108 Matching Annotations
  1. Jul 2026
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    Septin7 is essential in early hematopoiesis, but redundant at later stages
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    biorxiv.org/content/10.1101/2025.04.22.649981v4
  3. Feb 2026
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    Cryo-EM structure of the tetra-phosphorylated R-domain in Ycf1 reveals key interactions for transport regulation
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    biorxiv.org/content/10.1101/2024.03.06.583773v2
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    Amyloid-β fibrils accumulated in preeclamptic placentas suppress syncytialization of cytotrophoblasts
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    biorxiv.org/content/10.1101/2025.03.06.641957v1
  6. May 2025
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    The late onset Alzheimer’s disease risk factor iRhom2/RHBDF2 is a modifier of microglial TREM2 proteolysis
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    biorxiv.org/content/10.1101/2024.09.13.612888v1
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    Variety in the USP deubiquitinase catalytic mechanism
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    biorxiv.org/content/10.1101/2023.07.24.550302v2
  9. Dec 2024
  10. www.biorxiv.org www.biorxiv.org
    4G cloning: rapid gene assembly for expression of multisubunit protein complexes in diverse hosts
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    biorxiv.org/content/10.1101/2024.06.17.599261v1
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    Structural basis for inhibition of mycobacterial ATP synthase by squaramides and second generation diarylquinolines
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    biorxiv.org/content/10.1101/2023.02.03.527018v1
  12. Nov 2024
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    An auto-release mechanism for HMCES-DNA-protein crosslinks
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    biorxiv.org/content/10.1101/2022.12.18.520715v1
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    The hGID GID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration
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    biorxiv.org/content/10.1101/2023.07.20.549906v1
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    Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish
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    biorxiv.org/content/10.1101/2024.03.17.585386v1
  16. Oct 2024
  17. www.biorxiv.org www.biorxiv.org
    Non-redundant roles for the human mRNA decapping cofactor paralogs DCP1a and DCP1b
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    biorxiv.org/content/10.1101/2023.10.19.563039v1
  18. Sep 2024
  19. www.biorxiv.org www.biorxiv.org
    De-tensioning of collagen fibers optimizes endometrial receptivity and improves the rate of embryo implantation
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    biorxiv.org/lookup/doi/10.1101/2022.01.18.476712
  20. Aug 2024
  21. www.biorxiv.org www.biorxiv.org
    Multi-modal adaptor-clathrin contacts drive coated vesicleassembly
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    biorxiv.org/content/10.1101/2021.05.22.445240v1
  22. Jun 2024
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    The type of DNA damage response after Decitabine treatment depends on the level of DNMT activity
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    biorxiv.org/content/10.1101/2023.09.02.556017v2
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    Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome
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    biorxiv.org/content/10.1101/2022.06.14.495968v1
  25. May 2024
  26. www.biorxiv.org www.biorxiv.org
    Difluoromethylornithine rebalances aberrant polyamine ratios in Snyder-Robinson syndrome: mechanism of action and therapeutic potential
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    biorxiv.org/content/10.1101/2023.03.30.534977v2
  27. Mar 2024
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    Regulation of branched versus linear Arp2/3-generated actin filaments
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    biorxiv.org/content/10.1101/2022.05.06.490861v1
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    Structural and biochemical insights into heterotetramer formation between human oncogenic K-Ras4BG12V and Rgl2, a RalA/B activator
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    biorxiv.org/content/10.1101/2022.10.10.511529v8
  30. Jan 2024
  31. www.biorxiv.org www.biorxiv.org
    Human RAD52 stimulates the RAD51-mediated homology search
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    biorxiv.org/content/10.1101/2022.06.27.497340v1
  32. www.biorxiv.org www.biorxiv.org
    The structural basis for deubiquitination by the fingerless USP-type effector TssM
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    biorxiv.org/content/10.1101/2023.08.01.551441v1
  33. Dec 2023
  34. www.biorxiv.org www.biorxiv.org
    Monomeric α-Synuclein activates the Plasma Membrane Calcium Pump
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    biorxiv.org/content/10.1101/2022.02.21.481193v2
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    Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface
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    biorxiv.org/content/10.1101/2022.10.14.512215v1
  36. www.biorxiv.org www.biorxiv.org
    Molecular view of ER membrane remodeling by the Sec61/TRAP translocon
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    biorxiv.org/content/10.1101/2022.09.30.510141v1
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    Mitochondrial phosphoproteomes are functionally specialized across tissues
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    biorxiv.org/content/10.1101/2022.03.23.485457v1
  38. www.biorxiv.org www.biorxiv.org
    DONSON is required for CMG helicase assembly in the mammalian cell cycle
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    biorxiv.org/content/10.1101/2023.08.16.553614v1
  39. Sep 2023
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    A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance
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    biorxiv.org/content/10.1101/2023.02.26.530079v2
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    Branched chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast
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    biorxiv.org/content/10.1101/2023.01.10.523468v2
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    Calculating ATP production rates from oxidative phosphorylation and glycolysis during cell activation
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    biorxiv.org/content/10.1101/2022.04.16.488523v2
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    Distant sequence regions of JBP1 contribute to J-DNA binding
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    biorxiv.org/content/10.1101/2023.01.23.525147v1
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    Phosphorylation controls spatial and temporal activities of motor-PRC1 complexes to complete mitosis
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    biorxiv.org/content/10.1101/2023.03.11.531660v1
  45. Aug 2023
  46. www.biorxiv.org www.biorxiv.org
    The C-terminal tail of CSNAP attenuates the CSN complex
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    biorxiv.org/content/10.1101/2022.07.18.500399v1
  47. Jul 2023
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    Characterization of the REC114-MEI4-IHO1 complex regulating meiotic DNA double-strand break formation
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    biorxiv.org/content/10.1101/2023.01.11.523614v1
  49. www.biorxiv.org www.biorxiv.org
    The cytochrome b carboxyl-terminal region is necessary for mitochondrial Complex III assembly
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    biorxiv.org/content/10.1101/2022.11.25.517933v1
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    Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes.
