- Dec 2020
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www.thelancet.com www.thelancet.com
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Voysey, M., Clemens, S. A. C., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B., Baillie, V. L., Barnabas, S. L., Bhorat, Q. E., Bibi, S., Briner, C., Cicconi, P., Collins, A. M., Colin-Jones, R., Cutland, C. L., Darton, T. C., Dheda, K., Duncan, C. J. A., … Zuidewind, P. (2020). Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: An interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)32661-1
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- Sep 2020
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www.bmj.com www.bmj.com
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Siemieniuk, R. A., Bartoszko, J. J., Ge, L., Zeraatkar, D., Izcovich, A., Kum, E., Pardo-Hernandez, H., Rochwerg, B., Lamontagne, F., Han, M. A., Liu, Q., Agarwal, A., Agoritsas, T., Chu, D. K., Couban, R., Darzi, A., Devji, T., Fang, B., Fang, C., … Brignardello-Petersen, R. (2020). Drug treatments for covid-19: Living systematic review and network meta-analysis. BMJ, 370. https://doi.org/10.1136/bmj.m2980
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- Aug 2020
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jamanetwork.com jamanetwork.com
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Califf, Robert M., Adrian F. Hernandez, and Martin Landray. ‘Weighing the Benefits and Risks of Proliferating Observational Treatment Assessments: Observational Cacophony, Randomized Harmony’. JAMA 324, no. 7 (18 August 2020): 625–26. https://doi.org/10.1001/jama.2020.13319.
Tags
- benefits and risks
- false confidence
- causation
- proliferating observational treatment
- risks
- benefits
- treatment
- lang:en
- COVID-19
- epidemiology
- nonrandomised studies
- is:report
- randomised clinical trials
- assessments
- reliable truth
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Annotators
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Field, S. M., Hoek, J. M., de Vries, Y. A., Linde, M., Pittelkow, M., Muradchanian, J., & van Ravenzwaaij, D. (2020, July 30). Rethinking Remdesivir for COVID-19: A Bayesian Reanalysis of Trial Findings. https://doi.org/10.31222/osf.io/2kam7
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- Jun 2020
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behavioralscientist.org behavioralscientist.org
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Gauri, V. (2020 April 30). Behavioral Public Policy Faces a Crisis. Behavioral Scientist. https://behavioralscientist.org/behavioral-public-policy-faces-a-crisis/
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eml.berkeley.edu eml.berkeley.edu
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DellaVigna, S & Linos E. (2020). RCTs to scale: Comprehensive evidence from two nudge units. UC Berkeley. https://eml.berkeley.edu/~sdellavi/wp/NudgeToScale2020-03-20.pdf
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www.vox.com www.vox.com
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Matthews, D. (2020, May 20). How exposing healthy volunteers to Covid-19 for vaccine testing would work. Vox. https://www.vox.com/future-perfect/2020/5/20/21258725/covid-19-human-challenge-trials-vaccine-update-sars-cov-2
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- May 2020
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www.nature.com www.nature.com
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Callaway, E. (2020). The race for coronavirus vaccines: A graphical guide. Nature, 580(7805), 576–577. https://doi.org/10.1038/d41586-020-01221-y
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- Mar 2020
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www.clinicaltrials.gov www.clinicaltrials.gov
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215 clinical trials
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docs.google.com docs.google.com
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337 clinical trials
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- Mar 2017
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vivisectioninformation.com vivisectioninformation.com
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Unfortunately, penicillin was ineffective against the rabbit's infection. Disappointed, Fleming set the drug aside for a decade, as the rabbits had "proved" the drug was useless as a systemic medication.Years later, he administered the drug in desperation to a dying patient, for whom all other treatments were ineffectual. The penicillin performed a miracle, and the rest is history.
Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.
Article: Understanding animal research
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www.understandinganimalresearch.org.uk www.understandinganimalresearch.org.uk
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Had Fleming himself carried out a simple and well established animal test - the mouse protection test - the potential of his discovery might have been realised 10 years earlier
Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.
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- Sep 2015
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www.americanyawp.com www.americanyawp.com
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III. Turmoil in Britain
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