10 Matching Annotations
  1. May 2020
    1. 16S sequencing showed that nicotine perturbed bacterial diversity and community composition of gut microbiota more pronouncedly in HFD mice.

      Note that nicotine by itself had minimal impact on the microbiome. Nicotine speeds up transit through the intestine. Thus, the reason nicotine plus a high fat diet was detrimental is likely that nicotine is increasing the throughput of harmful prebiotics (e.g. protein in particular). When lots of fiber and resistant starch is present (will need to see if they provide this info for their diets), then nicotine mostly just carries it to the small intestine faster (and possibly reduces fermentation time).

      Given that opioids have a negative effect on the microbiome, I was expecting nicotine to have a positive effect. Perhaps it would have a positive effect were there more resistant starch in the diet.

    1. Results reveal a significant shift in the gut microbiome and metabolome within one day following morphine treatment compared to that observed after placebo. Morphine-induced gut microbial dysbiosis exhibited distinct characteristic signatures, including significant increase in communities associated with pathogenic function, decrease in communities associated with stress tolerance and significant impairment in bile acids and morphine-3-glucuronide/morphine biotransformation in the gut.

      Unsurprisingly, various substances appear to disrupt the microbiome; artificial sweeteners are not unique. Given that I don't worry about opioids, I probably shouldn't worry about sweeteners.

      However, opioids are known for causing constipation. That is to say, they have a clear effect on digestion. Perhaps I should worry about opioids rather than not worry about sweeteners.

  2. Dec 2019
    1. But, if you take a supplement containing 1,250 milligrams, your body seems to realize that’s too much—and so, clamps down on absorption at the intestinal lining level, and you end up absorbing less than half.

      (see 45 seconds into video)

      This could be very handy for lowering the pH of the gut (increasing the acidity). As explained in other Greger videos, an acidic gut is desirable because good gut bacteria produce acids and thus are the bacteria that thrive in an acidic environment.

      Currently, I'm taking magnesium citrate. My concern is that the unabsorbed magnesium is alkalinizing my gut. Vitamic C should be able to counteract this (assuming it is indeed an issue). That does make the assumption, however, that the hydrogen ion makes it to the large intestine. That is to say, that the ascorbate does not become a conjugate base.

  3. Nov 2019
    1. key challenge is to quantify the functional roles of bacterial taxa in nature to understand how the properties of ecosystems change over time or under different environmental conditions
    2. Hemicellulase activity was elevated in pairwise mixtures of communities that placed interacting phylotypes together (interactions, n = 9 mixtures) but not in communities that did not place interacting phylotypes together (no interactions, n = 56 mixtures)

      Very interesting way to validate correlative phenotypes in communities

  4. Oct 2019
  5. Apr 2018
  6. Sep 2017
  7. Apr 2017
    1. I have had IBS essentially all my life. At least as far back as I can remember. This is a very interesting experiement. Hopefully scientists can use this as a springboard for either further research, or ideally, to find a solution. IBS negatively impacts quality of life for many sufferers.

      Isn't the flipped experiment a clear indication that FTT (fecal transplant therapy) can help alleviating IBS? If the reverse is true, there might be great value in getting your microbiome fixed/infused by healthy microbiota from donors.

  8. Jun 2015
    1. “Disinfectants have no place in a normal household

      This is such a substantial mindshift and companies have spent years and billions persuading us otherwise. We urgently need to understand how to be clean but not sterile