67 Matching Annotations
  1. Jun 2022
    1. Maybe it’s time we talk about it?

      Yes, long overdue!

      Coming to terms with potential near term extinction of our species, and many others along with it, is a macro-level reflection of the personal and inescapable, existential crisis that all human, and other living beings have to contend with, our own personal, individual mortality. Our personal death can also be interpreted as an extinction event - all appearances are extinguished.

      The self-created eco-crisis, with accelerating degradation of nature cannot help but touch a nerve because it is now becoming a daily reminder of our collective vulnerability, Mortality salience of this scale can create enormous amounts of anxiety. We can no longer hide from our mortality when the news is blaring large scale changes every few weeks. It leaves us feeling helpless...just like we are at the time of our own personal death.

      In a world that is in denial of death, as pointed out by Ernest Becker in his 1973 Pulitzer-prize winning book of the same title, the signs of a climate system and biosphere in collapse is a frightening reminder of our own death.

      Straying from the natural wonderment each human being is born with, we already condition ourselves to live with an existential dread as Becker pointed out:

      "Man is literally split in two: he has an awareness of his own splendid uniqueness in that he sticks out of nature with a towering majesty, and yet he goes back into the ground a few feet in order to blindly and dumbly rot and disappear forever."

      Beckerian writer Glenn Hughes explores a way to authentically confront this dread, citing Socrates as an example. Three paragraphs from Hughes article point this out, citing Socrates as exemplary:

      "Now Becker doesn’t always emphasize this second possibility of authentic faith. One can get the impression from much of his work that any affirmation of enduring meaning is simply a denial of death and the embrace of a lie. But I believe the view expressed in the fifth chapter of The Denial of Death is his more nuanced and genuine position. And I think it will be worthwhile to develop his idea of a courageous breaking away from culturally-supported immortality systems by looking back in history to a character who many people have thought of as an epitome of a self-realized person, someone who neither accepts his culture’s standardized hero-systems, nor fears death: the philosopher Socrates."

      "Death is a mystery. Maybe it is annihilation. One simply can’t know otherwise. Socrates is psychologically open to his physical death and possible utter annihilation. But still this does not unnerve him. And if we pursue the question: why not?–we do not have to look far in Plato’s portrait of Socrates for some answers. Plato understood, and captured in his Dialogues, a crucial element in the shaping of Socrates’ character: his willingness to let the fact of death fully penetrate his consciousness. This experience of being fully open to death is so important to Socrates that he makes a point of using it to define his way of life, the life of a philosophos–a “lover of wisdom.” " "So we have come to the crucial point. The Socratic catharsis is a matter of letting death penetrate the self. It is the acceptance of the perishing of everything that will perish. In this acceptance a person imaginatively experiences the death of the body and the possibility of complete annihilation. This is “to ‘taste” death with the lips of your living body [so] that you … know emotionally that you are a creature who will die; “it is the passage into nothing” in which “a corner is turned within one.” And it is this very experience, and no other, that enables a person to act with genuine moral freedom and autonomy, guided by morals and not just attraction and impulses."

      https://ernestbecker.org/lecture-6-denial/

  2. Mar 2022
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  4. Jan 2022
    1. Fernandez-Castaneda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., Yalcin, B., Taylor, K. R., Dutton, S., Acosta-Alvarez, L., Ni, L., Contreras-Esquivel, D., Gehlhausen, J. R., Klein, J., Lucas, C., Mao, T., Silva, J., Pena-Hernandez, M., Tabachnikova, A., … Monje, M. (2022). Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain (p. 2022.01.07.475453). https://doi.org/10.1101/2022.01.07.475453

  5. Dec 2021
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  11. May 2021
    1. Larger, blinded, randomized control trials are still ongoing to confirm the efficacy of CP treatment, the RECOVERY trial in Oxford is one such Phase 3 trial of CP (NCT04381936).

