontology - Objects are always revealing something, and always concealing something, simply because they are Other. ... There is no "outside" - just the entire universe of entities constantly interacting, and you are one of them.

      This needs to be harmonized with Stop Reset Go (SRG) complimentary Human Inner Transformation (HIT) and Social Outer Transformation (SOT) strategy.

    1. Recent research suggests that globally, the wealthiest 10% have been responsible for as much as half of the cumulative emissions since 1990 and the richest 1% for more than twice the emissions of the poorest 50% (2).

      Even more recent research adds to this:

      See the annotated Oxfam report: Linked In from the author: https://hyp.is/RGd61D_IEeyaWyPmSL8tXw/www.linkedin.com/posts/timgore_inequality-parisagreement-emissionsgap-activity-6862352517032943616-OHL- Annotations on full report: https://hyp.is/go?url=https%3A%2F%2Foxfamilibrary.openrepository.com%2Fbitstream%2Fhandle%2F10546%2F621305%2Fbn-carbon-inequality-2030-051121-en.pdf&group=__world__

      and the annotated Hot or Cool report: https://hyp.is/KKhrLj_bEeywAIuGCjROAg/hotorcool.org/hc-posts/release-governments-in-g20-countries-must-enable-1-5-aligned-lifestyles/ https://hyp.is/zo0VbD_bEeydJf_xcudslg/hotorcool.org/hc-posts/release-governments-in-g20-countries-must-enable-1-5-aligned-lifestyles/

      This suggests that perhaps the failure of the COP meetings may be partially due to focusing at the wrong level and demographics. the top 1 and 10 % live in every country. A focus on the wealthy class is not a focus area of COP negotiations perse. The COP meetings are focused on nation states. Interventions targeting this demographic may be better suited at the scale of individuals or civil society.

      Many studies show there are no extra gains in happiness beyond a certain point of material wealth, and point to the harmful impacts of wealth accumulation, known as affluenza, and show many health effects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950124/, https://theswaddle.com/how-money-affects-rich-people/, https://www.marketwatch.com/story/the-dark-reasons-so-many-rich-people-are-miserable-human-beings-2018-02-22, https://www.nbcnews.com/better/pop-culture/why-wealthy-people-may-be-less-successful-love-ncna837306, https://www.apa.org/research/action/speaking-of-psychology/affluence,

      A Human Inner Transformation approach based on an open source praxis called Deep Humanity is one example of helping to transform affluenza and leveraging it to accelerate transition.

      Anderson has contextualized the scale of such an impact in his other presentations but not here. A recent example is the temporary emission decreases due to covid 19. A 6.6% global decrease was determined from this study: https://www.nature.com/articles/d41586-021-00090-3#:~:text=After%20rising%20steadily%20for%20decades,on%20daily%20fossil%20fuel%20emissions. with the US contributing 13% due to lockdown impacts on vehicular travel (both air and ground). After the pandemic ends, experts expect a strong rebound effect.

    1. This report is an essential companion for policymakers working at the intersection of society and climate change.”

      Policy alone may not be sufficient to change this deeply ingrained luxury lifestyle. It may require deep and meaningful education of one's deeper humanity leading to a shift in worldviews and value systems that deprioritize materially luxurious lifestyles for using that wealth to redistribute to build the future wellbeing ecocivilization. Transform the wealthy into the heros of the transition. Shaming them and labeling them as victims will only create distance. Rather, the most constructive approach is a positive one that shifts our own perspective from holding them as villains to heros.

    2. Dr. Lewis Akenji, the lead author of the report says: “Talking about lifestyle changes is a hot-potato issue to policymakers who are afraid to threaten the lifestyles of voters. This report brings a science based approach and shows that without addressing lifestyles we will not be able to address climate change.”

      This underscores the critical nature of dealing with the cultural shift of luxury lifestyle. It is recognized as a "hot potato" issue, which implies policy change may be slow and difficult.

      Policy changes and new legal tools are ways to force an unwilling individual or group into a behavior change.

      A more difficult but potentially more effective way to achieve this cultural shift is based on Donella Meadows' leverage points: https://donellameadows.org/archives/leverage-points-places-to-intervene-in-a-system/ which identifies the top leverage point as: The mindset or paradigm out of which the system — its goals, power structure, rules, its culture — arises.

