- Aug 2024
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Eric Topol. (2021, October 27). 'The benefit of a third [booster] dose in reducing transmission is sizeable and increases with vaccine coverage and contact rates among individuals." https://medrxiv.org/content/10.1101/2021.10.25.21265500v1 by @billygardner and @DiseaseEcology https://t.co/zAZcJgF1nJ [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1453153076165021696
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- Apr 2022
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ReconfigBehSci [@SciBeh]. ‘RT @vikkypaedia: B.1.1.529 Seems to Have Gone from 0.1% to 50% in Just a Couple of Weeks, When It Took Delta Several Months to Achieve That…’. Tweet. Twitter, 26 November 2021. https://twitter.com/SciBeh/status/1464194450406752282.
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ReconfigBehSci. (2021, March 5). RT @theAliceRoberts: A new study predicts the effect of fully reopening schools—Pushing R up from 0.8 to between 1.1-1.5. R is very abst… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1369569328920727553
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Amy Maxmen, PhD. (2020, August 26). 🙄The CDC’s only substantial communication with the public in the pandemic is through its MMW Reports. But the irrelevant & erroneous 1st line of this latest report suggests political meddling to me. (The WHO doesn’t declare pandemics. They declare PHEICs, which they did Jan 30) https://t.co/Y1NlHbQIYQ [Tweet]. @amymaxmen. https://twitter.com/amymaxmen/status/1298660729080356864
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ReconfigBehSci. (2021, February 9). RT @ChristoPhraser: Our paper on evaluating the first three months of the NHS COVID-19 app is out now as a pre-print. A 🧵 1/n https://t.co/… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1359132102927798275
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ReconfigBehSci. (2020, November 3). As debate on ‘saving the economy versus saving lives’ marches on, it’s worth noting that this type of contrast actually has a name in fallacy research: Https://t.co/N8U4ABWTuh it’s also worth noting that there is now a substantial number of research articles on the topic. 1/n [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1323603017179013130
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Miguel Hernán. (2021, February 15). To all who claim that there’s no evidence that #SARSCoV2 is transmitted in bars: If the risk of transmitting #SARSCoV2 is provenly greater in crowded indoor places, why should bars be magically protected? Burden of the proof is on bar’s owners, not on scientists @BillHanage [Tweet]. @_MiguelHernan. https://twitter.com/_MiguelHernan/status/1361463022187864066
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(1) ReconfigBehSci on Twitter: ‘RT @ahandvanish: New paper on 10,024 breakthrough infections shows that vaccination does not prevent #LongCovid. Https://t.co/8WurrqXRwy…’ / Twitter. (n.d.). Retrieved 29 October 2021, from https://twitter.com/SciBeh/status/1453638123624226822
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Moritz Gerstung. (2021, November 1). An update on currently circulating SARS-CoV-2 variants in England beyond AY.4.2. Based on data released weekly to http://covid19.sanger.ac.uk we’ve been monitoring the speed of spread of currently 232 lineages. It’s a very dynamic situation and at times hard to stay on top. 🧵 [Tweet]. @MoritzGerstung. https://twitter.com/MoritzGerstung/status/1455136551407689734
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ReconfigBehSci on Twitter: ‘RT @MOUGK: @AineToole and @viralverity built this incredible tool to visualise, integrate and track VOCs https://t.co/MRPJqdAkJ9 more updat…’ / Twitter. (n.d.). Retrieved 16 August 2021, from https://twitter.com/SciBeh/status/1395144412741603329
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ReconfigBehSci on Twitter: ‘RT @theosanderson: Introducing 🌳https://t.co/m8MusGFkpI: a new tool that lets you dive into a tree of more than a million public SARS-CoV-2…’ / Twitter. (n.d.). Retrieved 16 August 2021, from https://twitter.com/SciBeh/status/1412418927871864835
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Comparative sensitivity evaluation for 122 CE-marked rapid diagnostic tests for SARS-CoV-2 antigen, Germany, September 2020 to April 2021
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Eric Topol. (2021, October 27). 'The benefit of a third [booster] dose in reducing transmission is sizeable and increases with vaccine coverage and contact rates among individuals." https://medrxiv.org/content/10.1101/2021.10.25.21265500v1 by @billygardner and @DiseaseEcology https://t.co/zAZcJgF1nJ [Tweet]. @EricTopol. https://twitter.com/EricTopol/status/1453153076165021696
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Eliminating Covid-19 seemed theoretically possible, because the original 2002 SARS virus ultimately disappeared.
Eliminating SARS-CoV-2 was deemed plausible, because SARS-CoV-1 had been eliminated.
