- Apr 2022
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www.science.org www.science.org
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Mathew, D., Giles, J. R., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., Kuri-Cervantes, L., Pampena, M. B., D’Andrea, K., Manne, S., Chen, Z., Huang, Y. J., Reilly, J. P., Weisman, A. R., Ittner, C. A. G., Kuthuru, O., Dougherty, J., Nzingha, K., … Wherry, E. J. (2020). Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications. Science, 369(6508), eabc8511. https://doi.org/10.1126/science.abc8511
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Varmus, H. (2021, August 31). Covid has revealed the need for genomic sequencing around the world. Financial Times. https://www.ft.com/content/342fd3c3-5a22-49a0-9cef-135f2ccd8700
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twitter.com twitter.com
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Edward Nirenberg 🇺🇦 [@ENirenberg]. (2021, November 30). This is also not limited to the vaccine- any infection we encounter will do the same thing. It’s how we evolved to get around a massive genetic and bioenergetic challenge and it’s brilliant and it’s happening all the time regardless of any vaccines we get. [Tweet]. Twitter. https://twitter.com/ENirenberg/status/1465698637434933254
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twitter.com twitter.com
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Katherine J. Wu, Ph.D. (2021, December 29). I wrote (last week!) about the future of boosting—How many more shots will we need? Will they all contain the same ingredients? Ultimately, it depends on our immune systems, how the virus looks, and how much of the virus is around. 1/3 https://t.co/bJKYyriE9a [Tweet]. @KatherineJWu. https://twitter.com/KatherineJWu/status/1476249881073303552
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twitter.com twitter.com
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ReconfigBehSci. (2022, January 31). RT @fascinatorfun: Interesting as 🇩🇰 Omicron BA2 wave started sooner than 🇬🇧 “We conclude that Omicron BA.2 is inherently substantially m… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1488152457012297736
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Pavord, S., Hunt, B. J., Horner, D., Bewley, S., & Karpusheff, J. (2021). Vaccine induced immune thrombocytopenia and thrombosis: Summary of NICE guidance. BMJ, 375, n2195. https://doi.org/10.1136/bmj.n2195
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- Mar 2022
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pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
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Bellesi, S., Metafuni, E., Hohaus, S., Maiolo, E., Marchionni, F., D’Innocenzo, S., La Sorda, M., Ferraironi, M., Ramundo, F., Fantoni, M., Murri, R., Cingolani, A., Sica, S., Gasbarrini, A., Sanguinetti, M., Chiusolo, P., & De Stefano, V. (2020). Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients. British Journal of Haematology, 191(2), 207–211. https://doi.org/10.1111/bjh.17034
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theconversation.com theconversation.com
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Lee, A., Cheng, K. K., Cruickshank, S., & Greenhalgh, T. (n.d.). “We suppressed our scientific imagination”: Four experts examine the big successes and failures of the COVID response so far. The Conversation. Retrieved March 31, 2022, from http://theconversation.com/we-suppressed-our-scientific-imagination-four-experts-examine-the-big-successes-and-failures-of-the-covid-response-so-far-178705
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kareem.substack.com kareem.substack.com
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Abdul-Jabbar, K. (2021, November 8). Aaron Rodgers Didn’t Just Lie [Substack newsletter]. Kareem Abdul-Jabbar. https://kareem.substack.com/p/aaron-rodgers-didnt-just-lie
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hackmd.io hackmd.io
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Myths about COVID-19 vaccination. (n.d.). HackMD. Retrieved March 23, 2022, from https://hackmd.io/@scibehC19vax/misinfo_myths
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www.science.org www.science.org
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Altmann, D. M., & Boyton, R. J. (2022). COVID-19 vaccination: The road ahead. Science, 375(6585), 1127–1132. https://doi.org/10.1126/science.abn1755
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www.theguardian.com www.theguardian.com
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Al Newman. (2022, March 8). @danaparish @jennybluebird2U To your point: Https://t.co/CsULpIACoI [Tweet]. @AlNewman_. https://twitter.com/AlNewman_/status/1501056062262333441
