23 Matching Annotations
  1. Sep 2020
    1. HARs are short stretches of DNA that while conserved in other species, underwent rapid evolution in humans following our split with chimpanzees, presumably since they provided some benefit specific to our species. Rather than encoding for proteins themselves, HARs often help regulate neighboring genes. Since both schizophrenia and HARs appear to be for the most part human-specific, the researchers wondered if there might be a connection between the two.dfp.loadAds("right2","MPU2","dfp-right2-article-1")Advertisement

      Schizophrenia is unique to humans. There are also regions that human and other species have, but have undergone more rapid evolution in humans called Human Accelerated regions (HAR).

      Maybe these HARs and Schizophrenia are linked.

      Also HARs are regions whose purpose is to regulate the expression of other genes, not so much directly code for a protein.

    2. numerous non-human species suffer from psychiatric symptoms. Birds obsess; horses on occasion get pathologically compulsive; dolphins and whales—especially those in captivity—self-mutilate. And that thing when your dog woefully watches you pull out of the driveway from the window—that might be DSM-certified separation anxiety. "Every animal with a mind has the capacity to lose hold of it from time to time" wrote science historian and author Dr. Laurel Braitman in "Animal Madness

      Animals can have psychiatric issues as well.

      Examples include:

      • Dolphins that self-mutilate when in captivity
      • Horses that can get pathologically compulsive
      • Brides that obsess
    3. schizophrenia. Though psychotic animals may exist, psychosis has never been observed outside of our own species; whereas depression, OCD, and anxiety traits have been reported in many non-human species

      Humans are the only ones that develop schizophrenia

  2. Aug 2020
    1. Well, you don’t have to choose another niche. Writing about niche topics is not the only approach. You can write about popular topics and provide value by giving those topics your own unique take. You won’t get exceedingly rich, but you may find more success.

      You don't have to differentiate yourself by WHAT you write (niche topics) but you can do so by HOW you write (writing style.

      • Write about popular topics with you own spin
      • May not become rich but you will get somewhere
      • Popular topics are popular for a reason. They will bring you decent success.
    2. After all, you need to find your niche. So what do you do? You begin by concocting the weirdest flavors:Salmon-flavored ice cream.Trout-flavored ice cream.Sardine-flavored ice cream.Tuna-flavored ice cream.

      Finding is a Niche is always necessary.

      Its like Vanilla vs. Fish Flavored Ice Cream

      There are plenty of people selling Vanilla, Chocolate, and strawberry and making money. They might not get all the market share but they will sell far more and be liked than any fish flavored ice cream.

    1. 7 powerful questions you can ask your friends, family and co-workers in your next conversation

      1.What are you most grateful for, right now, in this movement? - Help the conversation focus on more positive and grateful side of life.

      2.Working on any exciting personal project lately? - People love talking about their side hustles so this can help you get closer

      3.What's working well for you right now? - Helps transition from negative --> positive. Another question can be: How are you taking care of yourself right now?

      4.What shows, podcasts, or books are you making time for right now? - These sources is where alot of people spend their time on so it makes sense to ask about these. Good conversation starters.

      1. What do you do to get rid of stress?

      6.What would be your perfect weekend? - Have plenty to talk about on this

      7.What are you looking forward to in the future? - People have plans and helps get an idea of their motivations.

    1. Medium itself conducted a study on the optimal reading time. They analyzed loads of data and came to the conclusion that 7 minutes is the optimal length for a post. However, the data varies widely and anything from 4–8 minutes performs great.

      Medium conducted a study and found that optimal reading time is 7 minutes.

      Anything from 4-8 minutes performs great.

    2. Using only half the word count then a conventional text, lead to an increase of usability by 58%. So generally, we can conclude that shorter texts are not only easier to read, but also more likely to be remembered

      Shorter the word count/article size will increase retention.

      700 to 1000 words is good. Just keep it concise.

      Shorter articles are more attractive

    3. Dr. Jakob Nielsen conducted an interesting study on how the average person reads an online article. The short version is: They don’t. He found out, that the reader scans the page, rather than reading it word for word. Thus, he concluded that it’s not the content length that scares off your reader, but how scannable your text is.

      Study shows that the scannability of an article is more important for retention than the length.

      Key factors that are responsible for retaining readers is:

      1.Highlighted keywords- Bold to express important information.

      2.Meaningful subtitles - Someone reading only the subtitles must have a good idea of what the article is about

      3.Variety - Bullet points, different sized sentences and paragraphs, pictures/graphics, and so on.

      4.Credibility - Gotta look like you know what you're talking about.

    4. You have 9 seconds to convince9 seconds is the attention span of a goldfish. And your average reader. Within this short period of time, the person clicking on your article will decide if it’s worth reading.

      Attention span for articles is around 9 seconds.

      9 Seconds is the window to convince someone to keep reading.

    1. When large amounts of money are created out of thin air and that currency is not spent, when that money eventually is spent, it can lead to larger than normal amounts of inflation that devalue the money you’ve worked hard for.

      Velocity of Money - How much money has passed through multiple people's eyes.

      • When velocity decreases, but the government keeps creating money, inflation can occur in larger than normal amounts.
    2. billionaire investor, George Soros, called the stock market a bubble. “Investors are in a bubble fueled by Fed liquidity,” he says and that’s why he “no longer participates.”

      This is what I was thinking: the stock market is fed by liquidity by the government. I am not sure how to think about it in the long run.

      If I keep money in the stock market, the government keeps pumping money, inflation raises, then my money is just constantly devalued. I really don't know

    3. Negative interest ratesNegative interest rates can be bad for you because it means you have to pay to store your money.

