14 Matching Annotations
  1. Mar 2022
    1. There are a few things we know that promote longevity and healthspan. Caloric restriction and intermittent fasting are one of the most effective ways of doing so as shown by research in virtually all species.

      This could explain why Dr Clemens' [[PKD]] protocol has me around 1,000 calories a day

    1. Valter Longo, PhD has been studying an aspect of fasting and autophagy that is fascinating enough, I wanted to include it in it’s own section. One area of his research focuses on how fasting induces differential stress resistance to make chemotherapy far more effective. In a food scarce environment, normal cells become more resistant to oxidative stress, but cancer cells don’t. Remember, cancer cells are broken cells. Something went wrong with them and they are replicating out of control. Being broken means they don’t retain all the typical functions and protective mechanisms of normal cells, like antioxidant generation. That’s one of the reasons cancer cells switch their metabolism from oxidative phosphorylation to glycolysis even in the presence of oxygen. It’s known as the Warburg effect. There are many theories on why this happens, but one is because cancer cells are more sensitive to the reactive oxygen species created during normal metabolism. Eating creates an environment where cancer cells thrive and normal cells are stressed. Cancer cells need an environment rich with sugar, growth factors (like IGF-1) and amino acids like glutamine. For normal cells, metabolism creates reactive oxygen species and triggers an immune response to deal with all the pathogens riding along on top of your meals. However, when you fast, normal cells become 1000 times more resistant to reactive oxygen species, but cancer cells do not. This same starvation-protection also makes normal cells far more resistant to chemotherapy drugs.

      So fasting helps protect healthy cells and weakens cancerous ones. That's cool. But then it says cacer clles need sugar, growth factors like [[IGF-1]] and amino acids like glutamine. The [[Carnivore Diet]] is going to increse IGF-1 and amino acid levels but should starve the cancer cells of sugar. Given Dr Clemens' success treating cancer with the [[PKD]] protocol I'm inferring that it's the triad that needs to be inn place and if sugar is missing then the other factors being elevated eoesn't matter that much.

  2. Oct 2021
    1. 4:42 "as monks and mediators, we only eat once in the morning." This seems quite plausibly an acquired wisdom, as opposed to a quirk of the practice. While I've not yet read much of the science myself, I've heard a great deal about the benefits of intermittent fasting. Moreover, there's interesting research suggesting that making breakfast your biggest meal provides benefits. I would not be at all surprised if eating only once in the morning is the optimal approach.

  3. Apr 2021
    1. We have explored some of the most popular fasting apps available in the market, used them for some time, and sifted only high-performing apps for you. Go through our list of best fasting apps for android and iOS and choose one which is suitable for you
  4. Aug 2020
  5. Jul 2020
  6. Apr 2020
    1. the likely reason why fasting later became associated with the run-up to Easter is that people started holding baptisms at Easter. The three-week long preparation for becoming a Christian through baptism included fasting, and as baptism became more strongly associated with Easter in the fourth century AD, it is possible that fasting in the lead-up became more generalised to include people who were already Christians

      Makes a connection between fasting and Easter baptism

    2. Peter I of Alexandria in the fourth century who connected Christian penitential (still not Lenten) fasting to Jesus’s 40-day fast in the wilderness:

      This shows a late dating for the "idea" of a Lenten 40-day fast. It also shows how disconnected the practice is from the narrative it attempts to draw form. Initially, fasting potentially also connected with leading up to Easter baptism is now drawing from Jesus 40-day POST baptismal fast prior to temptation.

    3. earliest reference to a sustained fast of more than two or three days is in the Didascalia, a Syrian Christian document probably from the the third century AD. Therefore you shall fast in the days of the Pascha from the tenth, which is the second day of the week; and you shall sustain yourselves with bread and salt and water only, at the ninth hour, until the fifth day of the week. But on the Friday and on the Sabbath fast wholly, and taste nothing … For thus did we also fast, when our Lord suffered, for a testimony of the three days … This text connects a six-day fast with Easter and with Jesus’s suffering, but surprisingly still not with Jesus’s 40-day temptation

      Evidence of fasting of yet another different length (6 days total) and form (several days bread, salt and water). Advocates fasting on Sabbath which would be a break from Jewish tradition.

      Noted the disconnect with connection to 40 day temptation and instead after a few days of bread and water re-connects to the Fri-Sat 40 Hour type fast around Jesus in the grave.

    4. John Chrysostom (c. 349-407), writing against Christians sharing anything in common with Jews, admonishes Christians who fast on the Jewish Day of Atonement, Yom Kippur

      Seems to indicate that there was still quite disparate fasting practice across the Christian world as late as this

  7. Jun 2019
  8. Feb 2019
    1. eating in a ‘twelve hour window’

      Ha! I recently ran across sever people pushing fasting apps including one called Zero which encourages fasting for 16 hours (or essentially skipping one meal a day.)

      Many have been quietly pushing this for the past few years in relation to things like the paleo diet, etc. I'll also note that Nassim Nicholas Taleb has mentioned something like it frequently (since you mention flaneuring below).

  9. Apr 2016
    1. But I think the most sensible way forward would be to synthesize this effect with drugs

      This is contrary to common sense, practicality, and the study results.

    2. People are better eating on a regular basis.

      I am not aware of any evidence of this. Statements such as these (as well as the previous two sentences) are why expert opinion is considered to be in the the lowest group of levels of scientific evidence.