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insights.som.yale.edu insights.som.yale.edu
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Health & Veritas: Is Long COVID One Disease or Many? (Ep. 19). (n.d.). Yale Insights. Retrieved 21 March 2022, from https://insights.som.yale.edu/insights/health-veritas-is-long-covid-one-disease-or-many-ep-19
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www.news18.com www.news18.com
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Corbevax: All About India’s First Protein Sub-Unit Covid Vaccine to be Given to 12-14 Age Group From Today. (2022, March 16). News18. https://www.news18.com/news/india/corbevax-all-about-indias-first-protein-sub-unit-covid-vaccine-to-be-given-to-12-14-age-group-from-today-4874345.html
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www.theatlantic.com www.theatlantic.com
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Wu, K. J. (2021, December 29). Our Relationship With COVID Vaccines Is Just Getting Started. The Atlantic. https://www.theatlantic.com/science/archive/2021/12/how-many-covid-19-booster-shots/621132/
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twitter.com twitter.com
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Anthony J Leonardi, PhD, MS. (2022, February 28). Damn, nice find https://t.co/cJRhB2k4zH [Tweet]. @fitterhappierAJ. https://twitter.com/fitterhappierAJ/status/1498113886846914567
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- Feb 2022
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www.theguardian.com www.theguardian.com
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Ball, P. (2022, February 26). Will we get a single, variant-proof vaccine for Covid? The Observer. https://www.theguardian.com/society/2022/feb/26/will-we-get-a-single-variant-proof-vaccine-for-covid
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twitter.com twitter.com
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Meaghan Kall. (2022, February 17). BA.2 risk assessment New this week is upgrading Immune Evasion—Amber 🟨 from low to moderate that BA.2 is antigentically different to BA.1 Unsurprising given the mutation profile, with BA.2 slightly more immune evasive than BA.1 on neuts studies https://t.co/n6DWtiRaNH [Tweet]. @kallmemeg. https://twitter.com/kallmemeg/status/1494100170195312646
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www.nejm.org www.nejm.org
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Altarawneh, H. N., Chemaitelly, H., Hasan, M. R., Ayoub, H. H., Qassim, S., AlMukdad, S., Coyle, P., Yassine, H. M., Al-Khatib, H. A., Benslimane, F. M., Al-Kanaani, Z., Al-Kuwari, E., Jeremijenko, A., Kaleeckal, A. H., Latif, A. N., Shaik, R. M., Abdul-Rahim, H. F., Nasrallah, G. K., Al-Kuwari, M. G., … Abu-Raddad, L. J. (2022). Protection against the Omicron Variant from Previous SARS-CoV-2 Infection. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMc2200133
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www.medrxiv.org www.medrxiv.org
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Lyngse, F. P., Mortensen, L. H., Denwood, M. J., Christiansen, L. E., Møller, C. H., Skov, R. L., Spiess, K., Fomsgaard, A., Lassaunière, M. M., Rasmussen, M., Stegger, M., Nielsen, C., Sieber, R. N., Cohen, A. S., Møller, F. T., Overvad, M., Mølbak, K., Krause, T. G., & Kirkeby, C. T. (2021). SARS-CoV-2 Omicron VOC Transmission in Danish Households (p. 2021.12.27.21268278). medRxiv. https://doi.org/10.1101/2021.12.27.21268278
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twitter.com twitter.com
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Eric Feigl-Ding. (2022, January 13). WATCH📺—Despite 97.5% of all adults in England🏴 with antibodies to #COVID19 (via vax/infection)–hospitalizations still surging. Why? Because variants like #Omicron are adapting. Need multivalent vax, plus ➡️N95 & ventilation are agnostic to variants—Key! Https://t.co/gDNRJIWojX [Tweet]. @DrEricDing. https://twitter.com/DrEricDing/status/1481732793482813443
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www.theatlantic.com www.theatlantic.com
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Yong, E. (2022, February 16). The Millions of People Stuck in Pandemic Limbo. The Atlantic. https://www.theatlantic.com/health/archive/2022/02/covid-pandemic-immunocompromised-risk-vaccines/622094/
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www.mercurynews.com www.mercurynews.com
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Living with COVID-19: How the virus could turn into the common cold, or something far worse. (2022, January 9). The Mercury News. https://www.mercurynews.com/2022/01/09/living-with-covid-19-how-the-virus-could-turn-into-the-common-cold-or-something-far-worse
