13 Matching Annotations
  1. Last 7 days
    1. We have demonstrated that small RNAs can tightly repress their target genes when their synthesis rate is smaller than some threshold, but have little or no effect when the synthesis rate is much larger than that threshold
    2. a threshold-linear response with a tunable threshold, a robust noise resistance characteristic, and a built-in capability for hierarchical cross-talk.
    1. In particular, small RNAs are shown to establish a threshold for the expression of their target, providing safety mechanism against random fluctuations and transient signals. The threshold level is set by the transcription rate of the small RNA and can thus be modulated dynamically to reflect changing environmental conditions.
  2. Oct 2018
  3. Sep 2018
  4. Jun 2018
    1. Dnmt2 mediates intergenerational transmission of paternally acquired metabolic disorders through sperm small non-coding RNAs

      Queuosine metabolite necessary for DNMT2-induced tRNA modification; salvaged from bacteria of microbiome

  5. Mar 2018
  6. Feb 2018
  7. Nov 2017
  8. Oct 2017
  9. Nov 2016
    1. Two new molecular catalysts of water oxidation have been synthesized by a team of brilliant scientists from the U.S. Department of Energy’s Brookhaven National Laboratory. These new molecular catalysts – complexes of ruthenium which are surrounded by the binding molecules, and they contain phosphonate groups.