for - evolutionary biology - Weissman barrier - refuted by modern research - Denis Noble

for - evolutionary biology - Denis Noble - journey from reductionist to non-reductionist - ion channel and cell membrane work - connects to bioelectricity in the entire body

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for - evolutionary biology - human culture - why it is dominant - openendedness

summary - the claim of this paper is that culture is not something unique to humans, but what is is - our open-ended understanding of the world that allows us to fractally nest many different subtasks.

for - example - evolutionary biology - openendedness - making breakfast

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for - crisis management - cellular biology example - Michael Levin

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Annotating the syllabus allows you to identify questions and clarify course expectations, in addition to practicing using the annotation tool.

Biology is the study of life and living organisms, encompassing everything from the smallest microorganisms to the largest ecosystems. It's a field that reveals the intricate processes that sustain life, offering insights into the complexity of the natural world and the interdependence of all living things.

for - planetary boundaries - ocean biology - net primary production

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Everywhere this term appears below, please also consider the lack of language to describe genesis as a whole:

• Life Itself
• A Revolution in Biology - by Kasra - Bits of Wonder

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for - follow up - book - The Music of Life - Biology Beyond Genes

to - book - The Music of Life - Biology Beyond Genes - https://hyp.is/OI8RVBYIEe-t-rObPCPKoQ/www.univ.ox.ac.uk/book/the-music-of-life-biology-beyond-genes/

for - individual / collective gestalt - gene centrism - paradigm shift - adjacency - mistake of 20th century biology - reductionism - separating organism from environment - individual / collective gestalt, individual / environment gestalt - quote - mistake of 20th century biology - Ray Noble - key insight - mistake of 20th century biology- Ray Noble

quote - mistake of 20th century biology - Ray Noble - (see below)

• I think one of the other mistakes that have been made in biology of the 20th century
  • was to treat organisms as if they existed within an environment that was sort of like some nebulous box as it were
  • and you could study the organism by taking it out
  • and you study it in isolation
• It's the beginning of reductionism in a sense because
  • you taken it away from the environment but the organism has an intimate relationship with the environment
• It's feeding both
  • to the environment and
  • from the environment
• What is that environment?
  • That environment in large part is
    • other organisms of the same species but
    • other organisms of different species
• and it's in a continuous bubble of change
• It's like a cauldron of change
• So the big question for life is
  • how do you maintain yourself in this cauldron of change?
• You cannot do it by standing still
• You have to respond to it
  • so it's not surprising therefore that you find that you know organisms have mechanisms for responding to those changes

adjacency - mistake of 20th century biology - between - reductionism - separating organism from environment - individual / collective gestalt, - individual / environment gestalt - adjacency relationship - The mistake that 20th century biology has made is in - ascribing too much power to the gene, and - minimizing the role of epigenetics - Focusing the majority of attention and resources on the genes of the organism, and - defocusing attention on the organisms (epigenetic) interactions with the environment, including both - biotic elements and - abiotic elements - It's not the case that the genes are the major determinant factor and the epigenetics play a minor role - It IS the case that epigenetics play an equally important role in transmitting and assimilating features into the genome - The individual organism is intertwingled with its environment and with other living organisms - The individual / collective gestalt and the individual / environment gestalt is the appropriate unit of study

for - paradigm shift - evolutionary biology - epigenetic's critical role in inheritance - experimental proof - C. Elegan - Oded Rechavi

for - explanation - evolutionary biology - neo-darwinian mistake - view of epigenetic inheritance

explanation - evolutionary biology - neo-darwinian mistake - view of epigenetic inheritance - Neo-darwinians believe that epigenetic inheritance is only short lived. - However, the Noble brothers contend that if the changes in the environment last for many generations, - the epigenetic change can exceed a threshold and become permanently assimilated into the genome - Such a threshold is plausible because without it, a permanent change encoded into the genome would be maladaptive if the environmental change reverted back to the previous state

