4 Matching Annotations
  1. Apr 2022
    1. While it was once regarded as a low-level, “primitive” instinct, researchers arecoming to recognize that imitation—at least as practiced by humans, includingvery young ones—is a complex and sophisticated capacity. Although non-humananimals do imitate, their mimicry differs in important ways from ours. Forexample, young humans’ copying is unique in that children are quite selectiveabout whom they choose to imitate. Even preschoolers prefer to imitate peoplewho have shown themselves to be knowledgeable and competent. Researchshows that while toddlers will choose to copy their mothers rather than a personthey’ve just met, as children grow older they become increasingly willing tocopy a stranger if the stranger appears to have special expertise. By the time achild reaches age seven, Mom no longer knows best.

      Studies have shown that humans are highly selective about whom they choose to imitate. Children up to age seven show a propensity to imitate their parents over strangers and after that they primarily imitate people who have shown themselves to be knowledgeable and competent within an area of expertise.

      This has applications to teaching with respect to math shaming. A teacher who says that math is personally hard for them is likely to be signaling to students that what they're teaching is not based on experience and expertise and thus demotivating the student from following and imitating their example.

  2. Aug 2020
    1. Luban, J., Sattler, R., Mühlberger, E., Graci, J. D., Cao, L., Weetall, M., Trotta, C., Colacino, J. M., Bavari, S., Strambio-De-Castillia, C., Suder, E. L., Wang, Y., Soloveva, V., Cintron-Lue, K., Naryshkin, N. A., Pykett, M., Welch, E. M., O’Keefe, K., Kong, R., … Peltz, S. (2020). The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines. BioRxiv, 2020.08.05.238394. https://doi.org/10.1101/2020.08.05.238394

  3. Apr 2020
    1. Mixed the plate thoroughly and incubated for one hour at room temperature. Then 5 μL development solution was added to each well and the plate was incubated for 1h at room temperature;

      the compound and kinase are incubated together for at least 2 hours. And 2 hours is enough for covalent adduct to form. if compound can form covalent adduct with FGFR1, why FGFR1 inhibition IC50 is so poor?