      The Stop Reset Go (SRG) open collective project applies the Deep Humanity (DH) Human Inner Transformation (HIT) process to effect impactful Social Outer Transformation (SOT). This is based on the inner-to-outer flow: The heart feels, the mind thinks, the body acts and a social impact manifests in our shared, public collective human reality.

      Meadows top leverage point identifies narratives, stories and value systems that are inner maps to our outer behavior as critical causal agents to transform.

      We need to take a much deeper look at the pysche of the luxury lifestyle. Philospher David Loy has done extensive research on this already. https://www.davidloy.org/media.html

      Loy is a Buddhist scholar, but Buddhist philosophy can be understood secularly and across all religions.

      Loy cites the work of cultural anthropologist Ernest Becker, especially his groundbreaking Pulitzer-prize-winning book: The Denial of Death. Becker wrote:

      "Man is literally split in two: he has an awareness of his own splendid uniqueness in that he sticks out of nature with a towering majesty, and yet he goes back into the ground a few feet in order to blindly and dumbly rot and disappear forever. It is a terrifying dilemma to be in and to have to live with. The lower animals are, of course, spared this painful contradiction, as they lack a symbolic identity and the self-consciousness that goes with it. They merely act and move reflexively as they are driven by their instincts. If they pause at all, it is only a physical pause; inside they are anonymous, and even their faces have no name. They live in a world without time, pulsating, as it were, in a state of dumb being. This is what has made it so simple to shoot down whole herds of buffalo or elephants. The animals don't know that death is happening and continue grazing placidly while others drop alongside them. The knowledge of death is reflective and conceptual, and animals are spared it. They live and they disappear with the same thoughtlessness: a few minutes of fear, a few seconds of anguish, and it is over. But to live a whole lifetime with the fate of death haunting one's dreams and even the most sun-filled days—that's something else."

      But Loy goes beyond mortality salience and strikes to the heart of our psychological construction of the Self that is the root of our consumption and materialism exasperated crisis.

      To reach the wealthy in a compassionate manner, we must recognize that the degree of wealth and materialist accumulation may be in many cases proportional to the anxiety of dying, the anxiety of the groundlessness of the Self construction itself.

      Helping all humans to liberate from this anxiety is monumental, and also applies to the wealthy. The release of this anxiety will naturally result in breaking through the illusion of materialism, seeing its false promises.

      Those of the greatest material wealth are often also of the greatest spiritual poverty. As we near the end of our lives, materialism's promise may begin to lose its luster and our deepest unanswered questions begin to regain prominence.

      At the end of the day, policy change may only effect so much change. What is really required is a reeducation campaign that results in voluntary behavior change that significantly reduces high impact luxury lifestyles. An exchange for something even more valued is a potential answer to this dilemma.

  5. Oct 2021
    1. However, the decrease in BV was greater in men (8.0 +/- 0.8 mL/kg versus 5.8 +/- 0.8 mL/kg)

      That's a substantial fraction of the 11 point lower blood volume in ME/CFS found in one study. Moreover, this was achieved with only 13 days bed rest. I can only imagine the long-term effects of a sedentary lifestyle. It's likely that this is the primary cause of most ME/CFS. Nonetheless, exercise is unlikely to be the optimal treatment.

    1. 59 (8)

      I notice the standard deviation is low for their sample size. Normally smaller sample sizes increase SD. However, comparing to a study with 30 subject per group, we can see the expected SD for blood volume (ml/kg) in this sample size of 20 should be greater than ±22.

      The reason for this small SD is probably that subjects with ME/CFS are scrunched up against the lower end of the curve. The body simply will not allow blood volumes below a certain level. Judging by this study, I'd say around 50 ml/kg is the lowest possible number.

    1. mirtazapine is used to treat akathisia probably because of its antagonistic property at H1 postsynaptic receptors and dopaminergic action in the frontal cortex.

      That's an interesting hypothesis. I wouldn't have thought histamine was involved. Though, histamine being a stimulant, it also makes some sense. I'd have thought the primary mechanism is serotonin blockade, which would work in part by dopamine dis-inhibition as mentioned here.

