- Mar 2022
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www.theatlantic.com www.theatlantic.com
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Heathers, J. (2021, October 23). The Real Scandal About Ivermectin. The Atlantic. https://www.theatlantic.com/science/archive/2021/10/ivermectin-research-problems/620473/
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twitter.com twitter.com
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Edward Nirenberg 🇺🇦. (2022, March 2). I see a lot of people sharing a document from Pfizer describing pharmacovigilance data from spontaneous reporting and the vast, vast majority of people are not interpreting it correctly so here’s a thread on what it actually says. 🧵 https://phmpt.org/wp-content/uploads/2021/11/5.3.6-postmarketing-experience.pdf [Tweet]. @ENirenberg. https://twitter.com/ENirenberg/status/1498852915758485509
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www.theguardian.com www.theguardian.com
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Geddes, L., & correspondent, L. G. S. (2022, March 2). Scientists seek to solve mystery of why some people do not catch Covid. The Guardian. https://www.theguardian.com/world/2022/mar/02/scientists-seek-to-solve-mystery-of-why-some-people-do-not-catch-covid
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- Feb 2022
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gidmk.medium.com gidmk.medium.com
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Nerd, G. M.-K. H. (2022, February 25). The Jury is Still Out on Ivermectin. Medium. https://gidmk.medium.com/the-jury-is-still-out-on-ivermectin-7d0a1895549
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Mancini, D. P., & Smyth, J. (2022, February 16). Merck struggles to win European approval for Covid-19 antiviral pill. Financial Times. https://www.ft.com/content/2cf0b6cc-b07b-4ff9-a833-42eb1798a576
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www.theatlantic.com www.theatlantic.com
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Yong, E. (2022, February 16). The Millions of People Stuck in Pandemic Limbo. The Atlantic. https://www.theatlantic.com/health/archive/2022/02/covid-pandemic-immunocompromised-risk-vaccines/622094/
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assets.publishing.service.gov.uk assets.publishing.service.gov.uk
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Academics: Viral Evolution Scenarios, 10 February 2022. (n.d.). GOV.UK. Retrieved February 14, 2022, from https://www.gov.uk/government/publications/academics-viral-evolution-scenarios-10-february-2022
Tags
- antiviral drug resistance
- therapeutic
- surveillance
- vaccine
- variant
- transmissibility
- lang:en
- vaccination
- antigenic escape
- COVID-19
- heterogeneity
- immune escape
- testing
- severity
- waning immunity
- prediction
- viral evolution
- infection
- vaccine efficacy
- protection
- UK
- is:report
- scenario
- immunity
Annotators
URL
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twitter.com twitter.com
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ReconfigBehSci. (2022, January 20). @timcolbourn @OmicronData I’m sorry but I genuinely do not see how this is a response to what I said about the presuppositions in the ‘delay framing’? This reply is about your views on disease burden, not -as mine is- how choice of terminology implicitly shapes the argument space [Tweet]. @i. https://twitter.com/i/web/status/1484191657318879234
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www.bmj.com www.bmj.com
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Agarwal, A., Rochwerg, B., Lamontagne, F., Siemieniuk, R. A., Agoritsas, T., Askie, L., Lytvyn, L., Leo, Y.-S., Macdonald, H., Zeng, L., Amin, W., Barragan, F. A., Bausch, F. J., Burhan, E., Calfee, C. S., Cecconi, M., Chanda, D., Dat, V. Q., Sutter, A. D., … Vandvik, P. O. (2020). A living WHO guideline on drugs for covid-19. BMJ, 370, m3379. https://doi.org/10.1136/bmj.m3379
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www.nature.com www.nature.com
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Meng, B., Abdullahi, A., Ferreira, I. A. T. M., Goonawardane, N., Saito, A., Kimura, I., Yamasoba, D., Gerber, P. P., Fatihi, S., Rathore, S., Zepeda, S. K., Papa, G., Kemp, S. A., Ikeda, T., Toyoda, M., Tan, T. S., Kuramochi, J., Mitsunaga, S., Ueno, T., … Gupta, R. K. (2022). Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature, 1–1. https://doi.org/10.1038/s41586-022-04474-x
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- Nov 2021
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www.science.org www.science.org
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Couzin-Frankel, J. (2021). Antiviral pills could change pandemic’s course. Science, 374(6569), 799–800. https://doi.org/10.1126/science.acx9605
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- Oct 2021
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www.nature.com www.nature.com
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Mallapaty, S. (2021). The search for people who never get COVID. Nature. https://doi.org/10.1038/d41586-021-02978-6
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www.smh.com.au www.smh.com.au
