4 Matching Annotations
  1. Nov 2021
    1. The average circulating blood volume in schizo-phrenia is 3917 cc. as compared with 4573 cc. in manic-depressivepsychosi

      That's nearly a 15% reduction! It's also comparable to reductions seen in CFS (though CFS was per weight rather than per surface area, they should be comparable metrics). However, this is in comparison to bipolar, who themselves probably lack normal blood volume, so it's possible schizophrenia is a more extreme version of CFS where the blood volume is radically reduced. Will need more studies.

  2. Oct 2021
    1. 59 (8)

      I notice the standard deviation is low for their sample size. Normally smaller sample sizes increase SD. However, comparing to a study with 30 subject per group, we can see the expected SD for blood volume (ml/kg) in this sample size of 20 should be greater than ±22.

      The reason for this small SD is probably that subjects with ME/CFS are scrunched up against the lower end of the curve. The body simply will not allow blood volumes below a certain level. Judging by this study, I'd say around 50 ml/kg is the lowest possible number.

  3. Jan 2020
    1. RESULTS: In the hypothyroid state, the plasma volume measured by dilution of 125I-albumin (APV) was higher than the calculated plasma volume (CPV) from packed red cell mass, suggesting an extravascular escape of albumin. After substitutive therapy, the CPV showed a statistical increase (P < 0.05), whereas APV remained unchanged. Both ERPF and GFR increased after thyroxine therapy (p < 0.05). In the subclinical group, blood volumes and renal function were similar to those found in the other group of patients when in the euthyroid state.

      If this holds true, I'd expect rapid blood volume expansion from thyroid hormone. I'm also interested in whether thyroid hormone stimulates the production of albumin, given its anabolic properties.

    1. Thyrotoxicosis creates a hyperdynamic circulatory state because of a marked fall in peripheral vascular resistance and associated increase in venous return, increased total blood volume, increased cardiac contractility and heart rate.

      If the mechanism is really the same as alpha blockers, then the blood volume expansion may be expected to be similar in constitution. However, I would expect more red blood cells in thyroid mediated volume expansion compared to alpha blockers. The reason, obviously, is because of the increased oxygen demand from thyroid hormone.