- Sep 2021
- Jul 2021
The present study indicates sildenafil as a potential adjunctive treatment strategy for treatment of negative symptoms of schizophrenia.
In contrast, sildenafil appears not to provide any acute benefit, (study). I'd only expected benefit due to sleep enhancement, so lack of acute benefit was unsurprising to me.
Given that risperidone was likely taken at night, and sildenafil was likely taken at the same time, it's my opinion that the benefits in this study were due to sleep improvement. This may be via the circadian clock, or a more direct effect on sleep, or both.
My remaining question is whether sildenafil improves sleep in healthy subjects. I'm especially interested in combining sildenafil with 100 to 300 mcg melatonin. Will they have synergistic effect? I expect so.