1,103 Matching Annotations
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    TMX5/TXNDC15, a natural trapping mutant of the PDI family is a client of the proteostatic factor ERp44
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    1. EMBOpress 11 Oct 2024

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    biorxiv.org/content/10.1101/2024.06.12.598629v1
  3. www.biorxiv.org www.biorxiv.org
    Metabolic resistance of Abeta3pE-42, epitope of the anti-Alzheimer therapeutic antibody, donanemab.
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    1. EMBOpress 11 Oct 2024

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    biorxiv.org/content/10.1101/2024.01.30.578111v1
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    Dysfunctional β-cell longevity in diabetes relies on energy conservation and positive epistasis
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    1. EMBOpress 08 Oct 2024

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    biorxiv.org/content/10.1101/2024.03.18.585508v1
  5. Oct 2024
  6. www.biorxiv.org www.biorxiv.org
    Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b
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    1. EMBOpress 04 Oct 2024

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    biorxiv.org/content/10.1101/2023.10.19.563039v1
  7. www.biorxiv.org www.biorxiv.org
    FAM111A regulates replication origin activation and cell fitness
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    1. EMBOpress 04 Oct 2024

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    biorxiv.org/content/10.1101/2020.04.22.055574v1
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    Regulation of proteostasis by sleep through autophagy in Drosophila models of Alzheimer's Disease
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    1. EMBOpress 04 Oct 2024

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    biorxiv.org/content/10.1101/2024.07.01.601554v1
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    Differential Modulation of Polycomb-Associated Histone Marks by cBAF, pBAF, and gBAF Complexes
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    1. EMBOpress 03 Oct 2024

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    biorxiv.org/content/10.1101/2023.09.23.557848v2
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    A Novel Role for CSA in the Regulation of Nuclear Envelope Integrity: Uncovering a Non-Canonical Function
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    1. EMBOpress 03 Oct 2024

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    biorxiv.org/content/10.1101/2023.12.14.571633v1
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    Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism
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    1. EMBOpress 03 Oct 2024

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    biorxiv.org/content/10.1101/2023.08.22.554238v1
  12. Sep 2024
  13. www.biorxiv.org www.biorxiv.org
    Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons
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    1. EMBOpress 24 Sep 2024

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    biorxiv.org/lookup/doi/10.1101/2023.10.02.560439
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    The mitotic surveillance pathway requires PLK1-dependent 53BP1 displacement from kinetochores
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    1. EMBOpress 13 Sep 2024

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    biorxiv.org/lookup/doi/10.1101/2023.03.27.534346
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    Proteomic analysis reveals microvesicles containing NAMPT as mediators of radiation resistance in glioma
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    1. EMBOpress 11 Sep 2024

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    biorxiv.org/lookup/doi/10.1101/2022.03.23.485479
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    De-tensioning of collagen fibers optimizes endometrial receptivity and improves the rate of embryo implantation
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    1. EMBOpress 10 Sep 2024

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    biorxiv.org/lookup/doi/10.1101/2022.01.18.476712
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    A highly scalable approach to topic modelling in single-cell data by approximate pseudobulk projection
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    1. EMBOpress 10 Sep 2024

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    biorxiv.org/lookup/doi/10.1101/2024.02.21.581497
  18. Aug 2024
  19. www.biorxiv.org www.biorxiv.org
    Passive diffusion accounts for the majority of intracellular vesicle transport
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    1. EMBOpress 20 Aug 2024

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    biorxiv.org/content/10.1101/2023.05.10.540182v1
  20. www.biorxiv.org www.biorxiv.org
    Multi-modal adaptor-clathrin contacts drive coated vesicleassembly
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    1. EMBOpress 20 Aug 2024

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    biorxiv.org/content/10.1101/2021.05.22.445240v1
  21. www.biorxiv.org www.biorxiv.org
    RedRibbon: A new rank-rank hypergeometric overlap pipeline to compare gene and transcript expression signatures
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    1. EMBOpress 01 Aug 2024