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    biorxiv.org/content/10.1101/2022.10.14.512296v1
  51. Jun 2023
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    Structural basis of ubiquitin-independent PP1 complex disassembly by p97
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    biorxiv.org/content/10.1101/2022.06.24.497491v1
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    Structure-based design and characterization of Parkin activating mutations
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    biorxiv.org/content/10.1101/2022.02.22.481412v1
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    Mitochondrial dysfunction rapidly modulates the abundance and thermal stability of cellular proteins
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    biorxiv.org/content/10.1101/2022.10.27.514032v1
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    Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases
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    biorxiv.org/content/10.1101/2023.01.02.522462v1
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    Multivalent BARD1-nucleosome interactions facilitate H2A ubiquitylation by BRCA1/BARD1
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    biorxiv.org/content/10.1101/2022.08.09.503292v2
  57. www.biorxiv.org www.biorxiv.org
    Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding
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    biorxiv.org/content/10.1101/2022.08.25.505310v1
  58. May 2023
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    A quantitative fluorescence-based approach to study mitochondrial protein import
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    biorxiv.org/content/10.1101/2022.10.10.511594v1
  60. Apr 2023
  61. www.biorxiv.org www.biorxiv.org
    The TUDOR domain of SMN is an H3K79me1 histone mark reader
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    biorxiv.org/content/10.1101/2022.10.06.511070v1
  62. Mar 2023
  63. www.biorxiv.org www.biorxiv.org
    Peroxisomes contribute to intracellular calcium dynamics
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    biorxiv.org/content/10.1101/2020.09.02.279174v1
  64. www.biorxiv.org www.biorxiv.org
    The cryo-EM structure of the CENP-A nucleosome in complex with ggKNL2
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    biorxiv.org/content/10.1101/2022.06.24.497480v1
  65. www.biorxiv.org www.biorxiv.org
    Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases
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    biorxiv.org/content/10.1101/2022.02.18.481032v1
  66. www.biorxiv.org www.biorxiv.org
    Structure and mechanism of a novel cytomegaloviral DCAF mediating interferon antagonism
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    biorxiv.org/content/10.1101/2022.05.05.490734v2
  67. Feb 2023
  68. www.biorxiv.org www.biorxiv.org
    MitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol
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    biorxiv.org/content/10.1101/2022.08.02.502474v1
  69. Jan 2023
  70. www.biorxiv.org www.biorxiv.org
    Structural and functional characterization of TraI from pKM101 reveals basis for DNA processing
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    biorxiv.org/content/10.1101/2022.06.02.494495v2
  71. Dec 2022
  72. www.biorxiv.org www.biorxiv.org
    Structural and biochemical basis of FANCI-FANCD2 interdependent ubiquitination
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    biorxiv.org/content/10.1101/2022.04.07.487446v2
  73. Nov 2022
  74. www.biorxiv.org www.biorxiv.org
    The E3 ligase RNF115 regulates phagosome maturation and host response to bacterial infection
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    biorxiv.org/content/10.1101/2021.07.13.452284v2
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    Structure and functional mapping of the KRAB-KAP1 repressor complex
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    biorxiv.org/content/10.1101/2022.03.17.484746v1
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    Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
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    biorxiv.org/content/10.1101/2020.08.24.265033v1
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    http://biorxiv.org/cgi/content/short/2020.11.10.376822
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    biorxiv.org/content/10.1101/2020.11.10.376822v2
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    Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity
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    biorxiv.org/content/10.1101/2021.11.11.468215v1
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    A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage
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    biorxiv.org/content/10.1101/2022.04.27.489752v1
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    Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms
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    biorxiv.org/content/10.1101/2021.10.12.464107v2
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    Cooperative Amyloid Fibre Binding and Disassembly by the Hsp70 disaggregase
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    biorxiv.org/content/10.1101/2021.08.29.458036v1
  82. www.biorxiv.org www.biorxiv.org
    Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome
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    biorxiv.org/content/10.1101/2021.04.13.439572v1
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    Structure of mammalian V-ATPase with the TLDc domain protein mEAK7 bound
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    biorxiv.org/content/10.1101/2021.11.03.466369v2
  84. May 2022
  85. www.biorxiv.org www.biorxiv.org
    Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26
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    biorxiv.org/content/10.1101/2021.09.20.461029v1
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    Structural basis for feedforward control in the PINK1/parkin pathway
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    biorxiv.org/content/10.1101/2021.08.16.456440v1
  87. Apr 2022
  88. www.biorxiv.org www.biorxiv.org
    Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores
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    biorxiv.org/content/10.1101/2021.12.03.471119v1
  89. Mar 2022
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    Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.
