191 Matching Annotations
  1. Mar 2023
  2. www.biorxiv.org www.biorxiv.org
    An extended DNA-free intranuclear compartment organizes centrosomal microtubules in Plasmodium falciparum
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.03.12.435157v2
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    Lack of peroxisomal catalase affects heat shock response in C. elegans
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.07.13.452156v1
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    Reconstitution of centrosome positioning by the production of pushing forces in microtubules growing against the actin network.
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.01.21.476947v1
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    Mild impairment of mitochondrial function increases longevity and pathogen resistance through ATFS-1-driven activation of p38-regulated innate immunity
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2021.03.31.437812v1
  6. www.biorxiv.org www.biorxiv.org
    Rabaptin5 targets autophagy to damaged early endosomes and Salmonella containing vacuoles by interaction with FIP200 and ATG16L1
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2020.09.01.277764v2
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    The spindle orienting machinery requires activation, not just localization
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.06.29.498167v1
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    Multinucleation resets human macrophages for specialized functions at the expense of mononuclear phagocyte identity
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    1. EMBOpress 15 Mar 2023

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    biorxiv.org/content/10.1101/2022.08.22.504763v1
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    Segregation of pathways leading to pexophagy
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    1. EMBOpress 09 Mar 2023

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    biorxiv.org/content/10.1101/2022.11.08.515582v1
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    The Proxitome of Arabidopsis Processing Bodies Reveals a Condensate-Membrane Interface Instructing Actin-Driven Directional Growth
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    1. EMBOpress 03 Mar 2023

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    biorxiv.org/content/10.1101/2022.06.03.494746v1
  11. Feb 2023
  12. www.biorxiv.org www.biorxiv.org
    Adenylyl cyclase 9 is auto-stimulated by its isoform-specific carboxyl terminal domain and equipped with paradigm-switching mechanisms.
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    1. EMBOpress 28 Feb 2023

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    biorxiv.org/content/10.1101/2022.06.05.494885v3
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    Transcription factor FOXM1 specifies the loading of chromatin DNA to extracellular vesicles
    1
    1. lifescienceeditors 27 Feb 2023

      Review coordinated by Life Science Editors

      Reviewed by: Dr. Helen Pickersgill, Life Science Editors

      Potential Conflicts of Interest: None

      Impact Point: Transcription factors may mediate the release of specific genes in extracellular vesicles that could be taken up by other cells and directly influence their behaviour.

      Background: Extracellular vesicles (EVs) are nanoscale, membrane-bound vesicles containing proteins, nucleic acids and lipids that are released by most cell types. Originally thought of as a cell waste disposal mechanism, they have since been rebranded as a means of intercellular communication, both short and long range, (like a cellular postal service), and can, for example, modify gene expression and function in recipient cells via the transfer of specific RNAs (DOI: 10.1038/s41580-020-0251-y). One interesting function for EVs was the recent discovery that antigen presenting cells (APCs) could donate telomeres via EVs to recipient T cells and rescue them from senescence (DOI: 10.1038/s41556-022-00991-z).

      Given EVs contain a wide variety of cargos derived from the secreting cells, which have been extensively profiled (e.g., DOI: 10.1016/j.cell.2020.07.009) they are particularly interesting as sources of biomarkers for diagnosing diseases such as cancer (e.g., DOI: 10.1038/s12276-019-0219-1). We might also be able to use them as stable delivery mechanisms for controlling cell behaviour or targeting therapeutics/diagnostics.

      We know quite a bit about how RNAs and proteins are selected for secretion by EVs (mediated by the autophagy protein LC3: e.g., DOIs: 10.1080/15548627.2020.1756557; 10.1038/s41556-019-0450-y). But little is known about DNA. DNA presents a particular challenge as it is packed up into the nucleus. This is also particularly important to understand in the context of horizontal gene transfer, i.e., passing functional genes between cells.

