• for: microbiome, gut health, MET in Individuality - microbiome, complexity - human microbiome, fermentation - health

• for:holistic medicine - example - oral microbiome and colon cancer, oral microbiome - colon cancer, bleeding gums - colon cancer, gingivitus - colon cancer, periodontitis - colon cancer, bloodstream translocation, complexity - example - human body - colon cancer - oral microbiome

• comment

  • colon cancer starts in the mouth!

• references

  • Oral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression (2022)

    • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824753/
    • Abstract
      • It is widely recognized that microbial disorders are involved in the pathogenesis of many malignant tumors.
      • The oral and intestinal tract are two of the overriding microbial habitats in the human body. Although they are anatomically and physiologically continuous, belonging to the openings at both ends of the digestive tract, the oral and intestinal microbiome do not cross talk with each other due to a variety of reasons, including
        • intestinal microbial colonization resistance and
        • chemical barriers in the upper digestive tract.
      • However, this balance can be upset in certain circumstances, such as
        • disruption of colonization resistance of gut microbes,
        • intestinal inflammation, and
        • disruption of the digestive tract chemical barrier.
      • Evidence is now accruing to suggest that the oral microbiome can colonize the gut, leading to dysregulation of the gut microbes.
      • Furthermore, the oral-gut microbes create an
        • intestinal inflammatory and
        • immunosuppressive microenvironment
      • conducive to
        • tumorigenesis and
        • progression of colorectal cancer (CRC).
      • Here, we review
        • the oral to intestinal microbial transmission and
        • the inflammatory and immunosuppressive microenvironment, induced by oral-gut axis microbes in the gut.
      • A superior comprehension of the contribution of the oral-intestinal microbes to CRC provides new insights into the prevention and treatment of CRC in the future.

  • Insights into oral microbiome and colorectal cancer – on the way of searching new perspectives (2023)

    • https://www.frontiersin.org/articles/10.3389/fcimb.2023.1159822/full
    • Abstract
      • Microbiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship.
      • These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients.
      • Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues.
      • Additionally, it has been proven that bacteria can migrate to other human body compartments and colonize them even although significant structural differences with the area of origin exist.
      • Such migrations have been clearly observed when the causes of genesis and progression of colorectal cancer (CRC) have been investigated.
      • It has been demonstrated that the oral microbiome is capable of penetrating into the large intestine and cause impairments leading to dysbiosis and stimulation of cancerogenic processes.
      • The main actors of such events seem to be oral pathogenic bacteria belonging to the red and orange complex (regarding classification of bacteria in the context of periodontal diseases), such as
        • Porphyromonas gingivalis and
        • Fusobacterium nucleatum respectively,
      • which are characterized by significant amount of cancerogenic virulence factors.
      • Further examination of oral microbiome and its impact on CRC may be crucial on early detection of this disease and would allow its use as a precise non-invasive biomarker.

• for: stats, stats - microbiome, human microbiome, stats - human microbiome
• stats
• paraphrase
  • One hundred trillion cells is the approximate number of microorganisms in your body,
  • that's ten times greater than the number of your own cells.
  • The micrbiome is about 2% of our body weight
  • That's about one and a half kilograms

!- For : microbiome health - fasting for 14 hours helps the migrating motor complex (MMC) maintain gut health

Question:

• In what way is the microbiota different in Parkinson’s disease patients compared to that of healthy people?
• Do we know anything about the correlation between the particular species of microbiota and the disease?
• Do we know anything about how the signals being sent from the gut to the brain are different from those in healthy individuals?

this is profound

Note that nicotine by itself had minimal impact on the microbiome. Nicotine speeds up transit through the intestine. Thus, the reason nicotine plus a high fat diet was detrimental is likely that nicotine is increasing the throughput of harmful prebiotics (e.g. protein in particular). When lots of fiber and resistant starch is present (will need to see if they provide this info for their diets), then nicotine mostly just carries it to the small intestine faster (and possibly reduces fermentation time).

Given that opioids have a negative effect on the microbiome, I was expecting nicotine to have a positive effect. Perhaps it would have a positive effect were there more resistant starch in the diet.

Unsurprisingly, various substances appear to disrupt the microbiome; artificial sweeteners are not unique. Given that I don't worry about opioids, I probably shouldn't worry about sweeteners.

However, opioids are known for causing constipation. That is to say, they have a clear effect on digestion. Perhaps I should worry about opioids rather than not worry about sweeteners.

(see 45 seconds into video)

This could be very handy for lowering the pH of the gut (increasing the acidity). As explained in other Greger videos, an acidic gut is desirable because good gut bacteria produce acids and thus are the bacteria that thrive in an acidic environment.

Currently, I'm taking magnesium citrate. My concern is that the unabsorbed magnesium is alkalinizing my gut. Vitamic C should be able to counteract this (assuming it is indeed an issue). That does make the assumption, however, that the hydrogen ion makes it to the large intestine. That is to say, that the ascorbate does not become a conjugate base.

Very interesting way to validate correlative phenotypes in communities

Isn't the flipped experiment a clear indication that FTT (fecal transplant therapy) can help alleviating IBS? If the reverse is true, there might be great value in getting your microbiome fixed/infused by healthy microbiota from donors.

This is such a substantial mindshift and companies have spent years and billions persuading us otherwise. We urgently need to understand how to be clean but not sterile