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This is good for my purposes. It means high doses can be taken for brain effects without disturbing stomach acidity. The question remains, of course, whether coinciding CNS tolerance develops.

H1 antihistamines enhance the opioid high in humans. Hospitals sometimes administer antihistamines in combination with opioids. It's not hard to find people online who are using this combination recreationally.

This suggests that a beta 2 agonist may be appropriate for sleep.

Note: they appear to be talking about the number of dreams recalled (due to awakenings) rather than the actual number of dreams.

Surprisingly, beta-blockers, unlike alpha-blockers, appear to impair sleep.

Surprisingly, beta-blockers, unlike alpha-blockers, appear detrimental to sleep. I would speculate that this could be the result of a shift in autonomic tone, similar to how caffeine tends to lower heart rate.