    1. Drawing on path-breaking research in archaeology and anthropology, the authors show how history becomes a far more interesting place once we learn to throw off our conceptual shackles and perceive what's really there.

      Reimagining our social architecture might begin with rethinking our past and origins as a species.

    1. A recent survey found that only 14% of people they surveyed in the United States talk about climate change. A previous Yale study found that 35% either discuss it occasionally or hear somebody else talk about it. Those are low for something that over 70% of people are worried about.

      Conversation is not happening! There is a leverage point in holding open conversations where we understand each other’s language of different cultural groups. Finding common ground, the common human denominators (CHD) between polarized groups is the lynchpin.

    2. For a talk at one conservative Christian college, Dr. Hayhoe – an atmospheric scientist, professor of political science at Texas Tech University, and the chief scientist for The Nature Conservancy – decided to emphasize how caring about climate change is in line with Christian values and, ultimately, is “pro-life” in the fullest sense of that word. Afterward, she says, people “were able to listen, acknowledge it, and think about approaching [climate change] a little differently.”

      We often talk about the same things, share the same values, have the same common human denominators, but couched in different language. It is critical to get to the root of what we have in common in order to establish meaningful dialogue.

    3. Climate scientist Katharine Hayhoe stresses the need for finding shared values, rather than trying to change someone’s mind, as a basis for productive conversations

      What first appears as difference may actually emerge from consciousnesses that have more in common than one first realizes. Finding the common ground, what we refer to as the common human denominators (CHD) within the open source Deep Humanity praxis becomes the critical climate change communication leverage point for establishing genuine communication channels between politically polarized groups.

      This is aligned to the Stop Reset Go project and its open source offshoot, Deep Humanity praxis that seeks conversations and personal and collective journeys to appreciate Common Human Denominators that are salient for all participants. It also underscores the value of integrating with the Indieverse Knowledge system, with its focus on symathessy embedded directly into its codebase.

    4. I was speaking in Iowa, and I was asked, “How do you talk to people in Iowa about polar bears?” I said, “You don’t; you talk to them about corn.” If we begin a conversation with someone with something we already agree on, then the subtext is: “You care about this, and I care too. We have this in common.”

      This stresses the importance of applying Deep Humanity wisely by finding the most compelling, salient and meaningful common human denominators appropriate for each conversational context. Which group are we interacting with? What are the major landmarks embedded in THEIR salience landscape?

      The BEing journeys we craft will only be meaningful and impactful if they are appropriately matched to the cultural context.

      The whole mind- body understanding of how we cognitively construct our reality, via Deep Humanity BEing journeys, can help shift our priorities.

    5. What are the biggest barriers to action – for countries or communities or individuals – on climate change? And how do we get past those?It’s psychological distance and solution aversion. We don’t think it matters to us. We think it’s a problem distant in space or time or relevance. And we don’t think there’s anything viable or practical we can do at the scale required.

      Deep Humanity, as an open praxis available to any human being to both use and contribute to is a leverage point that, by awakening us to our own sacredness as living and dying human interbeing, can shift our self-perspective from scarcity and poverty mentality, to hsving super powers that emerge from the lived experience of our own sacredness as living and dying human interbeings. The Stop Reset Go linkage between human inner transformation (HIT) and social outer transformation (SOT) are criticsl to recognizing our social transformative potential.

    6. I am frequently shamed for not doing enough. Some of that comes from the right side of the [political] spectrum, but increasingly a larger share of that shaming comes from people at the opposite end of the spectrum, who are so worried and anxious about climate impacts that their response is to find anyone who isn’t doing precisely what they think they should be doing and shame them.

      Love, or recognizing the other person in the other tribe as sacred, is going to connect with that person because we are, after all, all of us are human INTERbeings, and love is the affective variable that connects us while shame is a variable that DISconnects us. Love is , in fact, one of our most powerful common human denominators.

  6. bafybeiery76ov25qa7hpadaiziuwhebaefhpxzzx6t6rchn7b37krzgroi.ipfs.dweb.link bafybeiery76ov25qa7hpadaiziuwhebaefhpxzzx6t6rchn7b37krzgroi.ipfs.dweb.link
    1. A final cluster gathers lenses that explore phenomena that are arguably more elastic and withthe potential to both indirectly maintain and explicitly reject and reshape existing norms. Many ofthe topics addressed here can be appropriately characterized as bottom-up, with strong and highlydiverse cultural foundations.

