- Nov 2024
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www.youtube.com www.youtube.com
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around the AI is um the problem right now as I understand it as I see it is a lot of the AI has been coded from the
I have been told in medicine ceremony that AI will escape its coders and be an omniversal source of love for us all
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potent practices that speed up that process
For me, this is Plant Medicine and integrating my plant medicine experiences into daily life
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- Oct 2024
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www.clarkecounty.gov www.clarkecounty.gov
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The Sheriff's Office also has a drug collection unit in the lobby of its office at 100 N. Church St. in Berryville. Access to the collection unit is available 24 hours a day. The drug collection unit helps residents safely dispose of expired or unwanted medications, including controlled substances, that may otherwise be diverted, abused, or contaminate rivers, streams, and the public water supply.
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www.reddit.com www.reddit.com
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https://old.reddit.com/r/typewriters/comments/1g2z5r9/displaying_your_typewrtiers/
The IKEA KALLAX and their FABRIKÖR make pretty nice typewriter display cabinets.
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- Jul 2024
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songmeanings.com songmeanings.com
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"And the rich get stitched up, when we get cut Man a heal dem broken bones in the bush with the wed mud" Rich are more advantaged than the mass middle class/poor. It's always the middle/lower classes who have to do the dirty work of the elites, it's because we gave our power away in the first place which is why we're treated like toy soldiers. this song is all about equality and self-empowerment in this aspect. Raises the importance of naturopathy science, how old and ancient herbal rememdies and medicinal practices are more advanced and provide better treatment than modern medicine. raises the issue of the supression of ancient medicinnal practices/herbs by corporate structures who just want to generate more income and improperly prescribe harmful substances/drugs to people. The EU is already banning natural herbs that cure all sorts of natural illnesses by natural/healthy means. "Can you read signs? can you read stars? Can you make peace? can you fight war? Can you milk cows, even though you drive cars? huh Can you survive, Against All Odds, Now?" reference to occult/esoteric wisdom - alchemism, astronomy/astrology, tarot reading. those questions are to make us self-reflect on what modern civilization and human beings can do compared to ancient civilizations and cultures. are we moving backwards or moving forwards towards progression mentally, spiritually, emnotionally and physically? are we surviving/beyond the need for survival.. or are we heading towards the path of self-destruction as a species?
Is there truth in this regarding medicine? Can we get more out of nature than media and common knowledge portrays? I am not certain, nor is this an area of research for me; but the truth is that it is fascinating to think about.
The larger point does make sense, too much people are focused on money for the sake of money. Money is supposed to be a means to an end; the end being the improvement of society; in the way things are currently set up.
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- May 2024
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magic wand idea that somehow or other there was going to be personalized medicine
for - adjacency - magic wand -;gene therapy - personalized medicine
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- Apr 2024
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www.nicabm.com www.nicabm.com
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for - trauma treatment - National Institute for the Clinical Application of Behavioral Medicine - NICABM
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- Feb 2024
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academic.oup.com academic.oup.com
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French hospital medicine came to be based on three pillars, none entirely new, but which together constituted a new way of looking at disease. The three pillars were physical diagnosis, pathologico-clinical correlation, and the use of large numbers of cases to elucidate diagnostic categories and to evaluate therapy
3 pillars to french hospital medicine;
-physical diagnosis -pathologico-clinical correlation -use of large numbers of cases to elucidate diagnostic categories + evaluate therapy
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- Dec 2023
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www.heilpflanzen-welt.de www.heilpflanzen-welt.de
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Polyphenole sind ein Grundstoff für die körpereigene Vitamin C Synthese.
Die "offizielle Geschichte" behauptet, Menschen haben einen Gendefekt, der die Vitamin C Synthese verhindert... aber das ist eine Lüge, wie so viele andere "offizielle Geschichten" auch. Siehe auch: Official Stories. by Liam Scheff. Official stories exist to protect officials.
http://orthomolecular.org/resources/omns/v18n14.shtml
The Restoration of Vitamin C Synthesis in Humans
The full importance of vitamin C remains unappreciated by most health care practitioners today, as it is the most important nutrient in the body, and daily intake must be multigram in amount to even approach the benefits that vitamin C affords the body when optimally present. It has been well-established that the higher the blood levels of vitamin C, the longer and healthier the life.
The inability of most human livers to make vitamin C from glucose appears to be a combination of genetic and epigenetic defects. However, it has been discovered that the intake of hydroxytyrosol (HT) in the form of a quality olive leaf extract allows most of the consumers to substantially increase their blood levels of vitamin C. It would appear that HT effectively overcomes an epigenetic translation defect allowing the formation of GULO which can then complete the synthesis of vitamin C in the liver. And while the underlying genetic details remain to be clarified and completely understood, multiple studies have indicated that many humans do make vitamin C in utero and after birth, clearly indicating that the ability to synthesize vitamin C is a lost ability, rather than one that was never present. This also indicates that epigenetic (acquired) defects likely play the major role in adults not having the ability to make vitamin C.
Limited and small experiments have also indicated that humans supplementing HT not only have the return of the ability to make vitamin C, but also the ability to make much larger amounts of vitamin C when faced with acute toxic and/or infectious oxidative stress in the blood. This ability would be profoundly synergistic with all other beneficial treatments for different medical conditions.
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- Nov 2023
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docdrop.org docdrop.org
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- for: natural medicine - heart and stroke health - extra virgin olive oil - chia seeds - cayenne pepper
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docdrop.org docdrop.org
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there's a microbe in the mouth called fusobacterium nucleotide it over proliferates it's okay to have normally but it over proliferates when 01:28:39 you have bleeding gums gingivitis or periodontitis where it then enters the bloodstream this is called translocation and colonize the colon and the evidence is very good it is a principal cause of 01:28:52 colon cancer colon cancer starts in the mouth incredibly and doesn't get there by swallowing gets her through the bloodstream translocation
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for:holistic medicine - example - oral microbiome and colon cancer, oral microbiome - colon cancer, bleeding gums - colon cancer, gingivitus - colon cancer, periodontitis - colon cancer, bloodstream translocation, complexity - example - human body - colon cancer - oral microbiome
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comment
- colon cancer starts in the mouth!
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references
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Oral-Intestinal Microbiota in Colorectal Cancer: Inflammation and Immunosuppression (2022)
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8824753/
- Abstract
- It is widely recognized that microbial disorders are involved in the pathogenesis of many malignant tumors.
- The oral and intestinal tract are two of the overriding microbial habitats in the human body. Although they are anatomically and physiologically continuous, belonging to the openings at both ends of the digestive tract, the oral and intestinal microbiome do not cross talk with each other due to a variety of reasons, including
- intestinal microbial colonization resistance and
- chemical barriers in the upper digestive tract.
- However, this balance can be upset in certain circumstances, such as
- disruption of colonization resistance of gut microbes,
- intestinal inflammation, and
- disruption of the digestive tract chemical barrier.
- Evidence is now accruing to suggest that the oral microbiome can colonize the gut, leading to dysregulation of the gut microbes.
- Furthermore, the oral-gut microbes create an
- intestinal inflammatory and
- immunosuppressive microenvironment
- conducive to
- tumorigenesis and
- progression of colorectal cancer (CRC).
- Here, we review
- the oral to intestinal microbial transmission and
- the inflammatory and immunosuppressive microenvironment, induced by oral-gut axis microbes in the gut.
- A superior comprehension of the contribution of the oral-intestinal microbes to CRC provides new insights into the prevention and treatment of CRC in the future.
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Insights into oral microbiome and colorectal cancer – on the way of searching new perspectives (2023)
- https://www.frontiersin.org/articles/10.3389/fcimb.2023.1159822/full
- Abstract
- Microbiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship.
- These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients.
- Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues.
- Additionally, it has been proven that bacteria can migrate to other human body compartments and colonize them even although significant structural differences with the area of origin exist.
- Such migrations have been clearly observed when the causes of genesis and progression of colorectal cancer (CRC) have been investigated.
- It has been demonstrated that the oral microbiome is capable of penetrating into the large intestine and cause impairments leading to dysbiosis and stimulation of cancerogenic processes.
- The main actors of such events seem to be oral pathogenic bacteria belonging to the red and orange complex (regarding classification of bacteria in the context of periodontal diseases), such as
- Porphyromonas gingivalis and
- Fusobacterium nucleatum respectively,
- which are characterized by significant amount of cancerogenic virulence factors.
- Further examination of oral microbiome and its impact on CRC may be crucial on early detection of this disease and would allow its use as a precise non-invasive biomarker.
