- May 2024
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www.univ.ox.ac.uk www.univ.ox.ac.uk
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for - critique of - Gene Centricity - Denis Noble
from - youtube -Evolution 2 Podcast Interview - Denis Noble - Book - Understanding Living Systems - https://hyp.is/-EuWvBYHEe-t9xtn9h1dhA/docdrop.org/video/oHZI1zZ_BhY/
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if you want to age well do something it can be dancing it can be music it can be all sorts swimming 00:56:47 whatever but do something that's the first bit of advice to those who want to make sure that they stay um on top
for - health advice - aging well - Denis Noble
health advice - aging well - ll if you want to age well do something! - It can be - dancing - music - swimming - whatever but do something - That's the first bit of advice to those who want to make sure that they stay on top
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you may never change it back just as we 00:34:52 may not change back genetic manipulation we might do in in the germline which is a reason we should be very cautious about doing it
for - progress trap - genetic engineering - Denis Noble
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for - Denis Noble - Ready Noble - evolutionary biology - critique of Richard Dawkins Selfish Gene theory - critique of gene centrism - book - Understanding Living Systems - human agency
summary - In this informative interview, brothers Denis and Ray Noble discuss their new book - Understanding Living Systems, and - dispel the 70 year old narrative of Gene centrism and the selfish gene as determining the high level behaviour of living organisms
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www.nature.com www.nature.com
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for - recombination of proteins in higher level proteins - from - youtube - Evolution 2 podcast interview - book - Understanding Living Systems - Denis Noble - Ray Noble
from - youtube - Evolution 2 podcast interview - book - Understanding Living Systems - Denis Noble - Ray Noble - https://hyp.is/OttWABYFEe--gLNFyeNyTw/docdrop.org/video/oHZI1zZ_BhY/
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english.tau.ac.il english.tau.ac.il
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for - Oded Rechavi - neurobiology - gene centrism - critique - from - youtube podcast interview - book - Understanding Living Systems - Ray Noble - Denis Noble
summary - Rechavi performed experiments with C Elegan and demonstrated that it possesses a type of neuron that - produces RNA that in response to elevated temperature change is transmitted to reproductive cells so that the offsprings encode it in the genome, and it is better adapted to deal with elevated temperatures
question - How many species do this? Is it generally found throughout nature?
from - outube podcast interview - book - Understanding Living Systems - Ray Noble - Denis Noble - https://hyp.is/OUlGVBXrEe-iaBeZhH_4DQ/docdrop.org/video/oHZI1zZ_BhY/
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a more holistic approach to the organism rather than a reductionist one I'm afraid we have to because 00:26:36 reductionism has failed
for - quote - reductionism has failed - Denis Noble
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could physiology rescue genomics
for - follow up - paper - Could physiology rescue genomics?
to - Could physiology rescue genomics? - https://hyp.is/bslQ-BVVEe-hgF-rrNmjrA/academic.oup.com/biolinnean/article/139/4/357/6604006
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if you could correct this Gene would we have the future reassured and we can then avoid all of these diseases I very much doubt it and I think it's very dangerous 00:23:49 because
for - adjacency - progress trap - Crispr - gene therapy - Denis Noble - human genome project
adjacency - between - human genome project - gene therapy - Crispr - progress trap - adjacency relationship - The idea that we can find specific causal relationships between genes and disease and use gene therapy to cure disease, - an envisioned goal of the human genome project - can be very dangerous because - usually one gene collaborates with many other genes to bring about an effect - If we don't know all the relationships, we can bring about a progress trap
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if I met a robot that looked very much like a beautiful girl and everything went fine together with her and me but
for - comparison - human vs AI robot - Denis Noble
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essentially Darwin would never have been a neo-darwinian
for - quote - Darwin would never have been a Neo-Darwinian - Denis Noble
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you've used a metaphor in the past of thinking of genes not as a as a code as you said but as a kind of musical score
for - metaphor - genes - musical scores - Denis Noble
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if we didn't have people who were wrong we wouldn't be where we are
for - quote - being wrong - Denis Noble
quote - Being wrong - Denis Noble - If we didn't have people who were wrong - we wouldn't be where we are
Tags
- to - paper - Could physiology rescue genomics? - Denis Noble
- quote - Reductionism has failed - Denis Noble
- quote - Darwin would never have been a neo-darwinian
- metaphor - genes - musical scores - Denis Noble
- comparison - human vs AI robot - Denis Noble
- quote - Being wrong - Denis Noble
- adjacency - human genome project - gene therapy - Crispr - progress trap - Denis Noble
- quote - Denis Noble
Annotators
URL
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models.cellml.org models.cellml.org
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for - physiology rescues evolutionary biology - Denis Noble
from - youtube - IAI interview - Why Dawkins is Wrong - Denis Noble
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academic.oup.com academic.oup.com
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for - paper - Physiology restores purpose to evolutionary biology - Denis Noble - Raymond Noble - year - 2023
from - youtube - IAI interview - Why Dawkins is wrong - Denis Noble - https://hyp.is/eqKOYhVVEe-XVKuwMtOTTg/docdrop.org/video/dCLRKP9NW8I/
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four 00:08:25 major common misunderstandings that have infected our understanding of what it is to be a living system
for - molecular biology - paradigm shift - living system - 4 common misunderstandings - book - Understanding Living Systems - 4 common misunderstandings
4 common misunderstandings of living systems - 1. The central dogma of molecular biology - one way causation - Genes (DNA) to - proteins to - organism - 2. The Weismann Barrier - 3. DNA as self-replicator - 4. Separation of Replicator (DNA) and Vehicle (Living cell) are completely separate
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a baby cannot be born selfish it simply has needs
for - quote - Denis Noble - quote - baby not born selfish
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biology Beyond The 00:00:19 genome
for - book - Biology Beyond the Genome - author - scientist - biologist - Denis Noble - book - Understanding Living Systems
Tags
- quote Denis Noble
- book - Understanding Living Systems - 4 common misunderstandings
- Denis Noble
- quote - baby not born selfish
- book - Understanding Living Systems
- molecular biology - paradigm shift - Denis Noble
- book - Biology Beyond the Genome
- living system - 4 common misunderstandings
Annotators
URL
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www.researchgate.net www.researchgate.net
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for - Keith Baverstock - paper - The Gene and Appraisal
from - youtube - Biology Beyond the Gene - Denis Noble - https://hyp.is/UrvwdhVDEe-QWrPAx9y1aw/docdrop.org/video/bzXFSufDDn8/
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