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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Academics: Viral Evolution Scenarios, 10 February 2022. (n.d.). GOV.UK. Retrieved February 14, 2022, from https://www.gov.uk/government/publications/academics-viral-evolution-scenarios-10-february-2022
Tags
- lang:en
- transmissibility
- vaccine efficacy
- is:report
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- COVID-19
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Annotators
URL
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www.theguardian.com www.theguardian.com
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Beaumont, P. (2021, December 17). T-cells in Pfizer Covid jab recipients stay robust against severe illness. The Guardian. https://www.theguardian.com/world/2021/dec/17/t-cells-pfizer-covid-jab-robust-against-severe-illness-south-africa-research
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twitter.com twitter.com
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Anthony J Leonardi, PhD, MS. (2022, January 22). Wow. This is concerning. H/t @ForesightWisdom it is learning to become more chronic. Https://t.co/XwFR4D0kiy [Tweet]. @fitterhappierAJ. https://twitter.com/fitterhappierAJ/status/1484996537889476610
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www.youtube.com www.youtube.com
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American Medical Association (AMA). (2021, December 6). Peter Hotez, MD, PhD, on the omicron variant and Delta winter surge | COVID-19 Update for Dec. 6, 20. https://www.youtube.com/watch?v=WnfpC1_N2Mg
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twitter.com twitter.com
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Ulrich Elling. (2022, January 12). While #Omicron BA.1 leads the race, the little sister BA.2 is catching up in numbers. They are rather different with likely functional implications. BA.2 might be more immune evasive in RBD, less in NTD. And due to reduced mutation load in NTD maybe different fusion properties? Https://t.co/kEACjzQDs3 [Tweet]. @EllingUlrich. https://twitter.com/EllingUlrich/status/1481214901997682692
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www.medrxiv.org www.medrxiv.org
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Vanshylla, K., Tober-Lau, P., Gruell, H., Muenn, F., Eggeling, R., Pfeifer, N., Le, N. H., Landgraf, I., Kurth, F., Sander, L. E., & Klein, F. (2022). Durability of Omicron-neutralizing serum activity following mRNA booster immunization in elderly individuals (p. 2022.02.02.22270302). medRxiv. https://doi.org/10.1101/2022.02.02.22270302
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www.nature.com www.nature.com
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Adam, D. (2022). Will Omicron end the pandemic? Here’s what experts say. Nature, 602(7895), 20–21. https://doi.org/10.1038/d41586-022-00210-7
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twitter.com twitter.com
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ScienceUpFirst, LaScienced’Abord. (2022, February 1). Got Omicron? You are not alone! See our thread on what we know so far 👇 🧵 [1/11] #ScienceUpFirst https://t.co/7Hi3lHo5LS [Tweet]. @ScienceUpFirst. https://twitter.com/ScienceUpFirst/status/1488601396421316613
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Tayag, Y. (2022, January 31). What causes long Covid? Scientists are zeroing in on the answer. Vox. https://www.vox.com/22906853/omicron-long-covid-vaccinated-symptoms-cause
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- Jan 2022
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www.medrxiv.org www.medrxiv.org
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Gentles, L. E., Kehoe, L., Crawford, K. H. D., Lacombe, K., Dickerson, J., Wolf, C., Yuan, J., Schuler, S., Watson, J. T., Nyanseor, S., Briggs-Hagen, M., Saydah, S., Midgley, C. M., Pringle, K., Chu, H., Bloom, J. D., & Englund, J. A. (2022). Dynamics of infection-elicited SARS-CoV-2 antibodies in children over time (p. 2022.01.14.22269235). medRxiv. https://doi.org/10.1101/2022.01.14.22269235
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www.statnews.com www.statnews.com
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Early data indicate vaccines still protect against Omicron’s sister variant, BA.2. (2022, January 28). STAT. https://www.statnews.com/2022/01/28/early-data-indicate-vaccines-still-protect-against-omicrons-sister-variant-ba-2/
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www.bmj.com www.bmj.com
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Taylor, L. (2022). Covid-19: CoronaVac immunity is strongest after boosting with a different vaccine. BMJ, 376, o210. https://doi.org/10.1136/bmj.o210
