22 Matching Annotations
  1. Last 7 days
    1. a threshold-linear response with a tunable threshold, a robust noise resistance characteristic, and a built-in capability for hierarchical cross-talk.
    1. In particular, small RNAs are shown to establish a threshold for the expression of their target, providing safety mechanism against random fluctuations and transient signals. The threshold level is set by the transcription rate of the small RNA and can thus be modulated dynamically to reflect changing environmental conditions.
  2. sackler.tufts.edu sackler.tufts.edu
    1. bacteria generally express genes only when and where needed, and thus do not readily reveal their pathogenic armament outside of infected tissues
  3. Oct 2019
    1. regulate gene expression, typically by occluding or exposing regulatory features, such as ribosome binding sites (RBSs) in the case of translation or intrinsic terminator hairpins in the case of transcription
  4. Jul 2019
    1. Cardinal Health said that it has learned from its experience, increasing training and doing a better job to “spot, stop and report suspicious orders,” company spokeswoman Brandi Martin wrote.

      Because companies are incentivized to sell however, it will require governmental oversight and regulation to fix this problem.

  5. Feb 2019
    1. But there’s no reason that Google and Facebook shouldn’t be accepting deposits, facilitating payments, making loans, managing assets, running quantitative investment funds.

      Except that there's a hesitation among tech firms to enter heavily regulated industries.

  6. Nov 2018
    1. If there is a sector more ripe for the reinvigoration of antitrust regulation, I do not know it.
    2. When a dominant firm buys its a nascent challenger, alarm bells are supposed to ring. Yet both American and European regulators found themselves unable to find anything wrong with the takeover.
  7. Aug 2018
    1. But that state of consciousness that permits the growth of liberalism seems to stabilize in the way one would expect at the end of history if it is underwritten by the abundance of a modern free market economy.

      Writers spend an awful lot of time focused too carefully on the free market economy, but don't acknowledge a lot of the major benefits of the non-free market parts which are undertaken and executed often by governments and regulatory environments. (Hacker & Pierson, 2016)

    1. to learn how to better understand students like Cory and how to use that understanding to both connect with the student in the classroom as well as how to better address behavioral issues, and to also learn how to better control my emotions as a teacher so that I can both address situations with a clear mind, as well as go home


  8. Jul 2018
    1. When it comes to democracy and human rights, a Jeffersonian internet is clearly a safer choice. With Web 3.0 still in its infancy, the West at least will need to find other ways to rein in the online giants. The obvious alternative is regulation.
  9. May 2018
    1. Who is responsible for the actions of AI? How should liability be determined for their mistakes? Can a legal system designed by humans keep pace with activities produced by an AI capable of outthinking and potentially outmaneuvering them?

      Politically, people have been pushing deregulation for decades, but we have regulations for a reason, as these questions illustrate.

  10. Jan 2018
  11. Sep 2017
    1. Co-regulation encompasses initiatives in which government and industry share responsibility for drafting and en-forcing regulatory standards
    2. policy makers and scholars should explore an alternative approach known as “co-regulation.
  12. May 2017
    1. The regulation of an entire burgeoning industry, and the interpretation of the Constitution in the digital age, could be impacted by the court’s decision in a case inspired by Pokémon.

      This is a really interesting case. How have I not heard of it?

  13. Mar 2017
    1. Shell

      The decision to veto the proposed pipeline in accordance with Mr. Berger’s recommendation substantially slowed, but did not stop the search for oil in the Arctic. Over the next 40 years, oil companies such as Shell, Exxon, and Chevron would continue their search in a region expected to contain 13% of the world’s undiscovered oil and 30% of its natural gas.1 But in 2015, Shell, the last remaining company in the American Arctic, announced it would halt its exploratory drilling. This would mark the end of their $7 billion venture into Alaska’s Chuckchi Sea. The well, the Burger J, stretched to a depth of 6,800 feet and showed indications of oil and gas, but amid relatively low oil prices, less than $50 a barrel, and the expense necessary to drill in this section of the ocean they have decided to cease operations. The company originally planned on drill two wells to greater than 8,000 feet, but in the wake of Shell grounding its Kulluck drilling rig, this number was halved by President Obama’s administration.2 This grounding was found to be, in part, the result of Shell’s ill-fated attempt to avoid paying millions of dollars in tax liability. Fortune’s Jon Birger noted in his visit to the rig after it was grounded that it was well prepared to prevent the incident that destroyed BP’s Deepwater Horizon, but, startlingly, was less equipped to deal with the unique weather conditions posed by drilling in the Arctic.3 The Berger report may not have halted Shell’s Artic exploration but a combination of regulatory restrictions and low oil prices seem to have done just that.