      Main question: How does a cell ‘select’ specific DNA cargo from the nucleus and enable it to be released by EVs?

      The advance: They discover that a transcription factor (FOXM1) plays a central role in mediating DNA release in EVs.

      Results: • FOXM1 and LC3 (autophagy protein) colocalize and interact in cultured cells (coIP endogenous and exogenous, EMSA, immunostaining and identify an FOXM1-binding domain mutant). • FOXM1, LC3 and DNA colocalise in the cytoplasm in cultured cells, which increases upon starvation-induced autophagy (immunofluorescence). • FOXM1 and LC3 are found in EVs released from cultured cells (Western blot). • 15,544 DNA identified in EVs released from cultured cells (evDNA sequencing), of which 25 overlapped with DNA loci binding FOXM1 (ChIP). • FOXM1-bound nuclear DNA is transported to the cytoplasm upon induction of autophagy and is released in EVs in cultured cells (knock-in tagged chromatin with CRISPR-cas9, IF and PCR). This is dependent on FOXM1 (knock-out in cultured cells).

      Significance: Transcription factors display strong DNA binding specificity and so are ideal candidates for directing specific genes into EVs for potential transfer to recipient cells.

      Remaining questions/points: Care needs to be taken with regard to purification of EVs. Are the FOXM1-DNAs in the EVs functional in recipient cells? Is the DNA being actively ‘selected’ for an intercellular signalling purpose or is this just random degradation? Is it all FOXM1 bound DNA that has the potential to be trafficked to EVs or just a subset? Do other transcription factors have the same function or is it specific to this protein/family? Does this mechanism occur in other contexts (e.g., in vivo, under disease conditions).

      extracellular vesicles cell biology transcription factors
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    biorxiv.org/content/10.1101/2022.01.27.477315v3
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    Lung macrophages utilize cathepsin K-dependent phagosomal machinery to degrade intracellular collagen
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    1. EMBOpress 15 Feb 2023

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    biorxiv.org/content/10.1101/2022.05.16.492085v1
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    The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex
    1
    1. EMBOpress 15 Feb 2023

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    biorxiv.org/content/10.1101/2021.09.20.461067v1
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    Retromer oligomerization drives SNX-BAR coat assembly and membrane constriction
    1
    1. EMBOpress 15 Feb 2023

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    biorxiv.org/content/10.1101/2022.07.27.501715v1
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    Ciliary tip actin dynamics regulate the cadence of photoreceptor disc formation
    1
    1. lifescienceeditors 09 Feb 2023

      Review coordinated by Life Science Editors.

      Reviewed by: Dr. Angela Andersen, Life Science Editors

      Potential Conflicts of Interest: Dr. Mill has worked with Life Science Editors on other manuscripts.

      Background: Retinitis pigmentosa (RP) is a group of rare eye diseases that cause vision loss. Symptoms usually start in childhood, and most people eventually lose most of their sight. There is no cure for RP. Mutations in retinitis pigmentosa GTPase regulator (RPGR) cause RP and compromise the renewal of light-sensitive “disc” membranes (specialized cilia) at the outer segment of photoreceptors, resulting in the loss of these cells over time. Evidence suggests that disc formation is similar to the release of ectosomes (small extracellular vesicles) and that both rely on the actin cytoskeleton. Knockdown of RPGR in retinal pigmented epithelium cells showed stronger actin filaments and reduced cilia suggesting that it may regulate nascent photoreceptor disc formation by regulating actin-mediated membrane extension in the retina (Gakovic et al., Human Molecular Genetics, 2011). In addition, RPGR patient iPSC-retinal models displayed phenotypes consistent with abnormal actin regulation (Megaw et al., Nature Communications, 2017; Karam et al., J Personalized Medicine, 2022).

      Question: What function of RPGR is compromised in photoreceptors to cause RP?