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Alexander, H. (2021, October 21). How a false science ‘cure’ became Australia’s contribution to the pandemic. The Sydney Morning Herald. https://www.smh.com.au/national/how-a-false-science-cure-became-australia-s-contribution-to-the-pandemic-20211013-p58zp3.html
Tags
- ivermectin
- lang:en
- overdose
- cure
- contribution
- is:article
- false science
- Australia
- death
- scientist
- COVID-19
- testing
- laboratory
- pandemic
- drug
- dread
Annotators
URL
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science.thewire.in science.thewire.in
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Aeschlimann, J. R. (2021, October 15). Ivermectin Treats Many Infections in Humans – Just Not COVID-19. The Wire Science. https://science.thewire.in/health/ivermectin-treats-many-infections-in-humans-just-not-covid-19/
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timesofindia.indiatimes.com timesofindia.indiatimes.com
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ICMR drops Ivermectin, Hydroxychloroquine drugs from Covid treatment. (2021, September 24). The Times of India. https://timesofindia.indiatimes.com/india/icmr-drops-ivermectin-hydroxychloroquine-drugs-from-covid-treatment/articleshow/86475906.cms?__twitter_impression=true
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Abbas-Hanif, A., Modi, N., Smith, S. K., & Majeed, A. (2021). Covid-19 treatments and vaccines must be evaluated in pregnancy. BMJ, n2377. https://doi.org/10.1136/bmj.n2377
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Willyard, C. (2021). How antiviral pill molnupiravir shot ahead in the COVID drug hunt. Nature. https://doi.org/10.1038/d41586-021-02783-1
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www.theguardian.com www.theguardian.com
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Robins-Early, N. (2021, September 24). Desperation, misinformation: How the ivermectin craze spread across the world. The Guardian. https://www.theguardian.com/world/2021/sep/24/ivermectin-covid-peru-misinformation
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www.hindustantimes.com www.hindustantimes.com
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ICMR removes Ivermectin, HCQ from revised guidelines on Covid-19 treatment. (2021, September 24). Hindustan Times. https://www.hindustantimes.com/india-news/icmr-removes-ivermectin-hcq-from-revised-guidelines-on-covid-19-treatment-101632461755113.html
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Maxmen, Amy. ‘The Fight to Manufacture COVID Vaccines in Lower-Income Countries’. Nature 597, no. 7877 (15 September 2021): 455–57. https://doi.org/10.1038/d41586-021-02383-z.
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- Sep 2021
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www.fda.gov www.fda.gov
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Commissioner, O. of the. (2021, August 16). Coronavirus (COVID-19) Update: FDA Authorizes Additional Vaccine Dose for Certain Immunocompromised Individuals. FDA. https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-authorizes-additional-vaccine-dose-certain-immunocompromised
Tags
- immuncompromise
- Moderna
- dose
- is:news
- vaccine
- lang:en
- USA
- Pfizer-BioNTech
- COVID-19
- FDA
- Food and Drug Administration
Annotators
URL
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- Jun 2021
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www.theguardian.com www.theguardian.com
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Rapid Covid tests used in mass UK programme get scathing US report | Coronavirus | The Guardian. (n.d.). Retrieved June 12, 2021, from https://www.theguardian.com/world/2021/jun/11/us-health-agency-gives-innova-lateral-flow-covid-tests-scathing-review
Tags
- is:news
- FDA
- lang:en
- mass testing
- government
- COVID-19
- lateral flow
- USA
- risk
- US Food and Drug Agency
- Innova
- concern
- rapid COVID test
- data
- UK
- accuracy
- intervention
Annotators
URL
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www.theguardian.com www.theguardian.com
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Summers, C. (2021, June 8). Oxygen shortages are killing thousands. Why aren’t we doing more about this? | Charlotte Summers. The Guardian. http://www.theguardian.com/commentisfree/2021/jun/08/oxygen-shortages-killing-vaccines-drugs
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www.migrationencounters.org www.migrationencounters.org
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And that's the day I got caught up with the blunt in my ear and the security caught me. From there on, I had to go to court fighting the cases and then basically I just like—
Time in US - encounters with police - arrest Drug - taking drugs
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When you smoke, it makes you feel like nothing is important. All your problems go away basically. And it was just like a coping mechanism to just go on every day with my life. I felt like if I didn't have that, there was no point. My life was whack.... There was one point in time that I had to smoke before I do something fun.
