Eric Topol. (2021, October 27). 'The benefit of a third [booster] dose in reducing transmission is sizeable and increases with vaccine coverage and contact rates among individuals." https://medrxiv.org/content/10.1101/2021.10.25.21265500v1 by @billygardner and @DiseaseEcology https://t.co/zAZcJgF1nJ [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1453153076165021696

Eric Topol. (2021, October 27). 'The benefit of a third [booster] dose in reducing transmission is sizeable and increases with vaccine coverage and contact rates among individuals." https://medrxiv.org/content/10.1101/2021.10.25.21265500v1 by @billygardner and @DiseaseEcology https://t.co/zAZcJgF1nJ [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1453153076165021696

Moritz Gerstung. (2021, November 1). An update on currently circulating SARS-CoV-2 variants in England beyond AY.4.2. Based on data released weekly to http://covid19.sanger.ac.uk we’ve been monitoring the speed of spread of currently 232 lineages. It’s a very dynamic situation and at times hard to stay on top. 🧵 [Tweet]. @MoritzGerstung. https://twitter.com/MoritzGerstung/status/1455136551407689734

Eliminating SARS-CoV-2 was deemed plausible, because SARS-CoV-1 had been eliminated.

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ReconfigBehSci on Twitter: ‘RT @MOUGK: @AineToole and @viralverity built this incredible tool to visualise, integrate and track VOCs https://t.co/MRPJqdAkJ9 more updat…’ / Twitter. (n.d.). Retrieved 16 August 2021, from https://twitter.com/SciBeh/status/1395144412741603329

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Prof. Devi Sridhar. “Rest of the World Watching Closely: ‘In Scotland, Estimated That 92.5% of Adults Would Have Tested Positive for Antibodies against SARS-CoV-2 on a Blood Test in the Week Beginning 12 July 2021’- Is This Enough to Dampen Transmission & Protect under 12s from Infection? Under 18s?” Tweet. @devisridhar (blog), August 4, 2021. https://twitter.com/devisridhar/status/1422852550957617157.

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Miguel Hernán. (2021, February 15). To all who claim that there’s no evidence that #SARSCoV2 is transmitted in bars: If the risk of transmitting #SARSCoV2 is provenly greater in crowded indoor places, why should bars be magically protected? Burden of the proof is on bar’s owners, not on scientists @BillHanage [Tweet]. @_MiguelHernan. https://twitter.com/_MiguelHernan/status/1361463022187864066

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Since publication, the FDA has rescinded its authorisation of bamlanivimab (LY-CoV555), due to its lack of efficacy against circulating variants of concern, particularly B.1.351 (South African), as a result of E484K substitution A,B. Eli Lilly are now pursuing the use of their combination therapy of bamlanivimab with etesevimab (LY-CoV016).

The antibody cocktail REGN-CoV2 showed sustained efficacy against tested variant strains and thus remains a viable treatment option. However, a mutational library scan by Starr et al. revealed that a single amino acid change (E406W) is all that is required for a future variant to escape this therapy C.

Circulating variants highlight the limited efficacy of monoclonal antibodies to an evolving virus, particularly in those which are restricted to the RBD. A diverse panel of monoclonal antibodies, which bind subdominant epitopes may be a more sustainable approach.

A – Wang, P et al. Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7. 2021. Nature. https://doi.org/10.1038/s41586-021-03398-2

B – Starr, T.N.et al. Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal LY-CoV555 and its cocktail with LY-CoV016. 2021. Cell Reports Medicine. https://doi.org/10.1016/j.xcrm.2021.100255

C – Starr, T.N.et al. Prospective mapping of viral mutations that escape antibodies used to treat COVID-19. 2021. Science. https://doi.org/10.1126/science.abf9302

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Experiencing enough viral drift to produce an influenza variant capable of escaping population immunity is believed to take years of global circulation (not weeks of local circulation).

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Amy Maxmen, PhD. (2020, August 26). 🙄The CDC’s only substantial communication with the public in the pandemic is through its MMW Reports. But the irrelevant & erroneous 1st line of this latest report suggests political meddling to me. (The WHO doesn’t declare pandemics. They declare PHEICs, which they did Jan 30) https://t.co/Y1NlHbQIYQ [Tweet]. @amymaxmen. https://twitter.com/amymaxmen/status/1298660729080356864

ReconfigBehSci. (2021, February 9). RT @ChristoPhraser: Our paper on evaluating the first three months of the NHS COVID-19 app is out now as a pre-print. A 🧵 1/n https://t.co/… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1359132102927798275

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COVID-19 Living Evidence. (2020, October 23). Weekly update of COAP As of 23.10.2020, we have indexed 80588 publications: 8902 pre-prints 71686 peer-reviewed publications Pre-prints: BioRxiv, MedRxiv Peer-reviewed: PubMed, EMBASE https://t.co/RaDy1Wm4Hq https://t.co/FYRaYPe8oG [Tweet]. @evidencelive. https://twitter.com/evidencelive/status/1319578431848353793

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ReconfigBehSci. (2020, November 3). As debate on ‘saving the economy versus saving lives’ marches on, it’s worth noting that this type of contrast actually has a name in fallacy research: Https://t.co/N8U4ABWTuh it’s also worth noting that there is now a substantial number of research articles on the topic. 1/n [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1323603017179013130

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ReconfigBehSci. (2021, March 5). RT @theAliceRoberts: A new study predicts the effect of fully reopening schools—Pushing R up from 0.8 to between 1.1-1.5. R is very abst… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1369569328920727553

David R Tomlinson 💙. (2021, March 5). Truth. 💙 @FreshAirNHS @theRCN @TheBMA @mancunianmedic @DrLindaDykes @Chakladar_A @KGadhok https://t.co/Ke2C84KuaT https://t.co/C469qvrSoK [Tweet]. @DRTomlinsonEP. https://twitter.com/DRTomlinsonEP/status/1367962251211202566

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What would be the limit of detection of the new variants in the wastewater by this NGS based sequencing method?

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1169 proteins

180 nucleotides,1221 proteins

174 genomes

1442 genomes

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