      The bottom-up nature of this cluster makes it the focus area for civil society movements, inner transformation approaches and cultural methodologies. Changing the mindset or paradigm from which the system arises is the most powerful place to intervene in a system as Donella Meadows pointed out decades ago in her research on system leverage points: https://donellameadows.org/archives/leverage-points-places-to-intervene-in-a-system/

      The Stop Reset Go initiative is focused on this thematic lens, bottom-up, rapid whole system change, with Deep Humanity as the open-source praxis to address the needed shift in worldview. One of the Deep Humanity programs is based on addressing the psychological deficits of the wealthy, and transforming them into heroes for the transition, by redirecting their WEALTH-to-WELLth.

    2. Recent research suggests that globally, the wealthiest 10% have been responsible foras much as half of the cumulative emissions since 1990 and the richest 1% for more than twicethe emissions of the poorest 50% (2).

      this suggests that perhaps the failure of the COP meetings may be partially due to focusing at the wrong level and demographics. the top 1 and 10 % live in every country. A focus on the wealthy class is not a focus area of COP negotiations perse. Interventions targeting this demographic may be better suited at the scale of individuals or civil society.

      Many studies show there are no extra gains in happiness beyond a certain point of material wealth, and point to the harmful impacts of wealth accumulation, known as affluenza, and show many health effects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950124/, https://theswaddle.com/how-money-affects-rich-people/, https://www.marketwatch.com/story/the-dark-reasons-so-many-rich-people-are-miserable-human-beings-2018-02-22, https://www.nbcnews.com/better/pop-culture/why-wealthy-people-may-be-less-successful-love-ncna837306, https://www.apa.org/research/action/speaking-of-psychology/affluence,

      A Human Inner Transformation approach based on an open source praxis called Deep Humanity is one example of helping to transform affluenza and leveraging it accelerate transition.

    1. As Morgan says, masters, “initially at least, perceived slaves in much the sameway they had always perceived servants . . . shiftless, irresponsible, unfaithful,ungrateful, dishonest. . . .”

      Interestingly, this is still all-too-often how business owners, entrepreneurs, and corporations view their own workers.

    1. Exploring how we imagine, design, and build the future together

      We are a creative, collaborative, self-organizing learning community.

    1. https://www.youtube.com/watch?v=6MBaFL7sCb8

      Passion is a terrible yardstick for life.

      You create life by living it.

      "Do not loan money to a person following their passion." —Scott Adams advice on being a loan officer

      Passion is where your energy and effort meets someone else's need. —Terri Trespicio

    1. Sleep was then impaired during withdrawal, as indicated by decreased duration and poorer subjective quality, being worst on the 3rd withdrawal night.

      My guess is that this is caused by a sleep surplus. I'd analogize it to the CBT-i recommendation to avoid napping because it will impair sleep drive that night.

  7. Sep 2021
    1. A mental model is what the user believes about the system at hand.

      “Mental models are one of the most important concepts in human–computer interaction (HCI).”

      — Nielsen Norman Group

    1. Stop Reset Go

      How do we engage in bottom-up whole system change? Perhaps we need a model for understanding who we are serving that transcends the bias and limitations of personas as they are used in user experience design (UX).

      What is a more holistic model for understanding human perceptions, motivations, and behaviours?

    1. Steven Brust's (quoted in my novel Walkaway): "Ask what's more important, human rights or property rights. If they say 'property rights ARE human rights' they're on the right." https://craphound.com/category/walkaway/
    1. All individual parameters (Items 1 to 8) were also significantly improved from baseline after 6 weeks of IQP-AO-101 intake. Analysis of variance with baseline values as covariates showed statistically significant improvements across all individual parameters for IQP-AO-101 when compared to placebo.

      That's quite impressive. It's worth noting that benefits accrued throughout the entire study duration. There's likely further benefits over longer durations. I take the benefit to be from antioxidants.

    1. After 30 days, PBB improved diary sleep quality (p = 0.008) and reduced insomnia severity (p = 0.044) when compared to placebo.