      Advance: The authors generated novel Rpgr mutant mice harboring human disease-causing mutations that recapitulate human disease phenotypes: aborted membrane shedding as ectosome-like vesicles, photoreceptor death and visual loss. RPGR is located at the site of disc formation – to test if it plays a role in disc genesis, they engineered a novel reporter mouse to track outer segment turnover. Rhodopsin was tagged with the self-labelling peptide SNAP- Rhodopsin is the major protein component of outer segment discs, and so incubating RhodSNAP retinal slice cultures with SNAP fluorophores results in outer segment labelling. Perturbation of RPGR resulted in a slowed rate of disc formation, leading to shortened outer segments and increased vesicle shedding. To me, the breakthrough is in the last figure: the actin depolymerizing drug Cytochalasin D in PBS was injected intravitreally, and fixed retinas were analyzed 6 hours later by electron microscopy. Cytochalasin D treatment significantly reduced the number of shed vesicles from the base of the outer segment in Rpgr-mutant mice (they now look like wild-type).

      Significance: Nails down the disease-relevant function of RPGR and a molecular mechanism of RP in photoreceptor cells, in vivo, in mice. Pharmacological rescue not only demonstrates the importance of the mechanism to disease but also sheds light on a potential therapeutic avenue for RP.

      cell biology disease mechanism
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    biorxiv.org/content/10.1101/2022.11.10.516020v1
  18. Jan 2023
  19. www.biorxiv.org www.biorxiv.org
    SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.
    1
    1. EMBOpress 27 Jan 2023

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    biorxiv.org/content/10.1101/2022.02.13.480288v1
  20. www.biorxiv.org www.biorxiv.org
    Plasma membrane topography governs the three-dimensional dynamic localization of IgM B cell receptor clusters
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    1. EMBOpress 27 Jan 2023

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    biorxiv.org/content/10.1101/2022.04.29.489661v1
  21. www.biorxiv.org www.biorxiv.org
    CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium
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    1. EMBOpress 24 Jan 2023

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    biorxiv.org/content/10.1101/2022.01.28.478171v1
  22. www.biorxiv.org www.biorxiv.org
    Nuclear envelope reshaping around the vacuole determines the morphology of the ribosomal DNA
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    1. EMBOpress 18 Jan 2023

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    biorxiv.org/content/10.1101/2021.06.23.449658v1
  23. Dec 2022
  24. www.biorxiv.org www.biorxiv.org
    Endoplasmic Reticulum membranes are continuously required to maintain mitotic spindle size and forces
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    1. EMBOpress 16 Dec 2022

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    biorxiv.org/content/10.1101/2022.05.14.491942v1
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    When Yeast Cells Change their Mind: Cell Cycle 'Start' is Reversible under Starvation
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    1. EMBOpress 16 Dec 2022

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    biorxiv.org/content/10.1101/2021.10.31.466668v1
  26. Nov 2022
  27. www.biorxiv.org www.biorxiv.org
    The AAA-ATPase Atad1 and its partners promote degradation of desmin intermediate filaments in muscle
    1
    1. EMBOpress 24 Nov 2022

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    biorxiv.org/content/10.1101/2022.01.24.477493v2
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    Live-cell chromosome dynamics in Arabidopsis thaliana reveals increased chromatin mobility in response to DNA damage
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    1. EMBOpress 24 Nov 2022

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    biorxiv.org/content/10.1101/2021.11.03.466744v2
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    Miro GTPase domains regulate assembly of the mitochondrial motor-adaptor complex
    1
    1. EMBOpress 23 Nov 2022