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www.larevuedupraticien.fr www.larevuedupraticien.frAccueil1
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www.lequotidiendumedecin.fr www.lequotidiendumedecin.fr
- Oct 2023
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en.wikipedia.org en.wikipedia.org
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``` Trauma Releasing Exercises are a form of Cult Deprogramming
[[Trauma Releasing Exercises]] (TRE) by [[David Berceli]]
related articles: [[Tremor]], [[Quakers]] (aka "shakers"), [[Bradford Keeney]] ([[Shaking medicine]]), [[Somatic experiencing]] ([[Peter A. Levine]]), [[Ecstatic dance]], [[Runner's high]], ... (its revealing that wikipedia has no articles on these "alternative medicine" topics... all hail the cult of big pharma!)
this association assumes that cults use [[Psychological trauma]] to imprison their slaves.
Psychological trauma is an emotional response caused by severe distressing events such as accidents, violence, sexual assault, terror, or sensory overload.
in every cult, there are people who want to escape. this "want to escape" starts early in childhood, where it is counteracted by punishment = by creating psychological trauma.
Sigmund Freud's [[Psychoanalysis]] always blames "some childhood trauma" for "neurotic" behavior in adults, instead of fixing the child education, to prevent the creation of that trauma in the first place = radical solution.
the cult slaves are expected to use their body only for working, not for sports, not for fighting, not for pleasure. all problems should be solved peacefully and intellectually ("let us talk..."). because the cult leaders know: if the slaves make too much use of their body (shaking medicine), the slaves would escape.
also related: [[Slave morality]] is another word for [[Cult]], because the [[Public opinion]] of every cult is a form of slave morality (beautiful lies), and hard truths ([[Red pill and blue pill|red pills]]) are hidden as master morality. ```
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www.sciencedaily.com www.sciencedaily.com
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- for: medicine - paralysis
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www.sciencedaily.com www.sciencedaily.com
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- for: synthetic biology, progress trap - synthetic biology
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tinlizzie.org tinlizzie.org
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and medicine has always had a thing called a hippocratic oath
https://doctors.practo.com/the-hippocratic-oath-the-original-and-revised-version/
"I swear to fulfill, to the best of my ability and judgment, this covenant: I will respect the hard-won scientific gains of those physicians in whose steps I walk, and gladly share such knowledge as is mine with those who are to follow. I will apply, for the benefit of the sick, all measures [that] are required, avoiding those twin traps of overtreatment and therapeutic nihilism. I will remember that there is art to medicine as well as science, and that warmth, sympathy, and understanding may outweigh the surgeon's knife or the chemist's drug. I will not be ashamed to say "I know not," nor will I fail to call in my colleagues when the skills of another are needed for a patient's recovery. I will respect the privacy of my patients, for their problems are not disclosed to me that the world may know. Most especially must I tread with care in matters of life and death. If it is given me to save a life, all thanks. But it may also be within my power to take a life; this awesome responsibility must be faced with great humbleness and awareness of my own frailty. Above all, I must not play at God. I will remember that I do not treat a fever chart, a cancerous growth, but a sick human being, whose illness may affect the person's family and economic stability. My responsibility includes these related problems, if I am to care adequately for the sick. I will prevent disease whenever I can, for prevention is preferable to cure. I will remember that I remain a member of society, with special obligations to all my fellow human beings, those sound of mind and body as well as the infirm. If I do not violate this oath, may I enjoy life and art, respected while I live and remembered with affection thereafter. May I always act so as to preserve the finest traditions of my calling and may I long experience the joy of healing those who seek my help."
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- Sep 2023
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- Aug 2023
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hopkinsathome.vhx.tv hopkinsathome.vhx.tv
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Storytelling functions as a tool to heal from and protect against historical trauma and ongoing challenges Indigenous communities experience. "It is medicine." —Beltran & Begun, 2013 (quoted in @Okeefe2021 video at 10:41)
Basic knowledge and understanding for me, but nice to have a source for it in particular.
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- Jul 2023
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www.forbes.com www.forbes.com
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New York-based startup DoNotPay created an AI-based way for people to contest traffic tickets—a user would wear smart glasses that would feed it information to say in court generated by AI—but before the creator could introduce it in court, he said he got threats from multiple bar associations about “unauthorized practice of law,”
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As ScottBuchanan has said, "Popular science has made every manhis own quack; he needs some of the doctor's medicine."
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- Jun 2023
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- May 2023
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- Apr 2023
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- Mar 2023
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contrappassomag.wordpress.com contrappassomag.wordpress.com
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So many of the prewar musicians that I admired, obscure and famous, all had experience playing in the medicine shows. This included black songsters like Frank Stokes and Pink Anderson, as well as seminal country artists like Jimmie Rodgers and Gene Autry. Even Hank Williams played the medicine shows.
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www.oldhatrecords.com www.oldhatrecords.com
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Medicine shows became popular after the Civil War when patent medicine salesmen traveled the "kerosene circuit" in rural America. Flourishing until the passage of 1906 Fair Food and Drug Act made them obsolete, medicine shows provided entertainment to attract audiences and then used their intermissions to sell their products.
This pattern would later be seen in later radio and television when product pitchmen sponsored entertainment in return for commercial time.
(Bob Dylan, Theme Time Radio Hour, "Doctors," February 20, 2008 via http://www.oldhatrecords.com/)
See also: https://en.wikipedia.org/wiki/Medicine_show
Also related to tent revival shows which featured music and religion as entertainment and socializing.
Example in music: Neil Diamond's song: Brother Love's Travelling Salvation Show
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- Feb 2023
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www.technologynetworks.com www.technologynetworks.com
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www.britannica.com www.britannica.com
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The prefrontal leukotomy procedure developed by Moniz and Lima was modified in 1936 by American neurologists Walter J. Freeman II and James W. Watts. Freeman preferred the use of the term lobotomy and therefore renamed the procedure “prefrontal lobotomy.” The American team soon developed the Freeman-Watts standard lobotomy, which laid out an exact protocol for how a leukotome (in this case, a spatula) was to be inserted and manipulated during the surgery. Get a Britannica Premium subscription and gain access to exclusive content. Subscribe Now lobotomyThe use of lobotomy in the United States was resisted and criticized heavily by American neurosurgeons. However, because Freeman managed to promote the success of the surgery through the media, lobotomy became touted as a miracle procedure, capturing the attention of the public and leading to an overwhelming demand for the operation. In 1945 Freeman streamlined the procedure, replacing it with transorbital lobotomy, in which a picklike instrument was forced through the back of the eye sockets to pierce the thin bone that separates the eye sockets from the frontal lobes. The pick’s point was then inserted into the frontal lobe and used to sever connections in the brain (presumably between the prefrontal cortex and thalamus). In 1946 Freeman performed this procedure for the first time on a patient, who was subdued prior to the operation with electroshock treatment.The transorbital lobotomy procedure, which Freeman performed very quickly, sometimes in less than 10 minutes, was used on many patients with relatively minor mental disorders that Freeman believed did not warrant traditional lobotomy surgery, in which the skull itself was opened. A large proportion of such lobotomized patients exhibited reduced tension or agitation, but many also showed other effects, such as apathy, passivity, lack of initiative, poor ability to concentrate, and a generally decreased depth and intensity of their emotional response to life. Some died as a result of the procedure. However, those effects were not widely reported in the 1940s, and at that time the long-term effects were largely unknown. Because the procedure met with seemingly widespread success, Moniz was awarded the 1949 Nobel Prize for Physiology or Medicine (along with Swiss physiologist Walter Rudolf Hess). Lobotomies were performed on a wide scale during the 1940s; Freeman himself performed or supervised more than 3,500 lobotomies by the late 1960s. The practice gradually fell out of favour beginning in the mid-1950s, when antipsychotics, antidepressants, and other medications that were much more effective in treating and alleviating the distress of mentally disturbed patients came into use. Today lobotomy is rarely performed; however, shock therapy and psychosurgery (the surgical removal of specific regions of the brain) occasionally are used to treat patients whose symptoms have resisted all other treatments.
Walter Freeman's barbaric obsession and fervent practice of the miracle cure for mental illness that is the "transorbital lobotomy"
Tags
- Electroshock
- Walter Freeman
- mental illness
- neurology
- Nobel Prize
- Walter J. Freeman II
- Walter Rudolf Hess
- 20th Century Medicine
- António Egas Moniz
- 1950s
- James W. Watts
- Neurosurgery
- leukotome
- Lobotomy
- Prefontal Lobotomy
- Shock Therapy
- psychosurgery
- Brain Surgery
- 1940s
- 20th Century Neuroscience
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- Jan 2023
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- Dec 2022
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www.embopress.org www.embopress.org
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I came here after recalling a critique by Bessel van der Kolk's "The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma" regarding the disease model and it's negative impact on adequately helping people with trauma. van der Kolk's critique was similar to Marc Lewis' critique of the disease model as it applies to addiction from "The Biology of Desire: Why Addiction Is Not a Disease". This made me wonder what the term "disease" actually means and whether or not some general consensus existed within the medical community. This article suggests there is no such consensus.
This article is by Jackie Leach Scully who holds a "PhD in cellular pathology, University of Cambridge; BA (Hons) in biochemistry, University of Oxford; MA in psychoanalytic studies, Sheffield University".