for - quote - 70 years of evolutionary biology has to be undone

for - evolutionary biology - purpose in nature Denis Noble - Ray Noble

for - physiology rescues evolutionary biology - Denis Noble

from - youtube - IAI interview - Why Dawkins is Wrong - Denis Noble

for - paper - Physiology restores purpose to evolutionary biology - Denis Noble - Raymond Noble - year - 2023

from - youtube - IAI interview - Why Dawkins is wrong - Denis Noble - https://hyp.is/eqKOYhVVEe-XVKuwMtOTTg/docdrop.org/video/dCLRKP9NW8I/

for - key insight - eliminating cartesian dualism in biology - creativity - multi-scale explanation

key insight - eliminating cartesian dualism in biology - Noble advances a radical and simple explanation to explain how<br /> - higher level organisms and cellular mechanisms make the decisions that inform the genetic switches which decision path to make - The higher level system takes advantage of the random events in molecular mechanisms and chooses the ones that are most fit - This has the potential to explain creativity at all living scales, up to human consciousness itself!

for - molecular biology - paradigm shift - living system - 4 common misunderstandings - book - Understanding Living Systems - 4 common misunderstandings

4 common misunderstandings of living systems - 1. The central dogma of molecular biology - one way causation - Genes (DNA) to - proteins to - organism - 2. The Weismann Barrier - 3. DNA as self-replicator - 4. Separation of Replicator (DNA) and Vehicle (Living cell) are completely separate

for - book - Biology Beyond the Genome - author - scientist - biologist - Denis Noble - book - Understanding Living Systems

for - Keith Baverstock - paper - The Gene and Appraisal

from - youtube - Biology Beyond the Gene - Denis Noble - https://hyp.is/UrvwdhVDEe-QWrPAx9y1aw/docdrop.org/video/bzXFSufDDn8/

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adjacency - between - existential isolation - desire and fear - adjacency statement -Desire of the other emerges from a sense of lack in the totality of reality - fear of the other emerges from a sense of avoidance of aspects of reality - Biologically , we have an innate desire and fear instinct - We desire to that which helps us survive - We fear that which threatens our survival - The psychological construction of the self takes cues from this biological attraction and aversion - the self-consciousness of the biological self as individual that is a separate entity from the environment - It is interesting to ponder how we could reconcile this difference

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for - adjacency - microscopic biology - macroscopic ecology - multi-scale competency architecture - Michael Levin - Jonas Wickman - micro-to-macro

paper details - title - Eco-evolutionary emergence of macroecological scaling in plankton communities - author - Jonas Wickman - Elena Litchman - date - feb 15, 2024 - publication - Science VOL. 383, NO. 6684

reference - https://www.science.org/doi/10.1126/science.adk6901

summary - This is a very interesting finding that links rules in the micro world to behavior in the macro. - It is relevant to Michael Levin's research on multi-scale competency architecture

question - how would this impact the micro relations between - the microscopic world of humans - the normal macroscopic world of humans

for - litigation terrorism - ISDS - corporate tribunal system - Michael Levin - multi-scale competency architecture - example - adjacency - evolutionary biology - corporate law - climate crisis

adjacency - between - corporate law - climate crisis - evolutionary biology - cultural evolution - adjacency statement - Biologist Michael Levin's multi-scale competency architecture of evolutionary biology seems to apply here - in the field of corporate law - Corporations can be viewed as one level of a social superorganism in a cultural evolution process - Governments can be viewed similiarly, but at a higher level - The ISDS is being weaponized by the same corporations destroying the global environment to combat the enactment of government laws that pose a threat to their livelihood - Hence, the ISDS has been reconfigured to protect the destroyers of the environment so that they can avoid dealing with their unacceptable externalizations - The individual existing at the lower level of the multi-scale competency architecture(the corporation) is battling to survive against the wishes of the higher level individual (the government) in the same multi-scale competency architecture

