12 Matching Annotations
  1. May 2021
  2. Dec 2020
    1. In the second idea, German chemist Manfred Eigen described what he called a “hypercycle,” in which several autocatalytic sets combine to form a single larger one. Eigen’s variant introduces a crucial distinction: In a hypercycle, some of the chemicals are genes and are therefore made of DNA or some other nucleic acid, while others are proteins that are made-to-order based on the information in the genes. This system could evolve based on changes—mutations—in the genes, a function that Kauffman’s model lacked.
    2. In 1971 Gánti tackled the problem head-on in a new book, Az Élet Princípiuma, or The Principles of Life. Published only in Hungarian, this book contained the first version of his chemoton model, which described what he saw as the fundamental unit of life. However, this early model of the organism was incomplete, and it would take him another three years to publish what is now regarded as the definitive version—again only in Hungarian, in a paper that is not available online.
    3. In 1966 he published a book on molecular biology called Forradalom az Élet Kutatásában, or Revolution in Life Research, a dominant university textbook for years—partly because few others were available. The book asked whether science understood how life was organized, and concluded that it did not.
    4. That’s because he devised a model of the simplest possible living organism, which he called the chemoton, that points to an exciting explanation for how life on Earth began.

      Tibor Gánti

  3. Oct 2020
    1. they found that the glyoxylate and pyruvate reacted to make a range of compounds that included chemical analogues to all the intermediary products in the TCA cycle except for citric acid. Moreover, these products all formed in water within a single reaction vessel, at temperatures and pH conditions mild enough to be compatible with conditions on Earth.
    1. In the meantime, the classification of viruses remains unclear. Tupanviruses seem to be dependent on their hosts for very little, and other viruses, according to one preprint, even encode ribosomal proteins. “The gap between cellular organisms and viruses is starting to close,” Deeg said.

      Is there a graph of known viruses categoriezed by the machinery that they do or don't have? Can they be classified and sub-classified so that emergent patterns come forward thus allowing us to trace back their ancestry?

    1. Chetty is also using tax data to measure the long-term impacts of dozens of place-based interventions, such as enterprise zones, which use tax and other incentives to draw businesses into economically depressed areas.

      It wasn't this particular piece of text, but roughly at about here I had the thought that these communities could be looked at as life from an input /output perspective in relation to homeostasis. Essentially they're being slowly starved out and killed in a quietly moral yet amoral way. As a result entropy is slowly killing them and also causing problems for the society around them that blames the them for their own problems. Giving them some oxygen to breathe and thrive will fix so many of the problems.

