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Edward Nirenberg 🇺🇦. (2022, March 2). I see a lot of people sharing a document from Pfizer describing pharmacovigilance data from spontaneous reporting and the vast, vast majority of people are not interpreting it correctly so here’s a thread on what it actually says. 🧵 https://phmpt.org/wp-content/uploads/2021/11/5.3.6-postmarketing-experience.pdf [Tweet]. @ENirenberg. https://twitter.com/ENirenberg/status/1498852915758485509

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Yong, E. (2022, February 16). The Millions of People Stuck in Pandemic Limbo. The Atlantic. https://www.theatlantic.com/health/archive/2022/02/covid-pandemic-immunocompromised-risk-vaccines/622094/

Academics: Viral Evolution Scenarios, 10 February 2022. (n.d.). GOV.UK. Retrieved February 14, 2022, from https://www.gov.uk/government/publications/academics-viral-evolution-scenarios-10-february-2022

ReconfigBehSci. (2022, January 20). @timcolbourn @OmicronData I’m sorry but I genuinely do not see how this is a response to what I said about the presuppositions in the ‘delay framing’? This reply is about your views on disease burden, not -as mine is- how choice of terminology implicitly shapes the argument space [Tweet]. @i. https://twitter.com/i/web/status/1484191657318879234

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Meng, B., Abdullahi, A., Ferreira, I. A. T. M., Goonawardane, N., Saito, A., Kimura, I., Yamasoba, D., Gerber, P. P., Fatihi, S., Rathore, S., Zepeda, S. K., Papa, G., Kemp, S. A., Ikeda, T., Toyoda, M., Tan, T. S., Kuramochi, J., Mitsunaga, S., Ueno, T., … Gupta, R. K. (2022). Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity. Nature, 1–1. https://doi.org/10.1038/s41586-022-04474-x

Couzin-Frankel, J. (2021). Antiviral pills could change pandemic’s course. Science, 374(6569), 799–800. https://doi.org/10.1126/science.acx9605

Mallapaty, S. (2021). The search for people who never get COVID. Nature. https://doi.org/10.1038/d41586-021-02978-6

Alexander, H. (2021, October 21). How a false science ‘cure’ became Australia’s contribution to the pandemic. The Sydney Morning Herald. https://www.smh.com.au/national/how-a-false-science-cure-became-australia-s-contribution-to-the-pandemic-20211013-p58zp3.html

Aeschlimann, J. R. (2021, October 15). Ivermectin Treats Many Infections in Humans – Just Not COVID-19. The Wire Science. https://science.thewire.in/health/ivermectin-treats-many-infections-in-humans-just-not-covid-19/

ICMR drops Ivermectin, Hydroxychloroquine drugs from Covid treatment. (2021, September 24). The Times of India. https://timesofindia.indiatimes.com/india/icmr-drops-ivermectin-hydroxychloroquine-drugs-from-covid-treatment/articleshow/86475906.cms?__twitter_impression=true

Abbas-Hanif, A., Modi, N., Smith, S. K., & Majeed, A. (2021). Covid-19 treatments and vaccines must be evaluated in pregnancy. BMJ, n2377. https://doi.org/10.1136/bmj.n2377

Willyard, C. (2021). How antiviral pill molnupiravir shot ahead in the COVID drug hunt. Nature. https://doi.org/10.1038/d41586-021-02783-1

Robins-Early, N. (2021, September 24). Desperation, misinformation: How the ivermectin craze spread across the world. The Guardian. https://www.theguardian.com/world/2021/sep/24/ivermectin-covid-peru-misinformation

ICMR removes Ivermectin, HCQ from revised guidelines on Covid-19 treatment. (2021, September 24). Hindustan Times. https://www.hindustantimes.com/india-news/icmr-removes-ivermectin-hcq-from-revised-guidelines-on-covid-19-treatment-101632461755113.html

Maxmen, Amy. ‘The Fight to Manufacture COVID Vaccines in Lower-Income Countries’. Nature 597, no. 7877 (15 September 2021): 455–57. https://doi.org/10.1038/d41586-021-02383-z.

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Summers, C. (2021, June 8). Oxygen shortages are killing thousands. Why aren’t we doing more about this? | Charlotte Summers. The Guardian. http://www.theguardian.com/commentisfree/2021/jun/08/oxygen-shortages-killing-vaccines-drugs

Time in US - encounters with police - arrest Drug - taking drugs

Time in US - taking drugs - coping mechanism - addiction

Time in US - drugs - taking drugs - affiliation with gangs - fights

Leaving the US - reason for exit - drug possession

Deutsch, J. (2021, April 20). Oxford/AstraZeneca vaccine shortfall due to production woes in EU: Documents. POLITICO. https://www.politico.eu/article/astrazeneca-vaccine-shortfall-production-woes-documents/

EU drug agency denies already finding causal link between AstraZeneca vaccine and blood clots. (2021, April 6). The Guardian. http://www.theguardian.com/world/2021/apr/06/ema-denies-already-finding-causal-link-astrazeneca-vaccine-blood-clots

Gordon, D. E., Hiatt, J., Bouhaddou, M., Rezelj, V. V., Ulferts, S., Braberg, H., Jureka, A. S., Obernier, K., Guo, J. Z., Batra, J., Kaake, R. M., Weckstein, A. R., Owens, T. W., Gupta, M., Pourmal, S., Titus, E. W., Cakir, M., Soucheray, M., McGregor, M., … Krogan, N. J. (2020). Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370(6521). https://doi.org/10.1126/science.abe9403

Mannix, L. (2021, February 8). Where did these COVID-19 variants come from – and what are they? The Sydney Morning Herald. https://www.smh.com.au/national/what-do-new-variants-of-the-coronavirus-mean-for-us-20210126-p56wuo.html

Diseases, T. L. I. (2020). Curing COVID-19. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(20)30706-4

Exclusive: In Russia, a black market for HIV drug to try on coronavirus. (2020, April 20). Reuters. https://www.reuters.com/article/us-health-coronavirus-russia-hiv-exclusi-idUSKBN2220W1

What is the success rate of these programs? They DO NOT work... People with addiction problems need one on one help so they can understand their situation and what's going on i in their heads, and how they are impacting their children....

