204 Matching Annotations
  1. Aug 2026
    1. Briefing : Gestion des Pandémies et Enseignements de la Crise Covid-19

      Ce document de synthèse analyse les échanges issus de la table ronde « Pandémie : si ça recommence, on fait quoi ? ».

      Il compile les témoignages d'experts en épidémiologie, en biologie, en médecine et en sciences sociales sur les défaillances passées et les impératifs futurs en cas de nouvelle crise sanitaire.

      Résumé Exécutif

      La gestion de la pandémie de Covid-19 a révélé des failles systémiques majeures dans la communication publique, l'intégrité scientifique et les mécanismes de régulation.

      Les principaux points à retenir sont :

      • Faillite de la communication institutionnelle : Le manque de transparence (« l'aveu de l'ignorance ») et les injonctions contradictoires (masques, vaccins) ont nourri une défiance durable.

      • Crise de l'intégrité scientifique : La montée en puissance de figures charismatiques diffusant des études de faible qualité a submergé la parole scientifique rigoureuse, souvent au détriment des jeunes chercheurs et des lanceurs d'alerte.

      • Impunité et régulation : Le Conseil de l'Ordre et les instances judiciaires sont critiqués pour leur lenteur, voire leur inaction, face aux dérives déontologiques et à la désinformation.

      • Priorité à la prévention : L'utilisation de l'occupation des lits de réanimation comme unique métrique de gestion est jugée catastrophique ; une approche basée sur le dépistage précoce et des indicateurs de santé globale est préconisée.


      1. Analyse de la Gestion Sanitaire : Erreurs et Lacunes

      Les experts soulignent que la France, contrairement à d'autres pays ou régions, a péché par manque d'anticipation et par une rigidité décisionnelle.

      La problématique du dépistage et des données

      • Le rôle crucial du testing : L'absence de tests massifs et ciblés dès le début a rendu les autorités « aveugles » face à une transmission asymptomatique pourtant connue.

      • L'erreur des métriques : Mircea Sophonea critique la focalisation sur les lits de réanimation.

      Considérer la réanimation comme une « seconde chance » plutôt que de prévenir l'infection par une culture de la prévention est une erreur de politique sanitaire.

      • Modélisation : La France manquait, et manque toujours, d'équipes de modélisation des maladies infectieuses par rapport à des voisins comme la Suisse ou le Royaume-Uni.

      Le cas spécifique de la Suède

      • Loni Besançon rapporte l'échec de la stratégie suédoise initiale basée sur l'immunité collective sans vaccin.

      Le stratège en chef, Anders Tegnell, s'est trompé d'un facteur 2 sur les estimations de contamination (annonçant 60 % de la population de Stockholm infectée en avril 2020, contre 30 % en réalité).


      2. Communication Publique et Défiance Sociale

      Le document met en lumière un lien direct entre les mensonges institutionnels et l'adhésion aux thèses complotistes.

      | Problème de Communication | Conséquence Identifiée | | --- | --- | | Déni de l'incertitude | Les autorités n'ont pas osé dire « nous ne savons pas », poussant le public vers des figures offrant des certitudes (ex: Didier Raoult). | | Incohérence sur les masques | Le mensonge initial sur l'utilité des masques (pour masquer la pénurie) a brisé la confiance envers la parole publique. | | Rhéthorique anxiogène | Une communication basée sur la peur a généré des réactions irrationnelles de surprotection ou de rejet total. |

      Guillaume Limousin souligne que l'éducation ne suffit pas : la franchise et l'intégrité des dirigeants sont des leviers de confiance aussi puissants que l'instruction.


      3. L'Intégrité Scientifique à l'Épreuve

      La pandémie a vu l'émergence d'un « tsunami de désinformation » porté par des acteurs utilisant les codes de l'autorité scientifique pour diffuser des données erronées.

      • Le phénomène des « stars » en blouse blanche : Des publications ne dépassant pas le « niveau brevet des collèges » ont été promues par des professeurs de renom, rendant la tâche des débusqueurs de fake news (déshonneurs, menaces de mort) extrêmement difficile.