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for - multi scale competency architecture - Michael Levin - evolutionary biology - rapid whole system change - adjacency - multi scale competency architecture - rapid whole system change - stop reset go - Deep Humanity - Indyweb - Indranet - major evolutionary transition in individuality - MET - superorganism - cumulative cultural evolution of individuality

adjacency - between - multi scale competency architecture - rapid whole system change - progress trap - stop reset go - Deep Humanity - Indyweb - Indranet - major evolutionary transition in individuality - MET - superorganism - cumulative cultural evolution of individuality - adjacency statement - The idea of multi scale competency architecture can be extended to apply to the cultural level. - in the context of humanity's current existential poly /meta/ perma crisis, - rapid whole system change - (a cultural behavioural paradigm shift) - is required within a few short years - to avoid the worst impacts of - catastrophic, - anthropogenic - climate change, which is entangled with a host of other earth system boundary violations including - biodiversity loss - fresh water scarcity - - the driver of evolution through major evolutionary transitions in individuality has given rise to the level of cultural superorganisms that include all previous levels - progress and its intended consequences of progress traps play a major role in determining the future evolutionary trajectory of our and many other species - our species is faced with a few choice permutations in this regard: - individually regulate behaviour aligned with a future within earth system boundaries - collectively regulate behaviour aligned with a future within earth system boundaries - pursue sluggish green growth / carbon transition that is effectively tinkering at the margins of rapid whole system change - BAU - currently, there doesn't appear to be any feasible permutation of any of the above choices - There is insufficient worldview alignment to create the unity at scale for report whole system change - individual incumbent state and corporate actors still cling too tightly to the old, destructive regime, - creating friction that keeps the actual rate of change below the required - Stop Reset Go, couched within the Deep Humanity praxis and operationalized through the Indyweb / Indranet individual / collective open learning system provides a multi-dimensional tool for a deep educational paradigm shift that can accelerate both individual and collective upregulation of system change

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for - healthy eating - Dr. William Li - nutrition - healthy food - inflammation - angiogenesis

summary - A good interview about human health and healthy diet. William Li begins by talking about angiogenesis as a key aspect of human health - and how pathology of angiogenesis is at the root of many major diseases. - The interviewer then asks Dr. Li about the connection between another keystone disease, and angiogenesis. - Dr. Li then describes some healthy foods and good dietary practices including extra virgin olive oil.

adjacency - between - angiogenesis - inflammation - Micheal Levine's work - evolutionary biology - adjacency statement - they all seem related, as evolutionary biology has created legacy subsystems within the human body

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for - Michael Levin - Developmental biology - evolutionary biology

for - Micheal Levin - developmental biology - evolutionary biology - cellular intelligence

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• annotate

• for: evolutionary biology, big history, DH, Deep Humanity, theories of consciousness, ESP project, Earth Species Project, Michael Levin, animal communication, symbiocene

• title: The Deep History of Ourselves: The Four-Billion-Year Story of How We Got Conscious Brains

• author: Joseph LeDoux
• date: Jan. 2023

• doi: 0.1080/09515089.2022.2160311

• ABSTRACT

  • The essence of who we are depends on our brains.
  • They enable us to think, to
    • feel joy and sorrow,
    • communicate through speech,
    • reflect on the moments of our lives, and to
      • anticipate,
      • plan for, and
      • worry about our imagined futures.
  • Although some of our abilities are comparatively new, key features of our behavior have deep roots that can be traced to the beginning of life.
  • By following the story of behavior, step-by-step, over its roughly four-billion-year trajectory,
    • we come to understand both
      • how similar we are to all organisms that have ever lived, and
      • how different we are from even our closest animal relatives.
  • We care about our differences because they are ours. But differences do not make us superior; they simply make us different.

• comment

  • good article to contribute to a narrative of the symbiocene and a shift of humanity to belonging to nature as one species, instead of dominating nature as the apex species
• question
  • @Gyuri, Could indranet search algorithm have made the connection between this article and the symbiocene artilces in my mindplex had I not explicitly made the associations manually through my tags? It needs to be able to do this
• Also interesting to see how this materialistic outlook of consciousness
  • which is similiar to the Earth Species Project work and Michael Levin's work on synthesizing new laboratory life forms to answer evolutionary questions about intelligence
• relates to nonmaterial ideas about consciousness

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