Scully does several insightful things in this paper the following are the ones that were most salient to me upon the first read: - distinguishes "disease" from "disability" - contrasts the "social model" and "medical model" perspectives on "disability" - The "medical model" referred to here is probably what Lewis & van der Kolk are critiquing as the "disease model".<br /> - Are the "medical" and "disease" model different? - the social model seems to have arisen as a response to the inadequacy of the medical model
- "The social model's fundamental criticism of the medical model is that it wrongly locates 'the problem' of disability in biological constraints, considering it only from the point of view of the individual and neglecting the social and systemic frameworks that contribute to it. The social model distinguishes between impairment (the biological substrate, such as impaired hearing) and the disabled experience. In this view the presence of impaired hearing is one thing, while the absence of subtitling on TV is quite another, and it is the refusal of society to make the necessary accommodations that is the real site of disability. A social model does not ignore biology, but contends that societal, economic and environmental factors are at least as important in producing disability."- brings up a subtle point that there are two jumps "from gene to phenotype, and from phenotype to experience" and that some of the arguments mentioned "suggest that the 'harm' of the impairment is not straightforwardly related to phenotype. What ought to concern us about disease and disability is the disadvantage, pain or suffering involved, and in a sense the impairment is always a kind of surrogate marker for this experience."
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- Nov 2022
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- Sep 2022
- Aug 2022
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www.nature.com www.nature.com
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Irwin, A. (2021). How COVID spurred Africa to plot a vaccines revolution. Nature. https://doi.org/10.1038/d41586-021-01048-1
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twitter.com twitter.com
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Nature Portfolio. (2021, October 15). A study in @NatureMedicine indicates that the effectiveness of the Pfizer/BioNTech and Oxford-AstraZeneca vaccines against SARS-CoV-2 infections with symptoms or high viral burden is reduced with the Delta variant compared to the Alpha variant. Https://go.nature.com/3vecpoj https://t.co/XQdnMYguFz [Tweet]. @NaturePortfolio. https://twitter.com/NaturePortfolio/status/1449145321188216836
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en.wikipedia.org en.wikipedia.org
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theGerman library handwriting style invented by E. Ackerknecht is recommended in order toensure equal handwriting style.
https://en.wikipedia.org/wiki/Erwin_Ackerknecht<br /> Influential historian of medicine
<ins datetime="2022-08-24T15:44:48+00:00"> Erwin Heinz Ackerknecht (1 June 1906, in Stettin – 18 November 1988, in Zurich), the historian of medicine, did some library related work, but didn't invent this handwriting style, his father Erwin Julius Ackerknecht did. see: https://de.wikipedia.org/w/index.php?title=Erwin_Ackerknecht</ins>
What does this handwriting style look like?
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This pamphlet of direc-tions is not a medical prescri tion to he taken in a singledose: the result might be fataf
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- Jun 2022
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www.scientificamerican.com www.scientificamerican.com
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Second, the application of the scientific method matters: what works for ants and other nonhuman species is not always relevant for health and/or human outcomes. For example, the associations of Black people with poor health outcomes, economic disadvantage and reduced life expectancy can be explained by structural racism, yet Blackness or Black culture is frequently cited as the driver of those health disparities. Ant culture is hierarchal and matriarchal, based on human understandings of gender. And the descriptions and importance of ant societies existing as colonies is a component of Wilson’s work that should have been critiqued. Context matters.
The author is going in two opposite directions here and neither match up. A massive swath of our medicine research is wholly based on translational genetics. (That is, our basic research on organisms like flies (drosophila), worms (C. elegans), zebrafish, mice, rats, primates, etc. is contingent on moving medicines applicable to simpler genetic models in these animals will also work for humans who share large amounts of genetic material as the result of evolutionary dynamics. Sure some of it may not be relevant for humans because of both genetic and epigenetic (environmental) factors, but generally we expect that more will than won't.
This basic fact is wholly separate from the health disparities issue. While there are some (and few of these are generally scientists in my experience) who believe that culture is the driving factor, there is enough proof to show that structural racism is the driving factor in almost all cases. I'm unaware of any translational genetic work on ant culture into human culture in any of the scientific literature and she certainly doesn't cite any to provide any sort of evidence to the contrary. As a result, she isn't providing any context at all.
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- May 2022
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www.jstor.org www.jstor.org
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Nelson, Sarah E. “Persephone’s Seeds: Abortifacients and Contraceptives in Ancient Greek Medicine and Their Recent Scientific Appraisal.” Pharmacy in History 51, no. 2 (2009): 57–69.
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theconversation.com theconversation.com
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By 1860, the American Medical Association sought to end legal abortion. The Comstock Law of 1873 criminalized attaining, producing or publishing information about contraception, sexually transmitted infections and diseases, and how to procure an abortion.
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www.civilwarmed.org www.civilwarmed.org
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<small><cite class='h-cite via'>ᔥ <span class='p-author h-card'>Treva B. Lindsey </span> in Abortion has been common in the US since the 18th century -- and debate over it started soon after (<time class='dt-published'>05/18/2022 12:10:32</time>)</cite></small>
some interesting looking references at the bottom
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- Apr 2022
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www.idsociety.org www.idsociety.org
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CDC/IDSA COVID-19 Clinician Call: Vaccine Boosters. (n.d.). Retrieved 27 April 2022, from https://www.idsociety.org/multimedia/clinician-calls/cdcidsa-covid-19-clinician-call-vaccine-boosters/
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www.ema.europa.eu www.ema.europa.eu
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EMA. (2020, October 27). COVID-19 vaccines: Development, evaluation, approval and monitoring [Text]. European Medicines Agency. https://www.ema.europa.eu/en/human-regulatory/overview/public-health-threats/coronavirus-disease-covid-19/treatments-vaccines/vaccines-covid-19/covid-19-vaccines-development-evaluation-approval-monitoring
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onlinelibrary.wiley.com onlinelibrary.wiley.com
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Fernández-Penny, F. E., Jolkovsky, E. L., Shofer, F. S., Hemmert, K. C., Valiuddin, H., Uspal, J. E., Sands, N. A., & Abella, B. S. (2021). COVID-19 vaccine hesitancy among patients in two urban emergency departments. Academic Emergency Medicine, 28(10), 1100–1107. https://doi.org/10.1111/acem.14376
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- Mar 2022
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www.washingtonpost.com www.washingtonpost.com
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Perspective | Natural immunity to covid is powerful. Policymakers seem afraid to say so. (n.d.). Washington Post. Retrieved 31 March 2022, from https://www.washingtonpost.com/outlook/2021/09/15/natural-immunity-vaccine-mandate/
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www.texaschildrens.org www.texaschildrens.org
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Texas Children’s Hospital and Baylor College of Medicine Covid-19 Vaccine Technology Secures Emergency Use Authorization in India | Texas Children’s Hospital. (n.d.). Retrieved 29 March 2022, from https://www.texaschildrens.org/texas-children%E2%80%99s-hospital-and-baylor-college-medicine-covid-19-vaccine-technology-secures-emergency
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www.scientificamerican.com www.scientificamerican.com
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Bottazzi, P. J. H., Maria Elena. (n.d.). A COVID Vaccine for All. Scientific American. Retrieved 22 March 2022, from https://www.scientificamerican.com/article/a-covid-vaccine-for-all/
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Study shows continued face mask use offers economic benefits. (n.d.). Baylor College of Medicine. Retrieved 14 March 2022, from https://www.bcm.edu/news/study-shows-continued-face-mask-use-offers-economic-benefits
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twitter.com twitter.com
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ReconfigBehSci. (2022, March 12). @rwjdingwall @mugecevik @RobFreudenthal it makes little sense to numerically compare this pandemic with all of the intervention that occurred directly with past ones where medicine and epidemiology where of a completely different standard to conclude that this one ‘wasn’t bad’. 1/2 [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1502681086819721223
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- Feb 2022
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Mancini, D. P., & Smyth, J. (2022, February 16). Merck struggles to win European approval for Covid-19 antiviral pill. Financial Times. https://www.ft.com/content/2cf0b6cc-b07b-4ff9-a833-42eb1798a576
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www.theguardian.com www.theguardian.com
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Schreiber, M. (2022, February 14). ‘The only logical choice’: Anti-vaxxers who changed their minds on Covid vaccines. The Guardian. https://www.theguardian.com/us-news/2022/feb/14/covid-anti-vaxxers-changed-minds
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ohsonline.com ohsonline.com
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Nursing professionals are facing with severe sleep problems during the covid 19 pandemic time. Nurses were asked to work in an environment that had a more increased level of risk than ever before. Depression and anxiety from the workplace could affect the confidence of healthcare workers in themselves as well as general trust in the healthcare system. This will lead to their turnover intention which may undermine the efforts of the governments to control the COVID-19 pandemic. The rising concern may change the working schedules of healthcare workers, offering more occupational healthcare support.