  4. Jul 2019
    1. If all giant viruses turn out to share translation-related genes that are unique to their group, then it would mean they had a large common ancestor, an ancient virus that diversified over time, and it would lend support to the idea that giant viruses started out big and constitute their own domain of life.
    2. That mingling has sparked contentious debate among scientists about when and how giant viruses evolved. All of viral evolution is murky: Different groups of viruses likely had very different origins. Some may have been degenerate “escapees” from cellular genomes, while others descended directly from the primordial soup. “Still others have recombined and exchanged genes so many times in the course of evolution that we will never know where they originally came from,” Fischer said.
  5. Feb 2019
    1. ಅನಾದಿಯಾಗಿ ಪಶು ಪಾಶ ಮಲ ಮಯಾಕರ್ಮಗಳುಂಟಾದರೆ,ಈ ಜಗವನೊಬ್ಬರೂ ಸೃಷ್ಟಿಮಾಡಿದ ಕರ್ತುವಲ್ಲ.ಎಂದೆಂದೂ ಜಗವಿದ್ದಿತ್ತು ನಿತ್ಯವೆನ್ನು.ಎಂದೆಂದೂ ಜಗವಿದ್ದಿತ್ತೆಂಬೆಯಾದರೆ,ಶಿವನ ಸೃಷ್ಟಿ, ಸ್ಥಿತಿ, ಸಂಹಾರ, ಸ್ಥಿರೋಭಾವ, ಅನುಗ್ರಹವೆಂಬಪಂಚಕೃತ್ಯಗಳು ಹುಸಿಯೆಂದೆನ್ನು.ಶಿವನಿಗೆ ಸೃಷ್ಟಿ ಸ್ಥಿತಿ ಸಂಹಾರಾರ್ಥವುಂಟಾದರೆ,ಈ ಜಗತ್ತೆಲ್ಲವೂ ಶಿವನ ನೆನಹು ಮಾತ್ರದಿಂದ ಹುಟ್ಟಿತ್ತಲ್ಲದೆ,ಎಂದೆಂದೂ ಉಂಟೆಂಬುದು ಶೈವ ಪಶುಮತವಲ್ಲದೆ,ವೀರಶೈವರ ಮತವಲ್ಲ.ವೀರಶೈವರ ಮತವೆಂತೆಂದಡೆ:ಘನ ಗಂಬ್ಥೀರ ವಾರಿದ್ಥಿಯೊಳಗೆ ಫೇನತರಂಗಬುದ್ಬುದ ಶೀಕರಾದಿಗಳು ತೋರಿದಡೆ,ಆ ಸಾಗರ ಹೊರಗಾಗಿ ತೋರಬಲ್ಲವೇ?ಆ ಪರಶಿವಸಾಗರದಲ್ಲಿ ತೃಣಾದಿ ಬ್ರಹ್ಮಾಂತವಾದ ದೇಹಿಗಳುಉತ್ಪತ್ತಿಯಾಗಿ ಮತ್ತಲ್ಲಿಯೇ ಅಡಗುತ್ತಿಪ್ಪರು ನೋಡಾ.ಇದು ಕಾರಣ, ಲಿಂಗನಿರ್ಮಿತದಿಂದ ಜಗತ್ತಾಯಿತೆಂದೆ ಕಾಣಾ,ಮಹಾಲಿಂಗಗುರು ಶಿವಸಿದ್ಧೇಶ್ವರ ಪ್ರಭುವೇ.
  6. Nov 2018
    1. ಅನಾದಿಯಾಗಿ ಪಶು ಪಾಶ ಮಲ ಮಯಾಕರ್ಮಗಳುಂಟಾದರೆ,ಈ ಜಗವನೊಬ್ಬರೂ ಸೃಷ್ಟಿಮಾಡಿದ ಕರ್ತುವಲ್ಲ.ಎಂದೆಂದೂ ಜಗವಿದ್ದಿತ್ತು ನಿತ್ಯವೆನ್ನು.ಎಂದೆಂದೂ ಜಗವಿದ್ದಿತ್ತೆಂಬೆಯಾದರೆ,ಶಿವನ ಸೃಷ್ಟಿ, ಸ್ಥಿತಿ, ಸಂಹಾರ, ಸ್ಥಿರೋಭಾವ, ಅನುಗ್ರಹವೆಂಬಪಂಚಕೃತ್ಯಗಳು ಹುಸಿಯೆಂದೆನ್ನು.ಶಿವನಿಗೆ ಸೃಷ್ಟಿ ಸ್ಥಿತಿ ಸಂಹಾರಾರ್ಥವುಂಟಾದರೆ,ಈ ಜಗತ್ತೆಲ್ಲವೂ ಶಿವನ ನೆನಹು ಮಾತ್ರದಿಂದ ಹುಟ್ಟಿತ್ತಲ್ಲದೆ,ಎಂದೆಂದೂ ಉಂಟೆಂಬುದು ಶೈವ ಪಶುಮತವಲ್ಲದೆ,ವೀರಶೈವರ ಮತವಲ್ಲ.ವೀರಶೈವರ ಮತವೆಂತೆಂದಡೆ:ಘನ ಗಂಬ್ಥೀರ ವಾರಿದ್ಥಿಯೊಳಗೆ ಫೇನತರಂಗಬುದ್ಬುದ ಶೀಕರಾದಿಗಳು ತೋರಿದಡೆ,ಆ ಸಾಗರ ಹೊರಗಾಗಿ ತೋರಬಲ್ಲವೇ?ಆ ಪರಶಿವಸಾಗರದಲ್ಲಿ ತೃಣಾದಿ ಬ್ರಹ್ಮಾಂತವಾದ ದೇಹಿಗಳುಉತ್ಪತ್ತಿಯಾಗಿ ಮತ್ತಲ್ಲಿಯೇ ಅಡಗುತ್ತಿಪ್ಪರು ನೋಡಾ.ಇದು ಕಾರಣ, ಲಿಂಗನಿರ್ಮಿತದಿಂದ ಜಗತ್ತಾಯಿತೆಂದೆ ಕಾಣಾ,ಮಹಾಲಿಂಗಗುರು ಶಿವಸಿದ್ಧೇಶ್ವರ ಪ್ರಭುವೇ.