6 Matching Annotations
  1. Sep 2020
    1. HARs are short stretches of DNA that while conserved in other species, underwent rapid evolution in humans following our split with chimpanzees, presumably since they provided some benefit specific to our species. Rather than encoding for proteins themselves, HARs often help regulate neighboring genes. Since both schizophrenia and HARs appear to be for the most part human-specific, the researchers wondered if there might be a connection between the two.dfp.loadAds("right2","MPU2","dfp-right2-article-1")Advertisement

      Schizophrenia is unique to humans. There are also regions that human and other species have, but have undergone more rapid evolution in humans called Human Accelerated regions (HAR).

      Maybe these HARs and Schizophrenia are linked.

      Also HARs are regions whose purpose is to regulate the expression of other genes, not so much directly code for a protein.

    2. schizophrenia. Though psychotic animals may exist, psychosis has never been observed outside of our own species; whereas depression, OCD, and anxiety traits have been reported in many non-human species

      Humans are the only ones that develop schizophrenia

  2. Jun 2020
  3. May 2020
  4. Jun 2019
    1. SCN, hippocam-pus, piriform cortex, and cerebellum (Figure 2 and datanot shown). Lower levels ofmPer3RNA were detectedin neocortex. The sense (control) riboprobe had a repro-ducible, robust, anatomically specific pattern of hybrid-ization that did not overlap with the antisense probe.Specifically, the sense probe labeled the supraoptic andparaventricular nuclei of the hypothalamus (

      The paraventricular axis is interesting and could relate to chronic pain. It also has some linkage to schizophrenia and possibly low latent inhibition, IIRC. yes.It is the area I thought. How very curious. The pain drug developed in the 70's was Thalidomide, a disaster in Britain as the Ramones sang about and the American doctor who stopped it recieved a Presidential medal and was then tasked with reforming our system of clinical trials that we use today. https://www.ncbi.nlm.nih.gov/pubmed/31009420

  5. May 2018