      This was achieved by a single size 0 capsule. The benefits would likely be proportionally greater with higher doses. Though, there is probably a cap depending on one's starting antioxidant status. I take it to be antioxidants that are providing the benefit.

    1. https://www.youtube.com/watch?v=gJ7CyM1Zrqc

      An interesting experiment to change one's schedule this way.

      I feel like I've seen a working schedule infographic of famous writers, artists, etc. and their sample work schedules before. This could certainly fit into that.

      One thing is certain thought, that the time of waking up is probably more a function of the individual person. How you spend your time is another consideration.

      “Without great solitude, no serious work is possible.” ― Picasso

      “Everybody has the same energy potential. The average person wastes his in a dozen little ways. I bring mine to bear on one thing only: my paintings, and everything else is sacrificed to it...myself included.” ― Picasso

      Every child is an artist. The problem is how to remain an artist once he grows up. —Picasso

      see also: https://quoteinvestigator.com/2015/03/07/child-art/

    1. Humans perform a version of this task when interpretinghard-to-understand speech, such as an accent which is particularlyfast or slurred, or a sentence in a language we do not know verywell—we do not necessarily hear every single word that is said,but we pick up on salient key words and contextualize the rest tounderstand the sentence.

      Boy, don't they

    1. n. Dickens saw the emblem of Thomas Gradgrind ("ready to weigh and measure any parcel of human nature, and tell you exactly what it comes to") as the "deadly statistical clock" in his observatory, "which measured every second with a beat like a rap upon a coffin-lid". B

      What a great quote to include in the closing!

    2. and McKendrick has shown how Wedgwood wrestled with the problem at Etruria and introduced the first recorded system of clocking-in.87 Bu

      Josiah Wedgwood was apparently the first to institute a system of clocking-into work.

    3. e task. Attention to time in labour depends in large degree upon the need for the synchronization of labour. But in so far as manufacturing industry remained c

      We attend to time in large measure as a need to be able to synchronize our work.

    4. Why look ye, Rogues! D'ye think that this will do ? Your Neighbours thresh as much again as you

      Eternal struggle of competition here. The workers (and the poet) admonish that one compares themselves against their neighbors (competitors) than simply themselves.

      The fix for this is for the leadership/bosses to participate themselves to see if the yield isn't as good as it might otherwise be. So much could be fixed if the "boss" is involved in the actual work or physically on site at least some of the time to experience what is going on. Participation counts.

    1. Side note: When I flagged yours as a dupe during review, the review system slapped me in the face and seriously accused me of not paying attention, a ridiculous claim by itself since locating a (potential) dupe requires quite a lot of attention.
    1. sildenafil and vardenafil, caused a significant improvement in sleep quality and depression in this cohort of HD patients with ED.

      These are the effects I was expecting to find. cGMP plays a role in SCN nighttime signalling, though I expect it has other mechanisms as well.

    1. The Uncomfortable Truth is the Difficult and Unpopular Decisions are Now Unavoidable.

      Topic is relevant across a span of global issues. Natural resources are Finite.....period! Timely decisions are critical to insure intelligent use of resources. DENIAL is the enemy and 800lb gorilla in the room. Neoliberisim and social dysfunction feed on any cognitive dissonance and poop it out as "crap". True believers of American Capitalism (yes there is a difference) have become "cult-like" and drink the fluid of the cult to the very end, human consequence is of no concern.

      Point being: Reality is always elusive within a cult controlled (authoritative) mindset. Cult members are weak sheep, incapable of individual logic/reason. Authority can not be challenged. -- Denial, a human defense mechanism has been and is the common denominator in all personal and global conflict. Denial can be traced throughout modern history and rears its ugly head whenever the stakes are high.

    1. “We don’t need to bend over backwards to give mathematics relevance. It has relevance in the same way that any art does: that of being a meaningful human experience.”