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    biorxiv.org/content/10.1101/2022.05.13.491728v1
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    An ERAD-independent role for rhomboid pseudoprotease Dfm1 in mediating sphingolipid homeostasis
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2022.07.30.502165v1
  31. www.biorxiv.org www.biorxiv.org
    Parkin drives pS65-Ub turnover independently of canonical autophagy in Drosophila
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    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.06.10.447841v2
  32. www.biorxiv.org www.biorxiv.org
    Parkin coordinates mitochondrial lipid remodeling to execute mitophagy
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    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2020.02.28.970210v1
  33. www.biorxiv.org www.biorxiv.org
    Endothelial-immune crosstalk contributes to vasculopathy in non-alcoholic fatty liver disease
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    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.12.13.472411v1
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    The molecular architecture of cell cycle arrest
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    1. EMBOpress 21 Nov 2022

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      PeerReviewed EMBOPress Molecular Systems Biology cell biology
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    biorxiv.org/content/10.1101/2022.04.27.489684v1
  35. www.biorxiv.org www.biorxiv.org
    Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions
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    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.12.08.471723v2
  36. www.biorxiv.org www.biorxiv.org
    Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium
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    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2022.04.08.487404v1
  37. www.biorxiv.org www.biorxiv.org
    CRYPTOCHROME suppresses the circadian proteome and promotes protein homeostasis
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    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2020.05.16.099556v3
  38. www.biorxiv.org www.biorxiv.org
    Zika virus alters centrosome organization to suppress the innate immune response
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2020.09.15.298083v1
  39. www.biorxiv.org www.biorxiv.org
    Naked mole-rat hematopoietic stem and progenitors are highly quiescent with an inherent myeloid bias
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.08.01.454652v1
  40. www.biorxiv.org www.biorxiv.org
    Basal Neural Stem Cells in the Subventricular Zone Drive Postnatal Neurogenesis with Apical Stem Cells Acting as Proliferation Gatekeepers
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2020.11.20.391102v4
  41. www.biorxiv.org www.biorxiv.org
    Mitotic checkpoint gene expression is tuned by coding sequences
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.04.30.442180v2
  42. www.biorxiv.org www.biorxiv.org
    Lifespan can be extended during a specific time window early in life
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2022.02.18.480980v1
  43. www.biorxiv.org www.biorxiv.org
    Nuclear Pore Complex Acetylation Regulates mRNA Export and Cell Cycle Commitment in Budding Yeast
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.09.01.458533v3
  44. www.biorxiv.org www.biorxiv.org
    Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.07.08.451586v1
  45. www.biorxiv.org www.biorxiv.org
    Precise control of microtubule disassembly in living cells
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.10.08.463668v1
  46. www.biorxiv.org www.biorxiv.org
    Growth-dependent heterogeneity in the DNA damage response in Escherichia coli
    1
    1. EMBOpress 21 Nov 2022

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    biorxiv.org/content/10.1101/2021.05.06.442821v2
  47. Oct 2022
  48. www.biorxiv.org www.biorxiv.org
    Gain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions
    1
    1. EMBOpress 08 Oct 2022

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    biorxiv.org/content/10.1101/2022.04.03.486870v1
  49. Sep 2022
  50. www.biorxiv.org www.biorxiv.org
    Meiotic DNA breaks activate a streamlined phospho-signaling response that largely avoids protein level changes
    1
    1. EMBOpress 27 Sep 2022

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    biorxiv.org/content/10.1101/2022.02.24.481857v1
  51. Aug 2022
  52. www.biorxiv.org www.biorxiv.org
    Decreasing pdzd8-mediated mitochondrial-ER contacts in neurons improves fitness by increasing mitophagy
    1
    1. EMBOpress 31 Aug 2022

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    biorxiv.org/content/10.1101/2020.11.14.382861v1
  53. www.biorxiv.org www.biorxiv.org
    CFTR modulator response measurements in subjects with cystic fibrosis using 2D differentiated nasal epithelia converted into spheroids
    1
    1. EMBOpress 18 Aug 2022

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    biorxiv.org/content/10.1101/2021.07.20.453105v2
  54. www.biorxiv.org www.biorxiv.org
    ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1
    1
    1. EMBOpress 02 Aug 2022