      The RECOVERY trial in Oxford, with 5795 patients who were randomly allocated to receive convalescent plasma treatment and 5763 who received usual care alone, found that there was no statistically significant difference for 28-day mortality (24% for both groups, p-0.93) or the proportion of patients discharged from hospital within 28 days (66% CP vs 67% control, p=0.50) for the two groups. Additonally for patients without mechanical ventilation, there was no stastically significant difference in the intubation rate (28% CP vs 29% control, p=0.79).

      https://doi.org/10.1101/2021.03.09.21252736

      The trial showed convalescent plasma therapy had no benefit to patients with COVID-19. As a result the UK's health service has stopped collecting convalescent plasma from patients who had recovered from COVID-19.

      https://www.bbc.co.uk/news/health-55681051

      Additonally the NIH have halted a convalescent plasma trial for COVID-19 patients with mild symptoms stating that the "study shows that the treatment is safe, but provides no signifcant benefit in this group".

      https://www.nih.gov/news-events/news-releases/nih-halts-trial-covid-19-convalescent-plasma-emergency-department-patients-mild-symptoms

  12. Apr 2021
    1. r private Living Healthier Together Facebook page.

      "private facebook page" is the dumbest thing on this page..

  13. Mar 2021
  14. Feb 2021
    1. Nest’s mission is to be a welcoming and inclusive environment, offering a compassionate and holistic approach to healing and growth through energy, touch and movement.

      I think this is an awesome mission statement and that this owner/website designer took a business class and they understand mission, values, and vision.

  15. Jan 2021
    1. This study highlights the potential of digital technology expanding creative palettes and clinical intervention tools for therapeutic sessions.
    1. This shades into novel types of therapeutic approaches: perhaps we could simply pump energy into lower-frequency bands (perhaps harmonic stimulation centered at ~3-6hz) to kickstart emotional integration.

      [[micro-tonal therapy]] that uses empathy as resonance

  16. Dec 2020
    1. Instead of waiting for a magic fairy to appear and eliminate your problem so that you can enjoy life again, you might want to start adding those little positive events back onto your agenda despite the problem still being present

      This solution based therapy focuses on trying to get people active and engaged with life even when depressed.

      It is important to help patients experience those little positive events. These events can help people get back on track.

    2. If you need to imagine in concrete detail how you would notice that a problem disappeared, you are challenged to leave vague descriptions like “I’ll be happy”, “I’ll be less annoyed” behind.Vagueness in the end is a cognitive avoidance mechanism. It is easy to ruminate on general emotions and thoughts but very hard to imagine concrete outcomes and changes. We would rather not face precise thoughts, emotions or memories because they can be painful. Better to stay at a safe but vague distance.

      This is all about solution based therapy. We need concrete ways of fixing our problems.

      Vagueness is a cognitive avoidance strategy. It is a way to avoid digging deep.

      It is safer for our feelings to stay vague, but that is not where we need to improve.

  17. Nov 2020
    1. If the light is not quite so bright, chronic exposure over days to weeks can cause permanent damage. This is thought to be due to what is called photo-oxidative damage

      Just as one would expect, it appears that antioxidants can protect against this type of damage. Note that the study was in rats, but we have every reason to think it would work in humans. In particular, several studies showing that dietary antioxidants protect skin from sunlight in humans; it's should be essentially the same thing for the eyes.

    1. Rosemary enhanced the protective efficacy of AREDS and led to the greatest effect on the retinal genome in animals reared in high environmental light. Chronic administration of rosemary antioxidants may be a useful adjunct to the therapeutic benefit of AREDS in slowing disease progression in AMD.

      This is not in the least surprising. Dietary antioxidants also protect the skin during sunlight exposure.

      Oxidative stress likely also plays a role in diabetic retinopathy. It plays a role in the aging process itself. That said, there is probably a limit to protective powers of antioxidants. Nonetheless, I don't think that that limit has ever been realized in any population. I doubt we've even come close in rats.

  18. Sep 2020
    1. Specifically, social workers assist families by making referrals for alcohol and drug assessments, inpatient and outpatient treatment programs, family therapy, and support groups such as Alcoholics Anonymous

      What is the success rate of these programs? They DO NOT work... People with addiction problems need one on one help so they can understand their situation and what's going on i in their heads, and how they are impacting their children....

      The groups give them a swamp/ place to dwell. With Lillian, it was a place for her to feel sorry for herself and for others to "comfort" her. When she came home, we were the bad guys for not understanding.

      • programs are not a one size fit all. If they work at all.
    1. You can also find a therapist through “fast therapy” apps like TalkSpace, which connects you to a licensed therapist through not just video chat, but texting, too. Out-of-pocket TalkSpace subscriptions start at $260 per month — which sounds like a lot up front, but it gets you unlimited text, video, and audio access to a therapist five days a week. For comparison, IRL therapy might cost $200 per month in insurance copays for one 45-minute session once a week.

