3 Matching Annotations
  1. Aug 2020
    1. Luban, J., Sattler, R., Mühlberger, E., Graci, J. D., Cao, L., Weetall, M., Trotta, C., Colacino, J. M., Bavari, S., Strambio-De-Castillia, C., Suder, E. L., Wang, Y., Soloveva, V., Cintron-Lue, K., Naryshkin, N. A., Pykett, M., Welch, E. M., O’Keefe, K., Kong, R., … Peltz, S. (2020). The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines. BioRxiv, 2020.08.05.238394. https://doi.org/10.1101/2020.08.05.238394

  2. Apr 2020
    1. Mixed the plate thoroughly and incubated for one hour at room temperature. Then 5 μL development solution was added to each well and the plate was incubated for 1h at room temperature;

      the compound and kinase are incubated together for at least 2 hours. And 2 hours is enough for covalent adduct to form. if compound can form covalent adduct with FGFR1, why FGFR1 inhibition IC50 is so poor?