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www.nature.com www.nature.com
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Zimmerman, M. I., Porter, J. R., Ward, M. D., Singh, S., Vithani, N., Meller, A., Mallimadugula, U. L., Kuhn, C. E., Borowsky, J. H., Wiewiora, R. P., Hurley, M. F. D., Harbison, A. M., Fogarty, C. A., Coffland, J. E., Fadda, E., Voelz, V. A., Chodera, J. D., & Bowman, G. R. (2021). SARS-CoV-2 simulations go exascale to predict dramatic spike opening and cryptic pockets across the proteome. Nature Chemistry, 13(7), 651–659. https://doi.org/10.1038/s41557-021-00707-0
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Kozlov, M. (2022). How does Omicron spread so fast? A high viral load isn’t the answer. Nature. https://doi.org/10.1038/d41586-022-00129-z
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healthpolicy-watch.news healthpolicy-watch.news
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Backed By Science: Here’s How We Can Eliminate COVID-19 - Health Policy Watch. (2022, January 23). https://healthpolicy-watch.news/93258-2/
Tags
- mortality
- lang:en
- prevention
- herd immunity
- equity
- is:webpage
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- immunity
- pandemic management
- global coordination
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- COVID-19
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- WHO
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Annotators
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plus.tagesspiegel.de plus.tagesspiegel.de
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Karberg, S., & Friebe, R. (2022, January 18). Virologe Drosten im Interview: „Wie lange geht diese Quälerei noch weiter?“. https://plus.tagesspiegel.de/wissen/virologe-drosten-im-interview-wie-lange-geht-diese-qualerei-noch-weiter-361636.html
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www.theguardian.com www.theguardian.com
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Davis, N., & correspondent, N. D. S. (2022, January 21). Covid reinfection: How likely are you to catch virus multiple times? The Guardian. https://www.theguardian.com/world/2022/jan/21/covid-reinfection-how-likely-are-you-to-catch-virus-multiple-times
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www.frontiersin.org www.frontiersin.org
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Townsend, L., Dyer, A. H., Naughton, A., Kiersey, R., Holden, D., Gardiner, M., Dowds, J., O’Brien, K., Bannan, C., Nadarajan, P., Dunne, J., Martin-Loeches, I., Fallon, P. G., Bergin, C., O’Farrelly, C., Cheallaigh, C. N., Bourke, N. M., & Conlon, N. (2021). Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health. Frontiers in Immunology, 12. https://www.frontiersin.org/article/10.3389/fimmu.2021.676932
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Dolgin, E. (2022). Omicron thwarts some of the world’s most-used COVID vaccines. Nature. https://doi.org/10.1038/d41586-022-00079-6
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www.medrxiv.org www.medrxiv.org
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Home
Zuo, F., Abolhassani, H., Du, L., Piralla, A., Bertoglio, F., Campos-Mata, L. de, Wan, H., Schubert, M., Wang, Y., Sun, R., Cassaniti, I., Vlachiotis, S., Kumagai-Braesch, M., Andréll, J., Zhang, Z., Xue, Y., Wenzel, E. V., Calzolai, L., Varani, L., … Pan-Hammarström, Q. (2022). Heterologous immunization with inactivated vaccine followed by mRNA booster elicits strong humoral and cellular immune responses against the SARS-CoV-2 Omicron variant (p. 2022.01.04.22268755). https://doi.org/10.1101/2022.01.04.22268755
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www.reuters.com www.reuters.com
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Lapid, N. (2022, January 4). Covid Science: Virus leaves antibodies that may attack healthy tissues. Reuters. https://www.reuters.com/business/healthcare-pharmaceuticals/virus-leaves-antibodies-that-may-attack-healthy-tissues-b-cell-antibodies-2022-01-03/
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- Omicron
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Annotators
URL
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www.imperial.ac.uk www.imperial.ac.uk
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Omicron largely evades immunity from past infection or two vaccine doses | Imperial News | Imperial College London. (n.d.). Imperial News. Retrieved January 12, 2022, from https://www.imperial.ac.uk/news/232698/omicron-largely-evades-immunity-from-past/
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www.medrxiv.org www.medrxiv.org