The groups give them a swamp/ place to dwell. With Lillian, it was a place for her to feel sorry for herself and for others to "comfort" her. When she came home, we were the bad guys for not understanding.

• programs are not a one size fit all. If they work at all.

Mathew, M. (2020). Lockdown stress amid COVID-19 on Alcoholics and Drug addicts [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/an8m4

Gorey, C. (2020, June 29). RCSI team to start trial for promising Covid-19 therapy for severe infections. Silicon Republic. https://www.siliconrepublic.com/innovation/rcsi-trial-covid-19-therapy-alpha-1-antitrypsin

Qin, M., Cao, Z., Wen, J., Yu, Q., Liu, C., Wang, F., Yang, F., Li, Y., Fishbein, G., Yan, S., Xu, B., Hou, Y., Ning, Z., Nie, K., Jiang, N., Liu, Z., Wu, J., Yu, Y., Li, H., … Lu, Y. (2020). An Antioxidant Enzyme Therapeutic for COVID-19. BioRxiv, 2020.07.15.205211. https://doi.org/10.1101/2020.07.15.205211

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Togoh, I. (n.d.). After Hydroxychloroquine, Trump Is Now Seeking To Get Another Unproven Drug Approved By The FDA: Report. Forbes. Retrieved August 22, 2020, from https://www.forbes.com/sites/isabeltogoh/2020/08/17/after-hydroxychloroquine-trump-is-now-seeking-to-get-another-unproven-drug-approved-by-the-fda-report/

Luban, J., Sattler, R., Mühlberger, E., Graci, J. D., Cao, L., Weetall, M., Trotta, C., Colacino, J. M., Bavari, S., Strambio-De-Castillia, C., Suder, E. L., Wang, Y., Soloveva, V., Cintron-Lue, K., Naryshkin, N. A., Pykett, M., Welch, E. M., O’Keefe, K., Kong, R., … Peltz, S. (2020). The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines. BioRxiv, 2020.08.05.238394. https://doi.org/10.1101/2020.08.05.238394

Lo, A. W., Siah, K. W., & Wong, C. H. (2020). Estimating Probabilities of Success of Vaccine and Other Anti-Infective Therapeutic Development Programs (Working Paper No. 27176; Working Paper Series). National Bureau of Economic Research. https://doi.org/10.3386/w27176

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Hoffmann, M., Mösbauer, K., Hofmann-Winkler, H., Kaul, A., Kleine-Weber, H., Krüger, N., Gassen, N. C., Müller, M. A., Drosten, C., & Pöhlmann, S. (2020). Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2. Nature, 1–5. https://doi.org/10.1038/s41586-020-2575-3

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Ledford, H. (2020). Coronavirus breakthrough: Dexamethasone is first drug shown to save lives. Nature, d41586-020-01824–01825. https://doi.org/10.1038/d41586-020-01824-5

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Weiss, S. (2020 April 04). How the coronavirus lockdown is hitting Mexico's drug cartels. DW. https://p.dw.com/p/3aOBU

Drug

This is good for my purposes. It means high doses can be taken for brain effects without disturbing stomach acidity. The question remains, of course, whether coinciding CNS tolerance develops.

H1 antihistamines enhance the opioid high in humans. Hospitals sometimes administer antihistamines in combination with opioids. It's not hard to find people online who are using this combination recreationally.

The man should be prosecuted. Evil!

Debate over drug policy has been a long history in the United States. More drugs are starting to be legal in the United States because some may be used for prescription for to treat a disease. There has been a bad side against prescription drugs because many Americans are abusing prescription drugs. Prescription drug abuse is a social problem in the United States. Some prescription drugs are leading to health issues because many people do not care about the side effects. Overall the annotation reminded me of todays issue against drugs and how we are using it against many different diseases.

Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.

Article: Understanding animal research

Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.

Article: Would drugs be safe for us without animal tests?

Nature Reviews Drug Discovery Top 10 is must to read

RxShoppingMart has added a brand new and an elegant transport and delivery mechanism inside the global ofonline drug. flat 5% reductions to our returning clients.

Surprisingly this author does not even seem to know the real history of homeopathy. It was invented in the late 18th century not the `late 1800's' (sic - incorrect use of apostrophe).

This paragraph displays amazing ignorance of drug development. Firstly,`allopathy' is a pejorative term invented by homeopaths. It has no meaning in science or medicine.

Whereas modern pharmacy grew out of certain historical practices such as herbal medicine, most modern drugs are designed from a detailed knowledge of biochemical mechanisms. They are not extracts, are not necessarily highly concentrated, and are formulated as a result of rigorous dose-ranging studies in human subjects. It is untrue to claim that the drug development process used today is similar to that used in the late 1800s.

I hope that the focus on prohibition by the drug policy reform movement helps sidestep a similar effect happening with cannabis.