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Clinical trials will most certainly first include those patients with the highest risk of relapse. However, long term, everything will depend on the risk/ benefit trade off: if an effective, simple, well-tolerated and cost-effective treatment was available (let's imagine a single short low-dose PD1 for any early Melanoma patient) that prevented progression for most patients would be very different from a highly toxic, expensive treatment that doesn't work for everyone (think Ipi 10mg/kg adjuvant)- so everything is in the trade-off

I quibble with the use of the word "extreme" here. The examples in this article seem more like issues of strong beliefs or unthinking comments, but hot moments also include deeply personal disclosures. Reserving counseling for "extreme" cases is stigmatizing, especially as we see more students in higher ed who have experience of mental health treatment. Many students involved in "hot moments" might benefit from being referred to the resources available in student life offices and/or counseling and faculty should be aware enough of these resources to suggest them with comfort.

writing = therapy :)

therapy with horses

Isn't the flipped experiment a clear indication that FTT (fecal transplant therapy) can help alleviating IBS? If the reverse is true, there might be great value in getting your microbiome fixed/infused by healthy microbiota from donors.