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Tseng, H. F., Ackerson, B. K., Luo, Y., Sy, L. S., Talarico, C., Tian, Y., Bruxvoort, K., Tupert, J. E., Florea, A., Ku, J. H., Lee, G. S., Choi, S. K., Takhar, H. S., Aragones, M., & Qian, L. (2022). Effectiveness of mRNA-1273 against SARS-CoV-2 omicron and delta variants (p. 2022.01.07.22268919). https://doi.org/10.1101/2022.01.07.22268919
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Iacobucci, G. (2022). Covid-19: Fourth vaccine doses—who needs them and why? BMJ, 376, o30. https://doi.org/10.1136/bmj.o30
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www.newscientist.com www.newscientist.com
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author.fullName}. (n.d.). 2022 preview: What will the coronavirus do next? New Scientist. Retrieved January 4, 2022, from https://www.newscientist.com/article/mg25233661-800-2022-preview-what-will-the-coronavirus-do-next/
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www.nature.com www.nature.com
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Carreño, J. M., Alshammary, H., Tcheou, J., Singh, G., Raskin, A., Kawabata, H., Sominsky, L., Clark, J., Adelsberg, D. C., Bielak, D., Gonzalez-Reiche, A. S., Dambrauskas, N., Vigdorovich, V., Group, P. S., Srivastava, K., Sather, D. N., Sordillo, E. M., Bajic, G., van Bakel, H., … Krammer, F. (2021). Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron. Nature. https://doi.org/10.1038/d41586-021-03846-z
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www.theguardian.com www.theguardian.com
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Davis, N., & correspondent, N. D. S. (2021, December 31). What do we know about the Omicron Covid variant so far? The Guardian. https://www.theguardian.com/world/2021/dec/31/what-do-we-know-about-the-omicron-covid-variant-so-far
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- Dec 2021
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www.washingtonpost.com www.washingtonpost.com
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Perspective | Even the best-case scenario with omicron will still be bad. (n.d.). Washington Post. Retrieved December 23, 2021, from https://www.washingtonpost.com/outlook/2021/12/21/omicron-mild-cases-numbers/
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twitter.com twitter.com
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Eric Topol. (2021, October 19). Just published @ScienceTM With blunting of the immune response, why it is so important for pregnant women to get a Covid vaccine https://science.org/doi/10.1126/scitranslmed.abm2070 w/ @ScienceVisuals https://t.co/aCY6LP4Taa [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1450475410328850435
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twitter.com twitter.com
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ReconfigBehSci. (2021, December 22). RT @chrischirp: Positivity rising steeply too—There are definitely many more people we aren’t catching https://t.co/4xDPwYQtrx [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1473695678610214927
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twitter.com twitter.com
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ReconfigBehSci. (2021, November 26). RT @PeterHotez: …this info is more relevant than immune escape. For instance the B.1.351 from ZA last year never really took off. So transm… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1464240155070447632
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www.nature.com www.nature.com
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Sefik, E., Israelow, B., Mirza, H., Zhao, J., Qu, R., Kaffe, E., Song, E., Halene, S., Meffre, E., Kluger, Y., Nussenzweig, M., Wilen, C. B., Iwasaki, A., & Flavell, R. A. (2021). A humanized mouse model of chronic COVID-19. Nature Biotechnology, 1–15. https://doi.org/10.1038/s41587-021-01155-4
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twitter.com twitter.com
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ReconfigBehSci. (2021, December 12). RT @florian_krammer: New preprint led by Kaori Sano in collaboration with @VivianaSimonLab https://medrxiv.org/content/10.1101/2021.12.06.21267352v1. Convalescent individual… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1469936301466079233
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www.reuters.com www.reuters.com
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Lubell, M. (2021, December 9). Doctors weigh COVID-19 impact on children as vaccine drives ramp up. Reuters. https://www.reuters.com/business/healthcare-pharmaceuticals/doctors-weigh-covid-19-impact-children-vaccine-drives-ramp-up-2021-12-09/
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www.nature.com www.nature.com
