35 Matching Annotations
  1. Sep 2020
    1. Specifically, social workers assist families by making referrals for alcohol and drug assessments, inpatient and outpatient treatment programs, family therapy, and support groups such as Alcoholics Anonymous

      What is the success rate of these programs? They DO NOT work... People with addiction problems need one on one help so they can understand their situation and what's going on i in their heads, and how they are impacting their children....

      The groups give them a swamp/ place to dwell. With Lillian, it was a place for her to feel sorry for herself and for others to "comfort" her. When she came home, we were the bad guys for not understanding.

      • programs are not a one size fit all. If they work at all.
  2. Aug 2020
    1. Chen, Y., Yang, W.-H., Huang, L.-M., Wang, Y.-C., Yang, C.-S., Liu, Y.-L., Hou, M.-H., Tsai, C.-L., Chou, Y.-Z., Huang, B.-Y., Hung, C.-F., Hung, Y.-L., Chen, J.-S., Chiang, Y.-P., Cho, D.-Y., Jeng, L.-B., Tsai, C.-H., & Hung, M.-C. (2020). Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 main protease by tafenoquine in vitro. BioRxiv, 2020.08.14.250258. https://doi.org/10.1101/2020.08.14.250258

    1. Luban, J., Sattler, R., Mühlberger, E., Graci, J. D., Cao, L., Weetall, M., Trotta, C., Colacino, J. M., Bavari, S., Strambio-De-Castillia, C., Suder, E. L., Wang, Y., Soloveva, V., Cintron-Lue, K., Naryshkin, N. A., Pykett, M., Welch, E. M., O’Keefe, K., Kong, R., … Peltz, S. (2020). The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines. BioRxiv, 2020.08.05.238394. https://doi.org/10.1101/2020.08.05.238394

  3. Jul 2020
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  7. Aug 2019
  8. Mar 2019
    1. CONCLUSION: Tolerance to famotidine occurs during continuous administration for 14 days, as previously shown in ranitidine studies.

      This is good for my purposes. It means high doses can be taken for brain effects without disturbing stomach acidity. The question remains, of course, whether coinciding CNS tolerance develops.

    1. We have previously shown that antinociceptive effects of morphine are enhanced in histamine H1 receptor gene knockout mice.

      H1 antihistamines enhance the opioid high in humans. Hospitals sometimes administer antihistamines in combination with opioids. It's not hard to find people online who are using this combination recreationally.

  9. Feb 2019
    1. The nomination has sparked criticism, however, over Mr Azar’s own track record at Eli Lilly, a pharmaceuticals giant that was one of several to repeatedly increased the price of insulin, a life-saving drug used to treat diabetes. 

      The man should be prosecuted. Evil!

  10. Mar 2018
    1. In the past decade, the academic debate over cognitive enhancement (CE) unfolded largely isolated from the notoriously thorny debates about drug policy reform and the successes and failures of the international drug control regime (ICR). In hindsight, this approach proved beneficial

      Debate over drug policy has been a long history in the United States. More drugs are starting to be legal in the United States because some may be used for prescription for to treat a disease. There has been a bad side against prescription drugs because many Americans are abusing prescription drugs. Prescription drug abuse is a social problem in the United States. Some prescription drugs are leading to health issues because many people do not care about the side effects. Overall the annotation reminded me of todays issue against drugs and how we are using it against many different diseases.

  11. Mar 2017
    1. Unfortunately, penicillin was ineffective against the rabbit's infection. Disappointed, Fleming set the drug aside for a decade, as the rabbits had "proved" the drug was useless as a systemic medication.Years later, he administered the drug in desperation to a dying patient, for whom all other treatments were ineffectual. The penicillin performed a miracle, and the rest is history.

      Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.

      Article: Understanding animal research

    1. Had Fleming himself carried out a simple and well established animal test - the mouse protection test - the potential of his discovery might have been realised 10 years earlier

      Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.

      Article: Would drugs be safe for us without animal tests?

  12. Dec 2016
  13. Sep 2016
  14. Sep 2015
    1. Examining a sample of states, Neal found that from 1985 to 2000, the likelihood of a long prison sentence nearly doubled for drug possession, tripled for drug trafficking
  15. Jul 2015
    1. Homeopathy, on the other hand, uses highly diluted and succussed doses of natural substances - usually plants and minerals.  It is this dilution that makes homeopathy safer than allopathy and herbalism, and the succussion that allows remedies to retain their effectiveness, despite their high dilution.  This ‘minimum dose’ concept is one of the key principles of homeopathy, also developed in the late 1800's.

      Surprisingly this author does not even seem to know the real history of homeopathy. It was invented in the late 18th century not the `late 1800's' (sic - incorrect use of apostrophe).

    2. Allopathy (pharmaceutical medicine) uses extracts of active ingredients, often sourced from the same plants used by herbalists and homeopaths, that are then reproduced synthetically and highly concentrated in laboratories for use as drugs.  This process is then patented, and was developed in the late 1800's. 

      This paragraph displays amazing ignorance of drug development. Firstly,`allopathy' is a pejorative term invented by homeopaths. It has no meaning in science or medicine.

      Whereas modern pharmacy grew out of certain historical practices such as herbal medicine, most modern drugs are designed from a detailed knowledge of biochemical mechanisms. They are not extracts, are not necessarily highly concentrated, and are formulated as a result of rigorous dose-ranging studies in human subjects. It is untrue to claim that the drug development process used today is similar to that used in the late 1800s.

  16. Jun 2015
    1. But the marriage equality movement has been curiously hostile to polygamy, and for a particularly unsatisfying reason: short-term political need.

      I hope that the focus on prohibition by the drug policy reform movement helps sidestep a similar effect happening with cannabis.