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Prof. Devi Sridhar. “Rest of the World Watching Closely: ‘In Scotland, Estimated That 92.5% of Adults Would Have Tested Positive for Antibodies against SARS-CoV-2 on a Blood Test in the Week Beginning 12 July 2021’- Is This Enough to Dampen Transmission & Protect under 12s from Infection? Under 18s?” Tweet. @devisridhar (blog), August 4, 2021. https://twitter.com/devisridhar/status/1422852550957617157.
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Since publication, the FDA has rescinded its authorisation of bamlanivimab (LY-CoV555), due to its lack of efficacy against circulating variants of concern, particularly B.1.351 (South African), as a result of E484K substitution A,B. Eli Lilly are now pursuing the use of their combination therapy of bamlanivimab with etesevimab (LY-CoV016).
The antibody cocktail REGN-CoV2 showed sustained efficacy against tested variant strains and thus remains a viable treatment option. However, a mutational library scan by Starr et al. revealed that a single amino acid change (E406W) is all that is required for a future variant to escape this therapy C.
Circulating variants highlight the limited efficacy of monoclonal antibodies to an evolving virus, particularly in those which are restricted to the RBD. A diverse panel of monoclonal antibodies, which bind subdominant epitopes may be a more sustainable approach.
A – Wang, P et al. Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7. 2021. Nature. https://doi.org/10.1038/s41586-021-03398-2
B – Starr, T.N.et al. Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal LY-CoV555 and its cocktail with LY-CoV016. 2021. Cell Reports Medicine. https://doi.org/10.1016/j.xcrm.2021.100255
C – Starr, T.N.et al. Prospective mapping of viral mutations that escape antibodies used to treat COVID-19. 2021. Science. https://doi.org/10.1126/science.abf9302
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Acquiring viral drift sufficient to produce new influenza strains capable of escaping population immunity is believed to take years of global circulation, not weeks of local circulation.
Experiencing enough viral drift to produce an influenza variant capable of escaping population immunity is believed to take years of global circulation (not weeks of local circulation).
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David R Tomlinson 💙. (2021, March 5). Truth. 💙 @FreshAirNHS @theRCN @TheBMA @mancunianmedic @DrLindaDykes @Chakladar_A @KGadhok https://t.co/Ke2C84KuaT https://t.co/C469qvrSoK [Tweet]. @DRTomlinsonEP. https://twitter.com/DRTomlinsonEP/status/1367962251211202566
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Virological. ‘Recombinant SARS-CoV-2 Genomes Involving Lineage B.1.1.7 in the UK - SARS-CoV-2 Coronavirus / SARS-CoV-2 Molecular Evolution’, 17 March 2021. https://virological.org/t/recombinant-sars-cov-2-genomes-involving-lineage-b-1-1-7-in-the-uk/658.
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Sridhar, Devi. ‘COVID-19: What Health Experts Could and Could Not Predict’. Nature Medicine 26, no. 12 (December 2020): 1812–1812. https://doi.org/10.1038/s41591-020-01170-z.
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- Feb 2021
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www.biorxiv.org www.biorxiv.org
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Wibmer, C. K., Ayres, F., Hermanus, T., Madzivhandila, M., Kgagudi, P., Lambson, B. E., Vermeulen, M., Berg, K. van den, Rossouw, T., Boswell, M., Ueckermann, V., Meiring, S., Gottberg, A. von, Cohen, C., Morris, L., Bhiman, J. N., & Moore, P. L. (2021). SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. BioRxiv, 2021.01.18.427166. https://doi.org/10.1101/2021.01.18.427166
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- Jan 2021
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Sadoff, J., Le Gars, M., Shukarev, G., Heerwegh, D., Truyers, C., de Groot, A. M., Stoop, J., Tete, S., Van Damme, W., Leroux-Roels, I., Berghmans, P.-J., Kimmel, M., Van Damme, P., de Hoon, J., Smith, W., Stephenson, K. E., De Rosa, S. C., Cohen, K. W., McElrath, M. J., … Schuitemaker, H. (2021). Interim Results of a Phase 1–2a Trial of Ad26.COV2.S Covid-19 Vaccine. New England Journal of Medicine, 0(0), null. https://doi.org/10.1056/NEJMoa2034201
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This variant presents 14 non-synonymous mutations, 6 synonymous mutations and 3 deletions. The multiple mutations present in the viral RNA encoding for the spike protein (S) are of most concern, such as the deletion Δ69-70, deletion Δ144, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H
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medrxiv.org medrxiv.org
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What would be the limit of detection of the new variants in the wastewater by this NGS based sequencing method?
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