The LLM took an entirely different route, using a formula that was well known in related parts of math, but which no one had thought to apply to this type of question.
大多数人认为数学突破需要全新的理论和创新方法，但作者认为AI能够通过重新组合和应用现有知识来解决问题，这挑战了人们对创新必须来自全新理论的认知，展示了AI独特的知识连接能力。
triggering homologous recombination and creating genetic instability10,11,12,13
dsDNA substrate is best for insertions or deletions greater than approximately 20 nucleotides, while ssDNA substrate is best for point mutations or changes of only a few base pairs.
Virological. ‘Recombinant SARS-CoV-2 Genomes Involving Lineage B.1.1.7 in the UK - SARS-CoV-2 Coronavirus / SARS-CoV-2 Molecular Evolution’, 17 March 2021. https://virological.org/t/recombinant-sars-cov-2-genomes-involving-lineage-b-1-1-7-in-the-uk/658.
Eric Feigl-Ding. (2020, December 6). HUMAN➡️MINKS➡️HUMAN transmission on mink farms in NL. 68% of the tested farm workers and/or contacts had evidence of #SARSCoV2 infection. The coronavirus mutated & even evolved within minks before transmitted back to humans—& keeps #COVID19 perpetuating. Https://t.co/5ARZ6Pq5mO https://t.co/fhrQC9ZVDo [Tweet]. @DrEricDing. https://twitter.com/DrEricDing/status/1335419078446551041
Aminimumof%20basepairsinacompletelyhomologoussegmentisrequiredforsignificantrecombination.Thereisanexponentialincreaseinthefre-quencyofrecombinationwhenthelengthofhomologousDNAisincreasedfrom20basepairsto74basepairsandanapparentlylinearincreasewithlongerDNAsegments.Mis-matcheswithinahomologoussegmentcandramaticallyde-creasethefrequencyofrecombination.
A minimum of 20 base pairs in a completely homologous segment is required for significant recombination. There is an exponential increase in the frequency of recombination when the length of homology increases from 20 to 74 bp and an apparently linear increase with longer DNA segments. Mismatches within a homologous segment can dramatically decrease the frequency of recombination.
How scientists know COVID-19 is way deadlier than the flu. (2020, July 2). Science. https://www.nationalgeographic.com/science/2020/07/coronavirus-deadlier-than-many-believed-infection-fatality-rate-cvd/
In E. coli, homologous recombination occurs most frequently when there is a contiguous stretch of sequence >25 bp