      • Isolement des chercheurs : Les jeunes chercheurs se sont retrouvés seuls face à des institutions entières, sans protection fonctionnelle de la part de leurs tutelles ou universités.

      • Profil des désinformateurs : Ces acteurs sont décrits comme des « profiteurs de crise » ayant des intérêts politiques ou financiers, se structurant désormais pour d'autres crises, notamment climatique.


      4. Responsabilités Institutionnelles et Judiciaires

      Un sentiment d'amertume prédomine concernant l'absence de sanctions contre les dérives médicales et scientifiques.

      • Le Conseil de l'Ordre des Médecins : Accusé d'inaction et de complaisance.

      Fantine rapporte avoir signalé des discours médicaux dangereux à quatre reprises, sans aucune suite.

      À l'inverse, certains membres du Conseil ont soutenu des tribunes jugées frauduleuses.

      • Lenteur de la justice : La désinformation biomédicale aurait causé des milliers de morts (chiffre estimé au Canada et extrapolé), mais les responsables ne sont pas inquiétés.

      • Rôle des élus : Jacques Oberti (député) reconnaît que l'État était « à l'ouest » au début de la crise, forçant les maires à improviser (fabrication de masques en tissu, recensement des chambres froides).


      5. Perspectives : « Si ça recommence, on fait quoi ? »

      Les recommandations pour l'avenir sont marquées par une volonté de sévérité et de restructuration :

      • Sanctions immédiates : Suspendre rapidement les professionnels de santé qui ne respectent pas les recommandations de la Direction Générale de la Santé (DGS) en période épidémique.

      • Transparence radicale : Admettre les erreurs et les mensonges passés pour reconstruire la confiance.

      • Indicateurs fixés à l'avance : Définir collectivement les seuils d'alerte et les efforts acceptables avant que la crise ne survienne.

      • Lutte contre l'impunité : Appliquer strictement les lois anti-fraude scientifique.

      Comme le souligne Guillaume Limousin, tant que le bénéfice (notoriété, argent) de la désinformation sera supérieur au risque (amendes, prison), le phénomène persistera.


      Citations Clés

      « On a vu des gens mourir de désinformation.

      Des gens en réanimation qui, au moment de mourir, disaient : "Putain, j'aurais dû me faire vacciner." » — Fantine

      « La métrique de l'occupation des lits en réanimation me semble être une catastrophe d'un point de vue de politique sanitaire. » — Mircea Sophonea

      « Si vous êtes un ordinateur purement rationnel, vous voyez qu'il y a un bénéfice à frauder et à mentir.

      Tant qu'on n'aura pas changé ça, on n'y arrivera pas. » — Guillaume Limousin

      « La seule leçon que je vois du Covid, c'est : racontez n'importe quoi, montrez votre tête à la télé, et vous aurez des centaines de milliers de fans et des revenus conséquents. » — Fabrice Franck

  2. Feb 2024
    1. si possono considerare al sicuro anche le persone non vaccinate

      Insomma secondo questo fake-author i non vaccinati si possono considerare "al sicuro". Magari organizzaranno un morbillo-party con cui proteggeranno i non vaccinati con uno o più dei 6 morbilli-virus mutanti ritrovati nei vaccini per uso pediatrico..Tutte le cose, prima di essere scritte, devono essere verificate e questo "autore" non presenta alcuno studio scientifico a supporto. Gli consiglieremo la visione del film-documento "Vaxxed"..