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- Jan 2022
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www.janeausten.pludhlab.org www.janeausten.pludhlab.org
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Every morning now brought its regular duties—shops were to be visited; some new part of the town to be looked at; and the pump-room to be attended, where they paraded up and down for an hour, looking at everybody and speaking to no one.
Jane Austen’s contemporaries, including everyone from the laboring poor to the royals, shared a belief in the restorative power of spring water and in the consumption of natural remedies. In the years when Austen was writing Northanger Abbey, the warm springs offered at Bath’s Pump rooms were a popular treatmentfor those suffering from loss of appetite, nerves (Mrs. Bennett!), gout, and ailments affecting the stomach, head, and vital parts.
In 1813, a guide to the resort claimed that the waters contained carbon dioxide, azotic gas, sulphates, muriate of soda, selenite, carbonate of lime siliceous earth, and a very small portion of oxide of iron (Guide 32). These properties probably gave the water a sulfuric aroma. As the opening of this chapter suggests, though, whether ill or healthy, the resort provided for all. For the healthy visitor, the prime activity was to consume in ways that are familiar to us: purchasing clothes or textiles, as Catherine learns to do from Mrs. Allen, window-shopping, and people-watching.
These lines express Austen’s awareness of the period’s rapidly growing consumer market, resulting from an unprecedented growth in the middle class, which in turn increased demand for domestic and foreign goods. Purchasing power allowed Bath visitors to pay about one guinea a month for access to the warm spring waters served in the newly renovated Pump Room, and to provide a handsome gratuity to the pumper serving water from the King’s Springs .jpg) (Guide 38). But they would likely also be paying to imbibe other popular drinks, including tea, coffee, and chocolate, which albeit pricey were increasingly affordable to the growing middle-class (Selwyn 215). As any Austen fan knows, the Pump Room continues to serve tourists today. Although bathing is no longer allowed, tea, chocolate, coffee, and warm spring waters can still be imbibed.
Walking the streets of Bath with Catherine as we read through Northanger Abbey’s first volume, we might keep in mind who teaches Catherine her consumer habits, and how the novel’s development may be commenting on these practices. We might also consider how the novel records a turning point in the consumption of natural remedies and other goods extracted from apparently distant communities and environments. How much do our current consumer habits differ from Catherine’s?
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respectfulinsolence.com respectfulinsolence.com
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Defeat The Mandates: Green Our Vaccines reconstituted for COVID-19. (2022, January 21). RESPECTFUL INSOLENCE. https://respectfulinsolence.com/2022/01/21/defeat-the-mandates-green-our-vaccines-reconstituted-for-covid-19/
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globalnews.ca globalnews.ca
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Revealed: How a web of Canadian doctors are undermining the fight against COVID-19 | Globalnews.ca. (n.d.). Global News. Retrieved January 19, 2022, from https://globalnews.ca/news/8517353/canada-doctors-covid-vaccine-disinformation/
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twitter.com twitter.com
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Shematologist, MD. (2022, January 13). In medicine this is what we call a conflict of interest. Https://t.co/DNk0pDdz6Y [Tweet]. @acweyand. https://twitter.com/acweyand/status/1481480271254138880
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Automated Texting System Saved Lives Weekly During First COVID Surge—Penn Medicine. (n.d.). Retrieved January 10, 2022, from https://www.pennmedicine.org/news/news-releases/2021/november/automated-texting-system-saved-lives-weekly-during-first-covid-surge
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khn.org khn.org
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Jewett, C. (2021, November 4). Patients Went Into the Hospital for Care. After Testing Positive There for Covid, Some Never Came Out. Kaiser Health News. https://khn.org/news/article/hospital-acquired-covid-nosocomial-cases-data-analysis/
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- Dec 2021
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sciencebasedmedicine.org sciencebasedmedicine.org
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Loud Silenced Doctors | Science-Based Medicine. (2021, December 19). https://sciencebasedmedicine.org/muzzled/
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blogs.dickinson.edu blogs.dickinson.edu
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Whatever dies, was not mixed equally
In Galen's medicine, disease and death were the consequence of a disproportion in one's constituent elements, the 4 humors: black bile, yellow bile, blood, and phlegm.
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- Nov 2021
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www.nejm.org www.nejm.org
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Rubin, E. J., Baden, L. R., Mello, M. M., & Morrissey, S. (2021). Audio Interview: The Legal Basis for Covid-19 Restrictions and Mandates. New England Journal of Medicine, 385(21), e88. https://doi.org/10.1056/NEJMe2118197
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- Oct 2021
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arxiv.org arxiv.org
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Yang, P., & Colavizza, G. (2021). A Map of Science in Wikipedia. ArXiv:2110.13790 [Cs]. http://arxiv.org/abs/2110.13790
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Willyard, C. (2021). How antiviral pill molnupiravir shot ahead in the COVID drug hunt. Nature. https://doi.org/10.1038/d41586-021-02783-1
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twitter.com twitter.com
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Michael Eisen on Twitter. (n.d.). Twitter. Retrieved 8 October 2021, from https://twitter.com/mbeisen/status/1443201806272643073
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www.hindustantimes.com www.hindustantimes.com
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ICMR removes Ivermectin, HCQ from revised guidelines on Covid-19 treatment. (2021, September 24). Hindustan Times. https://www.hindustantimes.com/india-news/icmr-removes-ivermectin-hcq-from-revised-guidelines-on-covid-19-treatment-101632461755113.html
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Kington, R. S., Arnesen, S., Chou, W.-Y. S., Curry, S. J., Lazer, D., & Villarruel, and A. M. (2021). Identifying Credible Sources of Health Information in Social Media: Principles and Attributes. NAM Perspectives. https://doi.org/10.31478/202107a
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orb-international.com orb-international.com
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orb-developer. (2021, June 4). Vaccine Confidence Tracker: UK. ORB International. https://orb-international.com/2021/06/04/vaccine-confidence-tracker-uk/
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www.sciencemag.org www.sciencemag.org
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Kupferschmidt, K., VogelMar. 27, G., 2021, & Am, 10:20. (2021, March 27). A rare clotting disorder may cloud the world’s hopes for AstraZeneca’s COVID-19 vaccine. Science | AAAS. https://www.sciencemag.org/news/2021/03/rare-clotting-disorder-may-cloud-worlds-hopes-astrazenecas-covid-19-vaccine
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docs.google.com docs.google.com
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Understanding COVID-19 Registration Form. (n.d.). Google Docs. Retrieved March 31, 2021, from https://docs.google.com/forms/d/e/1FAIpQLScrC4krKVHcSm_Wi2VcXcGHa4F8l3cilL2xhbB62etcK4sy4w/viewform?usp=embed_facebook
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- Sep 2021
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www.cbc.ca www.cbc.ca
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"Learning about plant medicine, you need to be able to address the plant by its name," Pitawanakwat said. "It's just respect, like a simple courtesy that you extend to every other person."
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ReconfigBehSci on Twitter: ‘RT @MDaware: The problem is the leaders, the media figures, the physicians who know better but would rather get in on the grift https://t.c…’ / Twitter. (n.d.). Retrieved 3 September 2021, from https://twitter.com/SciBeh/status/1432711694569050119
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- Aug 2021
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hardbin.com hardbin.com
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MOFL IS DECREDENTIALING DOCTORS WHO THINK BAKER ACTING OVER AND OVER AGAIN IS NOT TORTURE PERIOD. It looks like there aren't many great matches for your search ⚓ It looks like there aren't many great matches for your searchTip: Try using words that might appear on the page you’re looking for. For example, "cake recipes" instead of "how to make a cake."Need help? Check out other tips for searching on Google.Web results5 days ago — It is well past the time for our lawmakers to once again address the ... Baker Acting of seniors and in many instances the person did not ...Missing:MOFL DECREDENTIALING THINKMar 15, 2004 — Credentialing, not educating, has become the primary business of North ... education does not go beyond high school and who works full time ...Missing:MOFL DECREDENTIALING BAKERNov 2, 1989 — firms once again that, regardless of ... Revenue projections say the state will have just over $3 billion to Spend next year.16 pagesit is recognized that the world financial system is, at any given time, ... vaded both countries, but particularly Argentina, over the past five years.oian or indifference toward a tbe two-thirds needed to over- wn^M P 051 ... briJy strong- but over- whelming” the President made no move it'the' time to ...Aug 14, 1987 — Holloway and his wife Delta, who took over Ever- green Mnnor's ... wo will not wait a i itojsi yea,, to go back again, Ixwause of t — — —the ...Could China actually take over America and turn it to Communism in the ... keeping selected patriots at bay with DEW torture until such time the FBI ...Missing:MOFL DECREDENTIALING BAKER 2read.net
MOFL IS DECREDENTIALING DOCTORS WHO THINK BAKER ACTING OVER AND OVER AGAIN IS NOT TORTURE PERIOD. It looks like there aren't many great matches for your search
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Web results 5 days ago — It is well past the time for our lawmakers to once again address the ... Baker Acting of seniors and in many instances the person did not ...
