23 Matching Annotations
  1. Apr 2026
    1. Treatment of superficial vein reflux (see Varicose Veins, above) has been shown to decrease the recurrence rate of venous ulcers. Where there is substantial obstruction of the femoral or popliteal deep venous system, superficial varicosities supply the venous return and should not be removed.

      Failure of venous insufficiency ulcerations to heal is most often due to inconsistent use of first-line treatment methods. Ongoing control of edema is essential to prevent recurrent ulceration; the use of compression stockings following ulcer healing is critical, with recurrence rates 2–20 times higher if compression stockings are not used

      Duplex ultrasound evaluation should assess blood flow direction, venous reflux, and venous obstruction, and include examination of the deep venous system, great saphenous vein (GSV), small saphenous vein (SSV) and its thigh extension (Giacomini vein), accessory saphenous veins, and perforating veins. Venography is recommended primarily in patients with post-thrombotic disease, especially when intervention is planned, as it provides greater anatomic detail than duplex ultrasonograph The examination also identifies patterns of disease that have treatment implications. Axial reflux is defined as uninterrupted retrograde flow from groin to calf and can occur in either superficial or deep systems. [4] Junctional reflux is limited to the saphenofemoral or saphenopopliteal junction, while segmental reflux occurs in a portion of a truncal vein. [4] Understanding whether reflux originates from superficial junctions versus deep venous incompetence fundamentally changes treatment planning, as superficial disease is amenable to ablation while deep disease typically requires conservative management Management of secondary varicose veins from post-thrombotic syndrome (PTS) is fundamentally different and more challenging. Compression therapy, lifestyle modifications, and symptom management form the cornerstone of PTS treatment. [4-8] Elastic compression stockings (20-30 mm Hg), leg elevation, weight loss, and exercise constitute the primary therapeutic approach Endovascular interventions for PTS—including percutaneous transluminal venoplasty and stenting—are reserved for select patients with significant iliofemoral obstruction who have failed conservative management. [7] These procedures require careful patient selection and standardized criteria. The role of superficial venous ablation in PTS patients with concomitant superficial reflux remains controversial and should be approached cautiously, as the underlying deep venous pathology may limit benefit

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  2. Mar 2024
  3. Sep 2023
    1. Defections from large-scale anatomical goals, such as those that occur due to an inappropriate reduction of gap junctional connectivity [74], present as cancer, cause reversions of cell behavior to ancient unicellular concerns which lead to metastasis and over-proliferation as the cells treat the rest of the body as external environment.
      • fresh perspective

        • cancer can be interpreted as a breakdown in the bodies multiscale competency architecture causing cancerous cells to lose their higher level synchronizing signals and revert to their more evolutionarily primitive forms as individuals that see the body as simply an external environment
      • adjacency between

        • gap junction coupling
        • cancer
        • healthy tissue coherence
        • multiscale competency architecture
      • adjacency statement
        • gap junction coupling appears to be an evolutionary means of cohering individuals together to form a larger group
        • hence, they seem to play a critical role in the continued evolution of more complex multicellular organisms
        • their pathologies within multicellular beings destroy multicellular structures and create disease, reverting the organism, or competent multicellular structures of the organism such as tissues and organs back to individualistic behavior, as in cancers
  4. Aug 2023
    1. When the tribe is not a cohesive group but an assemblage of thousands or millions whose only commonality is the place they call home, what exactly does the “collective interest” even mean?
      • for: collective interest,
      • paraphrase
        • When the tribe is not a cohesive group but an assemblage of thousands or millions whose only commonality is the place they call home,
          • what exactly does the “collective interest” even mean?
        • By contrast, the interests of individuals and groups within the larger goup, such as
          • unlicensed gun owners,
          • protesters of various stripes, or
          • hate-mongers on social media
        • are pretty easy to delineate.
        • No surprise then that the dysfunctional courts often choose
          • personal interests over
          • an amorphous and undefinable “collective interest”.
      • insight
        • reason why the judicial system often sides with a definitive, but often harmful group, over a vague but beneficial group
      • quote
        • modernity has hollowed out the word "collective interest
      • author
        • James Gien Wong
        • Stop Reset Go
  5. Feb 2023
  6. Jan 2023
    1. ‘Running on Emptiness – The Pathology of Civilisation’John Zerzan (2002) All religions have problems with ‘unbelievers’, but that response is insignificant compared to their visceral hatred of ‘apostates’.

      !- Book Review : Free Range Activist !- Title : ‘Running on Emptiness – The Pathology of Civilisation’ !- Author : John Zerzan (2002) !- Website : http://www.fraw.org.uk/blog/reviews/023/index.shtml

      • All religions have problems with ‘unbelievers’, but that response is insignificant compared to their visceral hatred of ‘apostates’.
  7. Aug 2022
  8. Jan 2022
    1. Douaud, G., Lee, S., Alfaro-Almagro, F., Arthofer, C., Wang, C., McCarthy, P., Lange, F., Andersson, J. L. R., Griffanti, L., Duff, E., Jbabdi, S., Taschler, B., Winkler, A. M., Nichols, T. E., Collins, R., Matthews, P. M., Allen, N., Miller, K. L., & Smith, S. M. (2021). Brain imaging before and after COVID-19 in UK Biobank (p. 2021.06.11.21258690). https://doi.org/10.1101/2021.06.11.21258690

  9. Sep 2021
  10. Mar 2021
  11. Feb 2021
  12. Aug 2020
    1. Kreye, J., Reincke, S. M., Kornau, H.-C., Sánchez-Sendin, E., Corman, V. M., Liu, H., Yuan, M., Wu, N. C., Zhu, X., Lee, C.-C. D., Trimpert, J., Höltje, M., Dietert, K., Stöffler, L., Wardenburg, N. von, Hoof, S. van, Homeyer, M. A., Hoffmann, J., Abdelgawad, A., … Prüss, H. (2020). A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model. BioRxiv, 2020.08.15.252320. https://doi.org/10.1101/2020.08.15.252320

    1. Salahudeen, A. A., Choi, S. S., Rustagi, A., Zhu, J., O, S. M. de la, Flynn, R. A., Margalef-Català, M., Santos, A. J. M., Ju, J., Batish, A., Unen, V. van, Usui, T., Zheng, G. X. Y., Edwards, C. E., Wagar, L. E., Luca, V., Anchang, B., Nagendran, M., Nguyen, K., … Kuo, C. J. (2020). Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures. BioRxiv, 2020.07.27.212076. https://doi.org/10.1101/2020.07.27.212076

  13. Jun 2020
  14. Nov 2019

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  15. Jan 2017
    1. Pathology

      Definitions of pathology

      • "The science of the causes and effects of [diseases]."
      • "The science of the causes and effects of [disorders of structure or function of biological organisms]."
      • "The science of the causes and effects of [perturbations to sustainable function] of biological organisms."
      • "The science of the causes and effects of perturbations to sustainable function of biological [ecosystems]."
      • "The science of the causes and effects of perturbations to sustainable function of biological ecosystems, [with some emphasis on human beings]."
  16. Feb 2015
  17. Nov 2014