  3. Aug 2022
  4. Jun 2022
    1. Asked in a 2013 C-SPAN interview which presidents he admired, he cited Gerald R. Ford, a Republican who took office in 1974 in the wake of the Watergate scandal. Ford, he said, was “the most emotionally healthy.”“Not that the others were basket cases,” he said, but “they get that bug, and as the late and very great Mo Udall, who sought that office, once put it, the only known cure for the presidential virus is embalming fluid.”
  5. Apr 2022
    1. Covid One Year Ago. (2021, March 12). 12 March 2020 “The public could be putting themselves more at risk from contracting coronavirus by wearing face masks.” “Jenny Harries, England’s deputy chief medical officer, said the masks could ‘actually trap the virus’ and cause the person wearing it to breathe it in” https://t.co/ar5kOOxih3 [Tweet]. @YearCovid. https://twitter.com/YearCovid/status/1370307577888698369

    1. Katherine J. Wu, Ph.D. (2021, December 29). I wrote (last week!) about the future of boosting—How many more shots will we need? Will they all contain the same ingredients? Ultimately, it depends on our immune systems, how the virus looks, and how much of the virus is around. 1/3 https://t.co/bJKYyriE9a [Tweet]. @KatherineJWu. https://twitter.com/KatherineJWu/status/1476249881073303552

    1. Lawrence Gostin. (2022, January 1). History shows most pandemics last 2-3 years. Covid-19 has been a wily foe #NewYear2022 should see the pandemic’s end in highly vaccinated nations. Strive mightily to access vaccines everywhere But Covid-19 will remain endemic everywhere. The new normal means living with the virus [Tweet]. @LawrenceGostin. https://twitter.com/LawrenceGostin/status/1477087584459370507

  6. Mar 2022
    1. Mia Malan. (2021, November 25). [Thread] What is the potential impact of the new B.1.1.529 #COVID19 variant? @rjlessells: 1. It’s relatively simple to detect some B.1.1.529 cases, as it’s possible to use PCR tests to do this in some cases 2. B.1.1.529 = has many mutations across different parts of the virus https://t.co/ytktqLzJUi [Tweet]. @miamalan. https://twitter.com/miamalan/status/1463846528578109444

    1. Kerr, P. J., Cattadori, I. M., Liu, J., Sim, D. G., Dodds, J. W., Brooks, J. W., Kennett, M. J., Holmes, E. C., & Read, A. F. (2017). Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype. Proceedings of the National Academy of Sciences, 114(35), 9397–9402. https://doi.org/10.1073/pnas.1710336114

  7. Feb 2022
  8. Jan 2022
    1. Paolucci, S., Cassaniti, I., Novazzi, F., Fiorina, L., Piralla, A., Comolli, G., Bruno, R., Maserati, R., Gulminetti, R., Novati, S., Mojoli, F., Baldanti, F., Bruno, R., Mondelli, M., Brunetti, E., Matteo, A. D., Seminari, E., Maiocchi, L., Zuccaro, V., … Ferrari, A. (2021). EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count. International Journal of Infectious Diseases, 104, 315–319. https://doi.org/10.1016/j.ijid.2020.12.051

  9. Dec 2021
  10. Nov 2021
    1. our fourth point is that for something like eukaryotes and others where there is no immediate major system 00:25:30 transition we're really sort of saying is that they perhaps are critical to such a transition but not at the time necessarily that they have evolved so in essence we want to amp we want to bring in a new 00:25:43 term which we call facilitating evolutionary transition so it makes it is part of a major system transition but it clearly needs other 00:25:55 evolutionary events to go along with it and the final sort of point is that there are perhaps catalysts that are involved in this process and one of the major catalysts that may 00:26:12 have had effects throughout evolutionary history are viruses so viruses may have been key actors to help the transition from 00:26:23 rna to dna they may have uh produced or helped produce the nucleus in eukaryotes and we'll talk about a little bit later about the key role that viral genes play 00:26:36 in making sexual reproduction possible and even in placental mammals the evolution of a placenta so without viral genes being moved across 00:26:47 horizontally species some of these major transitions could never have happened so now we have sort of the complete integrated process of of our diagram and again the question 00:27:02 that we're really focusing on oftentimes is that last one yes when how and why do we get to a major system transition and how do nets mechs uh 00:27:15 fets and catalysts all play a role in these various transitions

      Viruses have played a key role in a number of different METs. This is an important insight that can contextualize the covid-19 pandemic.

