42 Matching Annotations
  1. Mar 2021
  2. Feb 2021
    1. Howard, J., Huang, A., Li, Z., Tufekci, Z., Zdimal, V., Westhuizen, H.-M. van der, Delft, A. von, Price, A., Fridman, L., Tang, L.-H., Tang, V., Watson, G. L., Bax, C. E., Shaikh, R., Questier, F., Hernandez, D., Chu, L. F., Ramirez, C. M., & Rimoin, A. W. (2021). An evidence review of face masks against COVID-19. Proceedings of the National Academy of Sciences, 118(4). https://doi.org/10.1073/pnas.2014564118

    1. However, most notably, COVID-19 patients are most often dying of acute respiratory distress syndrome (ARDS), which indicates that COVID-19 related cytokine storms, like the virus, are focused in the lower lung. This leads to the instances of acute pneumonia and the need for intubation and ventilator use.
    1. Nogués, X., Ovejero, D., Quesada-Gomez, J. M., Bouillon, R., Arenas, D., Pascual, J., Villar-Garcia, J., Rial, A., Gimenez-Argente, C., Cos, M. L., Rodriguez-Morera, J., Campodarve, I., Guerri-Fernandez, R., Pineda-Moncusí, M., & García-Giralt, N. (2021). Calcifediol Treatment and COVID-19-Related Outcomes (SSRN Scholarly Paper ID 3771318). Social Science Research Network. https://doi.org/10.2139/ssrn.3771318

    1. Hodcroft, E. B., Domman, D. B., Oguntuyo, K., Snyder, D. J., Diest, M. V., Densmore, K. H., Schwalm, K. C., Femling, J., Carroll, J. L., Scott, R. S., Whyte, M. M., Edwards, M. D., Hull, N. C., Kevil, C. G., Vanchiere, J. A., Lee, B., Dinwiddie, D. L., Cooper, V. S., & Kamil, J. P. (2021). Emergence in late 2020 of multiple lineages of SARS-CoV-2 Spike protein variants affecting amino acid position 677. MedRxiv, 2021.02.12.21251658. https://doi.org/10.1101/2021.02.12.21251658

  3. Sep 2020
  4. Aug 2020
    1. Chen, Y., Yang, W.-H., Huang, L.-M., Wang, Y.-C., Yang, C.-S., Liu, Y.-L., Hou, M.-H., Tsai, C.-L., Chou, Y.-Z., Huang, B.-Y., Hung, C.-F., Hung, Y.-L., Chen, J.-S., Chiang, Y.-P., Cho, D.-Y., Jeng, L.-B., Tsai, C.-H., & Hung, M.-C. (2020). Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 main protease by tafenoquine in vitro. BioRxiv, 2020.08.14.250258. https://doi.org/10.1101/2020.08.14.250258

  5. Jul 2020
    1. Zhong, H., Wang, Y., Shi, Z., Zhang, L., Ren, H., He, W., Zhang, Z., Zhu, A., Zhao, J., Xiao, F., Yang, F., Liang, T., Ye, F., Zhong, B., Ruan, S., Gan, M., Zhu, J., Li, F., Li, F., … Zhao, J. (2020). Characterization of Microbial Co-infections in the Respiratory Tract of hospitalized COVID-19 patients. MedRxiv, 2020.07.02.20143032. https://doi.org/10.1101/2020.07.02.20143032

  6. Jun 2020
  7. May 2020
  8. Apr 2020
    1. Jefferson, T., Jones, M., Al Ansari, L. A., Bawazeer, G., Beller, E., Clark, J., Conly, J., Del Mar, C., Dooley, E., Ferroni, E., Glasziou, P., Hoffman, T., Thorning, S., & Van Driel, M. (2020). Physical interventions to interrupt or reduce the spread of respiratory viruses. Part 1 - Face masks, eye protection and person distancing: Systematic review and meta-analysis [Preprint]. Public and Global Health. https://doi.org/10.1101/2020.03.30.20047217

    1. wastewater treatment disease transmission studies from that time did not usually consider respiratory pathogens.

      During the 1980s, there were few pathogens that were both known to initiate infection in the lungs and frequently occur in wastewater (U.S. Environmental Protection Agency, 1980). It was viewed as an anomaly if an enteric pathogen was “uniquely infectious by the aerosol route”, with the noted exception of the respiratory bacterium Mycobacterium tuberculosis



    1. Second, hypoxaemia may be also an important reason of cardiac injury. In Huang’s study, 32% COVID-19 patients had various degree of hypoxaemia and need required high-flow nasal cannula or higher-level oxygen support. In Chen’s study, up to 76% of patients require oxygen therapy. Due to severe 2019-nCoV infection, the pneumonia may cause significant gas exchange obstruction, leading to hypoxaemia, which significantly reduces the energy supply by cell metabolism, and increases anaerobic fermentation, causing intracellular acidosis and oxygen free radicals to destroy the phospholipid layer of cell membrane. Meanwhile, hypoxia-induced influx of calcium ions also leads to injury and apoptosis of cardiomyocytes.
  9. Mar 2020
    1. an abnormal noise from the upper airway might be audible during galloping, which usually is a sign that there is something amiss with the upper airway
  10. Jul 2018