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Adamo, S., Michler, J., Zurbuchen, Y., Cervia, C., Taeschler, P., Raeber, M. E., Sain, S. B., Nilsson, J., Moor, A. E., & Boyman, O. (2021). Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection. Nature, 1–9. https://doi.org/10.1038/s41586-021-04280-x
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twitter.com twitter.com
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Theo Sanderson. (2021, December 8). SGTF Regional data to Dec 6 from https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1039470/Omicron_SGTF_case_update.pdf (Last data point would be expected to be incomplete based on the dates and so to slightly understate growth. And also will already have moved substantially from the midpoint of that last week on 3rd Dec.) https://t.co/1L6tM0sXIZ [Tweet]. @theosanderson. https://twitter.com/theosanderson/status/1468648673668128775
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www.theatlantic.com www.theatlantic.com
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Zhang, S. (2021, December 8). Omicron’s Explosive Growth Is a Warning Sign. The Atlantic. https://www.theatlantic.com/health/archive/2021/12/omicron-spread-infection-severity/620948/
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aacijournal.biomedcentral.com aacijournal.biomedcentral.com
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Wagner, D. N., Marcon, A. R., & Caulfield, T. (2020). “Immune Boosting” in the time of COVID: Selling immunity on Instagram. Allergy, Asthma & Clinical Immunology, 16(1), 76. https://doi.org/10.1186/s13223-020-00474-6
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www.bmj.com www.bmj.com
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Mahase, E. (2021). Covid-19: Antibody boost after third dose varies greatly by vaccine, study finds. BMJ, 375, n3011. https://doi.org/10.1136/bmj.n3011
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www.statnews.com www.statnews.com
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Cause for optimism on Omicron: Our immune systems aren’t blank slates. (2021, December 1). STAT. https://www.statnews.com/2021/12/01/a-reason-for-optimism-on-omicron-our-immune-systems-are-not-blank-slates/
Tags
- mutation
- immunity
- lang:en
- vaccine efficacy
- is:news
- immune response
- previous infection
- variant
- vaccine
- immunology
- COVID-19
- Omicron
- protection
Annotators
URL
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twitter.com twitter.comTwitter1
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Kristian G. Andersen on Twitter. (n.d.). Twitter. Retrieved 3 December 2021, from https://twitter.com/K_G_Andersen/status/1465822536629821442
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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COVID-19 vaccine surveillance report—Week 47. (n.d.). 46.
Tags
- protection
- data
- lang:en
- delta
- vaccine efficacy
- is:report
- immune response
- approval
- safety profile
- research
- UKHSA
- COVID-19
- UK
- vaccine
- clinical trials
Annotators
URL
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www.thelancet.com www.thelancet.com
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Thiruvengadam, R., Awasthi, A., Medigeshi, G., Bhattacharya, S., Mani, S., Sivasubbu, S., Shrivastava, T., Samal, S., Rathna Murugesan, D., Koundinya Desiraju, B., Kshetrapal, P., Pandey, R., Scaria, V., Kumar Malik, P., Taneja, J., Binayke, A., Vohra, T., Zaheer, A., Rathore, D., … Garg, P. K. (2021). Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses. The Lancet Infectious Diseases, S1473309921006800. https://doi.org/10.1016/S1473-3099(21)00680-0
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- Nov 2021
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www.thelancet.com www.thelancet.com
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Wheatley, A. K., & Juno, J. A. (2021). COVID-19 vaccines in the age of the delta variant. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00688-5
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www.thelancet.com www.thelancet.com
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Thiruvengadam, R., Awasthi, A., Medigeshi, G., Bhattacharya, S., Mani, S., Sivasubbu, S., Shrivastava, T., Samal, S., Murugesan, D. R., Desiraju, B. K., Kshetrapal, P., Pandey, R., Scaria, V., Malik, P. K., Taneja, J., Binayke, A., Vohra, T., Zaheer, A., Rathore, D., … Garg, P. K. (2021). Effectiveness of ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 infection during the delta (B.1.617.2) variant surge in India: A test-negative, case-control study and a mechanistic study of post-vaccination immune responses. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(21)00680-0
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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SARS-CoV-2 variants of concern and variants under investigation. (2021). 45.