  11. Oct 2021
    1. Higdon, M. M., Wahl, B., Jones, C. B., Rosen, J. G., Truelove, S. A., Baidya, A., Nande, A. A., ShamaeiZadeh, P. A., Walter, K. K., Feikin, D. R., Patel, M. K., Knoll, M. D., & Hill, A. L. (2021). A systematic review of COVID-19 vaccine efficacy and effectiveness against SARS-CoV-2 infection and disease [Preprint]. Epidemiology. https://doi.org/10.1101/2021.09.17.21263549

  12. Sep 2021
    1. Kraemer, M. U. G., Hill, V., Ruis, C., Dellicour, S., Bajaj, S., McCrone, J. T., Baele, G., Parag, K. V., Battle, A. L., Gutierrez, B., Jackson, B., Colquhoun, R., O’Toole, Á., Klein, B., Vespignani, A., COVID-19 Genomics UK (COG-UK) Consortium‡, Volz, E., Faria, N. R., Aanensen, D. M., … Pybus, O. G. (2021). Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence. Science, 373(6557), 889–895. https://doi.org/10.1126/science.abj0113

  13. Aug 2021
  14. Jul 2021
  15. Jun 2021
  16. May 2021
    1. Gobeil, P., Pillet, S., Séguin, A., Boulay, I., Mahmood, A., Vinh, D. C., Charland, N., Boutet, P., Roman, F., Most, R. V. D., Perez, M. de los A. C., Ward, B. J., & Landry, N. (2021). Interim Report of a Phase 2 Randomized Trial of a Plant-Produced Virus-Like Particle Vaccine for Covid-19 in Healthy Adults Aged 18-64 and Older Adults Aged 65 and Older. MedRxiv, 2021.05.14.21257248. https://doi.org/10.1101/2021.05.14.21257248

    1. Howard, J., Huang, A., Li, Z., Tufekci, Z., Zdimal, V., Westhuizen, H.-M. van der, Delft, A. von, Price, A., Fridman, L., Tang, L.-H., Tang, V., Watson, G. L., Bax, C. E., Shaikh, R., Questier, F., Hernandez, D., Chu, L. F., Ramirez, C. M., & Rimoin, A. W. (2021). An evidence review of face masks against COVID-19. Proceedings of the National Academy of Sciences, 118(4). https://doi.org/10.1073/pnas.2014564118

    1. Erik Angner. (2021, February 17). One point that the pandemic has brought home to me is just how narrow people’s expertise is. I’m regularly surprised by how a celebrated professor of X can exhibit a sub-college-level understanding of Y, even when X and Y are related. /1 [Tweet]. @ErikAngner. https://twitter.com/ErikAngner/status/1362006859004141570

  17. Apr 2021
  18. Mar 2021
    1. Damialis, A., Gilles, S., Sofiev, M., Sofieva, V., Kolek, F., Bayr, D., Plaza, M. P., Leier-Wirtz, V., Kaschuba, S., Ziska, L. H., Bielory, L., Makra, L., Trigo, M. del M., Group, C.-19/POLLEN study, & Traidl-Hoffmann, C. (2021). Higher airborne pollen concentrations correlated with increased SARS-CoV-2 infection rates, as evidenced from 31 countries across the globe. Proceedings of the National Academy of Sciences, 118(12). https://doi.org/10.1073/pnas.2019034118

    1. Eran Segal. (2021, January 22). Israel: 2.4M after 1st dose (27% pop) 78% of all 60+ years old Despite that, we have a problem: Cities of lower socio-economic status and more cases get vaccinated less X: Socioeconomic rank Y: % 60+ years old vaccinated Color: Vaccination need ratio @MDCaspi by covid-19 cases https://t.co/t5vC8hjXA4 [Tweet]. @segal_eran. https://twitter.com/segal_eran/status/1352579515592138753