      1. Lavelle, Marianne. "Coast Guard blames Shell risk-taking in Kulluk rig accident." National Geographic. April 4, 2014. Accessed March 7, 2017. http://news.nationalgeographic.com/news/energy/2014/04/140404-coast-guard-blames-shell-in-kulluk-rig-accident/.
      2. Koch, Wendy. "3 reasons why Shell halted drilling in the Arctic." National Geographic. September 28, 2015. Accessed March 7, 2017. http://news.nationalgeographic.com/energy/2015/09/150928-3-reasons-shell-halted-drilling-in-the-arctic/.
      3. Birger, Jon. "What I learned aboard Shell's grounded Alaskan oil rig." Fortune. January 3, 2013. Accessed March 7, 2017. http://fortune.com/2013/01/03/what-i-learned-aboard-shells-grounded-alaskan-oil-rig/.
  14. Jan 2017
    1. the ability of an organization to rapidly adapt and steer itself in a new direction

      This is critical for financial services, given the intensity and frequency of regulations this millenia (2002 on). Having an organization that is agile, in addition to having infrastructure that is agile. Imagine a mortgage company that can consume new regulations by reading, analyzing and implementing in operations, compliance (tracking, attestation, reporting) with relative ease - massive competitive advantage. Now imagine a mortgage company that innovates and is ahead of regulations and is ensuring that they are competitive through efficiencies and innovative products without introducing unnecessary risk to customers or to themselves through questionable practices. Possibly unstoppable?

  15. May 2016
    1. Slower metabolisms were not the only reason the contestants regained weight, though. They constantly battled hunger, cravings and binges. The investigators found at least one reason: plummeting levels of leptin. The contestants started out with normal levels of leptin. By the season’s finale, they had almost no leptin at all, which would have made them ravenous all the time. As their weight returned, their leptin levels drifted up again, but only to about half of what they had been when the season began, the researchers found, thus helping to explain their urges to eat.Leptin is just one of a cluster of hormones that control hunger, and although Dr. Hall and his colleagues did not measure the rest of them, another group of researchers, in a different project, did. In a one-year study funded by Australia’s National Health and Medical Research Council, Dr. Joseph Proietto of the University of Melbourne and his colleagues recruited 50 overweight people who agreed to consume just 550 calories a day for eight or nine weeks. They lost an average of nearly 30 pounds, but over the next year, the pounds started coming back.
  16. Feb 2015
    1. Note: creating multiple accounts or teams solely to circumvent limits on the "purchased" in silico data is grounds for disqualification.

      Multi account rules

  17. Feb 2014
    1. e the core of commons-based peer production entails provisioning withou t direct appropriation and since indirect appropriation—intrinsic or extrinsic—does not rely on control of the information but on its widest possible availability, intellectual property offers no gain, only loss, to peer production. While it is true that free software currently uses copyright-based licensing to prevent certain kinds of defection from peer production processes, that strategy is needed only as a form of institutional jiujitsu to defend from intellectual property. 136 A complete absence of property in the software domain would be at least as congenial to free software development as the condition where property exists, but copyright permits free soft ware projects to use licensing to defend themselves from defection. The same protection from defection might be provided by other means as well, such as creating simple public mechanisms for contributing one’s work in a way that makes it unsusceptible to downstream appropriation—a conservancy of sorts. Regulators concerned with fostering innovation may better direct their efforts toward providing the institutional tools that would help thousands of people to collaborate without appropriating their joint product, making the information they produce freely availabl e rather than spending their efforts to increase the scope and sophistication of the mechanisms for private appropriation of this public good as they now do.

      Conservancy of sorts would not protect appropriation int he form of secrecy. But "widest possible availability" hints at a different kind of regulation, mandated revelation -- which is exactly what source requiring copyleft (ie *GPL) aims to do.

    1. National governments are also weighing in on the issue. The UK government aims this April to make text-mining for non-commercial purposes exempt from copyright, allowing academics to mine any content they have paid for.

      UK government intervening to make text-mining for non-commercial purposes exempt from copyright.