32 Matching Annotations
  1. Feb 2019
  2. Jan 2019
    1. Nodular melanoma ++ Nodular melanomas account for 20% of melanomas, are aggressive and invasive, and have no radial growth phase. They are typically found on the trunk and limbs of young to middle-aged individuals (see FIG. 125.8). It may have a ‘blueberry’-like nodule. Prognosis is determined by thickness at the time of excision. Dermatoscopy is usually less useful. ++ FIGURE 125.8 Nodular melanoma on the back. It has no radial growth phase and because it grows vertically can be readily misdiagnosed. The ABCD rule often does not apply but this lesion shows variable colours and an irregular border. Photo courtesy Robin Marks Graphic Jump LocationView Full Size| Favorite Figure|Download Slide (.ppt) ++ The early nodular melanoma problem4,5 ++ Nodular melanoma can present a diagnostic dilemma since the ABCD rule (see later in this chapter) often does not apply. The mnemonic EFG, standing for ‘Elevated’, ‘Firm’ and ‘Growing for more than 1 month’, is more appropriate. Early melanomas tend to be symmetrical, non-pigmented, even in colour, of small diameter and to grow vertically. ++ They are often mistaken for a haemangioma or a pyogenic granuloma. If one is suspicious, refer early to a specialist/specialist clinic. ++ Acral lentiginous melanoma ++ These typically occur on palms, soles and distal phalanges (see FIG. 125.9). They have a poorer prognosis than other types. They occur mainly in people with dark skin. ++ FIGURE 125.9 Acral lentiginous melanoma. A 30-year-old man presented with a ‘mole’ on his toe that had become ‘lumpier’. This type of melanoma, which occurs on the distal areas of the limbs, begins as a spreading pigmented, macule before developing into a nodule surrounded by a pigmented halo (as shown). Photo courtesy Robin Marks Graphic Jump LocationView Full Size| Favorite Figure|Download Slide (.ppt) ++ Desmoplastic melanoma4 ++ This is a rare and aggressive subtype of melanoma. They are often subtle

      nicely reviewed article.

  3. Dec 2018
    1. Zhou, W., Mukherjee, P., Kiebish, M. A., Markis, W. T., Mantis, J. G., & Seyfried, T. N. (2007). The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer. Nutrition & metabolism, 4(1), 5.
  4. Oct 2018
  5. May 2018
  6. Jan 2018
    1. Combination therapy strategies for improving PD-1 blockade efficacy

      Methods of augmenting PD-1 blockade against cancer involve concomitant CTLA-4 inhibition among others. Here is a visual representation of common biological pathways and cell types between these genes.

      “Immune

      https://www.biovista.com/vizit-research/#!bv_gid=1357fa5ee3b610d1918476e21c7be00c

  7. Dec 2017
  8. Nov 2017
    1. There are some other doctors that have looked at depriving cancer patients of all vitamin C for periods of time and then hitting them really hard with high doses of vitamin C as a possible way of inducing apoptosis in cancer cells. There’s a lot of research in this area and it’s not like it’s all worked out now. It’s more like we are in the early stages of flight and we need research is what we really need and unfortunately, it’s hard to come by at the funding for this particular area.

      Vitamin C Cancer

    1. pairwise overlaps using Fisher’s test and mutual exclusion (Leiserson et al., 2016xA weighted exact test for mutually exclusive mutations in cancer. Leiserson, M.D.M., Reyna, M.A., and Raphael, B.J. Bioinformatics. 2016; 32: i736–i745Crossref | PubMed | Scopus (4)See all ReferencesLeiserson et al., 2016)
    1. tier 1 contains all changes in the amino acid coding regions of annotated exons, consensus splice-site regions, and RNA genes (including microRNA genes). Tier 2 contains changes in highly conserved regions of the genome or regions that have regulatory potential. Tier 3 contains mutations in the nonrepetitive part of the genome that does not meet tier 2 criteria, and tier 4 contains mutations in the remainder of the genome
  9. Sep 2017
    1. One Test May Spot Cancer, Infections, Diabetes and More

      based on cell free DNA fragments in blood; DNA methylation patterns and fragment length distributions can inform on organ of origin.

  10. Jul 2017
    1. It might be possible, but there is, as yet, no solid evidence to support that belief.

      On cancer / Cannabis

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  11. Apr 2017
    1. The Administration could also exercise its regulatory authority—most potently, to direct the Centers for Medicare and Medicaid Services (CMS) to allow reimbursement for molecular profiling of cancers

      Perhaps the most important measure to keep precision medicine initiate alive. Surge in risk and treatment response prediction in genomic assays is of little value without practical means of affordable molecular profiling of a patient's tumor or more importantly, pre-diagnosis genomic screen.

    1. While it seems like such multiple mutations should be unlikely, computational biologist Niko Beerenwinkel of ETH Zurich in Basel, Switzerland, recently posted a preprint to bioRxiv suggesting that recurrent mutations can and do occur, and not infrequently (bioRxiv, doi:10.1101/094722, 2016).