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    biorxiv.org/content/10.1101/2021.12.22.473898v2
  55. Jun 2022
  56. www.biorxiv.org www.biorxiv.org
    Negative curvature-promoting lipids instruct nuclear ingression of low autophagic potential vacuoles
    1
    1. EMBOpress 13 Jun 2022

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    biorxiv.org/content/10.1101/2021.06.26.450031v1
  57. www.biorxiv.org www.biorxiv.org
    Map7D2 and Map7D1 facilitate microtubule stabilization through distinct mechanisms to control cell motility and neurite outgrowth.
    1
    1. EMBOpress 01 Jun 2022

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    biorxiv.org/content/10.1101/2021.10.27.466197v3
  58. May 2022
  59. www.biorxiv.org www.biorxiv.org
    Centrioles generate a local pulse of Polo/PLK1 activity to initiate mitotic centrosome assembly
    1
    1. EMBOpress 27 May 2022

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    biorxiv.org/content/10.1101/2021.10.26.465695v2
  60. www.biorxiv.org www.biorxiv.org
    CROP: A Retromer-PROPPIN complex mediating membrane fission in the endo-lysosomal system
    1
    1. EMBOpress 04 May 2022

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    biorxiv.org/content/10.1101/2021.09.06.459059v1
  61. Apr 2022
  62. www.biorxiv.org www.biorxiv.org
    Tricalbin proteins regulate plasma membrane phospholipid homeostasis
    1
    1. EMBOpress 30 Apr 2022

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    biorxiv.org/content/10.1101/2021.06.04.447076v1
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    A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters
    1
    1. EMBOpress 30 Apr 2022

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    biorxiv.org/content/10.1101/2021.09.02.458684v1
  64. www.biorxiv.org www.biorxiv.org
    A genetic program boosts mitochondrial function to power macrophage tissue invasion
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    biorxiv.org/content/10.1101/2021.02.18.431643v1
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    Quantitative analysis of nuclear pore complex organization in Schizosaccharomyces pombe
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    1. EMBOpress 23 Apr 2022

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    biorxiv.org/content/10.1101/2021.08.11.455278v1
  66. Mar 2022
  67. www.biorxiv.org www.biorxiv.org
    AGO1 regulates major satellite transcripts and H3K9me3 distribution at pericentromeric regions in mESCs
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    biorxiv.org/content/10.1101/2021.07.26.453733v2
  68. www.biorxiv.org www.biorxiv.org
    Autophagy suppression by TORC1 maintains epithelial plasma membrane integrity and inhibits syncytium formation
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    1. EMBOpress 23 Mar 2022

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    biorxiv.org/content/10.1101/2021.08.05.455228v1
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    Specialization of actin isoforms derived from the loss of key interactions with regulatory factors
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    1. EMBOpress 22 Mar 2022

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    biorxiv.org/content/10.1101/2021.02.09.430555v1
  70. www.biorxiv.org www.biorxiv.org
    ETV2 regulates PARP-1 binding protein to induce ER stress-mediated cell death in tuberin-deficient cells
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    1. EMBOpress 19 Mar 2022

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    biorxiv.org/content/10.1101/2021.11.08.467714v1
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    Quantitative Profiling of Adaptation to Cyclin E Overproduction
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    biorxiv.org/content/10.1101/2021.07.26.453751v3
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    B1-type cyclins control microtubule organization during cell division in Arabidopsis
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    biorxiv.org/content/10.1101/2021.06.29.450310v1
  73. www.biorxiv.org www.biorxiv.org
    Rewiring phospholipid biosynthesis reveals robustness in membrane homeostasis and uncovers lipid regulatory players.
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    biorxiv.org/content/10.1101/2021.07.20.453065v1
  74. www.biorxiv.org www.biorxiv.org
    Redundant and specific roles of EGFR ligands in the ERK activation waves during collective cell migration of MDCK cells
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    1. EMBOpress 10 Mar 2022