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    biorxiv.org/content/10.1101/2020.03.02.972950v5
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    Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation
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    biorxiv.org/content/10.1101/2021.04.30.442163v1
  92. Feb 2022
  93. www.biorxiv.org www.biorxiv.org
    Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids
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    biorxiv.org/content/10.1101/2020.06.08.140129v1
  94. Jan 2022
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    Nascent polypeptide within the exit tunnel ensures continuous translation elongation by stabilizing the translating ribosome
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    biorxiv.org/content/10.1101/2021.02.02.429294v3
  96. Dec 2021
  97. www.biorxiv.org www.biorxiv.org
    The human GID complex engages two independent modules for substrate recruitment
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    biorxiv.org/content/10.1101/2021.04.07.438752v1
  98. www.biorxiv.org www.biorxiv.org
    F-domain valency determines outcome of signaling through the angiopoietin pathway
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    biorxiv.org/content/10.1101/2020.09.19.304188v3
  99. Nov 2021
  100. www.biorxiv.org www.biorxiv.org
    Acyl chain shortening induced by inhibition of acetyl-CoA carboxylase renders phosphatidylcholine redundant
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    biorxiv.org/lookup/doi/10.1101/2021.02.08.429707
  101. www.biorxiv.org www.biorxiv.org
    Quantitative Proteomics Identifies PTP1B as Modulator of B Cell Antigen Receptor Signaling
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    biorxiv.org/lookup/doi/10.1101/2021.03.30.437652
  102. www.biorxiv.org www.biorxiv.org
    Structural basis for the specificity of PPM1H phosphatase for Rab GTPases
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    biorxiv.org/lookup/doi/10.1101/2021.02.17.431620
  103. Oct 2021
  104. www.biorxiv.org www.biorxiv.org
    Passive receptor dissociation driven by porin threading establishes active colicin transport through Escherichia coli OmpF
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    biorxiv.org/content/10.1101/2021.04.15.439832v1
  105. Jul 2021
  106. www.biorxiv.org www.biorxiv.org
    Nse5/6 inhibits the Smc5/6 ATPase to facilitate DNA substrate selection.
