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This variant presents 14 non-synonymous mutations, 6 synonymous mutations and 3 deletions. The multiple mutations present in the viral RNA encoding for the spike protein (S) are of most concern, such as the deletion Δ69-70, deletion Δ144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H
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Bloom Lab. (2020, June 18). "We've experimentally measured how all amino-acid mutations to the #SARSCoV2 spike RBD affect ACE2 binding and expression of folded protein in a deep mutational scanning study led by @tylernstarr & Allie Greaney:https://biorxiv.org/content/10.1101/2020.06.17.157982v1 Why is this important? (1/n)" Twitter. https://twitter.com/jbloom_lab/status/1273468539484213248
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Involucro multiorgánico.
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www.mpg.de www.mpg.de
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Dibujo muy bonito con énfasis en la proteína spike.
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twitter.com twitter.com
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SARS-CoV-2 en el epitelio respitario. Pendiente checar la fuente.
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twitter.com twitter.com
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Tweet de Nature Reviews Microbiology. Deadly killer.
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twitter.com twitter.com
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Choque cardiogénico con imagen ME.
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twitter.com twitter.com
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Tweet con un modelo tridimensional... Falta la fuente exacta.
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www.niaid.nih.gov www.niaid.nih.gov
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NIAID originales
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www.the-scientist.com www.the-scientist.com
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Imagen 3D en The Scientist
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www.nationalgeographic.com.es www.nationalgeographic.com.es
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Imágenes al microscopio en un artículo de divulgación de NatGeo España
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Imágenes del NIAID en artículo de NatGeo
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Esquema súper bonito de los blancos terapéuticos
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Estructura viral y respuesta del hospedero
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Inmunfluorescencia y efecto citopático
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Partículas virales en tejido renal
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Estructura cryo-EM del spike GP.
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Artículo con la primera descripción de casos de COVID-19 en China. ** Incluye la identificación del virus
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www.sciencedirect.com www.sciencedirect.com
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SARS-CoV PLpro
SARS-CoV PLpro PDB, 2fe8
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- Apr 2020
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jamanetwork-com.ezproxy.rice.edu jamanetwork-com.ezproxy.rice.edu
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We investigated the biodistribution of SARS-CoV-2 among different tissues of inpatients with coronavirus disease 2019 (COVID-19)
It would have been good to include 2-3 negative control samples in the data
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Four SARS-CoV-2 positive fecal specimens with high copy numbers were cultured
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pubs-acs-org.ezproxy.rice.edu pubs-acs-org.ezproxy.rice.edu
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Viruses have a direct connection to wastewater and drinking water purification when they are excreted in feces or urine
How does this compare with spit and nasal secretions which also connect to the wastewater? Is this a bigger source of viral particles in the case of a respiratory virus?
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Tang, J. W., & Settles, G. S. (2008). Coughing and Aerosols. New England Journal of Medicine, 359(15), e19. https://doi.org/10.1056/NEJMicm072576
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unidad_COVID2019 Investigaciones revisadas por pares de la fuente más confiable del mundo Página de acceso libre sin fines de lucro. Herramienta impulsada por la inteligencia artificial.
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www.cidrap.umn.edu www.cidrap.umn.eduCOVID-191
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unidad_COVID2019 Infografías sobre educación y manejo de los niños en casa. OMS
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unidad_COVID2019
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unidad_COVID2019
PMID: 31978945
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UNIDAD_COVID2019
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unidad_COVID2019
Calculadora de riesgo para predecir estado crítico al ingreso
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secardiologia.es secardiologia.es
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onlinelibrary.wiley.com onlinelibrary.wiley.com
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unidad_COVID2019
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interaktiv.morgenpost.de interaktiv.morgenpost.de
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doi.org doi.org
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stm-sciencemag-org.pbidi.unam.mx:2443 stm-sciencemag-org.pbidi.unam.mx:2443
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watermark.silverchair.com watermark.silverchair.com
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www-ncbi-nlm-nih-gov.pbidi.unam.mx:2443 www-ncbi-nlm-nih-gov.pbidi.unam.mx:2443
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