32 Matching Annotations
  1. Jul 2021
  2. Jun 2021
    1. Dr Emma Hodcroft. (2021, May 2). 🗓️https://t.co/wVE7ubYBoy is updated🗓️, with some cool new additions: - B.1.617.1/2 are added as 20A/S:154K & 20A/S:478K 🎉—Beautiful new name table 📑🍾—Mutation list displayed in full as a ‘side-sausage’🌭 Let’s take a tour... 😁 1/7 [Tweet]. @firefoxx66. https://twitter.com/firefoxx66/status/1388921325411053569

  3. May 2021
    1. .

      Since publication, the FDA has rescinded its authorisation of bamlanivimab (LY-CoV555), due to its lack of efficacy against circulating variants of concern, particularly B.1.351 (South African), as a result of E484K substitution A,B. Eli Lilly are now pursuing the use of their combination therapy of bamlanivimab with etesevimab (LY-CoV016).

      The antibody cocktail REGN-CoV2 showed sustained efficacy against tested variant strains and thus remains a viable treatment option. However, a mutational library scan by Starr et al. revealed that a single amino acid change (E406W) is all that is required for a future variant to escape this therapy C.

      Circulating variants highlight the limited efficacy of monoclonal antibodies to an evolving virus, particularly in those which are restricted to the RBD. A diverse panel of monoclonal antibodies, which bind subdominant epitopes may be a more sustainable approach.


      A – Wang, P et al. Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7. 2021. Nature. https://doi.org/10.1038/s41586-021-03398-2

      B – Starr, T.N.et al. Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal LY-CoV555 and its cocktail with LY-CoV016. 2021. Cell Reports Medicine. https://doi.org/10.1016/j.xcrm.2021.100255

      C – Starr, T.N.et al. Prospective mapping of viral mutations that escape antibodies used to treat COVID-19. 2021. Science. https://doi.org/10.1126/science.abf9302

  4. Apr 2021
    1. unexpected extra cluster of positive droplets with fluorescence intensity less than the cluster containing the target of interest can be caused by a sequence variant in the target of interest
  5. Mar 2021
    1. Wang, P., Nair, M. S., Liu, L., Iketani, S., Luo, Y., Guo, Y., Wang, M., Yu, J., Zhang, B., Kwong, P. D., Graham, B. S., Mascola, J. R., Chang, J. Y., Yin, M. T., Sobieszczyk, M., Kyratsous, C. A., Shapiro, L., Sheng, Z., Huang, Y., & Ho, D. D. (2021). Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7. Nature, 1–9. https://doi.org/10.1038/s41586-021-03398-2

    1. It does this by creating links to specially crafted URLs using custom schemes (ie. "txmt", "subl", "mvim"). I prefer to use standard CLI vim in iTerm.

      I have similar problem: want to use regular vim in tilix terminal

    1. vim-athena doesn't depend on or use any version of GTK+. If you use sudo apt-get build-dep vim-athena, it probably will install GTK+ and GNOME related libraries, because the vim-athena binary package is built from the same source package as vim and other vim-providing packages. In any case, you shouldn't need to build from source, as the binaries provided by vim-athena are already built against Athena and not against GTK+ or other graphical toolkits.
    2. Fortunately, vim officially supports some GUI's other than GTK+ and Qt, and one such build is officially packaged for Ubuntu. Just install the Athena version of vim, which is provided by the vim-athena package.
    3. If you built vim against Qt rather than GTK+ and python-complete still isn't working, that suggests the problem isn't actually a consequence of trying to link to both GTK+2 and GTK+3.
    4. How can I build vim with a gui without gtk?

      I had this question too, but didn't know that was the question I had... :)

    1. How to install VIM with all options/features? - VIM
    2. If you want to compile youself you can pass the --with-features=huge to the configure script. Note, however, this does not enable the different language bindings because those are mostly optional and also the various GUIs need to enabled specifically, because you can have only one gui.

      This explains why the standard vim package on ubuntu doesn't have GUI support (I was going to say because it wouldn't know which GUI you needed, but I think it would based on the Ubuntu variant: GNOME, KDE, etc.) (maybe because it wouldn't know whether you wanted GUI support at all)

      I was going to say because it wouldn't know which GUI you needed, but I think it would based on the Ubuntu variant: GNOME, KDE, etc.

      found answer to that: https://hyp.is/NyJRxIgqEeuNmWuaScborw/askubuntu.com/questions/345593/how-to-build-vim-with-gui-option-from-sources

      so you have to install a different package with GUI support, like vim-gtk or vim-athena

    1. vim-athena

      Importantly, to me, you can do this:

      /usr/bin/vim.athena --servername local
      
    2. Including the vim package, there appear to be at least six "vim-variants" (not including available documentation, or plugin packages) as well as the main vim package in both the main and universe repositories.
    1. If you call ./configure --enable-gui=auto, the build process will automatically build against whichever GUI libraries are available. A cursory glance suggests that gtk2 will be prioritised over gnome2.
  6. Feb 2021
  7. Jan 2021
  8. Jul 2020