Time in US - taking drugs - coping mechanism - addiction
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I don't like to be high because I used to fight a lot. I would always see that when I would smoke, I would always get beat up. This is an everyday thing fighting, because you have to. You are in the wrong hood, you're wearing the wrong color, you're going to get beat up.
Time in US - drugs - taking drugs - affiliation with gangs - fights
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It was a hotel casino. And the security stopped me and they told me, “What was that?” And since it was marijuana was illegal they told me I had to go to jail. So I went to jail. I stayed a day—
Leaving the US - reason for exit - drug possession
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- Apr 2021
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www.politico.eu www.politico.eu
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Deutsch, J. (2021, April 20). Oxford/AstraZeneca vaccine shortfall due to production woes in EU: Documents. POLITICO. https://www.politico.eu/article/astrazeneca-vaccine-shortfall-production-woes-documents/
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www.theguardian.com www.theguardian.com
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EU drug agency denies already finding causal link between AstraZeneca vaccine and blood clots. (2021, April 6). The Guardian. http://www.theguardian.com/world/2021/apr/06/ema-denies-already-finding-causal-link-astrazeneca-vaccine-blood-clots
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- Feb 2021
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science.sciencemag.org science.sciencemag.org
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Gordon, D. E., Hiatt, J., Bouhaddou, M., Rezelj, V. V., Ulferts, S., Braberg, H., Jureka, A. S., Obernier, K., Guo, J. Z., Batra, J., Kaake, R. M., Weckstein, A. R., Owens, T. W., Gupta, M., Pourmal, S., Titus, E. W., Cakir, M., Soucheray, M., McGregor, M., … Krogan, N. J. (2020). Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370(6521). https://doi.org/10.1126/science.abe9403
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Mannix, L. (2021, February 8). Where did these COVID-19 variants come from – and what are they? The Sydney Morning Herald. https://www.smh.com.au/national/what-do-new-variants-of-the-coronavirus-mean-for-us-20210126-p56wuo.html
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- Sep 2020
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www.thelancet.com www.thelancet.com
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Diseases, T. L. I. (2020). Curing COVID-19. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(20)30706-4
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www.reuters.com www.reuters.com
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Exclusive: In Russia, a black market for HIV drug to try on coronavirus. (2020, April 20). Reuters. https://www.reuters.com/article/us-health-coronavirus-russia-hiv-exclusi-idUSKBN2220W1
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search-credoreference-com.ccsf.idm.oclc.org search-credoreference-com.ccsf.idm.oclc.org
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Specifically, social workers assist families by making referrals for alcohol and drug assessments, inpatient and outpatient treatment programs, family therapy, and support groups such as Alcoholics Anonymous
What is the success rate of these programs? They DO NOT work... People with addiction problems need one on one help so they can understand their situation and what's going on i in their heads, and how they are impacting their children....
The groups give them a swamp/ place to dwell. With Lillian, it was a place for her to feel sorry for herself and for others to "comfort" her. When she came home, we were the bad guys for not understanding.
- programs are not a one size fit all. If they work at all.
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Mathew, M. (2020). Lockdown stress amid COVID-19 on Alcoholics and Drug addicts [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/an8m4
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- Aug 2020
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www.siliconrepublic.com www.siliconrepublic.com
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Gorey, C. (2020, June 29). RCSI team to start trial for promising Covid-19 therapy for severe infections. Silicon Republic. https://www.siliconrepublic.com/innovation/rcsi-trial-covid-19-therapy-alpha-1-antitrypsin
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www.biorxiv.org www.biorxiv.org
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Qin, M., Cao, Z., Wen, J., Yu, Q., Liu, C., Wang, F., Yang, F., Li, Y., Fishbein, G., Yan, S., Xu, B., Hou, Y., Ning, Z., Nie, K., Jiang, N., Liu, Z., Wu, J., Yu, Y., Li, H., … Lu, Y. (2020). An Antioxidant Enzyme Therapeutic for COVID-19. BioRxiv, 2020.07.15.205211. https://doi.org/10.1101/2020.07.15.205211
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www.biorxiv.org www.biorxiv.org
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Chen, Y., Yang, W.-H., Huang, L.-M., Wang, Y.-C., Yang, C.-S., Liu, Y.-L., Hou, M.-H., Tsai, C.-L., Chou, Y.-Z., Huang, B.-Y., Hung, C.-F., Hung, Y.-L., Chen, J.-S., Chiang, Y.-P., Cho, D.-Y., Jeng, L.-B., Tsai, C.-H., & Hung, M.-C. (2020). Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 main protease by tafenoquine in vitro. BioRxiv, 2020.08.14.250258. https://doi.org/10.1101/2020.08.14.250258
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www.forbes.com www.forbes.com