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jamanetwork.com jamanetwork.com
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It remains unclear whether the reduction in the neutralization sensitivity of the N501Y.V2 strain to vaccine-induced antibodies is enough to seriously reduce vaccine efficacy. First, mRNA vaccines also induce virus-specific helper T cells and cytotoxic T cells, both of which might be involved in protection against challenge. Also, the mRNA vaccines, in particular, induce such a strong NAb response that there could be enough “spare capacity” to deal with reductions in the sensitivity of the variant to NAbs. In other words, N501Y.V2 (and the related virus from Brazil) may be less sensitive to NAbs, but not to an extent that will cause widespread vaccine failure.
Variants that show reduced sensitivity to NAbs don't necessarily mean mRNA vaccine failure
New variants may emerge that show reduced sensitivity to NAbs.
This may not result in vaccine failure because:
- The mRNA vaccines induce such a strong NAb response, there will be enough spare capacity to deal with the virus.
- The mRNA vaccines also induce other virus specific protection such as helper T cells and cytotoxic T cells, which may not be affected by the reduction in NAb sensitivity.
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www.nature.com www.nature.com
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Reardon, S. (2021). Cuba’s bet on home-grown COVID vaccines is paying off. Nature. https://doi.org/10.1038/d41586-021-03470-x
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Gallagher, J. (2021, November 14). Covid vaccine ‘waning immunity’: How worried should I be? BBC News. https://www.bbc.com/news/health-59260294
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Scott, Jake, Aaron Richterman, and Muge Cevik. ‘Covid-19 Vaccination: Evidence of Waning Immunity Is Overstated’. BMJ 374 (23 September 2021): n2320. https://doi.org/10.1136/bmj.n2320.
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twitter.com twitter.com
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The Lancet Haematology. (2021, November 12). NEW Viewpoint by @Erik_Klok_MD, @MPaiMD, Menno Huisman & @ProfMakris discussing the epidemiology, pathophysiology, and optimal diagnostic and therapeutic management of vaccine-induced immune thrombotic thrombocytopenia #VITT #COVID19Vaccine https://thelancet.com/journals/lanhae/article/PIIS2352-3026(21)00306-9/fulltext https://t.co/9PbjaioA2T [Tweet]. @TheLancetHaem. https://twitter.com/TheLancetHaem/status/1459072729332826123
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www.medrxiv.org www.medrxiv.org
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Collier, A. Y., Brown, C. M., Mcmahan, K., Yu, J., Liu, J., Jacob-Dolan, C., Chandrashekar, A., Tierney, D., Ansel, J. L., Rowe, M., Sellers, D., Ahmad, K., Aguayo, R., Anioke, T., Gardner, S., Siamatu, M., Rivera, L. B., Hacker, M. R., Madoff, L. C., & Barouch, D. H. (2021). Immune Responses in Fully Vaccinated Individuals Following Breakthrough Infection with the SARS-CoV-2 Delta Variant in Provincetown, Massachusetts (p. 2021.10.18.21265113). https://doi.org/10.1101/2021.10.18.21265113
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- Oct 2021
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www.statnews.com www.statnews.com
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3 takeaways from the emergence of the ‘Delta Plus’ coronavirus variant. (2021, October 27). STAT. https://www.statnews.com/2021/10/27/3-takeaways-from-the-emergence-of-the-delta-plus-coronavirus-variant/
Tags
- emergence
- lang:en
- transmissibility
- takeaway
- immune system
- Delta variant
- variant
- is:article
- transmission
- question
- AY.4.2.