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    biorxiv.org/content/10.1101/2021.02.09.430422v1
  107. www.biorxiv.org www.biorxiv.org
    A phosphoproteomic approach reveals that PKD3 controls phenylalanine and tyrosine metabolism
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    biorxiv.org/content/10.1101/2020.07.20.211474v1
  108. www.biorxiv.org www.biorxiv.org
    Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
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    biorxiv.org/content/10.1101/2021.01.04.425171v1
  109. www.biorxiv.org www.biorxiv.org
    Increased levels of the mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol
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    biorxiv.org/content/10.1101/2021.02.02.429331v1
  110. www.biorxiv.org www.biorxiv.org
    Quantifying signal persistence in the T cell signaling network using an optically controllable antigen receptor
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    biorxiv.org/content/10.1101/2020.10.30.362194v1
  111. Apr 2021
  112. www.biorxiv.org www.biorxiv.org
    The structure of bacterial toxin CNFY reveals requirements for secretion, host cell recognition and endosomal release
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    biorxiv.org/content/10.1101/2020.04.07.029181v2
  113. Feb 2021
  114. www.biorxiv.org www.biorxiv.org
    Selective cross-linking of coinciding protein assemblies by in-gel cross-linking mass-spectrometry
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    biorxiv.org/content/10.1101/2020.07.10.193003v1
  115. www.biorxiv.org www.biorxiv.org
    In-depth and 3-Dimensional Exploration of the Budding Yeast Phosphoproteome
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    biorxiv.org/content/10.1101/700070v1
  116. www.biorxiv.org www.biorxiv.org
    Actin filament oxidation by MICAL1 suppresses protections from cofilin-induced disassembly
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    biorxiv.org/content/10.1101/2020.02.26.966614v1
  117. www.biorxiv.org www.biorxiv.org
    Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning & reduces neurodegeneration
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    biorxiv.org/content/10.1101/2020.03.15.992768v2
  118. www.biorxiv.org www.biorxiv.org
    https://doi.org/10.1101/2020.06.18.160614
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    biorxiv.org/content/10.1101/2020.06.18.160614v1
  119. www.biorxiv.org www.biorxiv.org
    G-Quadruplexes Act as Sequence Dependent Chaperones via Protein Oligomerization
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    biorxiv.org/content/10.1101/850263v1
  120. Oct 2020
  121. www.biorxiv.org www.biorxiv.org
    A meiosis-specific AAA+ assembly reveals repurposing of ORC during budding yeast gametogenesis
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    biorxiv.org/content/10.1101/598128v1
  122. www.biorxiv.org www.biorxiv.org
    An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella
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    biorxiv.org/content/10.1101/2020.07.01.182683v1
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    Diflunisal targets the HMGB1/CXCL12 heterocomplex and blocks immune cell recruitment
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    biorxiv.org/content/10.1101/563890v1
  124. Jul 2020
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    Identification and characterization of diverse OTU deubiquitinases in bacteria
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    biorxiv.org/content/10.1101/2020.03.28.013474v1
  126. www.biorxiv.org www.biorxiv.org
    Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA
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    biorxiv.org/content/10.1101/2020.02.03.931576v1
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    Beyond the seed: structural basis for supplementary mircoRNA targeting
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    biorxiv.org/content/10.1101/476960v1
  128. www.biorxiv.org www.biorxiv.org
    Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts
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    biorxiv.org/content/10.1101/755652v1
  129. www.biorxiv.org www.biorxiv.org
    TBK1-mediated phosphorylation of LC3C and GABARAP-L2 controls autophagosome shedding by ATG4 protease
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    biorxiv.org/content/10.1101/634519v1
  130. www.biorxiv.org www.biorxiv.org
    Characterisation of the c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replication
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    biorxiv.org/content/10.1101/634592v1
  131. Jun 2020
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    The structure of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR-fold
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    biorxiv.org/content/10.1101/709915v1
  133. www.biorxiv.org www.biorxiv.org
    Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry
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    biorxiv.org/content/10.1101/792671v3
  134. Nov 2019
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    S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate desmosome assembly and cell adhesion.
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    biorxiv.org/content/10.1101/481861v1
  136. www.biorxiv.org www.biorxiv.org
    An integrated workflow for cross-linking/mass spectrometry
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    biorxiv.org/content/10.1101/355396v2
  137. Sep 2019
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    Ncl1 mediated metabolic rewiring is critical during metabolic stress
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    biorxiv.org/content/10.1101/529578v3
  139. www.biorxiv.org www.biorxiv.org
    Molecular characterization of CHAD domains as inorganic polyphosphate binding modules
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    biorxiv.org/content/10.1101/567040v1
  140. www.biorxiv.org www.biorxiv.org
    Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
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    biorxiv.org/content/10.1101/430124v1
  141. www.biorxiv.org www.biorxiv.org
    The histone chaperone FACT modulates nucleosome structure by tethering its components
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    biorxiv.org/content/10.1101/309708v1
  142. www.biorxiv.org www.biorxiv.org
    Stalk-mediated communication in the dynein motor domain
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    biorxiv.org/content/10.1101/309179v2
  143. www.biorxiv.org www.biorxiv.org
    Structures of the heart specific SERCA2a Ca2+-ATPase
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    biorxiv.org/content/10.1101/344911v1
  144. www.biorxiv.org www.biorxiv.org
    Synergistic Recruitment of UbcH7~Ub and Phosphorylated Ubl Domain Triggers Parkin Activation
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    biorxiv.org/content/10.1101/344952v1
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    Structure of the human pro-myostatin precursor and determinants of growth factor latency
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    biorxiv.org/content/10.1101/153403v2
  146. www.biorxiv.org www.biorxiv.org
    Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation
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    Structural and Functional analysis of the GABARAP Interaction Motif (GIM).
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    biorxiv.org/content/early/2016/10/28/083659
  148. www.biorxiv.org www.biorxiv.org
    Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands
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    biorxiv.org/content/10.1101/101394v1