      Fig 1 of preprint: mutated allele may get lost due to LOH event or less likely due to recurrent mutation, and thus reverting to the original base.

      In the former event, SNV could be a preceding dominant negative loss-of-function event which may follow LOH event to remove the beneficial trait (SNV itself). This makes sense for a haploinsufficient gene. However, that's not a strictly speaking a recurrent mutation event as the latter is a copy number level and not mutation change.

  12. Mar 2017
    1. 9. And regular orgasms can reduce the risk of prostate cancer.

      The study that is hyperlinked in this article takes you to a blog post on the Harvard Medical School Prostate Knowlegde blog. They didn't do the study, but they wrote a post about two studies that were conducted on the topic and gave references, which made it nice to follow. After reading the two studies, i found that this title tends to be misleading in its statement. Both studies conducted found that men who ejaculate more than either 7 times per week or more than 21 times a month have a decreased risk of prostate cancer. To me, this is not regular orgasms, that amount seems to be on the higher end for most people and hard to continue through out your life. In conclusion, yes, more ejaculations can reduce your risk of prostate cancer, but the amount needed is high and must be started at a young age to fully reap the benefits.

      APA References:

      Giles, G.G., Severi, G., English, D.R., McCredie, M.R.E., Borland, R., Boyle, P., & Hopper, J.L. (2003). Sexual factors and prostate cancer. BJU International, 92(3), 211-216.

      Leitzmann, M.F., Platz, E.A., Stampfer, M.J., Willett, W.C., Giovannucci, E. (2004). Ejaculation frequency and subsequent risk of prostate cancer. JAMA: Journal of the American Medical Association, 291(13), 1578-1586.

      Links: http://jamanetwork.com/journals/jama/fullarticle/198487?=quot;,gt;

      http://onlinelibrary.wiley.com/doi/10.1046/j.1464-410X.2003.04319.x/full

    1. Research proving cannabis kills cancer cells has been suppressed since 1974.

      Like so many other kids I was told that marihuana kills brain cells and to stay away from it. When I saw this article it peeked my interest. I was skeptical of its truthfulness Then, I looked up the 1974 National Institute of Health referenced in the article. In the article I found evidence that an adenocarcinoma (cancer) tumor tested on mice resulted in inhibited and or reduced size when using delta-8-tetrahydrocannabinol (THC) and cannabinol (CBN). According to the study supported by the Public Health Service grant, the National Institute on Drug Abuse, Health Services & Mental Health Administration and by other grants. “Lewis lung adenocarcinoma growth was retarded by the oral administration of delta-9-tetrahydrocannabinol”. (A.E. Munson, L.S. Harris, M.A. Friedman, W.L Dewey, and R.A Carchman) National Cancer Institute, Vol. 55, No. 3, September 1975 and also I found a Canadian review article published in Current Oncology, “a large body of evidence shows that these molecules can decrease tumour growth in animal models of cancer.” The results of these studies leave me surprised. I found references that were opposite from what I have taught. Although, I would not advise the recreational use of smoking cannabis. I can see its usefulness in inhibiting and or reducing the size of cancerous tumors. I did not, however, find evidence to support the statement that cannabis kills cancer cells. In any case this subject is definitely warrants further study.

      References A.E. Munsion, L.S. Harris, M.A. Friedman, W. Dewey, and R.A. Carchman, Jornal of the National Cancer Institute, Vol. 55, No. 3, September 1975 Research Providing Cannabis Kills Cancer Cells Safely has been Suppressed since 1974 (2016, December 24). Retrieced March 9, 2017, from http://www.realfarmacy.com/research-proving-cannabis-kills-cancer-cells-safely-suppressed-since 1974 Ware, M. (n.d.). Cannabis and cancer: towards a new understanding. Retrieved March 29, 2017,

    1. A UConn engineering professor has uncovered new information about how particles behave in our bloodstream, an important advancement that could help pharmaceutical scientists develop more effective cancer drugs.

      What a great development!

  13. Feb 2017
  14. Sep 2016
  15. Mar 2016
  16. Feb 2015
  17. Dec 2014
    1. Hi

      In my opinion this site supports the use of unproven (experimental) therapies and disproven (proven to be not effective) therapies. This Cancer Society site presents a balanced aprroache which will help you to evaluate for yourself the use of alternative therapies. Using alternative therapies in cancer care

      Bridge

  18. Nov 2014
    1. Marijuana kills cancer cells in proportion to its dose and duration of treatment, researchers found, and whole plant cannabis rich in THC was more efficacious than pure, lab-grade THC alone.

      We clearly have a lot to learn about cannabinoids and terpenes. There are maybe medical breakthroughs to be made here, breakthroughs that have been delayed for decades by reactionary, draconian drug laws.

  19. May 2014