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    biorxiv.org/content/10.1101/2021.05.25.445569v1
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    The nucleoporin Nup50 activates the Ran guanyl-nucleotide exchange factor RCC1 to promote mitotic NPC assembly
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    1. EMBOpress 10 Mar 2022

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    biorxiv.org/content/10.1101/2021.03.31.437874v1
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    Balancing the length of distal tip is key for stability and signalling function of primary cilia
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    1. EMBOpress 09 Mar 2022

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    biorxiv.org/content/10.1101/2021.06.04.447095v1
  77. www.biorxiv.org www.biorxiv.org
    Recruitment of Scc2/4 to double strand breaks depends on &#x03B3;H2A and DNA end resection
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    biorxiv.org/content/10.1101/2021.07.09.451733v1
  78. Feb 2022
  79. www.biorxiv.org www.biorxiv.org
    EMC is required for biogenesis and membrane insertion of Xport-A, an essential chaperone of rhodopsin-1 and the TRP channel
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    1. EMBOpress 19 Feb 2022

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    biorxiv.org/content/10.1101/2021.02.01.429115v1
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    Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sorting
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    biorxiv.org/content/10.1101/2021.08.20.457087v1
  81. Jan 2022
  82. www.biorxiv.org www.biorxiv.org
    The SUMO Protease SENP3 Regulates Mitochondrial Autophagy Mediated by Fis1
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    1. EMBOpress 21 Jan 2022

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    biorxiv.org/content/10.1101/685834v1
  83. www.biorxiv.org www.biorxiv.org
    Electron Cryo-Tomography Structure of Axonemal Doublet Microtubule from Tetrahymena thermophila
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    biorxiv.org/content/10.1101/2021.07.13.452106v1
  84. www.biorxiv.org www.biorxiv.org
    Myosin VI regulates ciliogenesis by promoting the turnover of the centrosomal/satellite protein OFD1
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    biorxiv.org/content/10.1101/2021.06.18.448975v1
  85. Dec 2021
  86. www.biorxiv.org www.biorxiv.org
    Remodeling and activation mechanisms of outer arm dynein revealed by cryo-electron microscopy
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    biorxiv.org/content/10.1101/2020.11.30.404319v2
  87. www.biorxiv.org www.biorxiv.org
    Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy.
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    biorxiv.org/content/10.1101/2021.04.28.441730v1
  88. www.biorxiv.org www.biorxiv.org
    https://biorxiv.org/cgi/content/10.1101/2021.06.09.447484
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    1. EMBOpress 15 Dec 2021

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    biorxiv.org/content/10.1101/2021.06.09.447484v1
  89. www.biorxiv.org www.biorxiv.org
    RANKL from Bone Marrow Adipocytes Regulates Osteoclast Formation and Bone Loss in Mice
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    biorxiv.org/content/10.1101/2020.09.12.294348v4
  90. www.biorxiv.org www.biorxiv.org
    Chromosome length and gene density contribute to micronuclear membrane stability
    1
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    biorxiv.org/content/10.1101/2021.05.12.443914v1
  91. Nov 2021
  92. www.biorxiv.org www.biorxiv.org
    Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline
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    biorxiv.org/lookup/doi/10.1101/2021.07.29.454392
  93. Oct 2021
  94. www.biorxiv.org www.biorxiv.org
    Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors
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    biorxiv.org/lookup/doi/10.1101/2020.06.26.174185
  95. www.biorxiv.org www.biorxiv.org
    Control of endoplasmic reticulum membrane biogenesis by regulators of lipid metabolism
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    1. EMBOpress 26 Oct 2021