      [[TalkSpace]] has had some questionable pratices around ethics recently - source

    2. First, let’s figure out how you’re going to pay for it. If you don’t have insurance (or even if you do), there are resources available to you at no cost. Consider looking into Federally Qualified Health Centers, community-based centers that offer care including mental health and substance use services

      Services like [[InkBlot]], your works [[Health Care Spending Account]] - in the past I had good luck with the Aspiria - they got me setup with a good therapist from Shift Collab Therapy

      Even trying to figure out what my starting point was too much - but being able to use a service like that to help connect me was really important.

  19. Aug 2020
    1. Luban, J., Sattler, R., Mühlberger, E., Graci, J. D., Cao, L., Weetall, M., Trotta, C., Colacino, J. M., Bavari, S., Strambio-De-Castillia, C., Suder, E. L., Wang, Y., Soloveva, V., Cintron-Lue, K., Naryshkin, N. A., Pykett, M., Welch, E. M., O’Keefe, K., Kong, R., … Peltz, S. (2020). The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines. BioRxiv, 2020.08.05.238394. https://doi.org/10.1101/2020.08.05.238394

  20. Jul 2020
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  23. Apr 2020
    1. Abdulla, A., Wang, B., Qian, F., Kee, T., Blasiak, A., Ong, Y. H., Hooi, L., Parekh, F., Soriano, R., Olinger, G. G., Keppo, J., Hardesty, C. L., Chow, E. K., Ho, D., & Ding, X. (n.d.). Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention. Advanced Therapeutics, n/a(n/a), 2000034. https://doi.org/10.1002/adtp.202000034

  24. May 2019
    1. first target the patients at highest risk of relapse;

      Clinical trials will most certainly first include those patients with the highest risk of relapse. However, long term, everything will depend on the risk/ benefit trade off: if an effective, simple, well-tolerated and cost-effective treatment was available (let's imagine a single short low-dose PD1 for any early Melanoma patient) that prevented progression for most patients would be very different from a highly toxic, expensive treatment that doesn't work for everyone (think Ipi 10mg/kg adjuvant)- so everything is in the trade-off

  25. Feb 2019
    1. In extreme cases, urge them to see a counselor

      I quibble with the use of the word "extreme" here. The examples in this article seem more like issues of strong beliefs or unthinking comments, but hot moments also include deeply personal disclosures. Reserving counseling for "extreme" cases is stigmatizing, especially as we see more students in higher ed who have experience of mental health treatment. Many students involved in "hot moments" might benefit from being referred to the resources available in student life offices and/or counseling and faculty should be aware enough of these resources to suggest them with comfort.

  26. Jan 2019
    1. It’s not a problem I can solve, but it’s a reality I can acknowledge, a paradigm through which I can understand my actions.

      writing = therapy :)

  27. Aug 2018
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  29. Nov 2017
    1. Parent-Child Interaction Therapy (PCIT)  PCIT works with parents and children together, teaching them skills to interact in a positive, productive way. It is effective for kids between the ages of 2 and 7, and usually requires 14 to 17 weekly sessions. In PCIT, parents receive live coaching (via a bug in the ear) from a therapist who watches from behind a one-way mirror as they and their child perform a series of tasks, and parents practice specific responses to both desired and undesired behavior. PCIT is the most practice-intensive, Dr. Rouse says, as parents demonstrate mastery of each skill before going on to the next one. “It starts out with positive interactions, then waits till parents reach mastery of these skills before moving on to discipline strategies to improve oppositional behavior.” Dr. Rouse says he might propose PCIT if he feels that the parents need a lot of one-on-one attention in terms of how they’re interacting with their child, and “especially if it feels like there have been a lot of coercive negative interactions.” Sometimes it’s very important for parents, he adds, “to learn how to be with their kid in a positive way.” He adds that he doesn’t always suggest PCIT even if the child falls within PCIT’s age range. “It’s not just age, it’s looking at the situation. If there needs to be a really strong dose of positive interactions as the first thing and the child is under 7, I’ll lean more toward PCIT.”
  30. Apr 2017
    1. I have had IBS essentially all my life. At least as far back as I can remember. This is a very interesting experiement. Hopefully scientists can use this as a springboard for either further research, or ideally, to find a solution. IBS negatively impacts quality of life for many sufferers.

      Isn't the flipped experiment a clear indication that FTT (fecal transplant therapy) can help alleviating IBS? If the reverse is true, there might be great value in getting your microbiome fixed/infused by healthy microbiota from donors.