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Togoh, I. (n.d.). After Hydroxychloroquine, Trump Is Now Seeking To Get Another Unproven Drug Approved By The FDA: Report. Forbes. Retrieved August 22, 2020, from https://www.forbes.com/sites/isabeltogoh/2020/08/17/after-hydroxychloroquine-trump-is-now-seeking-to-get-another-unproven-drug-approved-by-the-fda-report/
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Luban, J., Sattler, R., Mühlberger, E., Graci, J. D., Cao, L., Weetall, M., Trotta, C., Colacino, J. M., Bavari, S., Strambio-De-Castillia, C., Suder, E. L., Wang, Y., Soloveva, V., Cintron-Lue, K., Naryshkin, N. A., Pykett, M., Welch, E. M., O’Keefe, K., Kong, R., … Peltz, S. (2020). The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines. BioRxiv, 2020.08.05.238394. https://doi.org/10.1101/2020.08.05.238394
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www.nber.org www.nber.org
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Lo, A. W., Siah, K. W., & Wong, C. H. (2020). Estimating Probabilities of Success of Vaccine and Other Anti-Infective Therapeutic Development Programs (Working Paper No. 27176; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27176
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www.nber.org www.nber.org
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Manski, C. F., & Tetenov, A. (2020). Statistical Decision Properties of Imprecise Trials Assessing COVID-19 Drugs (Working Paper No. 27293; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27293
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www.nature.com www.nature.com
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Hoffmann, M., Mösbauer, K., Hofmann-Winkler, H., Kaul, A., Kleine-Weber, H., Krüger, N., Gassen, N. C., Müller, M. A., Drosten, C., & Pöhlmann, S. (2020). Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2. Nature, 1–5. https://doi.org/10.1038/s41586-020-2575-3
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- Jul 2020
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www.newscientist.com www.newscientist.com
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Vaughan, A. (n.d.). Which covid-19 treatments work and how close are we to getting more? New Scientist. Retrieved 31 July 2020, from https://www.newscientist.com/article/2250176-which-covid-19-treatments-work-and-how-close-are-we-to-getting-more/
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- Jun 2020
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www.nature.com www.nature.com
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Ledford, H. (2020). Coronavirus breakthrough: Dexamethasone is first drug shown to save lives. Nature, d41586-020-01824–01825. https://doi.org/10.1038/d41586-020-01824-5
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www.theatlantic.com www.theatlantic.com
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Zhang, S. (2020, April 8). The Best Hopes for a Coronavirus Drug. The Atlantic. https://www.theatlantic.com/science/archive/2020/04/what-coronavirus-drug-will-look-like/609661/
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www.theguardian.com www.theguardian.com
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Boseley, Sarah, and Melissa Davey. ‘Covid-19: Lancet Retracts Paper That Halted Hydroxychloroquine Trials’. The Guardian, 4 June 2020, sec. World news. https://www.theguardian.com/world/2020/jun/04/covid-19-lancet-retracts-paper-that-halted-hydroxychloroquine-trials.
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- May 2020
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jamanetwork.com jamanetwork.com
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Stephenson, J. (2020). European Medicines Agency Tackles Potential Shortages of Drugs for Treating COVID-19. JAMA Health Forum, 1(4), e200485–e200485. https://doi.org/10.1001/jamahealthforum.2020.0485
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theconversation.com theconversation.com
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Hoffman, T. & Glasziou, P. (2020 May 05). Coronavirus: What if a vaccine doesn’t work? World Economic Forum. https://www.weforum.org/agenda/2020/05/vaccine-coronavirus-alternatives-covid19-vaccinations/
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www.thelancet.com www.thelancet.com
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Lipsitch, M., Perlman, S., & Waldor, M. K. (2020). Testing COVID-19 therapies to prevent progression of mild disease. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(20)30372-8
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- Apr 2020
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www.thelancet.com www.thelancet.com
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Mullard, A. (2020). Flooded by the torrent: The COVID-19 drug pipeline. The Lancet, 395(10232), 1245–1246. https://doi.org/10.1016/S0140-6736(20)30894-1
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www.dw.com www.dw.com
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Weiss, S. (2020 April 04). How the coronavirus lockdown is hitting Mexico's drug cartels. DW. https://p.dw.com/p/3aOBU
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- Aug 2019
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app.syrf.org.uk app.syrf.org.uk
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3,5,4'-trihydroxy-6,7,3'-trimethoxyflavone
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achillolide A
Drug
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- Mar 2019
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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CONCLUSION: Tolerance to famotidine occurs during continuous administration for 14 days, as previously shown in ranitidine studies.