      Negative Interest rates - When you have to pay to store money.

    4. Watch what the billionaires do, not what they say.

      Warren Buffet has transitioned his money from bank stocks to gold. This is an indication that Buffet is quietly betting against the US economy.

    1. The trick is to work at 85% capacity rather than 100%. It can be surprisingly challenging to take your effort down a notch and keep it there — especially right now when so many livelihoods feel precarious. But going full-throttle all the time actually works against you. When your mind is relaxed, you’re able to produce better, more thoughtful results.

      Rather than working 100% of the time most of the time, work 85%. This decreases stress and helps you last longer

    1. How to Get into Flow States, Quickly



      3.Something that inspires your work

      4.Warm-up - get your brain primed for the activity

      5.Sends chills down your spine - Watch something that Inspires you e.g. David Goggins

      6.Avoid distraction - Put phone away and noise cancelling headphones

    1. However, there is one important point: with the visualisation the feeling must be there too. When someone is seeing him/herself in for example delivering a speech for the first time on stage, they really must let the feeling build up in their hearts, minds and body too. Then the vibrations will do their "magic

      Comment in the article suggested that you should focus on visualizing the action AND emotion

    2. “In 2004, Cleveland Clinic physiologist Guang Yue wanted to know if merely thinking about lifting weights was enough to increase strength. Study subjects were divided into four groups. One group tried to strengthen their finger muscles with physical exercise; one tried to strengthen their finger muscles by only visualizing the exercise; another tried to increase arm strength through visualization; while the last group did nothing at all. The trial lasted twelve weeks.When it was over, those who did nothing saw no gains. The group that relied on physical training saw the greatest increase in strength-at 53 percent. But it’s the mental groups where things got curious. Folks who did no physical training but merely imagined their fingers going through precise exercise motions saw a 35 percent increase in strength, while the ones who visualized arm exercises saw a 13.5 percent increase in strength.”Let’s review — these participants did NOTHING BUT VISUALIZING and saw an increase of up to 35% in strength!But things are all the more convincing when you consider that a few years before Yue’s studies, neuroscientists found no difference between performing an action and merely imagining oneself performing that action-the same neuronal circuits fire in either case.

      Experiments have shown that simply visualizing an can have great impacts.

    3. consistently finding strong correlations between mental rehearsal-i.e., visualization-and better performance

      Visualization meditation has scientific backing

    1. what might be learned from the case. The answer, in part, is that prudent psychiatrists and other therapists will want to be thoughtful about how they arrange follow-up care for patients whom they can no longer see.Sometimes a general suggestion that a patient seek follow-up care will be adequate. However, as the patient's condition warrants, clinicians might choose, in ascending order of time commitment, to provide the patient with the name of a particular practitioner or facility, to contact the facility to ascertain that a clinician is willing to see the patient, to help the patient make an appointment, or, with the patient's permission, to make an appointment on the patient's behalf. In some cases, it may be appropriate to ask for the patient's permission to contact his or her family to indicate a need for follow-up and to encourage the family to make sure that follow-up takes place. But of these approaches, no specific one will always be indicated, and the degree of assistance rendered the patient should be calibrated to his or her individual needs.

      What can be learned from this case?

      • Carefully plan follow up plans with patients (general suggestion about follow up can be enough)
      • Ask patient for family information to help them get involved in the follow up process and help increase compliance.


      • Giving the specific name of a provider to follow up with
      • How to contact the facility,
      • See if who you provided/recommended is avaliable to take the patient
      • Help patient make the appointment or make it on their behalf (with permission)
    2. One final questionable aspect of the jury's verdict relates to the legal requirement that before a judgment of malpractice can be reached, any departures from the standard of care must be shown to have been the proximate cause of the resulting harms. The most common test for whether an act or omission constitutes a proximate cause is whether it was reasonably foreseeable at the time that the negligent act occurred that would result in the consequent harms. Williamson had no history of violent behavior and had never revealed a violent impulse during treatment. It is impossible to conclude that he was foreseeably dangerous at the time he was seen by Dr. Liptzin.

      The test for proximate cause "is whether it was reasonably foreseeable at the time that the negligent act occurred that would result in the consequent harms"

      In this case, Dr. Liptzin, having seen Williamson having no history of violence or anything else, could not reasonably foresee that Williamson was going to do something illegal.

    3. When a former psychiatric patient killed two people on the streets of Chapel Hill, North Carolina, and then sued the psychiatrist who had treated him for failing to prevent the murders, the mental health world dismissed the suit as frivolous. But when a jury agreed with the killer and awarded him $500,000 in damages, bewilderment was the order of the day (1). Can it be true, psychiatrists asked, that murder pays—as long as you can blame your psychiatrist for your deed?

      This is the case where it was initially ruled that the psychiatrist was the proximate cause for the patient, Williamson, to commit murder. Subsequent higher courts overturned this decision.

    1. “Henneman’s size principle” and it provides the basis for why Myo Reps work so well.Evolution is an effective optimizer. If you are wasting energy, you’re dead. That sounds harsh in the modern, comfortable world, but it’s true, and a large part of how our muscles contract. The brain — via the central nervous system — will only contract as few muscles as it takes to get the job done. If you are walking down the street at a moderate pace, only your weakest muscle fibers will activate, not your strongest ones.

      Henneman's Size Principle says that motor units are recruitted from small to large as the force required increases.

      We use the minimal amount of motor units to get the job done (efficiency). To grow muscles we need to overwork muscles to fatigue, which means doing high intensity or large load exercises.

      Excellent video on Myo Reps: https://www.youtube.com/watch?v=R3awPWm97dA