202 Matching Annotations
  1. Last 7 days
  2. Sep 2021
    1. Lee, J. W., Su, Y., Baloni, P., Chen, D., Pavlovitch-Bedzyk, A. J., Yuan, D., Duvvuri, V. R., Ng, R. H., Choi, J., Xie, J., Zhang, R., Murray, K., Kornilov, S., Smith, B., Magis, A. T., Hoon, D. S. B., Hadlock, J. J., Goldman, J. D., Price, N. D., … Heath, J. R. (2021). Integrated analysis of plasma and single immune cells uncovers metabolic changes in individuals with COVID-19. Nature Biotechnology, 1–11. https://doi.org/10.1038/s41587-021-01020-4

    1. Each cubic cell has 8 atoms in each corner of the cube, and that atom is shared with 8 neighboring cells. In the Body Centered Cubic Cell (BCC) there is an additional atom in the center of the cube, and in the face centered cubic cell, an atom is shared between two unit cells along the face.
    2. Figure12.1.112.1.1\PageIndex{1}: The 7 types of unit cells. In this class we will only look at cubic systems, and will identify 3 types of cubic unit cells (figure. 12.b)
    3. αα\large\alpha = angle in the yz plane ββ\large\beta = angle in the xz plane γγ\large\gamma = angle in the xy plane
    1. John Burn-Murdoch. (2021, August 23). NEW: in the last couple of weeks there have a lot of new studies out assessing vaccine efficacy, many of which have touched on the question of waning immunity. Unsurprisingly, these have prompted a lot of questions. Time for a thread to summarise what we do and don’t know: [Tweet]. @jburnmurdoch. https://twitter.com/jburnmurdoch/status/1429878189011111936

  3. Aug 2021
    1. however, it also led to some level of cell membrane damage

      the merged peptide led to some level of cell membrane damage

    2. Conjugation of our cyclic peptide at the C-terminal with cell penetrating peptide like TAT enabled cell penetrating

      cell penetrating peptide TAT conjugated with a peptide binder

  4. Jul 2021
    1. Keerthivasan, S., Şenbabaoğlu, Y., Martinez-Martin, N., Husain, B., Verschueren, E., Wong, A., Yang, Y. A., Sun, Y., Pham, V., Hinkle, T., Oei, Y., Madireddi, S., Corpuz, R., Tam, L., Carlisle, S., Roose-Girma, M., Modrusan, Z., Ye, Z., Koerber, J. T., & Turley, S. J. (2021). Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1. Immunity, 54(7), 1511-1526.e8. https://doi.org/10.1016/j.immuni.2021.06.012

  5. Jun 2021
    1. Parry, H. M., Tut, G., Faustini, S., Stephens, C., Saunders, P., Bentley, C., Hilyard, K., Brown, K., Amirthalingam, G., Charlton, S., Leung, S., Chiplin, E., Coombes, N. S., Bewley, K. R., Penn, E. J., Rowe, C., Otter, A., Watts, R., D’Arcangelo, S., … Moss, P. (2021). BNT162b2 Vaccination in People Over 80 Years of Age Induces Strong Humoral Immune Responses with Cross Neutralisation of P.1 Brazilian Variant. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3816840

  6. May 2021
  7. Apr 2021
    1. Trevor Bedford. (2021, January 14). After ~10 months of relative quiescence we’ve started to see some striking evolution of SARS-CoV-2 with a repeated evolutionary pattern in the SARS-CoV-2 variants of concern emerging from the UK, South Africa and Brazil. 1/19 [Tweet]. @trvrb. https://twitter.com/trvrb/status/1349774271095062528

  8. Feb 2021
  9. Nov 2020
    1. gametes

      These are an organisms reproductive cells which are commonly called sex cells. There are female gametes which are ova or egg cells and the male gametes which are called sperm. Gametes are haploid cells that carry only one copy for each chromosome.

  10. Oct 2020
    1. Passive transport

      The process of moving ions and other atomic/molecular substances across the cell membranes without the need of an input of energy. Instead, it relies on the system to grow during entropy.

    1. micro9laments

      Microfilaments are also known as actin filaments; which, are protein filaments that are within the cytoplasm that form part of the cytoskeleton of an Eukaryotic Cell. They help in the process of cell movement via the actin working with another protein myosin that create muscle movements, cytoplasmic streaming, and cell division.

    1. messenger RNA (mRNA)

      This is a single strand on an RNA molecule that leaves the the nucleus of a cell in order to relocate to the cytoplasm. This is where the mRNA can help create the protein for the cell in a process known as protein synthesis. The mRNA takes in information passed into it by DNA and decode it for the ribosomes to make more protein for the cell to live on.

  11. Sep 2020
    1. Le Bert, N., Tan, A. T., Kunasegaran, K., Tham, C. Y. L., Hafezi, M., Chia, A., Chng, M. H. Y., Lin, M., Tan, N., Linster, M., Chia, W. N., Chen, M. I.-C., Wang, L.-F., Ooi, E. E., Kalimuddin, S., Tambyah, P. A., Low, J. G.-H., Tan, Y.-J., & Bertoletti, A. (2020). SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature, 584(7821), 457–462. https://doi.org/10.1038/s41586-020-2550-z

  12. Aug 2020
    1. Mateus, J., Grifoni, A., Tarke, A., Sidney, J., Ramirez, S. I., Dan, J. M., Burger, Z. C., Rawlings, S. A., Smith, D. M., Phillips, E., Mallal, S., Lammers, M., Rubiro, P., Quiambao, L., Sutherland, A., Yu, E. D., Antunes, R. da S., Greenbaum, J., Frazier, A., … Weiskopf, D. (2020). Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. https://doi.org/10.1126/science.abd3871

    1. Ferretti, A. P., Kula, T., Wang, Y., Nguyen, D. M., Weinheimer, A., Dunlap, G. S., Xu, Q., Nabilsi, N., Perullo, C. R., Cristofaro, A. W., Whitton, H. J., Virbasius, A., Olivier, K. J., Baiamonte, L. B., Alistar, A. T., Whitman, E. D., Bertino, S. A., Chattopadhyay, S., & MacBeath, G. (2020). COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2. MedRxiv, 2020.07.24.20161653. https://doi.org/10.1101/2020.07.24.20161653

    1. Unterman, A., Sumida, T. S., Nouri, N., Yan, X., Zhao, A. Y., Gasque, V., Schupp, J. C., Asashima, H., Liu, Y., Cosme, C., Deng, W., Chen, M., Raredon, M. S. B., Hoehn, K., Wang, G., Wang, Z., Deiuliis, G., Ravindra, N. G., Li, N., … Cruz, C. S. D. (2020). Single-Cell Omics Reveals Dyssynchrony of the Innate and Adaptive Immune System in Progressive COVID-19. MedRxiv, 2020.07.16.20153437. https://doi.org/10.1101/2020.07.16.20153437

  13. Jul 2020
  14. Jun 2020
    1. Governments’ use of purchased location data has exploded in recent months, as officials around the world have sought insights on how people are moving around during the Covid-19 pandemic. In general, governments have assured their citizens that any location data collected by the marketing industry and used by public health entities is anonymous. But the movements of a phone give strong clues to its ownership—for example, where the phone is located during the evenings and overnight is likely where the phone owner lives. The identity of the phone’s owner can further be corroborated if their workplace, place of worship, therapist’s office or other information about their real-world activities are known to investigators.

      private data is not anonymous as is purported