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    biorxiv.org/content/10.1101/2022.08.31.505818v1
  22. Jul 2024
  23. www.biorxiv.org www.biorxiv.org
    Global Huntingtin Knockout in Adult Mice Leads to Fatal Neurodegeneration that Spares the Pancreas
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    1. EMBOpress 31 Jul 2024

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    biorxiv.org/content/10.1101/2024.01.11.575238v1
  24. www.biorxiv.org www.biorxiv.org
    Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
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    1. EMBOpress 30 Jul 2024

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    biorxiv.org/content/10.1101/2023.11.24.568591v2
  25. www.biorxiv.org www.biorxiv.org
    A large-scale cancer-specific protein-DNA interaction network
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    1. EMBOpress 30 Jul 2024

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    biorxiv.org/content/10.1101/2024.01.24.577099v1
  26. www.biorxiv.org www.biorxiv.org
    Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain
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    1. EMBOpress 24 Jul 2024

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    biorxiv.org/content/10.1101/2023.12.21.572875v2
  27. www.biorxiv.org www.biorxiv.org
    Exploring the molecular composition of the multipass translocon in its native membrane environment
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    1. EMBOpress 02 Jul 2024

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    biorxiv.org/content/10.1101/2023.11.28.569136v1
  28. www.biorxiv.org www.biorxiv.org
    Congress of multiple dimers is needed for cross-phosphorylation of IRE1α and its RNase activity
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    1. EMBOpress 02 Jul 2024

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    biorxiv.org/content/10.1101/2023.12.18.572154v1
  29. Jun 2024
  30. www.biorxiv.org www.biorxiv.org
    Translation inhibition efficacy does not determine the Plasmodium berghei liver stage antiplasmodial efficacy of protein synthesis inhibitors
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    1. EMBOpress 27 Jun 2024

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    biorxiv.org/content/10.1101/2023.12.07.570699v1
  31. www.biorxiv.org www.biorxiv.org
    The type of DNA damage response after Decitabine treatment depends on the level of DNMT activity
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    1. EMBOpress 26 Jun 2024

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    biorxiv.org/content/10.1101/2023.09.02.556017v2
  32. www.biorxiv.org www.biorxiv.org
    Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
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    1. EMBOpress 05 Jun 2024

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    biorxiv.org/content/10.1101/2022.06.14.495968v1
  33. www.biorxiv.org www.biorxiv.org
    Trim66 paternal deficiency causes intrauterine overgrowth
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    1. EMBOpress 04 Jun 2024

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    biorxiv.org/content/10.1101/2024.02.12.579976v1
  34. www.biorxiv.org www.biorxiv.org
    The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts
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    1. EMBOpress 04 Jun 2024

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    biorxiv.org/content/10.1101/2022.08.08.503265v1
  35. May 2024
  36. www.biorxiv.org www.biorxiv.org
    DNA binding site II is required for RAD51 recombinogenic activity in Arabidopsis thaliana
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    1. EMBOpress 31 May 2024

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    biorxiv.org/content/10.1101/2024.03.07.583932v1
  37. www.biorxiv.org www.biorxiv.org
    Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19
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    1. EMBOpress 31 May 2024

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    biorxiv.org/content/10.1101/2022.12.20.521247v1
  38. www.biorxiv.org www.biorxiv.org
    ERLIN1/2 scaffolds bridge TMUB1 and RNF170 and restrict cholesterol esterification to regulate the secretory pathway
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    1. EMBOpress 30 May 2024

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    biorxiv.org/content/10.1101/2024.01.17.576039v1
  39. www.biorxiv.org www.biorxiv.org
    K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific interactors.
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    1. EMBOpress 29 May 2024

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    biorxiv.org/content/10.1101/2024.01.08.574586v1
  40. www.biorxiv.org www.biorxiv.org
    IGHMBP2 deletion suppresses translation and activates the integrated stress response
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    1. EMBOpress 29 May 2024

