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Hilda Bastian, PhD. (2021, February 6). Unofficial unnamed AstraZeneca insider says they are doing the interim analysis for the US trial of the Oxford vaccine. AstraZeneca spokesperson says 4-6 weeks till data release. Https://t.co/VUHgbHN02d One is wrong? Or they’ll release only when have FDA minimum follow-up? Https://t.co/LgjfX8AIti [Tweet]. @hildabast. https://twitter.com/hildabast/status/1357862227106095105

ChAdOx1 nCov-19 provides minimal protection against mild-moderate COVID-19 infection from B.1.351 coronavirus variant in young South African adults | University of Oxford. (n.d.). Retrieved February 18, 2021, from https://www.ox.ac.uk/news/2021-02-07-chadox1-ncov-19-provides-minimal-protection-against-mild-moderate-covid-19-infection

Staff, R. (2021, February 6). AstraZeneca thinks shot can stop severe disease from South Africa COVID variant. Reuters. https://www.reuters.com/article/uk-health-coronavirus-astrazeneca-respon-idUKKBN2A60S2

Staff, R. (2021, February 5). AstraZeneca expects U.S. trial results in next 4-6 weeks, research chief says. Reuters. https://www.reuters.com/article/uk-health-coronavirus-astrazeneca-usa-idUSKBN2A522V

Steinhauser, G. (2021, February 7). Rollout of AstraZeneca Covid-19 Vaccine Halted in South Africa After Study. Wall Street Journal. https://www.wsj.com/articles/astrazeneca-vaccine-doesnt-protect-against-mild-and-moderate-cases-from-south-africa-strain-11612700385

Kai Kupferschmidt. (2021, March 16). “I’m not here to give you the outcome of any scientific review”, says EMA director Emer Cooke at start of press conference on AstraZeneca vaccine safety. ‘I’m here to explain the steps in the process, what we’re doing, and when you can expect us to come to a conclusion.’ [Tweet]. @kakape. https://twitter.com/kakape/status/1371811123197001729

the Guardian. ‘Small Number of Facebook Users Responsible for Most Covid Vaccine Skepticism – Report’, 16 March 2021. http://www.theguardian.com/technology/2021/mar/15/facebook-study-covid-vaccine-skepticism.

A Few People Developed a Rare Blood Disorder, Immune Thrombocytopenia, After Getting a COVID Vaccine | Health.com. (n.d.). Retrieved March 17, 2021, from https://www.health.com/condition/infectious-diseases/coronavirus/rare-blood-disorder-covid-vaccine-thrombocytopenia

London, Alex John, and Jonathan Kimmelman. ‘Against Pandemic Research Exceptionalism’. Science 368, no. 6490 (1 May 2020): 476–77. https://doi.org/10.1126/science.abc1731.

November 19: “Randomisation and control in the age of coronavirus?” (Stephen Senn). (2020, October 30). PhilStatWars. https://phil-stat-wars.com/2020/10/30/november-19-randomisation-and-control-in-the-age-of-coronavirus-stephen-senn/

ReconfigBehSci. (2020, October 31). RT @learnfromerror: PHIL STAT FORUM NOVEMBER 19; STEPHEN SENN ‘Randomisation and Control in the Age of Coronavirus?’ https://t.co/hqT8GWTqC… [Tweet]. @SciBeh. https://twitter.com/SciBeh/status/1323311706609721344

Voysey, M., Clemens, S. A. C., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B., Baillie, V. L., Barnabas, S. L., Bhorat, Q. E., Bibi, S., Briner, C., Cicconi, P., Collins, A. M., Colin-Jones, R., Cutland, C. L., Darton, T. C., Dheda, K., Duncan, C. J. A., … Zuidewind, P. (2020). Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: An interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet, 0(0). https://doi.org/10.1016/S0140-6736(20)32661-1

Siemieniuk, R. A., Bartoszko, J. J., Ge, L., Zeraatkar, D., Izcovich, A., Kum, E., Pardo-Hernandez, H., Rochwerg, B., Lamontagne, F., Han, M. A., Liu, Q., Agarwal, A., Agoritsas, T., Chu, D. K., Couban, R., Darzi, A., Devji, T., Fang, B., Fang, C., … Brignardello-Petersen, R. (2020). Drug treatments for covid-19: Living systematic review and network meta-analysis. BMJ, 370. https://doi.org/10.1136/bmj.m2980

Califf, Robert M., Adrian F. Hernandez, and Martin Landray. ‘Weighing the Benefits and Risks of Proliferating Observational Treatment Assessments: Observational Cacophony, Randomized Harmony’. JAMA 324, no. 7 (18 August 2020): 625–26. https://doi.org/10.1001/jama.2020.13319.

Field, S. M., Hoek, J. M., de Vries, Y. A., Linde, M., Pittelkow, M., Muradchanian, J., & van Ravenzwaaij, D. (2020, July 30). Rethinking Remdesivir for COVID-19: A Bayesian Reanalysis of Trial Findings. https://doi.org/10.31222/osf.io/2kam7

Gauri, V. (2020 April 30). Behavioral Public Policy Faces a Crisis. Behavioral Scientist. https://behavioralscientist.org/behavioral-public-policy-faces-a-crisis/

DellaVigna, S & Linos E. (2020). RCTs to scale: Comprehensive evidence from two nudge units. UC Berkeley. https://eml.berkeley.edu/~sdellavi/wp/NudgeToScale2020-03-20.pdf

Matthews, D. (2020, May 20). How exposing healthy volunteers to Covid-19 for vaccine testing would work. Vox. https://www.vox.com/future-perfect/2020/5/20/21258725/covid-19-human-challenge-trials-vaccine-update-sars-cov-2

Callaway, E. (2020). The race for coronavirus vaccines: A graphical guide. Nature, 580(7805), 576–577. https://doi.org/10.1038/d41586-020-01221-y

215 clinical trials

337 clinical trials

Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.

Article: Understanding animal research

Interesting how these two sources contradict each other with regards to why Fleming did not release Penicillin for ten years.

Article: Would drugs be safe for us without animal tests?

Week 5 Video Lecture