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    biorxiv.org/lookup/doi/10.1101/2020.02.23.961722
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    A dynamical extracellular matrix coat regulates moruloid-blastuloid transitions of ovarian cancer spheroids
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    biorxiv.org/content/10.1101/2020.07.03.186155v1
  97. www.biorxiv.org www.biorxiv.org
    Histone lysine crotonylation regulates cell-fate determination of neural stem/progenitor cells by activating bivalent promoters
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    biorxiv.org/content/10.1101/2020.05.27.118596v1
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    The Torsin/ NEP1R1-CTDNEP1/ Lipin axis regulates nuclear envelope lipid metabolism for nuclear pore complex insertion
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    biorxiv.org/content/10.1101/2020.07.05.188599v1
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    The Neutrophil
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    1. forbriger 03 Oct 2021

      Burn, G. L., Foti, A., Marsman, G., Patel, D. F., & Zychlinsky, A. (2021). The Neutrophil. Immunity, 54(7), 1377–1391. https://doi.org/10.1016/j.immuni.2021.06.006

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    cell.com/immunity/fulltext/S1074-7613(21)00250-8
  100. Sep 2021
  101. www.biorxiv.org www.biorxiv.org
    Host autophagy mediates organ wasting and nutrient mobilization for tumor growth
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    biorxiv.org/content/10.1101/2020.12.04.411561v1
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    Reciprocal Priming between RTKs within Recycling Endosomes Orchestrates Cellular Signaling Outputs
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    biorxiv.org/content/10.1101/2021.01.04.425243v2
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    A novel IKK- and proteasome-independent mechanism of RelA activation triggers senescence associated secretome via transcriptional repression of NFKBIA
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    biorxiv.org/content/10.1101/2019.12.19.882225v1
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    Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression.
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    biorxiv.org/content/10.1101/2020.09.15.297671v1
  105. Jul 2021
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    A polycomb-independent role of EZH2 in TGFβ1-damaged epithelium triggers a fibrotic cascade with mesenchymal cells
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    biorxiv.org/content/10.1101/2020.07.29.225300v1
  107. www.biorxiv.org www.biorxiv.org
    A highly conserved binding pocket on PP2A-B56 is required for shugoshin binding and cohesion protection
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    biorxiv.org/content/10.1101/2020.12.18.423432v1
  108. www.biorxiv.org www.biorxiv.org
    Aurora Kinase A proximity interactome reveals centriolar satellites as regulators of its function during primary cilium biogenesis
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    biorxiv.org/content/10.1101/2020.11.05.370320v1
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    A cryo-EM structure of metazoan TRAPPIII, the multisubunit complex that activates the GTPase Rab1
    1
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      PeerReviewed EMBOPress The EMBO Journal cell biology
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    biorxiv.org/content/10.1101/2020.12.17.423307v1
  110. www.biorxiv.org www.biorxiv.org
    Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress
    1
    1. EMBOpress 01 Jul 2021

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    biorxiv.org/content/10.1101/2020.07.15.203935v1
  111. Jun 2021
  112. www.biorxiv.org www.biorxiv.org
    Subepidermal blisters are healed by wedge-shaped keratinocytes of hair follicle origin
    1
    1. EMBOpress 08 Jun 2021

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    biorxiv.org/content/10.1101/2020.04.08.032326v2
  113. May 2021
  114. www.biorxiv.org www.biorxiv.org
    Gametic specialization of centromeric histone paralogs in Drosophila virilis
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    1. EMBOpress 19 May 2021

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    biorxiv.org/content/10.1101/530295v1
  115. www.biorxiv.org www.biorxiv.org
    CODEX, a neural network approach to explore signaling dynamics landscapes
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    1. EMBOpress 05 May 2021

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      PeerReviewed EMBOPress Molecular Systems Biology cell biology
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    biorxiv.org/lookup/doi/10.1101/2020.08.05.237842
  116. www.biorxiv.org www.biorxiv.org
    Carbonic anhydrase VII regulates dendritic spine morphology and density via actin filament bundling
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    1. EMBOpress 01 May 2021