This is good for my purposes. It means high doses can be taken for brain effects without disturbing stomach acidity. The question remains, of course, whether coinciding CNS tolerance develops.
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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We have previously shown that antinociceptive effects of morphine are enhanced in histamine H1 receptor gene knockout mice.
H1 antihistamines enhance the opioid high in humans. Hospitals sometimes administer antihistamines in combination with opioids. It's not hard to find people online who are using this combination recreationally.
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- Feb 2019
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www.independent.co.uk www.independent.co.uk
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The nomination has sparked criticism, however, over Mr Azar’s own track record at Eli Lilly, a pharmaceuticals giant that was one of several to repeatedly increased the price of insulin, a life-saving drug used to treat diabetes.
The man should be prosecuted. Evil!
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- Mar 2018
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www.mnemotext.com www.mnemotext.com
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In the past decade, the academic debate over cognitive enhancement (CE) unfolded largely isolated from the notoriously thorny debates about drug policy reform and the successes and failures of the international drug control regime (ICR). In hindsight, this approach proved beneficial
Debate over drug policy has been a long history in the United States. More drugs are starting to be legal in the United States because some may be used for prescription for to treat a disease. There has been a bad side against prescription drugs because many Americans are abusing prescription drugs. Prescription drug abuse is a social problem in the United States. Some prescription drugs are leading to health issues because many people do not care about the side effects. Overall the annotation reminded me of todays issue against drugs and how we are using it against many different diseases.
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- Mar 2017
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vivisectioninformation.com vivisectioninformation.com
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Unfortunately, penicillin was ineffective against the rabbit's infection. Disappointed, Fleming set the drug aside for a decade, as the rabbits had "proved" the drug was useless as a systemic medication.Years later, he administered the drug in desperation to a dying patient, for whom all other treatments were ineffectual. The penicillin performed a miracle, and the rest is history.
Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.
Article: Understanding animal research
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www.understandinganimalresearch.org.uk www.understandinganimalresearch.org.uk
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Had Fleming himself carried out a simple and well established animal test - the mouse protection test - the potential of his discovery might have been realised 10 years earlier
Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.
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- Dec 2016
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www.nature.com www.nature.com
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Top 10
Nature Reviews Drug Discovery Top 10 is must to read
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- Sep 2016
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rxshoppingmart.com rxshoppingmart.com
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RxShoppingMart has added a brand new and an elegant transport and delivery mechanism inside the global ofonline drug. flat 5% reductions to our returning clients.
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- Sep 2015
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www.theatlantic.com www.theatlantic.com
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Examining a sample of states, Neal found that from 1985 to 2000, the likelihood of a long prison sentence nearly doubled for drug possession, tripled for drug trafficking
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- Jul 2015
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www.hautmanhomeopathy.com www.hautmanhomeopathy.com
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Homeopathy, on the other hand, uses highly diluted and succussed doses of natural substances - usually plants and minerals. It is this dilution that makes homeopathy safer than allopathy and herbalism, and the succussion that allows remedies to retain their effectiveness, despite their high dilution. This ‘minimum dose’ concept is one of the key principles of homeopathy, also developed in the late 1800's.
Surprisingly this author does not even seem to know the real history of homeopathy. It was invented in the late 18th century not the `late 1800's' (sic - incorrect use of apostrophe).
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Allopathy (pharmaceutical medicine) uses extracts of active ingredients, often sourced from the same plants used by herbalists and homeopaths, that are then reproduced synthetically and highly concentrated in laboratories for use as drugs. This process is then patented, and was developed in the late 1800's.
This paragraph displays amazing ignorance of drug development. Firstly,`allopathy' is a pejorative term invented by homeopaths. It has no meaning in science or medicine.
Whereas modern pharmacy grew out of certain historical practices such as herbal medicine, most modern drugs are designed from a detailed knowledge of biochemical mechanisms. They are not extracts, are not necessarily highly concentrated, and are formulated as a result of rigorous dose-ranging studies in human subjects. It is untrue to claim that the drug development process used today is similar to that used in the late 1800s.
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- Jun 2015
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www.politico.com www.politico.com
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But the marriage equality movement has been curiously hostile to polygamy, and for a particularly unsatisfying reason: short-term political need.
I hope that the focus on prohibition by the drug policy reform movement helps sidestep a similar effect happening with cannabis.
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