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    biorxiv.org/content/10.1101/2023.12.11.571166v2
  41. www.biorxiv.org www.biorxiv.org
    http://biorxiv.org/cgi/content/short/2020.10.26.356014
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    1. EMBOpress 29 May 2024

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      PeerReviewed EMBOPress Molecular Systems Biology systems biology
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    biorxiv.org/content/10.1101/2020.10.26.356014v3
  42. www.biorxiv.org www.biorxiv.org
    Control of mammalian brain aging by the unfolded protein response (UPR)
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    1. EMBOpress 22 May 2024

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    biorxiv.org/content/10.1101/2020.04.13.039172v1
  43. www.biorxiv.org www.biorxiv.org
    Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential
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    1. EMBOpress 15 May 2024

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    biorxiv.org/content/10.1101/2023.03.30.534977v2
  44. www.biorxiv.org www.biorxiv.org
    Frataxin Deficiency Drives a Shift from Mitochondrial Metabolism to Glucose Catabolism, Triggering an Inflammatory Phenotype in Microglia
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    1. EMBOpress 08 May 2024

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    biorxiv.org/content/10.1101/2023.10.18.562916v1
  45. Apr 2024
  46. www.biorxiv.org www.biorxiv.org
    Integrative DNA methylation analysis of pediatric brain tumors reveals tumor type-specific developmental trajectories and epigenetic signatures of malignancy
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    1. EMBOpress 27 Apr 2024

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    biorxiv.org/content/10.1101/2022.03.14.483566v2
  47. www.biorxiv.org www.biorxiv.org
    pADP-ribosylation Regulates the Cytoplasmic Localization, Cleavage and Pro-apoptotic Function of HuR
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    1. EMBOpress 25 Apr 2024

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    biorxiv.org/content/10.1101/2023.08.07.552262v1
  48. www.biorxiv.org www.biorxiv.org
    Condensate functionalization with motors directs their nucleation in space and allows manipulating RNA localization
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    1. EMBOpress 23 Apr 2024

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    biorxiv.org/content/10.1101/2022.07.10.499452v1
  49. Mar 2024
  50. www.biorxiv.org www.biorxiv.org
    The P4-ATPase Drs2 regulates the homeostasis of Atg9
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    1. EMBOpress 29 Mar 2024

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    biorxiv.org/content/10.1101/2020.12.25.417865v3
  51. www.biorxiv.org www.biorxiv.org
    A YTHDF-PABP axis is required for m6A-mediated organogenesis in plants
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    1. EMBOpress 22 Mar 2024

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    biorxiv.org/content/10.1101/2023.07.03.547513v2
  52. www.biorxiv.org www.biorxiv.org
    Plant YTHDF proteins are direct effectors of antiviral immunity against an m6A-containing RNA virus
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    1. EMBOpress 20 Mar 2024

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    biorxiv.org/content/10.1101/2022.10.19.512835v1
  53. www.biorxiv.org www.biorxiv.org
    Circadian Transcriptomic and Epigenomic Remodeling in Response to Lipid Overload and Human Obesity
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    1. EMBOpress 09 Mar 2024

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    biorxiv.org/content/10.1101/2021.02.23.432336v4
  54. www.biorxiv.org www.biorxiv.org
    Regulation of branched versus linear Arp2/3-generated actin filaments
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    1. EMBOpress 07 Mar 2024

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    biorxiv.org/content/10.1101/2022.05.06.490861v1
  55. www.biorxiv.org www.biorxiv.org
    Extracellular vesicles and co-isolated endogenous retroviruses differently affect dendritic cells
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    1. EMBOpress 06 Mar 2024

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    biorxiv.org/content/10.1101/2023.01.27.525863v1
  56. www.biorxiv.org www.biorxiv.org
    Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2023.08.25.554811v1
  57. www.biorxiv.org www.biorxiv.org
    Structural and biochemical insights into heterotetramer formation between human oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
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    1. EMBOpress 05 Mar 2024

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    biorxiv.org/content/10.1101/2022.10.10.511529v8
  58. www.biorxiv.org www.biorxiv.org
    The memory of airway epithelium damage in smokers and COPD patients
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    1. EMBOpress 05 Mar 2024