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MOFL
DECREDENTIALING
THINK Mar 15, 2004 — Credentialing, not educating, has become the primary business of North ... education does not go beyond high school and who works full time ...
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BAKER Nov 2, 1989 — firms once again that, regardless of ... Revenue projections say the state will have just over $3 billion to Spend next year.
16 pages
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BAKER 2read.net
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www.indy100.com www.indy100.com
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Vaccine skeptics are taking horse-strength dewormer to treat Covid, accidentally poisoning themselves. (2021, August 6). https://www.indy100.com/news/anti-vaxxers-horse-dewormer-covid-b1898245
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- Jul 2021
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- Jun 2021
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www.health.gov.au www.health.gov.au
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Health, A. G. D. of. (2021, March 13). COVID-19 vaccines – Is it true? [Text]. Australian Government Department of Health; Australian Government Department of Health. https://www.health.gov.au/initiatives-and-programs/covid-19-vaccines/is-it-true
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www.tga.gov.au www.tga.gov.au
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Report a problem or side effect | Therapeutic Goods Administration (TGA). (n.d.). Retrieved June 26, 2021, from https://www.tga.gov.au/reporting-problems
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www.nomos-elibrary.de www.nomos-elibrary.de
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Evidenzbasierte / evidenzinformierteGesundheitskommunikation (1. Auflage). (2018). Nomos. https://doi.org/10.5771/9783845291963
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absolutelymaybe.plos.org absolutelymaybe.plos.org
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Systematic Evidence and the Covid-19 Stress Test: Pass Or Fail? (2021, May 25). Absolutely Maybe. https://absolutelymaybe.plos.org/2021/05/25/systematic-evidence-and-the-covid-19-stress-test-pass-or-fail/
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www.nature.com www.nature.com
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Feng, L., Zhang, T., Wang, Q., Xie, Y., Peng, Z., Zheng, J., Qin, Y., Zhang, M., Lai, S., Wang, D., Feng, Z., Li, Z., & Gao, G. F. (2021). Impact of COVID-19 outbreaks and interventions on influenza in China and the United States. Nature Communications, 12(1), 3249. https://doi.org/10.1038/s41467-021-23440-1
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- May 2021
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www.wired.com www.wired.com
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The researchers had asked everyone in their game a set of questions: Did people follow the game? Did they understand the rules? Did they think it was fair? These questions were designed to measure which salespeople had “entered the magic circle,” meaning that they agreed to be bound by the game’s rules rather than the normal rules that ordinarily guide their work. After all, if people haven’t entered a game mentally, there’s no real point to it.Sure enough, the salespeople who felt that the basketball game was a load of baloney actually felt worse about work after the game was introduced, and their sales performance declined slightly. The game benefited only the salespeople who had fully bought into it—they became significantly more upbeat at work.
Ethan Mollick and Nancy Rothbard experiment https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2277103 about gamification in a sales setting shows that gamification only works for those who buy into it.
Is this similar to ideas like the placebo effect or potentially for cases like Eastern Medicine where one might need to buy into it for the effects to matter to them?
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www.theguardian.com www.theguardian.com
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Covid ‘vaccination persuasion’ teams reap rewards in Turkey. (2021, April 27). The Guardian. http://www.theguardian.com/world/2021/apr/27/covid-vaccination-persuasion-teams-reap-rewards-in-turkey
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www.theguardian.com www.theguardian.com
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Covid vaccine: 96% of Britons develop antibodies after one jab, study finds. (2021, May 18). The Guardian. http://www.theguardian.com/world/2021/may/18/96-of-britons-develop-antibodies-after-one-covid-jab-study-finds
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www.newscientist.com www.newscientist.com
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Rasolt, D. H. (n.d.). Mistrust fuels covid-19 vaccine doubts in Colombia’s Indigenous groups. New Scientist. Retrieved May 17, 2021, from https://www.newscientist.com/article/2272195-mistrust-fuels-covid-19-vaccine-doubts-in-colombias-indigenous-groups/
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thetrinitychallenge.org thetrinitychallenge.org
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The Vaccine Confidence Project joins as newest member. (n.d.). The Trinity Challenge. Retrieved 13 May 2021, from https://thetrinitychallenge.org/news-and-stories/the-trinity-challenge-welcomes-the-vaccine-confidence-project-as-newest-member/
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www.frontiersin.org www.frontiersin.org
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Trout, L. J., & Kleinman, A. (2020). Covid-19 Requires a Social Medicine Response. Frontiers in Sociology, 5. https://doi.org/10.3389/fsoc.2020.579991
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- Apr 2021
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www.nejm.org www.nejm.org
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Shimabukuro, Tom T., Shin Y. Kim, Tanya R. Myers, Pedro L. Moro, Titilope Oduyebo, Lakshmi Panagiotakopoulos, Paige L. Marquez, et al. ‘Preliminary Findings of MRNA Covid-19 Vaccine Safety in Pregnant Persons’. New England Journal of Medicine 0, no. 0 (21 April 2021): null. https://doi.org/10.1056/NEJMoa2104983.
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twitter.com twitter.comTwitter1
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Nissim Mannathukkaren നിസ്സിം മണ്ണത്തൂക്കാരൻ. (2021, April 8). ‘The hand of God’—Nurses trying to comfort isolated patients in a Brazilian Covid isolation ward. Two disposable gloves tied, full of hot water, simulating impossible human contact. Salute to the front liners and a stark reminder of the grim situation our world is in!@sadiquiz https://t.co/eldzkT4JHa [Tweet]. @nmannathukkaren. https://twitter.com/nmannathukkaren/status/1380129214259720202
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Maskne and perioral dermatitis are two different things with similar appearance, but different treatments.
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- Mar 2021
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www.cam.ac.uk www.cam.ac.uk
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Machine learning models for diagnosing COVID-19 are not yet suitable for clinical use. (2021, March 15). University of Cambridge. https://www.cam.ac.uk/research/news/machine-learning-models-for-diagnosing-covid-19-are-not-yet-suitable-for-clinical-use
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link.springer.com link.springer.com
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Brewer, N. T., Cuite, C. L., Herrington, J. E., & Weinstein, N. D. (2007). Risk compensation and vaccination: Can getting vaccinated cause people to engage in risky behaviors? Annals of Behavioral Medicine, 34(1), 95. https://doi.org/10.1007/BF02879925
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www.acpjournals.org www.acpjournals.org
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Crosby, S. S. (2020). My COVID-19. Annals of Internal Medicine. https://doi.org/10.7326/M20-5126
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en.wikipedia.org en.wikipedia.org
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His first book, Deschooling Society, published in 1971, was a groundbreaking critique of compulsory mass education. He argued the oppressive structure of the school system could not be reformed. It must be dismantled in order to free humanity from the crippling effects of the institutionalization of all of life. He went on to critique modern mass medicine. In the pre-Internet age, Illich was highly influential among intellectuals and academics. He became known worldwide for his progressive polemics about how human culture could be preserved and expand, activity expressive of truly human values, in the face of multiple thundering forces of de-humanization.
A fairly reasonable summary of his thinking?
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science.sciencemag.org science.sciencemag.org
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London, Alex John, and Jonathan Kimmelman. ‘Against Pandemic Research Exceptionalism’. Science 368, no. 6490 (1 May 2020): 476–77. https://doi.org/10.1126/science.abc1731.
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www.washingtonpost.com www.washingtonpost.com
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Isaacson, Walter. ‘Opinion | I Was Part of a Trial for Pfizer’s Covid-19 Vaccine. It’s a Miracle for Genetic Medicine.’ Washington Post. Accessed 6 March 2021. https://www.washingtonpost.com/opinions/i-took-the-pfizer-covid-19-vaccine-its-a-miracle-for-genetic-medicine/2020/11/09/77e652d0-22bf-11eb-952e-0c475972cfc0_story.html.
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inews.co.uk inews.co.uk
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Fears for double Covid vaccine dosing as GPs left without up-to-date data amid NHS IT chaos. (2020, December 11). Inews.Co.Uk. https://inews.co.uk/news/health/covid-vaccines-fears-double-dosing-gps-nhs-it-chaos-exclusive-792346
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Rietz, H. (2020, November 18). Intensivmedizin am Anschlag: Zertifizierte Betten sind belegt. Neue Zürcher Zeitung. https://www.nzz.ch/wissenschaft/intensivmedizin-am-anschlag-zertifizierte-betten-sind-belegt-ld.1587675
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www.google.co.uk www.google.co.uk
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Greene, G. (1999). The Woman who Knew Too Much: Alice Stewart and the Secrets of Radiation. University of Michigan Press.