  19. Feb 2021
    1. Gordon, D. E., Hiatt, J., Bouhaddou, M., Rezelj, V. V., Ulferts, S., Braberg, H., Jureka, A. S., Obernier, K., Guo, J. Z., Batra, J., Kaake, R. M., Weckstein, A. R., Owens, T. W., Gupta, M., Pourmal, S., Titus, E. W., Cakir, M., Soucheray, M., McGregor, M., … Krogan, N. J. (2020). Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370(6521). https://doi.org/10.1126/science.abe9403

    1. Maryanne Garry 🐑🇳🇿. (2020, December 12). A person with the virus who, say, has lunch with friends is a witness to an event in which the virus was possibly transmitted, and a suspect who might have transmitted it to others. Our new paper in PoPS @lorraine_hope @rachelz @drayeshaverrall and Jamie Robertson https://t.co/FoOlx78HB2 [Tweet]. @drlambchop. https://twitter.com/drlambchop/status/1337676716936896512

    1. UK is with EU. (2021, January 18). ..The reason we are in this third lockdown is because of the anti lockdowners like Lord Sumption ..We are going in circles, countries who have done well controlled the virus and now have an economic recovery ..And every life matters #GMB @devisridhar speaking truth to power https://t.co/U3BBV0uUSb [Tweet]. @ukiswitheu. https://twitter.com/ukiswitheu/status/1351089812799950850

    1. Kit Yates. (2021, January 22). Is this lockdown 3.0 as tough as lockdown 1? Here are a few pieces of data from the @IndependentSage briefing which suggest that despite tackling a much more transmissible virus, lockdown is less strict, which might explain why we are only just keeping on top of cases. [Tweet]. @Kit_Yates_Maths. https://twitter.com/Kit_Yates_Maths/status/1352662085356937216

    1. Tang, J. W., Bahnfleth, W. P., Bluyssen, P. M., Buonanno, G., Jimenez, J. L., Kurnitski, J., Li, Y., Miller, S., Sekhar, C., Morawska, L., Marr, L. C., Melikov, A. K., Nazaroff, W. W., Nielsen, P. V., Tellier, R., Wargocki, P., & Dancer, S. J. (2021). Dismantling myths on the airborne transmission of severe acute respiratory syndrome coronavirus (SARS-CoV-2). Journal of Hospital Infection, 0(0). https://doi.org/10.1016/j.jhin.2020.12.022

    1. Fredericks DN, & Relman DA (1996). Sequence-based identification of microbial pathogens: a reconsideration of Koch’s postulates. Clinical microbiology reviews, 9 (1), 18-33 PMID: 8665474

      Repostulation of Koch's rules in the era of the virueses.

  20. Jan 2021
  21. Dec 2020
  22. Nov 2020
    1. If you get a positive PCR test and you want to be sure that what you’re finding is a true positive, then you have to perform a viral culture. What this means is that you take the sample, add it to respiratory cells in a petri dish, and see if you can get those cells to start producing new virus particles. If they do, then you know you have a true positive result. For this reason, viral culture is considered the “gold standard” method for diagnosis of viral infections. However, this method is rarely used in clinical practice, which means that in reality, a diagnosis is often made based entirely on the PCR test.

      [[Z: A positive PCR should be followed by a viral culture test to see if you're dealing with a live infection]]

      After a positive PCR test, you don't know if the virus is alive or not. To find this out you can add it to respiratory cells (in the case of a respiratory virus) and see if they start producing virus particles).

      [[Z: Viral culture tests are rarely used in clinical practice]]

      Positive diagnoses of COVID-19 are done base on PCR only.

  23. Oct 2020
  24. Sep 2020
    1. This nasty, mysterious virus will require us all to change our minds as scientists learn more, and we may have to give up some practices and beliefs about it that we now feel sure of.

      This virus has corrupted many people mentally and many people physicall.

