225 Matching Annotations
  1. Last 7 days
  2. Nov 2021
  3. Oct 2021
    1. Idea: May be the installation of some permanent implants with micro holes to relieve the pressure(liquid) would help? Does Spray (Oxymetazoline makers, multi-billion business) preventing human to achieve this? Must be as small as possible and multiple implants!

      annotation from my blog on nose congestion treatment.

    1. ReconfigBehSci. (2021, May 26). @Richard_Florida this is the Giesicke argument from Sweden- it makes sense only if you assume there will be no medical progress in the delay period. With vaccines and treatment improvements we know this to be empirically false. [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1397341753590489090

  4. Sep 2021
    1. Ben Collins on Twitter: “A quick thread: It’s hard to explain just how radicalized ivermectin and antivax Facebook groups have become in the last few weeks. They’re now telling people who get COVID to avoid the ICU and treat themselves, often by nebulizing hydrogen peroxide. So, how did we get here?” / Twitter. (n.d.). Retrieved September 26, 2021, from https://twitter.com/oneunderscore__/status/1441395300002848769?s=20

  5. Aug 2021
  6. Jul 2021
  7. Jun 2021
  8. May 2021
    1. Taddio, A., McMurtry, C. M., Shah, V., Riddell, R. P., Chambers, C. T., Noel, M., MacDonald, N. E., Rogers, J., Bucci, L. M., Mousmanis, P., Lang, E., Halperin, S. A., Bowles, S., Halpert, C., Ipp, M., Asmundson, G. J. G., Rieder, M. J., Robson, K., Uleryk, E., … Bleeker, E. V. (2015). Reducing pain during vaccine injections: Clinical practice guideline. CMAJ : Canadian Medical Association Journal, 187(13), 975–982. https://doi.org/10.1503/cmaj.150391

  9. Apr 2021
    1. Table 1:Potential treatments

      Blockade of NFkB/TLR4 pathway may also be beneficial due to the SARS-CoV-2 activation of TLR4 https://doi.org/10.1101/2020.12.18.423427

      Anti-viral neuraminidase inhibitors such as Oseltamivir or Zanamivir reduced neutrophil hyper-activation (via inhibition of host neuraminidase) and may present a new targeted therapeutic strategy https://doi.org/10.1101/2020.11.12.379115

      IL-18 blockade may represent a therapeutic option for COVID-19 as it may participate in hyperinflammation and tissue damage https://doi.org/10.1002/jcp.30008

      Increasing evidence that NK cells could be used as therapies for COVID-19 https://doi.org/10.1186/s40164-021-00199-1 as well as evidence for targeting specific mutants of COVID-19 with ‘off-the shelf’ CAR-NK cells https://doi.org/10.1101/2021.01.14.426742

  10. Mar 2021
    1. Rosendaal, F. R. (2020). Review of: “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial Gautret et al 2010, DOI:10.1016/j.ijantimicag.2020.105949. International Journal of Antimicrobial Agents, 106063. https://doi.org/10.1016/j.ijantimicag.2020.106063

  11. Feb 2021
    1. There are both broadly immunosuppressive approaches, such as high-dose corticosteroids, and more novel targeted approaches that go after inflammatory cytokine proteins
    2. There are also a few effective treatments for cytokine storms despite the fact that we still do not know exactly which treatments will ultimately be developed and recommended across the board for COVID-19 related cytokine storms.
    1. Nogués, X., Ovejero, D., Quesada-Gomez, J. M., Bouillon, R., Arenas, D., Pascual, J., Villar-Garcia, J., Rial, A., Gimenez-Argente, C., Cos, M. L., Rodriguez-Morera, J., Campodarve, I., Guerri-Fernandez, R., Pineda-Moncusí, M., & García-Giralt, N. (2021). Calcifediol Treatment and COVID-19-Related Outcomes (SSRN Scholarly Paper ID 3771318). Social Science Research Network. https://doi.org/10.2139/ssrn.3771318

  12. Jan 2021
  13. Dec 2020
    1. Emily. J. Miller. - FDA {@FDASpox} (2020) Convalescent plasma has shown to be beneficial for 35% of patients. This risk reduction figure - shown in chart below - is from @MayoClinic data from expanded access program that was analyzed by FDAA for the emergency use authorization announced today. Twitter. Retrieved from: https://twitter.com/FDASpox/status/1297706985039835136

  14. Oct 2020