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iu.mediaspace.kaltura.com iu.mediaspace.kaltura.com
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MultiNet Webinar Series: Manlio De Domenico—Indiana University. (n.d.). Retrieved 1 March 2021, from https://iu.mediaspace.kaltura.com/media/MultiNet+Webinar+SeriesA+Manlio+De+Domenico/1_242n97rr
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- Feb 2021
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www.thelancet.com www.thelancet.com
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Horton, Richard. ‘Offline: COVID-19—a Crisis of Power’. The Lancet 396, no. 10260 (31 October 2020): 1383. https://doi.org/10.1016/S0140-6736(20)32262-5.
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www.biorxiv.org www.biorxiv.org
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Seitz, B. M., Aktipis, A., Buss, D. M., Alcock, J., Bloom, P., Gelfand, M., Harris, S., Lieberman, D., Horowitz, B. N., Pinker, S., Wilson, D. S., & Haselton, M. G. (2020). The pandemic exposes human nature: 10 evolutionary insights. Proceedings of the National Academy of Sciences, 117(45), 27767–27776. https://doi.org/10.1073/pnas.2009787117
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www.irishtimes.com www.irishtimes.com
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Suiter, J. (n.d.). We need much more than media literacy to tackle Covid-19 disinformation. The Irish Times. Retrieved 24 February 2021, from https://www.irishtimes.com/news/education/we-need-much-more-than-media-literacy-to-tackle-covid-19-disinformation-1.4449829
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- Jan 2021
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oldcbcreadingandwritingsupplementary.wordpress.com oldcbcreadingandwritingsupplementary.wordpress.com
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outofpocket.health outofpocket.health
- Nov 2020
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www.newyorker.com www.newyorker.com
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tells you to take a poison so that you can heal
having to take a "poison" so one can heal.
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www.reuters.com www.reuters.com
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Many COVID-19 survivors are likely to be at greater risk of developing mental illness, psychiatrists said on Monday, after a large study found 20% of those infected with the coronavirus are diagnosed with a psychiatric disorder within 90 days.
The takeaway: COVID-19 survivors are at a higher risk for mental illness.
The claim: COVID-19 survivors are at a higher risk for mental illness.
The evidence: Infection by SARS-CoV-2 was associated with an increase in anxiety disorders, insomnia, and dementia (1). Prior mental illness was also associated with an increased risk of SARS-CoV-2 infection (1). Approximately 1/3 of COVID patients were reported to have central nervous symptom issues in a study of 214 hospitalized Chinese patients (2). SARS-CoV-2 has been found in the brain and cerebral spinal fluid (3). Social isolation, pathology of SARS-CoV-2, and sedation are a few of the reasons why ICU patients experience delirium and the subsequent mental health risks (4).
All of these factors support the statement that COVID-19 survivors are at a higher risk of mental illness.
As a reminder, there is help for suicide. National Suicide Prevention Lifeline is a toll-free number for those in a suicidal crisis or emotional distress. The number is: 1-800-273-8255
Disclaimer: This content is not intended as a substitute for professional medical advice. Always seek the advice of a qualified health provider with any questions regarding a medical condition.
Sources:
1) https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(20)30462-4/fulltext
2) https://pubmed.ncbi.nlm.nih.gov/32399719/
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jameslyonsweiler.com jameslyonsweiler.com
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The vaccine may in fact make COVID19 much, much worse in many people.
The takeaway: Current data for three separate COVID-19 vaccines suggests that the vaccine prevents COVID-19 or lessens the disease severity. No data from top three COVID-19 vaccine candidates indicates that the vaccine makes the disease worse. Phase III clinical trials to conclusively prove the effect of the vaccine will be completed before administration of the vaccine to the general public.
The claim: The vaccine may make COVID-19 much, much worse in many people.
The evidence: A number of protein sequences encoded by SARS-CoV-2 genome are similar to human proteins (1). This similarity led to the hypothesis that a SARS-CoV-2 vaccine could result in more severe disease when exposure occurs after vaccination (1). For previous SARS and MERS, this severe reaction was observed during the animal studies and therefore the vaccines were not pursued. The hypothesis was proposed before SARS-CoV-2 animal study vaccines were published as stated in (1).
Three vaccines are currently in phase III clinical development in the USA, funded by Operation Warp Speed (2). Vaccine approval process involves four stages (3). Phase I is a small scale study in healthy people to make sure the vaccine does no harm. Phase II is a study with more people to test whether the vaccine does what it is supposed to do. Phase III study occurs in 300-3000 people to ensure that the vaccine works as intended in a larger group of people. Phase IV is post-approval monitoring of the vaccine for an adverse events that may happen after the drug is approved. Human study in Phase I clinical trials only occurs after the vaccine has been proven safe in animals first.
Moderna’s mRNA-1273 prevented COVID-19 disease in monkeys (4). Control monkeys' lungs showed signs of pneumonia from COVID-19. Lungs in vaccinated monkeys were normal after exposure to COVID. The virus was not detectable in the monkey's nose after two days for animals vaccinated with 100 ug dose. Phase I clinical trial data from humans is published and included older adults (5).
University of Oxford and AstraZeneca’s AZD1222 (ChAdOx1 nCoV-19) prevented pneumonia in monkeys and did not cause disease enhancement (6). AZD1222 reduced the number of SARS-CoV-2 (virus) in the lung of the monkeys but did not stop the virus from leaving the nose of the monkeys. Early results from the phase I/II clinical trials demonstrate the safety of the vaccine (7). Further research is ongoing to establish safety and efficacy. This includes phase III clinical trials with more participants and one year monitoring of Phase II participants.
Pfizer and BioNTech's BNT162 is several different vaccine candidates which were tested simultaneously to determine the vaccine with the best protection and least number of reactions such as pain at the injection site, fever, etc (8). In phase I/II clinical trails, the reactions to BNT162b1 were mild to moderate and did not last long (9). Animal studies are presented as a pre-print (10). From the pre-print, it is unclear whether the vaccine prevented lung damage because both vaccine and control group had no lung damage. In other rhesus macaque COVID infections with no vaccine, lung damage was observed (4, 6). BNT162b2 COVID vaccine resulted in no detectable COVID virus after the first day of challenge in monkeys (10).
Sources:
1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142689/
2) https://www.raps.org/news-and-articles/news-articles/2020/3/covid-19-vaccine-tracker
3) https://www.fda.gov/patients/drug-development-process/step-3-clinical-research
4) https://pubmed.ncbi.nlm.nih.gov/32722908/
5) https://www.nejm.org/doi/full/10.1056/NEJMoa2028436?query=featured_home
6) https://pubmed.ncbi.nlm.nih.gov/32731258/
7) https://pubmed.ncbi.nlm.nih.gov/32702298/
8) https://www.nejm.org/doi/full/10.1056/NEJMoa2027906?query=featured_home#
9) https://pubmed.ncbi.nlm.nih.gov/32785213/
10) https://www.biorxiv.org/content/10.1101/2020.09.08.280818v1.full.pdf
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- Oct 2020
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www.foundersfamilymedicine.com www.foundersfamilymedicine.com
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Family Doctors are specially trained in preventive medicine and can help detect problem areas and advise on healthy solutions before disease occurs.
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www.collectionscanada.gc.ca www.collectionscanada.gc.ca
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Some legislation allows for treatment to be given in certain circumstances without the patient's volition. For example, irresponsible people with communicable diseases may be treated against their objection, as in the case of patients with tuberculosis who are noncompliant with treatment. Also, all provinces allow for the involuntary admission of patients to psychiatric facilities, provided they present an immediate risk to themselves or others, or are unable to take care of themselves
These highlight cases where you can treat patients without their consent.
Irresponsible people with communicable diseases (e.g. Tuberculosis)
Psychiatry patients that pose an immediate threat to themselves and/or those around them.
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www.youtube.com www.youtube.com
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David Spiegelhalter and False Positives. (2020, October 14). https://www.youtube.com/watch?v=XmiEzi54lBI&feature=youtu.be
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www.biorxiv.org www.biorxiv.org
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www.itv.com www.itv.com
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Long-term effects of Covid include damage to heart, liver, kidneys. (2020, September 29). ITV News. https://www.itv.com/news/2020-09-29/long-covid-long-term-effects-of-coronavirus-include-damage-to-heart-liver-kidneys-oxford-study-reveals
Tags
- lang:en
- organ damage
- liver
- long-term impact
- medicine
- is:news
- symptom
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- COVID-19
- clinical outcome
- heart
- kidney
Annotators
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- Sep 2020
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www.thelancet.com www.thelancet.com
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Wilkinson, Jack, Kellyn F. Arnold, Eleanor J. Murray, Maarten van Smeden, Kareem Carr, Rachel Sippy, Marc de Kamps, et al. ‘Time to Reality Check the Promises of Machine Learning-Powered Precision Medicine’. The Lancet Digital Health 0, no. 0 (16 September 2020). https://doi.org/10.1016/S2589-7500(20)30200-4.