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    biorxiv.org/content/10.1101/736868v1
  117. Apr 2021
  118. www.biorxiv.org www.biorxiv.org
    CDCP1 controls compensatory renal growth by integrating Src and Met signaling
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    1. EMBOpress 28 Apr 2021

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    biorxiv.org/content/10.1101/789339v2
  119. www.biorxiv.org www.biorxiv.org
    Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2
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    1. EMBOpress 24 Apr 2021

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    biorxiv.org/content/10.1101/2020.04.06.027896v2
  120. www.biorxiv.org www.biorxiv.org
    Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and -deficient cells
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    1. EMBOpress 24 Apr 2021

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    biorxiv.org/content/10.1101/2020.02.24.947168v1
  121. www.biorxiv.org www.biorxiv.org
    An ATM-MYBL2-CDC7 axis regulates replication initiation and prevents replication stress in pluripotent stem cells
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    1. EMBOpress 13 Apr 2021

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    biorxiv.org/content/10.1101/2020.06.04.131276v2
  122. www.biorxiv.org www.biorxiv.org
    Reflux of Endoplasmic Reticulum proteins to the cytosol yields inactivation of tumor suppressors
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    1. EMBOpress 07 Apr 2021

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    biorxiv.org/content/10.1101/2020.04.13.038935v1
  123. www.biorxiv.org www.biorxiv.org
    ALIX and ceramide differentially control polarized exosome release from epithelial cells
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    1. EMBOpress 06 Apr 2021

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    biorxiv.org/content/10.1101/2020.08.05.238931v1
  124. www.biorxiv.org www.biorxiv.org
    PTP-MEG2 regulates quantal size and fusion pore opening through two distinct structural bases and substrates
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    1. EMBOpress 05 Apr 2021

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    biorxiv.org/content/10.1101/822031v3
  125. www.biorxiv.org www.biorxiv.org
    RNA polymerase backtracking drives the accumulation of fission yeast condensin at active genes
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    1. EMBOpress 02 Apr 2021

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    biorxiv.org/content/10.1101/2020.11.13.381434v2
  126. www.biorxiv.org www.biorxiv.org
    LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade
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    1. EMBOpress 02 Apr 2021

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    biorxiv.org/content/10.1101/2020.04.28.065664v1
  127. www.biorxiv.org www.biorxiv.org
    Kinetochore individualization in meiosis I is required for centromeric cohesin removal in meiosis II
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    1. EMBOpress 02 Apr 2021

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    biorxiv.org/content/10.1101/2020.07.24.219873v1
  128. www.biorxiv.org www.biorxiv.org
    The multi-scale architecture of mammalian sperm flagella and implications for ciliary motility
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    1. EMBOpress 02 Apr 2021

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    biorxiv.org/content/10.1101/2020.11.18.388975v1
  129. www.biorxiv.org www.biorxiv.org
    Stable kinetochore-microtubule attachments restrict MTOC position and spindle elongation in acentrosomal oocytes
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    1. EMBOpress 02 Apr 2021

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    biorxiv.org/content/10.1101/2020.05.07.081786v1
  130. www.biorxiv.org www.biorxiv.org
    Self-assembly of multi-component mitochondrial nucleoids via phase separation
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    biorxiv.org/content/10.1101/822858v4
  131. Feb 2021
  132. www.biorxiv.org www.biorxiv.org
    Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate Plk1
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    1. EMBOpress 25 Feb 2021

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    biorxiv.org/content/10.1101/191437v2
  133. www.biorxiv.org www.biorxiv.org
    Htr6 and Sstr3 ciliary targeting relies on both IC3 loops and C-terminal tails
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    1. EMBOpress 25 Feb 2021

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    biorxiv.org/content/10.1101/2020.03.19.997262v1
  134. www.biorxiv.org www.biorxiv.org
    Overlapping oriC and centromere-like functions in secondary genome replicons determine their maintenance independent of chromosome I in Deinococcus radiodurans
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    1. EMBOpress 25 Feb 2021

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