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    Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography
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    Micronucleus Is Not a Potent Inducer of cGAS-STING Pathway
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    CLN3 deficiency leads to neurological and metabolic perturbations during early development
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    A nuclear signal in prophase determines centrosome positioning and ensures efficient mitotic spindle assembly
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    The origin, evolution and molecular diversity of the chemokine system
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  64. Feb 2024
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    Cryo-EM structure of lipid embedded human ABCA7 at 3.6 &Aring resolution
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    Canalisation and plasticity on the developmental manifold of Caenorhabditis elegans
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    Histology-associated transcriptomic heterogeneity in ovarian folliculogenesis revealed by quantitative single-cell RNA-sequencing for tissue sections with DRaqL
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    Pioneer activity distinguishes activating from non-activating pluripotency transcription factor binding sites
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    CRISPR-Cas9-mediated genome engineering exaggerates genomic deletion at 10q23.31 including the PTEN gene locus mimicking cancer profiles
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  70. Jan 2024
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    Convergent Insulin and TGF-β signalling drives cancer cachexia by promoting aberrant fatbody ECM accumulation in a Drosophila tumour model
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    Proteomic-based stratification of intermediate-risk prostate cancer patients
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    Human RAD52 stimulates the RAD51-mediated homology search
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    The structural basis for deubiquitination by the fingerless USP-type effector TssM
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    Changes in searching behaviour of CSL transcription complexes in Notch active conditions
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    Human liver organoids model progressive inflammatory and fibrotic injury in non-alcoholic fatty liver disease
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    Arp2/3 inhibition switches Eps8’s network associations to favour longer actin filament formation necessary for tunneling nanotubes
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  78. Dec 2023
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    Monomeric α-Synuclein activates the Plasma Membrane Calcium Pump
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    RIF1 ensures the organization of replication factories upon DNA replicative stress.
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    TUMOR ENDOTHELIAL CELL AUTOPHAGY IS A KEY VASCULAR-IMMUNE CHECKPOINT IN MELANOMA
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    Decline of DNA damage response along with myogenic differentiation
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    Enhancer-driven local 3D chromatin domain folding modulates transcription in human mammary tumor cells
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    Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface
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    The 5:2 diet does not increase adult hippocampal neurogenesis or enhance spatial memory in mice
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    Adult neural stem cells and neurogenesis are resilient to intermittent fasting
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    Adaptive Pathfinding by Nucleokinesis during Amoeboid Migration
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    The ribosome-associated chaperone Zuo1 controls translation upon TORC1 inhibition
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    Molecular view of ER membrane remodeling by the Sec61/TRAP translocon
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    Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex
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    Mitochondrial phosphoproteomes are functionally specialized across tissues
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    Protein phosphatase 1 regulates core PCP signaling
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    Blood flow diverts extracellular vesicles from endothelial degradative compartments to promote angiogenesis
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    Circadian oscillation in primary cilium length by clock genes regulate fibroblast cell migration
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    Propylene glycol inactivates respiratory viruses and prevents airborne transmission
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    The nucleolar protein GNL3 prevents resection of stalled replication forks.
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    The Response of the Eukaryotic Replisome to G-quadruplex- and i-motif-forming Sequences
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    Thiol reductive stress activates the hypoxia response pathway
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    Paralog dispensability shapes homozygous deletion patterns in tumor genomes
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    Enucleation of the C. elegans embryo revealed the mechanism of dynein-dependent spacing between microtubule asters
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    Epithelial lumen development requires differential participation of the vertebrate clathrin light chain isoforms with dominance of CLCa in vivo
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    Identification of FAM53C as a suppressive binding protein of a neurodevelopmental disorders-related kinase DYRK1A
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    Modeling of Aberrant Epithelial Reprogramming in Idiopathic Pulmonary Fibrosis using Human Induced Pluripotent Stem Cell-derived Alveolar Organoids
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    Detecting Cell Contact-dependent Gene Expression from Spatial Transcriptomics Data
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    Downregulation of stromal syntenin sustains AML development
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    Multi-omic network analysis identified betacellulin as a novel target of omega-3 fatty acid attenuation of western diet-induced nonalcoholic steatohepatitis
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    Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion
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    DONSON is required for CMG helicase assembly in the mammalian cell cycle
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    Automated staging of zebrafish embryos with deep learning
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    NRF2 connects Src tyrosine kinase to ferroptosis resistance in glioblastoma
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    MICA: A multi-omics method to predict gene regulatory networks in early human embryos
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      PeerReviewed EMBOPress Life Science Alliance developmental biology
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    biorxiv.org/content/10.1101/2023.02.03.527081v2
  112. www.biorxiv.org www.biorxiv.org
    Tetraspanner-based nanodomains modulate BAR domain-induced membrane curvature
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    1. EMBOpress 09 Dec 2023