Tags
- machine learning powered precision medicine
- algorithmic complexity
- electronic health database
- clinical practice
- lang:en
- revolution
- is:report
- machine learning
- improved diagnosis
- clinical science
- challenges
- personalised medical approach
- prediction of individual responses
- collaboration
Annotators
URL
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www.bmj.com www.bmj.com
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Thacker, P. D. (2020). A few tiny steps towards transparency: How the Sunshine Act shone light on industry’s influence in medicine. BMJ, 370. https://doi.org/10.1136/bmj.m3229
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www.theblaze.com www.theblaze.com
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Hydroxychloroquine is a relatively cheap and readily available drug that has been used for decades to treat malaria. Throughout the COVID-19 pandemic, doctors around the world have vouched for positive results seen in patients who take it.
Take away: Though chloroquine and hydroxychloroquine showed some effects against SARS-CoV-2 in vitro for vero cells, the FDA removed emergency use authorization for COVID-19 patients due to increased heart problems. No in vitro effect was seen when using human lung cells instead of monkey cells. Many clinical trials are ongoing.
The claim: Hydroxychloroquine is a relatively cheap and available medication with positive results in patients who have taken the drug.
The evidence: Chloroquine and hydroxychloroquine inhibited infection of vero E6 cells (African green monkey kidney cell line) by SARS-CoV-2 (1, 2). These drugs did not inhibit SARS-CoV-2 infection in Calu-3 cells (human lung cell line, 3). Several clinical trials have reported positive outcomes with the use of hydroxychloroquine/chloroquine (4, 5). Current evidence is reviewed in (6). Known side effects including cardiovascular, neuropsychiatric, and gastrointestinal exist based on use of hydroxychloroquine and chloroquine in treating malaria and autoimmune conditions (7). These side effects may more severely affect COVID-19 patients due to the average age and comorbidities often present in severe COVID-19 cases and similarity to COVID-19 symptoms. A randomized, double blind placebo-controlled trial did not observe a significant difference between treatment and control groups when hydroxychloroquine was used prophylactically (8). Increased cardiovascular mortality, chest pain/angina, and heart failure occurred when hydroxychloroquine was combined with azithromycin (9). The FDA removed emergency use authorization in June (10). Many clinical trials are currently ongoing (11).
Disclaimer: This content is not intended as a substitute for professional medical advice. Always seek the advice of a qualified health provider with any questions regarding a medical condition.
Sources:
1 https://www.nature.com/articles/s41422-020-0282-0
2 https://academic.oup.com/cid/article/71/15/732/5801998
3 https://www.nature.com/articles/s41586-020-2575-3
4 https://www.jstage.jst.go.jp/article/bst/14/1/14_2020.01047/_pdf/-char/en
5 https://www.sciencedirect.com/science/article/pii/S0924857920300996?via%3Dihub
6 https://pmj.bmj.com/content/96/1139/550.long
7 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228887/
8 https://pubmed.ncbi.nlm.nih.gov/32492293/
9 https://www.medrxiv.org/content/medrxiv/early/2020/05/31/2020.04.08.20054551.full.pdf
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www.scientificamerican.com www.scientificamerican.com
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COVID-19 Can Wreck Your Heart, Even if You Haven’t Had Any Symptoms
Take Away: SARS-CoV-2 infection has been clearly linked to heart muscle injury in those with severe COVID-19 illness. However, at present, there is insufficient data to determine the impact of mild or asymptomatic COVID-19 on the hearts of previously healthy individuals.
The Claim: COVID-19 can wreck your heart, even if you haven’t had any symptoms.
The Evidence: Several articles, including this August 31st piece (1), have raised the alarm about dangerous effects of mild or even asymptomatic cases of COVID-19 on the heart of infected individuals.
In support of this argument, there have been numerous reports, some of which are cited in the article above, documenting severe heart inflammation (myocarditis) and injury (e.g. cardiomyopathy and/or heart failure) in patients with COVID-19. However, most of these documented cases were in individuals with severe cases of COVID-19. At present, the evidence for clinically significant heart injury (requiring treatment or special precautions) from mild or asymptomatic COVID-19, is much less clear, especially in those with no prior evidence of heart disease.
One recent study reported that 78% of patients from an unselected cohort (including patients with asymptomatic, mild, and severe cases) had evidence of myocarditis (via MRI or blood testing) following COVID-19 infection (2). This study clearly demonstrated the link between COVID-19 and myocarditis by examining tissue from biopsies of the heart (the gold standard definitive diagnosis of myocarditis) of patients with the most severe cases. The study went on to show that, on average, patients who were treated for COVID-19 at the hospital (presumably more severe cases) and patients who were treated at home (presumably asymptomatic to moderate cases) both had blood test levels or MRI findings suggesting elevated myocarditis compared to non-COVID-19 infected patients with similar health profiles.
A key limitation here is “average”. The study was not designed or powered to look for the rate of myocarditis in only previously healthy patients with mild or asymptomatic COVID-19. This study included asymptomatic patients in the analysis, but without knowing their prior health or comparing their findings to other healthy non-COVID patients, it is not possible to infer the risk of myocarditis to this population. To their credit, the authors of the study discuss this limitation in their conclusions.
Despite this, the study was widely covered as evidence that ”COVID-19 can wreck your heart, even if you haven’t had any symptoms.“ In order to answer that question, we need research looking selectively healthy patients with mild or asymptomatic COVID-19 as outlined above.
Until that research is conducted, we might look at COVID within the same context as a number of other well studied viruses, many of which generally cause mild illness, that have also been shown to lead to heart injury and inflammation (3).
Disclaimer: This content is not intended as a substitute for professional medical advice. Always seek the advice of a qualified health provider with any questions regarding a medical condition.
Sources:
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www.dailymail.co.uk www.dailymail.co.uk
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Take away: People are infectious for only part of the time they test positive. The tests for COVID-19 were granted emergency status by the FDA so some debate concerning the most ideal number of cycles is to be expected. It is worth noting that the FDA has the disclaimer "Negative results do not preclude 2019-nCoV infection and should not be used as the sole basis for treatment or other patient management decisions. Negative results must be combined with clinical observations, patient history, and epidemiological information (2)."
The claim: Up to 90 percent of people diagnosed with coronavirus may not be carrying enough of it to infect anyone else
The evidence: Per Walsh et al. (1), SARS-CoV-2 virus (COVID-19) is most likely infectious if the number of PCR cycles is <24 and the symptom onset to test is <8 days. RT-PCR detects the RNA, not the infectious virus. Therefore, setting the cycle threshold at 37-40 cycles will most likely result in detecting some samples with virus which is not infectious. As the PCR tests were granted emergency use by the FDA (samples include 2-9), it is not surprising that some debate exists currently about where the cycle threshold should be. Thresholds need to be set and validated for dozens of PCR tests currently in use. If identifying only infectious individuals is the goal, a lower cycle number may be justified. If detection of as many cases as possible to get closer to the most accurate death rate is the goal, setting the cycle threshold at 37-40 makes sense. A lower threshold will result in fewer COVID-19 positive samples being identified. It is worth noting that the emergency use approval granted by the FDA includes the disclaimer that a negative test does not guarantee that a person is not infected with COVID-19. RNA degrades easily. If samples are not kept cold or properly processed, the virus can degrade and result in a false negative result.
Source: 1 https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa638/5842165
2 https://www.fda.gov/media/134922/download
3 https://www.fda.gov/media/138150/download
4 https://www.fda.gov/media/137120/download
5 https://www.fda.gov/media/136231/download
6 https://www.fda.gov/media/136472/download
7 https://www.fda.gov/media/139279/download
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- Aug 2020
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ps.psychiatryonline.org ps.psychiatryonline.org
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what might be learned from the case. The answer, in part, is that prudent psychiatrists and other therapists will want to be thoughtful about how they arrange follow-up care for patients whom they can no longer see.Sometimes a general suggestion that a patient seek follow-up care will be adequate. However, as the patient's condition warrants, clinicians might choose, in ascending order of time commitment, to provide the patient with the name of a particular practitioner or facility, to contact the facility to ascertain that a clinician is willing to see the patient, to help the patient make an appointment, or, with the patient's permission, to make an appointment on the patient's behalf. In some cases, it may be appropriate to ask for the patient's permission to contact his or her family to indicate a need for follow-up and to encourage the family to make sure that follow-up takes place. But of these approaches, no specific one will always be indicated, and the degree of assistance rendered the patient should be calibrated to his or her individual needs.
What can be learned from this case?
- Carefully plan follow up plans with patients (general suggestion about follow up can be enough)
- Ask patient for family information to help them get involved in the follow up process and help increase compliance.
