- Feb 2022
Afkhami, S., D’Agostino, M. R., Zhang, A., Stacey, H. D., Marzok, A., Kang, A., Singh, R., Bavananthasivam, J., Ye, G., Luo, X., Wang, F., Ang, J. C., Zganiacz, A., Sankar, U., Kazhdan, N., Koenig, J. F. E., Phelps, A., Gameiro, S. F., Tang, S., … Xing, Z. (2022). Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2. Cell, S0092867422001453. https://doi.org/10.1016/j.cell.2022.02.005
Prof. Akiko Iwasaki. (2022, January 27). Vaccines that reduce infection & disease are needed to combat the pandemic. Here, @tianyangmao @BenIsraelow et al. Describe our new mucosal booster strategy, Prime and Spike, to induce such immunity via nasal delivery of unadjuvanted spike vaccine 🧵 (1/) https://biorxiv.org/content/10.1101/2022.01.24.477597v1 https://t.co/bcB5MFph9F [Tweet]. @VirusesImmunity. https://twitter.com/VirusesImmunity/status/1486510697332842498
- prime and spike
- nasal delivery
- clinical trials
- spike protein
- Dec 2017
A beneficial impact of the fat quality on insulin sensitivity is not seen in individuals with a high fat intake (> 37E%).
This is likely do to the reduced carbohydrate intake rather than increased fat intake. Since carbohydrates generally insulin sensitivity, it's likely that this additional insulin resistance is acting as a confounder (as well as, presumably, a standard deviation widener). Thus, I would expect similar results during hypocaloric carbohydrate restriction.
- diabetes / insulin sensitivity/resistance / blood sugar
- fatty acid / fat / LCSFA(s) /
- diet health lifestyle disease prevention and reversal food nutrients nutrition eat
- saturated fatty acid fat LCSFAs unsaturated ceramide intramuscular triglycerides intramyocellular lipid
- diabetes insulin sensitivity resistance blood sugar
- research note