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    biorxiv.org/content/10.1101/2022.11.21.517310v1
  113. www.biorxiv.org www.biorxiv.org
    YAP antagonizes TEAD-mediated AR signaling and prostate cancer growth
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    1. EMBOpress 01 Dec 2023

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      PeerReviewed EMBOPress The EMBO Journal cancer biology
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    biorxiv.org/content/10.1101/2022.08.01.502314v1
  114. Nov 2023
  115. www.biorxiv.org www.biorxiv.org
    Expansion microscopy reveals subdomains in C. elegans germ granules
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    1. EMBOpress 30 Nov 2023

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    biorxiv.org/content/10.1101/2022.05.29.493872v1
  116. www.biorxiv.org www.biorxiv.org
    A bifunctional kinase-phosphatase module integrates mitotic checkpoint and error-correction signalling to ensure mitotic fidelity
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    1. EMBOpress 30 Nov 2023

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    biorxiv.org/content/10.1101/2022.05.22.492960v2
  117. www.biorxiv.org www.biorxiv.org
    SARS-CoV-2 ORF3c suppresses immune activation by inhibiting innate sensing
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    1. EMBOpress 29 Nov 2023

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    biorxiv.org/content/10.1101/2023.02.27.530232v2
  118. www.biorxiv.org www.biorxiv.org
    Vimentin intermediate filaments organize organellar architecture in response to ER stress
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    1. EMBOpress 28 Nov 2023

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    biorxiv.org/content/10.1101/2022.03.24.485587v1
  119. www.biorxiv.org www.biorxiv.org
    Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2
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    1. EMBOpress 22 Nov 2023

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    biorxiv.org/content/10.1101/2023.09.07.556670v1
  120. www.biorxiv.org www.biorxiv.org
    A region-resolved proteomic map of the human brain enabled by high-throughput proteomics
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    1. EMBOpress 21 Nov 2023

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    biorxiv.org/content/10.1101/2023.06.05.543676v1
  121. www.biorxiv.org www.biorxiv.org
    Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screens
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    1. EMBOpress 21 Nov 2023

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    biorxiv.org/content/10.1101/2023.02.22.529573v2
  122. www.biorxiv.org www.biorxiv.org
    Comprehensive comparison of female germ cell development in vitro and in vivo identifies epigenetic gene regulation crucial for oocyte development and embryonic competence
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    1. EMBOpress 17 Nov 2023

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    biorxiv.org/content/10.1101/2023.02.15.528760v1
  123. www.biorxiv.org www.biorxiv.org
    A network of small RNAs regulates sporulation initiation in C. difficile
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    1. EMBOpress 15 Nov 2023

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    biorxiv.org/content/10.1101/2022.10.17.512509v1
  124. www.biorxiv.org www.biorxiv.org
    http://biorxiv.org/cgi/content/short/2021.01.06.425396
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  125. www.biorxiv.org www.biorxiv.org
    Enhanced Airway Epithelial Response to SARS-CoV-2 Infection in Children is Critically Tuned by the Cross-Talk Between Immune and Epithelial Cells
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    1. EMBOpress 10 Nov 2023

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