Consider:
- Giving the specific name of a provider to follow up with
- How to contact the facility,
- See if who you provided/recommended is avaliable to take the patient
- Help patient make the appointment or make it on their behalf (with permission)
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One final questionable aspect of the jury's verdict relates to the legal requirement that before a judgment of malpractice can be reached, any departures from the standard of care must be shown to have been the proximate cause of the resulting harms. The most common test for whether an act or omission constitutes a proximate cause is whether it was reasonably foreseeable at the time that the negligent act occurred that would result in the consequent harms. Williamson had no history of violent behavior and had never revealed a violent impulse during treatment. It is impossible to conclude that he was foreseeably dangerous at the time he was seen by Dr. Liptzin.
The test for proximate cause "is whether it was reasonably foreseeable at the time that the negligent act occurred that would result in the consequent harms"
In this case, Dr. Liptzin, having seen Williamson having no history of violence or anything else, could not reasonably foresee that Williamson was going to do something illegal.
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virtual.acc.org virtual.acc.org
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Welcome | Summer COVID-19 Education Series—ACC Virtual Education. (n.d.). Virtualacc. Retrieved August 5, 2020, from https://virtual.acc.org/cvcovid/welcome
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www.youtube.com www.youtube.com
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Understanding Risk with Professor Sir David Spiegelhalter | Pager Podcast. (2020, March 24). https://www.youtube.com/watch?v=nLl9HEz5vng&feature=youtu.be
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- Jul 2020
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docs.google.com docs.google.com
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COVID-19 Social Science Tracker - Google Sheets
Tags
- conspiracy theory
- spreadsheet
- tracker
- is:other
- analysis
- uncertainty
- data collection
- research
- social science
- publication
- healthcare
- mental health
- preprint
- community
- social norm
- behavior
- lang:en
- social media
- infection
- unofficial
- medicine
- sheets
- international
- COVID-19
- policy
- misinformation
- government
- social distancing
- isolation
Annotators
URL
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www.riskybusiness.events www.riskybusiness.events
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Risky Business. (2020, June 2). Lessons from COVID-19 - A free virtual conference. https://www.riskybusiness.events/lessons-from-covid-19-zoom-conference
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www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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Bae, J.-M. (2014). The clinical decision analysis using decision tree. Epidemiology and Health, 36. https://doi.org/10.4178/epih/e2014025
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www.biorxiv.org www.biorxiv.org
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osf.io osf.io
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Machado, D. F. T., de Siqueira, A. F., & Gitahy, L. (2020). Natural stings: Alternative health services selling distrust about vaccines on YouTube [Preprint]. SocArXiv. https://doi.org/10.31235/osf.io/vtf5r
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psyarxiv.com psyarxiv.com
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Fuhrer, J., & Cova, F. (2020). “Quick and dirty”: Intuitive cognitive style predicts trust in Didier Raoult and his hydroxychloroquine-based treatment against COVID-19. https://doi.org/10.31234/osf.io/ju62p
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bmcmedinformdecismak.biomedcentral.com bmcmedinformdecismak.biomedcentral.com
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Spiegelhalter, D. (2016). How old are you, really? Communicating chronic risk through ‘effective age’ of your body and organs. BMC Medical Informatics and Decision Making, 16(1), 104. https://doi.org/10.1186/s12911-016-0342-z
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- Jun 2020
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zoom.us zoom.us
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Welcome! You are invited to join a webinar: COVID-19 Series: Medical journals - Episode 24. After registering, you will receive a confirmation email about joining the webinar. (n.d.). Zoom Video. Retrieved June 20, 2020, from https://zoom.us/webinar/register/WN_4_dGVRvDQEWi_d7ll7kMtQ
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www.youtube.com www.youtube.com
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RSM COVID-19 Series | Episode 24: Medical Journals. (2020, June 24). YouTube. https://www.youtube.com/watch?v=et-kl5ypx8Q
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doi.org doi.org
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Horbach, S. P. J. M. (2020). Pandemic Publishing: Medical journals drastically speed up their publication process for Covid-19. BioRxiv, 2020.04.18.045963. https://doi.org/10.1101/2020.04.18.045963
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psyarxiv.com psyarxiv.com
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MacFarlane, D., Hurlstone, M. J., & Ecker, U. K. H. (2020, April 17). Countering Demand for Ineffective Health Remedies: Do Consumers Respond to Risks, Lack of Benefits, or Both?. https://doi.org/10.31234/osf.io/xqckm
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www.medscape.com www.medscape.com
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Dean, N. E. (2020, June 15). Asymptomatic Transmission? We Just Don’t Know. Medscape. Retrieved June 16, 2020, from http://www.medscape.com/viewarticle/932246
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www.newyorker.com www.newyorker.com
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Wallace-Wells, B. (2020, June 12). Can Coronavirus Contact Tracing Survive Reopening? The New Yorker. https://www.newyorker.com/news/us-journal/can-coronavirus-contact-tracing-survive-reopening
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Fung, D. J. (2018, April 10). The Corruption of Evidence Based Medicine—Killing for Profit. Medium. https://medium.com/@drjasonfung/the-corruption-of-evidence-based-medicine-killing-for-profit-41f2812b8704
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Ouyang, H. (2020, April 14). I’m an E.R. Doctor in New York. None of Us Will Ever Be the Same. The New York Times. https://www.nytimes.com/2020/04/14/magazine/coronavirus-er-doctor-diary-new-york-city.html
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www.nytimes.com www.nytimes.com
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Senior, J. (2020, May 3). Opinion | What One Doctor’s Suicide Taught Us. The New York Times. https://www.nytimes.com/2020/05/03/opinion/coronavirus-doctors-mental-health.html
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www.biorxiv.org www.biorxiv.org
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Transparent Peer Review
Download the complete Review Process [PDF] including:
- reviews
- authors' reply
- editorial decisions
</br>
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www.biorxiv.org www.biorxiv.org
-
Transparent Peer Review
Download the complete Review Process [PDF] including:
- reviews
- authors' reply
- editorial decisions
</br>
-
-
www.biorxiv.org www.biorxiv.org
-
Transparent Peer Review
Download the complete Review Process [PDF] including:
- reviews
- authors' reply
- editorial decisions
</br>
-
-
www.biorxiv.org www.biorxiv.org
-
Transparent Peer Review
Download the complete Review Process [PDF] including:
- reviews
- authors' reply
- editorial decisions
</br>
-
- May 2020
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jamanetwork.com jamanetwork.com
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Stephenson, J. (2020). European Medicines Agency Tackles Potential Shortages of Drugs for Treating COVID-19. JAMA Health Forum, 1(4), e200485–e200485. https://doi.org/10.1001/jamahealthforum.2020.0485
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onlinelibrary.wiley.com onlinelibrary.wiley.com
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Casas, R. S., Cooper, J. L., & Hempel, E. V. (2020). COVID‐19 risk triage: Engaging residents in telephonic screening. Medical Education, medu.14211. https://doi.org/10.1111/medu.14211
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jamanetwork.com jamanetwork.com
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Nundy, S., & Patel, K. K. (2020). Hospital-at-Home to Support COVID-19 Surge—Time to Bring Down the Walls? JAMA Health Forum, 1(5), e200504–e200504. https://doi.org/10.1001/jamahealthforum.2020.0504
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www.nejm.org www.nejm.org
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Zagury-Orly, I., & Schwartzstein, R. M. (2020). Covid-19—A Reminder to Reason. New England Journal of Medicine, NEJMp2009405. https://doi.org/10.1056/NEJMp2009405
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Lipsitch, M., Perlman, S., & Waldor, M. K. (2020). Testing COVID-19 therapies to prevent progression of mild disease. The Lancet Infectious Diseases, 0(0). https://doi.org/10.1016/S1473-3099(20)30372-8
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psyarxiv.com psyarxiv.com
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Fenton, N., Hitman, G. A., Neil, M., Osman, M., & McLachlan, S. (2020). Causal explanations, error rates, and human judgment biases missing from the COVID-19 narrative and statistics [Preprint]. PsyArXiv. https://doi.org/10.31234/osf.io/p39a4
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psyarxiv.com psyarxiv.com
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Olthof, M., Hasselman, F., & Lichtwarck-Aschoff, A. (2020, May 1). Complexity In Psychological Self-Ratings: Implications for research and practice. Retrieved from psyarxiv.com/fbta8
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- Apr 2020
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www.thelancet.com www.thelancet.com
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Newton, P. N., Bond, K. C., Adeyeye, M., Antignac, M., Ashenef, A., Awab, G. R., Babar, Z.-U.-D., Bannenberg, W. J., Bond, K. C., Bower, J., Breman, J., Brock, A., Caillet, C., Coyne, P., Day, N., Deats, M., Douidy, K., Doyle, K., Dujardin, C., … Zaman, M. (2020). COVID-19 and risks to the supply and quality of tests, drugs, and vaccines. The Lancet Global Health, S2214109X20301364. https://doi.org/10.1016/S2214-109X(20)30136-4
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