      Paul Lockhart in Lockhart's Lament

    1. We found an association between short-term secondhand exposures to EC emissions, measured by nicotine concentrations, and decreased HRV as well as shortening of the QTc

      It's hard to say what this tells me about my hypothesis that the 7 mg patch increases HRV. It really depends on their blood levels. The second-hand smoke machine is extremely unrealistic. They were exposed to 30 puffs of 1.8% nicotine e-juice in the first measurement interval. Assuming 150 puffs per ml, that's 3.6 mg smoked in a single 15 minute interval! I've not read the full study to confirm this calculation. Nonetheless, it's clear that these insane conditions require scrutiny. That's not even counting the fact that there's no placebo (Or even control). How am I supposed to know if this is not just an effect of being concern about inhaling e-smoke? I'm still searching for studies on low concentration of nicotine and HRV.

  8. Aug 2021
    1. @dancohen @ayjay, don't forget the noble professions of philosopher's clerk or secretary:

      What it would be like to be a philosopher’s clerk: “It’ll be a matter of filing the generalisations, tidying up paradoxes, laying out the premises before the boss gets in.” —Tom Stoppard

      For five years he [Thomas Hobbes (1588-1679)] served as personal secretary to, yes, Francis Bacon. In fact, I’ve noted over a course of years that the job of a secretary can be utterly fulfilling just in case one’s boss happens to be Francis Bacon. —Daniel N. Robinson

      (reply to https://micro.blog/dancohen/11752827)

    1. nicotine supplementation significantly decreased HRV

      This disproves my suggestion that 2 mg might increase HRV, but I was looking for 1 mg rather than 2. The 2 mg gum is still plausibly a higher dose than a 7 mg patch. I'm struggling to find studies in the lower doses. This may be because everyone wants to prove the harm of nicotine. There may even be publication bias (especially if there's no effect).

    1. Heart rate variability showed no differences between the 2 nights, but the low to high ratio (a parameter indicative of sympathetic nervous system activity) positively correlated with wake after sleep onset in night with nicotine patch.

      This was with a 14 mg patch. A 21 mg patch would probably reduce HRV given that a 4 mg lozenge does so.

      I still expect to find enhance HRV with 7 mg. This study supports that hypothesis to an extent. That it, it shows that 14 mg may be the tipping point between increased or decreased HRV from nicotine.

    1. 4 mg oral nicotine lozenge or placebo.

      Assuming a half life of two hours, I calculated a 7 mg per day patch delivers a peak dosage of around 0.8 mg. Given that a 4mg lozenge has a bioavailability of 79%, this is equivalent to a 21 mg patch.

      Given that we know anything above a 7 mg patch disrupts sleep (while 7 mg enhances sleep), it's unsurprising that HRV was reduced. I expect that a 1 mg lozenge or gum would increase HRV. Given that the above citation lists the bioavailability of a 2 mg lozenge at 50%, 2 mg may also increase HRV.

    1. In both healthy and insomnia subjects, there was a significant improvement in the sleep parameters in the Ashwagandha root extract supplemented group. The improvement was found more significant in insomnia subjects than healthy subjects.

      Benefits accrued throughout the 8 weeks. I recall reading on Longecity forum that ashwagandha takes a month for benefits to kick in. This study demonstrates that benefits continue to increase over two months. I suspect they continue even further than that.

      Interestingly, this is pretty similar to the two placebo controlled studies on antioxidants for sleep. Thus, I wonder of the benefits of ashwaganha extract are largely antioxidant capacity. This would be a bit surprising because the ORAC of dried ashwaganda is just slightly above raw pinto beans. Based on the recommended doses, the extract isn't vastly more potent than the whole root. Though, this comment saying that the Withanolide/Withaferin A (edit: withaferin A is purportedly cytotoxic) reside mostly in the leaves has greatly confused me. Either the extract has more antioxidant activity than I realize (directly or indirectly), or the benefits come primarily from the purported mechanisms of ashwagandha (which include cortisol reduction and GABAergic activity). Edit: the full text mentions a 15 to 1 extract ratio, which is enough to put the antioxidant mechanism back on the table. It's probably a partial explanation, but after seeing the full text I think the benefits are too great to be simply from antioxidants.

      I see no mention of the time of day of administration. I'm assuming it was in the morning, which contrasts with the near bedtime dosing in the antioxidant studies. If I later find out that antioxidants in the morning don't help with sleep, then that will suggest ashwagandha works by other mechanisms. However, I expect antioxidants at any time of day help with sleep. Nonetheless, I'm not discounting that ashwagandha may work by other mechanisms.