- COVID-19
- evolution
- virus
Annotators
URL
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www.nature.com www.nature.com
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Sun, W., Liu, Y., Amanat, F., González-Domínguez, I., McCroskery, S., Slamanig, S., Coughlan, L., Rosado, V., Lemus, N., Jangra, S., Rathnasinghe, R., Schotsaert, M., Martinez, J. L., Sano, K., Mena, I., Innis, B. L., Wirachwong, P., Thai, D. H., Oliveira, R. D. N., … Palese, P. (2021). A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses. Nature Communications, 12(1), 6197. https://doi.org/10.1038/s41467-021-26499-y
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www.nature.com www.nature.com
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Pozzetto, B., Legros, V., Djebali, S., Barateau, V., Guibert, N., Villard, M., Peyrot, L., Allatif, O., Fassier, J.-B., Massardier-Pilonchéry, A., Brengel-Pesce, K., Yaugel-Novoa, M., Denolly, S., Boson, B., Bourlet, T., Bal, A., Valette, M., Andrieu, T., Lina, B., … Trouillet-Assant, S. (2021). Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination. Nature, 1–9. https://doi.org/10.1038/s41586-021-04120-y
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journalistsresource.org journalistsresource.org
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Covering COVID-19 vaccine boosters: 4 tips and a timeline. (n.d.). Retrieved October 25, 2021, from https://journalistsresource.org/home/covid-19-boosters-tip-sheet/
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www.theguardian.com www.theguardian.com
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Davis, N. (2021, October 18). Valneva Covid vaccine could be as effective as Oxford jab, study suggests. The Guardian. https://www.theguardian.com/society/2021/oct/18/valneva-covid-vaccine-could-be-as-effective-as-oxford-jab-study-suggests
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www.news-medical.net www.news-medical.net
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Thomas, L. (2021, October 14). SARS-CoV-2 induces tissue immune memory. News-Medical.Net. https://www.news-medical.net/news/20211014/SARS-CoV-2-induces-tissue-immune-memory.aspx
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twitter.com twitter.com
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ReconfigBehSci. (2021, July 6). RT @mvankerkhove: I’m struggling with how best to stress how fragile the global situation is, so I’ll be blunt: Each week >2.6 million cas… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1412416348676820992
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www.immunology.org www.immunology.org
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COVID-19 immunity: Natural infection compared to vaccination | British Society for Immunology. (n.d.). Retrieved October 10, 2021, from https://www.immunology.org/coronavirus/connect-coronavirus-public-engagement-resources/covid-immunity-natural-infection-vaccine
Tags
- infographic
- immunity
- lang:en
- immune response
- is:webpage
- immunology
- variant
- natural infection
- COVID-19
- UK
- vaccine
- protection
Annotators
URL
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www.ema.europa.eu www.ema.europa.eu
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Comirnaty and Spikevax: EMA recommendations on extra doses and boosters | European Medicines Agency. (n.d.). Retrieved October 8, 2021, from https://www.ema.europa.eu/en/news/comirnaty-spikevax-ema-recommendations-extra-doses-boosters
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www.sciencedirect.com www.sciencedirect.com
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Karlsson, L. C., Soveri, A., Lewandowsky, S., Karlsson, L., Karlsson, H., Nolvi, S., Karukivi, M., Lindfelt, M., & Antfolk, J. (2022). The behavioral immune system and vaccination intentions during the coronavirus pandemic. Personality and Individual Differences, 185, 111295. https://doi.org/10.1016/j.paid.2021.111295
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twitter.com twitter.com
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Pablo Tsukayama on Twitter. (n.d.). Twitter. Retrieved 4 October 2021, from https://twitter.com/pablotsukayama/status/1435725621599027202
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