  25. Aug 2020
    1. Candido, D. S., Claro, I. M., Jesus, J. G. de, Souza, W. M., Moreira, F. R. R., Dellicour, S., Mellan, T. A., Plessis, L. du, Pereira, R. H. M., Sales, F. C. S., Manuli, E. R., Thézé, J., Almeida, L., Menezes, M. T., Voloch, C. M., Fumagalli, M. J., Coletti, T. M., Silva, C. A. M. da, Ramundo, M. S., … Faria, N. R. (2020). Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science. https://doi.org/10.1126/science.abd2161

    1. Sun, W., McCroskery, S., Liu, W.-C., Leist, S. R., Liu, Y., Albrecht, R. A., Slamanig, S., Oliva, J., Amanat, F., Schäfer, A., Dinnon, K. H., Innis, B. L., García-Sastre, A., Krammer, F., Baric, R. S., & Palese, P. (2020). A Newcastle disease virus (NDV) expressing membrane-anchored spike as a cost-effective inactivated SARS-CoV-2 vaccine. BioRxiv, 2020.07.30.229120. https://doi.org/10.1101/2020.07.30.229120

  26. Jul 2020
  27. Jun 2020
    1. Komentar umum

      • Makalah ini membahas aspek yang belum pernah dibahas sebelumnya, walaupun fragmen-fragmen isu ini sudah ditampilkan di berbagai media sejak masa awal Indonesia menangani virus ini secara serius.

      • Menampilkan milestone di sini ide yang baik. Saran saja untuk juga menampilkannya dalam bentuk visual.

  28. May 2020
    1. Research on enveloped virus presence and fate in water is hindered by the lack of proven detection methods. Detecting and quantifying viruses in environmental samples requires first concentrating the viruses in the sample into a smaller volume to improve detection limits
    1. The 1MDS-method and the HA-method did not provide as high recovery yields of the virions as the Mg-method.

      The reason for this could be the beef extract used to elute the virions from both these membranes. The other two successful methods (Mg and Al) used H2SO4 for elution.

  29. Apr 2020
    1. a defined quantity of a nonhuman control virus (seal herpes virus [SHV], kindly provided by H. G. M. Niesters, University of Rotterdam, The Netherlands) was spiked into each sample prior to DNA and RNA extraction. Since constant DNA quantities of the control virus are coextracted even when RNA isolation kits are used (H. G. M. Niesters, personal communication; our own unpublished observations), the virus can also serve as a control in RNA virus detection assays.
    1. Jefferson, T., Jones, M., Al Ansari, L. A., Bawazeer, G., Beller, E., Clark, J., Conly, J., Del Mar, C., Dooley, E., Ferroni, E., Glasziou, P., Hoffman, T., Thorning, S., & Van Driel, M. (2020). Physical interventions to interrupt or reduce the spread of respiratory viruses. Part 1 - Face masks, eye protection and person distancing: Systematic review and meta-analysis [Preprint]. Public and Global Health. https://doi.org/10.1101/2020.03.30.20047217

  30. Mar 2020
    1. Real data shows that book sales are down some 25 percent during this lockdown. People are not actually buying books—not in physical shops (understandably), and online sales are plummeting too. So, either Italians are rereading all the volumes they have at home, or they’re just lying.
    2. As a freelance writer, I say to myself that the lockdown doesn’t change much from before. I stay in my pajamas all day, as before, plus there is the cancellation of all social activities. No more endless dinner parties or pointless meetings. It’s so relieving.

      It's the same for University students, excluded the few hours of weekly lectures

    3. The turning point, for me at least, came when I learned that someone real, someone on the fringe of my immediate circle, was in mortal danger. It was the 70-year-old father of a friend of a friend. He died. But the scariest and saddest thing is how he died: alone, in an intensive care unit, with no chance to say goodbye to his loved ones. For now, funerals are also prohibited. That is how one dies in the time of the coronavirus. This is the most terrible thing.When you hear stories like that, you start following the rules. You are suddenly ready to stay home. You wear your mask, and you don’t feel like making jokes about the virus. You get depressed.

      The turning point of attitude and behavior related to Corona Virus

  31. Feb 2020
  32. Aug 2019