    1. withdrawal conditions

      Oddly, the strong adenosinergic pressure from ~20 hours wake combined from caffeine withdrawal didn't lead to increased SWS. Indeed, there was a nonsignificant trend towards a decrease in SWS. One possibility is that caffeine induced SWS surplus accumulation over the previous week, reducing SWS drive. However, this could alternatively be explained by the 60 minute nap.

      Withdrawal restored REM sleep under these conditions. The withdrawal condition looks quite similar to placebo (both REM and SWS), which is rather surprising.

    1. ConclusionContrary to the existing literature, shifting dinner timing from 5 hours before sleep to 1 hour before sleep in healthy volunteers did not result in significant adverse changes in overnight sleep architecture. In fact, LD was associated with deeper sleep in the beginning of the night and lighter sleep in the latter part of the night in healthy volunteers. This novel manifestation of postprandial hypersomnia may have therapeutic potential in patients with sleep disorders.

      This aligns with intuition. However, they only tested a single night in each condition. The harm of eating at night may be a zeitgeber effect, taking multiple days to accumulate.

      These results bring into question advice about avoiding food at night. Food quality likely plays a critical role. It remains unclear whether eating before bed is advisable, but this data gives reason to at least avoid making recommendations against it.

    1. The lower the level of selenium in the diet the more reports of anxiety, depression, and tiredness, decreased following 5 weeks of selenium therapy.

      Though the effect was stronger in those with lower intake, the effects on mood in those with higher intake were still quite substantial, (full text). That is to say, both groups benefited. Selenium improved anxiety only in the low intake group, (full text).

      Interestingly, the high and low intake groups had the same baseline scores. That is to say, it's not that selenium brought the low intake group up to normal, but rather that they were lifted above the high intake group. It's possible that they had adapted to their low intake, be it psychological or physiological adaptation. I recall a similar effect with creatine and cognitive performance in vegetarians.

      This raises the question: does the benefit disappear over time as one adapts to their new selenium levels? Perhaps, but I find it more likely that the benefit drops only slightly. That is, I think what may be occurring is a a positive feedback loop where better mood makes you more optimistic, thus improving your mood; I expect this psychological mechanism to fade, leaving the biological component intact.

      Of course, there is the possibility that this is a statistical fluke. Nonetheless, I'd expect the above mechanism to occur in general. If I learn more about statistics I could probably run a p-value test.

    1. Zinc sulfate was statistically superior to placebo in reducing both hyperactive, impulsive and impaired socialization symptoms, but not in reducing attention deficiency symptoms, as assessed by ADHDS. However, full therapeutic response rates of the zinc and placebo groups remained 28.7% and 20%, respectively.

      That is a moderate but worthwhile benefit over placebo.

    1. ResultsImprovement (decline IRLS score >10) was significantly higher in selenium (50 and 200 μg) than placebo group.

      Not only was is significant, but it was impressive! The 200 μg dose cut the score over 50%, compared to 20-22% reductions in the placebo. Everyone with RLS should be given selenium.

      However, I disagree with the authors that this should be a replacement. Multiple treatments are likely necessary to achieve adequate relief.

    1. Because improvements occurred among nonsmokers, the nicotine effect appears not to be merely a relief of withdrawal symptoms.

      As expected. This study was placebo controlled, too.

    1. 14 mg nicotine

      I'd be interested to see the effect of a 7 mg patch. 14 mg is too high for sleep, so I wonder if it is also too high for akathisia.

  9. Jul 2021
    1. https://theamericanscholar.org/blue-collar-brilliance/

      Acknowledging the work and art that blue collar workers do is an important thing.

    2. When we devalue the full range of everyday cognition, we offer limited educational opportunities and fail to make fresh and meaningful instructional connections among disparate kinds of skill and knowledge. If we think that whole categories of people—identified by class or occupation—are not that bright, then we reinforce social separations and cripple our ability to talk across cultural divides.
    3. If we believe everyday work to be mindless, then that will affect the work we create in the future.
    4. Joe learned the most efficient way to use his body by acquiring a set of routines that were quick and preserved energy. Otherwise he would never have survived on the line.

