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  1. Apr 2017
    1. While it seems like such multiple mutations should be unlikely, computational biologist Niko Beerenwinkel of ETH Zurich in Basel, Switzerland, recently posted a preprint to bioRxiv suggesting that recurrent mutations can and do occur, and not infrequently (bioRxiv, doi:10.1101/094722, 2016).

      Fig 1 of preprint: mutated allele may get lost due to LOH event or less likely due to recurrent mutation, and thus reverting to the original base.

      In the former event, SNV could be a preceding dominant negative loss-of-function event which may follow LOH event to remove the beneficial trait (SNV itself). This makes sense for a haploinsufficient gene. However, that's not a strictly speaking a recurrent mutation event as the latter is a copy number level and not mutation change.