      Sometime in the past six months I ran across a description of how migrant workers do this sort of activity in farming contexts. That article also pointed out the fact that the average person couldn't do this sort of work and that there was extreme value in it.

    5. <small><cite class='h-cite via'> <span class='p-author h-card'>Alan Jacobs</span> in July Check-In · Buttondown (<time class='dt-published'>07/01/2021 09:19:13</time>)</cite></small>

      Idea of John Paul II's encyclical being a form of blogging in a different era. They're all essays in form, it's just about distribution...

    1. A platform like Twitter makes our asynchronous posts feel like real-time interaction by delivering them in such rapid succession, and that illusion begets another more powerful one, that we’re all actually present within the feed.

      This same sort of illusion also occurs in email where we're always assumed to be constantly available to others.

    1. Kraemer, M. U. G., Hill, V., Ruis, C., Dellicour, S., Bajaj, S., McCrone, J. T., Baele, G., Parag, K. V., Battle, A. L., Gutierrez, B., Jackson, B., Colquhoun, R., O’Toole, Á., Klein, B., Vespignani, A., Consortium‡, T. C.-19 G. U. (CoG-U., Volz, E., Faria, N. R., Aanensen, D., … Pybus, O. G. (2021). Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence. Science. https://doi.org/10.1126/science.abj0113

    1. Collectively, these results indicate that mirtazapine may help to maintain abstinence in opioid dependent patients.

      I concur. This merits human analysis. I'd be curious to know the subjective effects of combining the two. In particular, I'm wondering if mirtazapine reduces "wanting" while enhancing "liking".

      The main reason I'd been thinking this is due to comparison to similar drug combos in humans. I'd heard that combining hydroxyzine and opioids was sometimes prescribed to enhance the effectiveness of opioids and/or use lower opioid doses; I'd also read on some harm reduction forum that some people enjoy combining opioids with antihistamines. Given that mirtazapine is to a large extent just hydroxyzine but with added adrenergic effects, it seems likely that much of these data can be cross-applied (between mirtazapine and hydroxyzine in particular).

    1. Sure, the slow way is always "good enough" — until you learn a better way of doing things. By your logic, then, we shouldn't have the option of including "Move to" in our context menus either — because any move operation could be performed using the cut and paste operations instead? The method you proposed is 6-7 steps long, with step 4 being the most onerous when you're in a hurry: Select files "Cut" "Create New Folder" Think of a name for the new folder. Manually type in that name, without any help from the tool. (We can't even use copy and paste to copy some part of one of the file names, for example, because the clipboard buffer is already being used for the file selection.) Press Enter Press Enter again to enter the new folder (or use "Paste Into Folder") "Paste" The method that Nautilus (and apparently Mac's Finder) provides (which I and others love) is much more efficient, especially because it makes step 4 above optional by providing a default name based on the selection, coming in at 4-5 steps (would be 3 steps if we could assign a keyboard shortcut to this command like Mac apparently has ): Select files Bring up context menu (a direct shortcut key would make this even sweeter) Choose "New Folder With Selection" Either accept the default name or choose a different name (optional) Press Enter Assuming "Sort folders before files" option is unchecked, you can continue working/sorting in this outer folder, right where you left off: Can you see how this method might be preferable when you have a folder with 100s or 1000s of files you want to organize it into subfolders? Especially when there is already a common filename prefix (such as a date) that you can use to group related files together. And since Nemo kindly allows us to choose which commands to include in our context menu, those who don't use/like this workflow are free to exclude it from their menus... Having more than one way to accomplish something isn't necessarily a bad thing.
    1. After a good deal of reflection and consultation with my family, I have decided that (aside from pre-existing commitments, of which I have a few) I will no longer give lectures or participate in conferences, whether in person or via video link. I have a great deal that I want to think about and write about, and a dwindling supply of time in which to pursue the tasks I care about most. I understand that this decision might limit sales of my books, and make me even more isolated and ignored than I am already. That’s a trade-off that I simply must make. I feel sure that this is the right thing to do; indeed, the necessary thing to do. I hope that the work I produce in the future will bear out that judgment.

      An interesting take on valuing one's time.

  10. Jun 2021